This study examined the effectiveness of three instructional and assessment strategies on conceptual understanding of the DNA molecule. Specifically, a model building task was utilized to determine if physical model construction, digital model construction with a touchscreen tablet computer, or paper worksheet activity effected conceptual understanding during the initial exposure to an abstract science concept. The DNA molecule was chosen as an exemplary three-dimensional, abstract concept with physical and digital model building interventions. Conceptual understanding was measured using an objective quiz, a drawing of a DNA molecule, and a hand-written explanation of DNA. Conceptual understanding was measured immediately after intervention and again two months later. The study examined effects to conceptual understanding of model building by comparing physical models constructed using foam pieces and digital models constructed using a touchscreen tablet computer. A control group completed a paper worksheet activity on the topic of DNA. In all conditions, an instructional video about DNA was used to standardize the content taught. To account for the potential covariates of spatial ability and attitudes to scientific inquiry, participants completed a mental rotation test to measure spatial ability and an attitudes to scientific inquiry survey. A total of 161 students across six intact 9th-grade Living Environment classrooms participated in the study. The results from the three conceptual understanding measures were compared among the three groups at both immediate and delayed post-test timepoints as well as across the two post-test timepoints. For both immediate and delayed post-test, there were no differences among the groups for the objective quiz measure. However, the physical model group outperformed the digital model and control groups in both the drawing and explanation measures at both timepoints (p < 0.01). Across the two timepoints, the control group showed a significant degree of forgetting for the objective quiz measure (p < 0.001) and the digital group demonstrated a significant degree of forgetting for the objective quiz measure (p = 0.03) and drawing measure (p < 0.001). There was a significant difference between the delayed post-test and pre-test of the objective quiz for the physical model group (p < 0.001) and no significant difference between the post-test and delayed post-test for the objective quiz for the physical model group suggesting long-term conceptual understanding and retention. Overall, the physical model group demonstrated greater conceptual understanding at immediate and delayed timepoints for the drawing and explanation measures as well as significant retention of conceptual understanding of DNA as measured by the objective quiz across three timepoints. The digital model group demonstrated a greater degree of forgetting for objective quiz and drawing measures as well as underperformed in the three conceptual understanding measures at both post-test and delayed post-test timepoints. This suggests that the greater degree of physical, haptic manipulation of a three-dimensional model aids in conceptual understanding at all three measures as well as long-term memory when compared with the limited haptic interactions with a two-dimensional touchscreen device.

Networked virtual reality environments including virtual worlds devoted to entertainment, online socializing and remote collaboration have grown in popularity with the rise of commercially available consumer graphics hardware and the growing ubiquity of the Internet. These virtual worlds are typified by a persistent simulated three-dimensional space that communicates over a computer network, where users interact with the environment and each other through digital avatars. Development of these virtual worlds challenges the limits of the networking infrastructure, 3D streaming graphics techniques, and the distributed computing design of the virtual world systems that manages the simulation. In this dissertation, we explore solutions to different aspects of the overall problem of developing a general purpose, networked virtual environment, focusing on the networking and software system issues. Specifically, we show how to improve the networking infrastructure to better support the high packet-rate traffic that is typical of virtual worlds, efficiently stream terrain data for remote rendering, and construct a dynamically adaptive distributed systems framework suitable for virtual world simulations.

Cette thèse se propose de mettre au point, grâce aux nouveaux outils informatiques, une méthode d’étude originale de l’espace funéraire en offrant une restitution tridimensionnelle de la sépulture, de l’architecture aux sujets. La découverte en 2003, d’un secteur de la catacombe des Saints Pierre-et-Marcelin (Rome, Italie), encore inexploré et original dans son organisation, a initié ce travail. Plusieurs tombes, datées des Ier-IIIe s. ap. J.-C, accueillent une succession de dépôts d’un grand nombre d’inhumés. La complexité des ensembles funéraires de ce secteur a nécessité le recours à de nouvelles formes de représentation pour l’analyse. L’objectif de cette thèse est d’établir un protocole de modélisation des sépultures multiples adapté à la stratification complexe des dépôts. Nos recherches ont porté, dans un premier temps sur l’élaboration et le test d’un processus de modélisation adaptés aux deux tombes étudiées et dans un second temps sur l’analyse des temps chronologiques et de la gestion des dépôts. Nos recherches ont abouti à la mise au point d’une méthodologie d’acquisition et de restitution de l’ensemble des vestiges osseux, de l’appareil funéraire et de l’espace funéraire. La modélisation 3D a permis par la visualisation tridimensionnelle une étude fine individuelle, une analyse des relations entre les différents sujets et de l’évolution taphonomique des dépôts confirmant la simultanéité des dépôts au sein des niveaux et entre les niveaux en rapport avec une crise de mortalité.L’application d'un protocole d'enregistrement puis de restitutions sur cette catacombe pourra contribuer à l'élaboration d'une méthode pour l'approche des sépultures plurielles. / The aim of this thesis is to perform, with the help of new informatics tools, an original study method of funerary space and offers a three-dimensional modelling of burial from architecture to individuals. This work was initiated by the discovery in 2003 of Saint Peter and Marcellinus catacombs parts, unexplored and original in its organisation. Several tombs, dated of 1st-3rd s A.D, received many buried. The complexity of tombs of central sector catacombs needs a new type of representation for analysis. The thesis goal is to establish a modelling process for several burials, adapt with deposit complex stratification. At first, our study was about the conception and the test of a modelling protocol adapted to the two study tombs, and after, to analyze chronological times and deposit management. Our research has result to acquisition and restitution process development of all human remains, funerary device and funerary space. The 3D modelling permits by the 3D visualisation, an advanced study, analyses of relations between different individuals and taphonomic evolution of deposit which confirmed the simultaneous deposit into levels and between levels linked to death's crisis.The application of a record protocol then restitution on these catacombs must contribute to a conception method for the approach of plural burials.

Orientador: João Antônio Pereira / Resumo: O uso de ferramentas computacionais atualmente está auxiliando o aprimoramento dos processos e procedimentos de análise e simulações em inúmeras áreas do conhecimento humano. A tomografia computadorizada (TC) é uma ferramenta de diagnóstico já consolidada na área médica e atualmente começa a ser utilizada como uma ferramenta para algo ainda mais inovador, a geração de modelos tridimensionais de órgãos ou estruturas ósseas do paciente para uso na criação de biomodelos e fabricação de próteses personalizadas. Biomodelos são cópias físicas das estruturas anatômicas de regiões ou orgãos do corpo humano utilizados para diagnóstico e planejamento cirúrgico. O uso de imagens tomográficas para geração de modelos 3D tem despertado um grande interesse na área médica e de bioengenharia. Além da criação do biomodelo é possível, com o uso das imagens, a geração de modelos computacionais representativos, possibilitando com isso, a realização de diversas simulações e análises biomecânicas da região ou órgão de interesse, visando a fabricação de próteses ou órteses personalizadas. Neste trabalho é apresentada uma metodologia para a geração de modelos matemáticos tridimensionais a partir de tomografias computadorizadas com o objetivo de estudar e analisar um implante personalizado da ATM (Articulação Temporomandibular), solicitado mecanicamente e fabricado em liga de titânio (Ti6Al4V) pelo processo de manufatura aditiva rápida do tipo DMLS (Sinterização Direta de Metais a Laser). Através do m... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The use of computational tools is currently helping to improve the processes and procedures of analysis and simulations in many areas of human knowledge. Computed tomography (CT) is a diagnostic tool already consolidated in the medical field and is now being used as a tool for something even more innovative, the generation of three-dimensional models of organs or bone structures of the patient for use in the creation of biomodels and Manufacture of customized prostheses. Biomodels are physical copies of the anatomical structures of regions or organs of the human body used for diagnosis and surgical planning. The use of tomographic images for generating 3D models has aroused great interest in the medical and bioengineering field. Besides the creation of the biomodel it is possible, through the use of the images, the generation of representative computational models, making possible the accomplishment of several simulations and biomechanical analyzes of the region or organ of interest, aiming at the manufacture of customized prostheses or orthoses. In this work is presented a methodology for the generation of three-dimensional mathematical models from CT scans in order to build, study and analyze a custom implant TMJ (Temporomandibular Joint), requested mechanically and made of titanium alloy (Ti6Al4V) by the prototyping process of type DMLS (Direct Metal Laser Sintering). Through the model created for the TMJ region, computational simulations of stresses and deformations were ... (Complete abstract click electronic access below) / Doutor

Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-10-04T19:09:24Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) tese mariana viana para BC revisado profa Rita.pdf: 5880006 bytes, checksum: 58b21f8952495e3aba8663b4efa5c48c (MD5) / Made available in DSpace on 2016-10-04T19:09:24Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) tese mariana viana para BC revisado profa Rita.pdf: 5880006 bytes, checksum: 58b21f8952495e3aba8663b4efa5c48c (MD5) Previous issue date: 2016-02-12 / Capes / O câncer de mama desenvolve-se de maneira silenciosa, podendo levar a óbito se não for tratado em sua fase inicial. Por este motivo, é necessário desenvolver técnicas para sua detecção precoce. A carcinogênese altera a temperatura dos tecidos na região afetada e o uso da simulação computacional calcula como ocorre tal fenômeno. A imagem por infravermelho é capaz de indicar a distribuição superficial de temperatura e a comparação destes valores com os cálculos obtidos na simulação computacional é uma ferramenta promissora para a detecção precoce do câncer de mama. O objetivo desta tese é construir a geometria substituta tridimensional (3D) da mama feminina a partir de imagens por infravermelho da paciente. Isso possibilita o cálculo da distribuição de temperatura através de software de dinâmica dos fluidos computacional (CFD – Computational Fluid Dynamics). O corregistro de uma prótese mamária externa aos contornos da paciente modelou a superfície da geometria tridimensional da mama. No interior dessa geometria existem os lóbulos mamários, os ductos lactíferos, o tecido adiposo da mama e a lesão conforme indicado no exame de ultrassonografia da paciente. Um software de CFD realizou o preparo da geometria e subsequente cálculo da distribuição de temperatura na mama. Um estudo de caso verificou o impacto da inserção das estruturas citadas na geometria substituta. O erro entre as temperaturas máximas indicadas pela imagem por infravermelho das pacientes na região da pele sobre a anomalia e a temperatura máxima alcançada no cálculo de temperatura sobre a região correspondente na geometria substituta foi de 0,20%. A geometria 3D aqui apresentada adequa-se aos contornos de cada paciente e é mais próxima da mama real do que a geometria substituta 3D obtida pelo escaneamento de próteses mamárias externas e outras apresentadas na literatura técnica. Além disso, a geometria desenvolvida permitiu o cálculo de temperatura nos casos em que não era possível com a geometria anteriormente utilizada. / Breast cancer develops silently and can lead to death if not treated in its early stages. For this reason, it is necessary to develop techniques for its early detection. The carcinogenesis changes the temperature of the tissue in the affected area, the use of computer simulation to evaluate how such a phenomenon occurs. The infrared image can indicate the surface temperature distribution, and the comparison of these figures with the calculations obtained in a computer simulation is a promising tool for early detection of breast cancer. The purpose of this thesis is to build three-dimensional (3D) surrogate geometry of the female breast from infrared images of the patient. It allows the calculation of the distribution of temperature through Computational Fluid Dynamics (CFD) software. The breast prosthesis co-registration to the contours of the patient modeled the external surface of the 3D geometry of the breast. Within this geometry, there are mammary lobules, lactiferous ducts and adipose tissue of the breast and the lesion as indicated in the ultrasound examination of the patient. CFD software performed the preparation of the geometry and subsequent calculation of the breast temperature distribution. A case study verified the impact of the insertion of such structures in the surrogate geometry. The error between the maximum temperature indicated by the infrared image of the patient in the area of the skin over the abnormality and the maximum temperature achieved in the temperature calculation in the corresponding region in the surrogate geometry were 0.20%. The 3D geometry presented here fits the contours of each patient, and it is closer to the real breast than the surrogate 3D geometries acquired by the scanning of external breast prostheses and others ones presented in the technical literature. Furthermore, the modeled geometry allowed the temperature calculation in cases where it was not possible with the geometry that was previously used.

Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-04-04T15:04:20Z No. of bitstreams: 1 joanadedornellascysneirosgomesdeamorim.pdf: 1811388 bytes, checksum: 09763f5f5602a497decd667655eb0c68 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-04-24T03:56:58Z (GMT) No. of bitstreams: 1 joanadedornellascysneirosgomesdeamorim.pdf: 1811388 bytes, checksum: 09763f5f5602a497decd667655eb0c68 (MD5) / Made available in DSpace on 2016-04-24T03:56:58Z (GMT). No. of bitstreams: 1 joanadedornellascysneirosgomesdeamorim.pdf: 1811388 bytes, checksum: 09763f5f5602a497decd667655eb0c68 (MD5) Previous issue date: 2013-02-27 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A autotomia caudal é uma resposta anti-predação voluntária amplamente empregada por lagartos. Suas consequências estão bem descritas na literatura, mas os fatores envolvidos na sua ocorrência carecem de aprofundamento. Pretendeu-se então averiguar se há diferença tanto na propensão à autotomia quanto no padrão de crescimento corporal e caudal de indivíduos com tamanho corporal diferente durante as estações quente/chuvosa (verão tropical) e fria/seca (inverno tropical). Para tanto foram mantidos em terrários externos três grupos experimentais (n = 19) de massas corpóreas diferentes (P1, P2 e P3), cujas caudas foram autotomizadas por constrição mecânica, medindo-se a pressão exercida e o tempo até a soltura da cauda. Dados morfométricos foram aferidos semanalmente e avaliados usando o test T bicaudal para amostras não pareadas, comparando-se as variáveis em função do peso corporal. As porções caudais liberadas foram conservadas em álcool e dissecadas, assim como quatro lagartos que morreram ao longo dos experimentos. A anatomia caudal foi analisada e comparada com descrições existentes. Elaborou-se um modelo tridimensional passível de ser usado como ferramenta didática e analítica. Foram encontradas em média 32 vértebras caudais em T. itambere. A maioria dos parâmetros avaliados não apresentou significância estatística, devido ao pequeno número amostral, mas tendências e possibilidades são apresentadas e discutidas em vista da literatura atual. Foi significativa a relação inversa entre temperatura cloacal e tempo até a autotomia. / Autotomy is an anti-predator behavior widely employed by lizards. The energetic consequences of this process are vastly describe in literature, yet the details involved in it’s occurrence lack thoroughness. This study intent to evaluate if there are differences related to body weight in propensity to realize autotomy, in body and caudal growth, both during the hot/wet season (tropical summer) and the cold/dry season (tropical winter). To accomplish that three groups of lizards (n = 19) with different body mass (P1, P2 and P3) were kept in out-doors cages during cold (July to September 2012) and hot seasons (November 2012 to January 2013). Autotomy was induced by constriction of the tail, while measuring the pression applie to it’s surface as well as the time until it’s release. Morphometric data was assessed weekly and processed using two-tailed t-test for unpaired samples, comparing variables according to body weight. The released portion of the tail was preserved in alcohol and dissected, as were the four lizards that happened to die during the experimental process. Caudal anatomy was analyzed and compare with preexisting descriptions. A three-dimensional model with didactic and analytic potential was elaborated. We found an average of 32 caudal vertebraes in T. itambere. Most of the analyzed parameters did not present statistical significance, due to the small sample size. However we present and discuss every tendency and possibility in face of the current literature. We did found a significant inverse relation between cloacal temperature and the time subjects took to undergo autotomy.

Underground excavations break the balance of the initial stress field and cause stress redistributions in the surrounding rock masses. Problems normally arise as the stress exceeds the rock mass strength. In addition, the rock mass contains preexisting defects, such as the fissures, fractures, joints, faults, shear zones, dikes, etc., which could significantly weaken the rock mass strength and make the rock mass behavior complicated. The stability of underground excavations is of great importance to an operating mine project since it ensures the safety of the working environment and the successful ore exploration. Due to the complex geological conditions and engineering disturbances, the assessment of rock mass stability for a practical engineering problem is extremely challenging and difficult, which needs to be solved by the modern numerical methods. In this dissertation, the rock mass stability around tunnels in an underground mine in the USA was investigated by performing three-dimensional modeling using the 3DEC 3-Dimensional Distinct Element Code. Comprehensive stress analyses were respectively carried out on a preliminary model and a more advanced model. In the preliminary study, the built model contains the inclined lithologies, a non-persistent fault, and a convoluted tunnel system. The geomechanical property values used for the rock masses and discontinuities in the numerical model were estimated using the available geotechnical information and the experience of the research group. The Mohr-Coulomb and strain softening constitutive relations were prescribed for the rock masses; the coulomb slip joint model was assigned for the discontinuities. The influence of the boundary conditions, block constitutive models, horizontal in situ stress and rock support system on the tunnel stability was investigated. The rock mass behavior was quantified using the results of stress, displacement, and yielded zones around the tunnels. It showed that the roller boundary conditions resulted in slightly different but comparable results with the combined boundary conditions (roller and stress combined) where K0 equals to 0.4 or 0.5. Whereas the in-situ stress field for a complex geological system can only be obtained by applying proper boundary stresses and then by performing stress analysis. The softening behavior of the rock masses caused more deformations and yielded zones around the tunnels; the rock masses around the tunnels were observed to reach the residual strength values, which can be treated as failed areas. In addition, the M-C and s-s rock masses reacted differently as the K0 value changed. At K0=1.0, the tunnels seemed to be the most stable; K0=1.5, however, provided the worst scenario with roof and floor problems. With respect to the effectiveness of the support system, a large amount of the bonds of the supports was failing, thus, the deformations and yielded zones around the tunnels were slightly improved. Finally, comparisons between the numerical modeling results and the field measurements implied the applicability of strain softening behavior and a K0 value between 0.5 and 1.0 for the mine. Based on the specific geological, geotechnical, and construction information, a numerical model incorporating accurate features was developed. It includes a non-planar, weak interlayer, the persistent and non-persistent faults, and the open and backfilled excavations. The mechanical property values used for the rock masses and faults were estimated based on the laboratory test results of the intact rock and smooth joints. The strain softening behavior was specified for the rock masses belonging to the average quality, and the rock masses that reached residual strengths were assumed to be failing. The linear relations between the fault stiffnesses and normal stress were described using the continuously yielding joint model. To simulate the mine construction process in the field, the sequential excavation, backfilling, and supporting procedures were numerically implemented; additionally, a novel routine was applied to account for the delayed installation of the supports. Results showed that the tunnels close to the fault and the backfilled area were less stable. Most of the displacements around the tunnels occurred within a distance of zero to 2 or 3 m from the tunnel surface. The varying K0 value caused great changes in the rock mass behavior and the shear behavior of the major fault; significant instability of the tunnels was triggered by the high horizontal in situ stress. Parametric studies on the rock mass condition, rock mass residual strengths, and fault property values showed that the tunnel stability was more sensitive to the former two factors than the last one. A systematic investigation was conducted to evaluate the current rock supports installed at the mine where the increasing stress relaxation was incorporated. The deformations and of the failure zone thicknesses around the tunnels were reduced up to 8% and 20% after applying the supports instantaneously, and the reductions were improved by the delayed installation of supports. Additionally, the safety of supports was evaluated by the bond shear and bolt tensile failures, which was also improved with incorporation of delayed supporting. It was found that the current rock supports are insufficient in length, bond and tensile strengths. Therefore, a stronger support system was suggested. The stronger supports worked better in stabilizing the tunnels. Based on the deformations and failures of the rock masses, the length of the bolts on walls was suggested to be 4-5 m. At the end, the horizontal convergence strain predicted by the numerical simulations were calculated at two locations where the tape extensometers were installed. Good agreements with the field measurements were obtained for the cases that have the average rock mass properties and K0 values in the range 0.5-1.25.

High image fidelity in Magnetic Resonance Imaging (MRI) relies on precise magnetic field control of encoding gradient fields and background B0 magnetic fields. To ensure a high degree of accuracy in the spatial location of the proton spins and the resultant object geometry, conventional image encoding using linear gradient fields, as well as advanced techniques with non-linear encoding, requires field generating hardware capable of excellent field shaping capabilities and accuracy. Non-homogeneous B0 background fields in MR imaging cause faster relaxation, signal dropout, and geometry distortion, resulting in inferior image quality and reduced diagnostic accuracy. Besides manufacturing imperfections in the magnet and site conditions, the magnetic field inside the imaging object is not homogeneous due to the differences in geometries and magnetic properties of individual human tissues, which is recognized as the primary source of B0 variation in MRI. Considering the differences of B0 conditions across subjects, it is essential for MR imaging to utilize flexible B0 shimming techniques such as active shimming in order to produce a highly homogeneous B0 field. The control capability and optimized control strategy for these magnetic fields require the development of new hardware and methodologies. B0 background field generated by the magnet and the encoding gradient field from gradient coil are two critical pillars of MR imaging. Since the multi-coil array provides advanced shim capability and is proven to be capable of imaging encoding with a compact size, it is considered a perfect component as a combination of B0 shim coil and encoding gradient coil for an accessible head-only MR scanner. MR scanners like this type provide unique features that will enable researchers to develop new MRI methodologies and conduct research into the functionalities of the human brain through more natural human behaviors. Its clinical applications will be more accessible to the general population for disease screening and diagnosis due to its portability and low energy requirements. Since the multi-coil array has the advantage of smaller volume and wall thickness than the traditional gradient coil, its design and implementation is challenging because of its compact space, irregular curved shape of coil elements, mechanical reliability requirements during scan and good thermal control for long working periods. It was the challenges involved in the design and implementation of the multi-coil array that initiated the first project of my dissertation. In this project, we present 1) a novel molding method for the construction of resin-impregnated wire patterns with irregular curved shapes along with a microcontroller-driven motorized machine for automated coil construction, 2) the design and validation of a water-cooling system using multiple parallel pipes impregnated with thermal epoxy, 3) a quality-controlled procedure of building the multi-coil array employing the technique of vacuum resin infusion. A multi-coil array was fabricated successfully and evaluated in multiple sites and then integrated into the first-prototype of the accessible head-only MR scanner. The similar quality of experimental images from the fabricated multi-coil array compared to those from conventional gradient coils indicates that the multi-coil array can effectively shape fields for both image encoding and B0 shimming. Our lab has shown that multi-coil technology offers advanced shim capability when imaging the human brain, but it could potentially benefit the imaging of other organs like the heart. The MR imaging of the heart is subject to dark band artifacts or signal loss caused by B0 inhomogeneity, which can result in misinterpretation of lesions and a reduction in diagnostic accuracy. It has been demonstrated in a recent study that the use of multi-coil techniques can significantly reduce B0 inhomogeneity within the heart based on shim analysis using in vivo B0 maps. Multi-coil arrays are not a standard configuration in commercial scanners but are normally used for research, B0 shimming is typically implemented by using the commonly-installed spherical harmonic shim coils in the first, second, and potentially third orders. The development of multi-coil technology, more in-depth design of the coil structure and geometry as well as the optimal use of the current spherical harmonic shim technology require a thorough understanding of cardiac B0 conditions across subjects and at a population level. Since the in vivo cardiac B0 measurement is not a routine clinical protocol and dedicated in vivo measurement for a large sample size are extremely labor intensive and expensive, the lack of such B0 data is a long-standing problem, especially for the subject groups like pediatric or elderly patients who cannot undergo B0 map measurement with breath hold. This challenge could be resolved by the use of B0 simulation on the basis of structural images from different imaging modalities, assuming that the B0 distributions inside the human heart depends on the anatomical structures surrounding heart and across the entire body. The challenge and assumption led to my second project regarding B0 magnetic field simulation in the human heart. We proposed a novel B0 simulation approach based on chest-abdomen-pelvis structural CT images and validated it using in vivo acquired B0 maps in the heart from the same subjects. This B0 simulation approach was then applied to CT images from more than one thousand subjects and the resultant large set of simulated B0 maps were analyzed with different shim types for searching optimal shim solution based on popular spherical harmonic decomposition. The derived B0 conditions were also statistically analyzed for potential correlation and linear association with demographic parameters of these subjects for investigating potential population-based shim strategy. By the use of in vivo acquisition, we also investigated the B0 magnetic field variation across cardiac cycle and evaluated the impact of these variations on in vivo cardiac B0 shimming. The results of this study allow us to better understand the primary sources and characteristics of B0 distributions in the heart as well as pave the way for developing optimal B0 shim methods within heart in both subject-specific and population-based manners.

[pt] Simulações numéricas tendem a simplificar o comportamento de problemas reais, na maioria das vezes pela adoção de um modelo 2D para descrição da resposta hidráulico-mecânica de barragens de terra, escavações, fundações, etc., com base na maior facilidade da construção geométrica de malhas, rapidez de processamento, simplicidade na introdução das condições de contorno, menor dificuldade na obtenção dos parâmetros de engenharia, etc. Entretanto, para certos fenômenos como o fluxo através de barragem em vales estreitos ou no rebaixamento do lençol freático para execução de escavações para construção de fundações, os efeitos tridimensionais podem afetar consideravelmente os resultados obtidos com uma solução simplificada, seja em termos de vazão, cargas, gradientes hidráulicos ou fatores de segurança. Esta dissertação tem como objetivo principal analisar problemas de fluxo, na condição transiente e/ou permanente, considerando solos saturados e parcialmente saturados, em simulações 2D e 3D pelo método dos elementos finitos buscando destacar as principais diferenças entre as respostas obtidas, ressaltando as principais vantagens e dificuldades da realização de uma simulação 3D em relação a uma análise simplificada 2D. Os exemplos numéricos abordados neste trabalho se referem à barragem de terra Macusani, no Peru, à escavação realizada para construção das estruturas da Pequena Central Elétrica Canoa Quebrada - MT e ao rebaixamento do lençol freático para construção das fundações do shopping Brooklin na cidade de São Paulo - SP. / [en] Numerical simulations tend to simplify the behavior of real problems, mainly through the choice of 2D models to describe the hydromechanical responses of earth dams, excavations, foundations, etc., partly because it is easier to construct geometrical meshes, it is simpler to impose the required boundary conditions, the computer calculations are done more rapidly and the estimation of the engineering parameters, either through field or laboratory tests, are less difficulty than it would be if the problem was treated as a complete 3D case. However, for certain phenomena such as the flow of water through dams situated in narrow valleys or the water drawdown in excavations for construction of building foundations, 3D effects can considerably affect the results when compared to a simplified 2D solution, either in terms of quantity of flow, hydraulic heads and gradients, security factors, etc. The main goal of this dissertation is the analysis of flow problems, both in transient and permanent conditions, considering fully saturated or partially saturated soils, employing 2D and 3D numerical models based on the finite element method in order to highlight the main differences between the computed answers, emphasizing the advantages and difficulties of both approaches. The numerical examples studied in this work are the earth dam Macusani, situated in Peru, the excavation carried out for the construction of the structures in the small hydroelectric plant Canoa Quebrada - MT, and groundwater drawdown for the execution of the foundations of the Brooklin shopping mall, in the city of São Paulo - SP.

Au travers de l’ensemble de ces travaux, l’objectif principal consiste à valider la pertinence de la construction et de l’utilisation de modèles 3D géométriques ou paramétriques orientés BIM/hBIM pour des analyses numériques. Il s’agit notamment d’études structurales dans le cas de bâtiments historiques ainsi que la planification potentielle de travaux de restauration, rénovation énergétique et réhabilitation. Des travaux d’exploitation complémentaires des données et des nuages de points, pour la détection, la segmentation et l’extraction d’entités géométriques ont également été intégrés dans les travaux et la méthodologie proposée. Le processus de traitement des données, modélisation géométrique ou paramétrique et leur exploitation, proposé dans ces travaux, contribue à améliorer et mieux comprendre les contraintes et enjeux des différentes configurations et conditions liées aux cas d’études et aux contraintes spécifiques propres aux types de constructions. Les contributions proposées pour les différentes méthodes de modélisation géométriques et paramétriques à partir des nuages de points, sont abordées par la construction de modèles géométriques orientés BIM ou hBIM. De même, les processus de détection d’éléments surfaciques et d’extraction de données à partir de nuages de points mis en place sont présentés. La mise en application de ces méthodes de modélisation est systématiquement illustrée par différents cas d’étude, dont l’ensemble des travaux relatifs ont été effectués dans le cadre de cette thèse. Le but est dès lors de démontrer l’intérêt et la pertinence de ces méthodes numériques en fonction du contexte, des besoins et des études envisagées, par exemple avec la flèche de la cathédrale de Senlis (Oise) et le site de l’Hermitage (Oise). Des analyses numériques de type éléments finis permettent ensuite de valider la pertinence de telles démarches. / Throughout this work, the main objective is to validate the relevance of construction and use of geometric or parametric 3D models BIM or hBlM-oriented for numerical analyzes. These include structural studies in the case of historic buildings, as well as planning for restoration work, energy renovation and rehabilitation. Complementary data mining and use of point clouds for the detection, segmentation and extraction of geometric features have also been integrated into the work and proposed methodology. The process of data processing, geometric or parametric modeling and their exploitation, proposed in this work, contributes to improve and understand better the constraints and stakes of the different configurations and conditions related to the case studies and the specific constraints specific to the types of constructions. The contributions proposed for the different geometric and parametric modeling methods from point clouds are addressed by the construction of geometric models BIM or hBlM-oriented. Similarly, the process of surface detection, extraction of data and elements from point clouds are presented. The application of these modeling methods is systematically illustrated by different case studies, all of whose relative work has been carried out within the framework of this thesis. The goal is therefore to demonstrate the interest and relevance of these numerical methods according to the context, needs and studies envisaged, for example with the spire of the Senlis cathedral (Oise) and the Hermitage site (Oise). Numerical analyzes with finite element method are used to validate the relevance of these approaches.