The purpose of the present study is to assess the explanatory value of the concept of the World Soul in the cosmological account of Plato&rsquo / s Timaeus. The World Soul plays a crucial role in the account of the world of Becoming in the Timaeus and in Plato&rsquo / s philosophy of science. The World Soul explains why there is motion at all in the universe and sustains the regularity and uniformity of the motion of the celestial objects. Its constitution and the way it is generated by the Demiurge endow it an intermediary status between the world of Being and the world of Becoming. Through this status the World Soul facilitates the applicability of the items of the former world (Forms and Numbers) in the explanation of the latter, hence makes natural science possible. The appreciation of the place of the World Soul in the natural philosophy of Plato leads us to a better place to view Plato&rsquo / s contribution to ancient natural philosophy and science.

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Resume The disertation is conceived as a case study focused on the influence of introducing the quality standards of social services in a daily centre for people with mental and combined disability. It deals with the theoretical outline of the issues, particularly The Law of Social Services n. 108/2006 in the current version of later phrasing and amendment, and the quality standards of social services in relation to mentally disabled people. It also concerns with the formation of the Diakonie of the Czech Protestant Church, the Ratolest Centre in Prague and the evaluation of practical results of the introducing of the quality standards of social services in daily work of the concerned centre from the point of its staff and ordinary practice. The work on the standards in Ratolest Centre can be devided in three main stages. The first stage concerns the years 2004-2007, when the standards were intensely but not continually worked on. The work was primarily organized by one member of the staff and the management of the Centre. In this phase it meant mainly changes of practical dealing and communication with the clients. The methodology was worked out according to the momentary need, in methodological issues was no uniting character and respecting the standards was dispersed in different documents. On this stage...

Nowadays the insufficient facilities of social and health care institutions in Rokycany region don{\crq}t get a motivation to participate in finance of different institutions, in spite of the fact that they are placed in its territory, and provide services for their citizens.From the point of view of residential structure in Rokycany region it seems to be clear that the region itself has to play a big role so that the services would be provided even in small municipalities, and distant urban areas of the region. The above remarks confirm the hypothesis: 1. Social hospitalization in a health care institution results in insufficient facilities of places in retirement homes and in residence institutions of social care. I propose to improve the organiation of social and health care services for old and handicapped people in SO ORP Rokycany region, which I can regard as an availability of social and health care services in the whole region, as an icrease and enlargement of the social services mainly in non-governmental and nonprofitable sector, and as an increase of the quality of provided social services. The range of social hospitalization in Rokycany hospital, Corp., conditions was investigated within the practical part of my thesis. Both aims were fulfilled by working up the practical part of the thesis, and by carrying out the social demographic analysis. By observing the basic data and information while observing the social care in the health care institution, it definitely bears to the hypothesi 2.: The refund of social hospitalization doesn{\crq}t include the costs of sickbed in a health care institution, which is contributing tounfavourable economical situation in a health care institution. The new law doesn{\crq}t solve this problem of financing the social sickbeds. This law insufficiently solves conditions of social allowance belonging, on the contrary, the allowence depends on agreement.This results in repeated and longtime people{\crq}s hospitalization,who are being given this health care allowance. I think it is necessary to ammend the accepted law 108/2006, of Law Digest, abot social services. The matter of finance of longtime hospitalization in health care institution could be solved by the items up increase for longtime lying people. I can see the other aspect of solution in setting up the clear conditions to provide the social care allowance.

The aim of this diploma thesis was to map a current range of social services for users with multiple disabilities over 18 years from České Budějovice and the surrounding area and also to find an interest in individual types of social services from a perspective of their legal representatives. The theoretical part deals with a concept of the combined disability and its basic division. Further it devotes in detail to social services that are determined for clients with multiple disabilities over 18 years. A part of the theoretical there is also a list of organizations currently providing social services for this target group in České Budějovice and surroundings. A conclusion of the theoretical part devotes to a community planning, its history and present days in the South Bohemian region as well as directly in the town of České Budějovice. The practical part has been processed by a quantitative research method, specifically in a form of an anonymous questionnaire survey and it provides a comprehensive information on a fact, which social services are currently used by the legal representatives of the users with multiple disabilities over 18 years from České Budějovice, what services they are in future interested in and how they would imagine their functioning. This part also summarizes information how the legal representatives of users with combined disabilities over 18 years participate in an establishment of new social services and it maps their awareness of the community planning. The conclusions of the diploma thesis should serve as a feedback to organizations providing social services for users with multiple disabilities over 18 years. Furthermore, they could be used as a source for the community plan and to help for an extension of the offer of provided social services in České Budějovice.

Paper covers educational training of social services workers who are supposed to have achieved the prescribed qualifications in compliance with the above-mentioned act, or who are supposed to achieve the respective qualifications by means of the so-called qualifications course for workres engaged in social services. Assisting professions are characterized , in particular, by the fact that persons engaged in them are exposed to a more intense contact with people than other professions are. Performance of such professions is associated with great commitment and responsibility. Therefore, workers engaged in social services are exposed to risk of burnout syndrome development to a higher extent than people working in other professions. This syndrome is experienced most frequently as a feeling of mental, physical and emotional exhaustion and not only does it result in deterioration of the quality of services provided, it has very adverse consequences for a social services worker affected by burnout syndrome as well. The work resulted in finding that no improvement of the Burnout Syndrome Manifestation Inventory score was found and that no influence on attitudes to burnout syndrome on the part of most workers engaged in social services after completion of the qualification course was observable. The workers themselves feel that there is no link between the qualification course and the quality of services provided by them.

Act No. 108/2006 Coll., on social services and bureaucratization of the activities of NGOs This thesis deals with the Social Services Act (No. 108/2006 Coll.) in the context of the bureaucratization of the activities of nongovernmental organizations (NGOs) that are providers of social services. The first order of business is to answer the question whether the law contains elements of the bureaucracy, which the law establishes in the activities of social services providers. A second related objective is to determine whether NGO consider the elements of bureaucracy contained in the Act on Social Services as the main obstacles for the way they operate and whether in connection with their introduction observe within their organization typical dysfunctions associated with the process of bureaucratization. Theoretical background and set of research tools are based on R.H. Hall's research in the field of dimensional analysis of elements present in the structure of bureaucratic organizations. As a research method to achieve the first objective is used quantitative content analysis. The results of the analysis confirm that the Social Services Act contains elements that bureaucratise activities of social services providers. As a research method to achieve the second objective of the thesis is a quantitative...

Die Überlebensrate von Patienten mit duktalem Adenokarzinom des Pankreas ist sowohl in primär resektablen als auch im lokal fortgeschrittenen und metastasierten Stadium kurz. Das duktale Adenokarzinom des Pankreas breitet sich rasch aus und wird aufgrund fehlender Frühsymptome oft erst im fortgeschrittenen Stadium diagnostiziert. Gegenwärtig fehlen spezifische Tumormarker, die eine frühzeitige Diagnose erlauben würden. Aufgrund zahlreicher Mechanismen der primären und sekundären Chemoresistenz ist das Pankreaskarzinom verhältnismäßig resistent gegenüber konventioneller systemisch verabreichter Chemotherapie, antikörperbasierten sowie niedermolekularen Therapiestrategien, Enzyminhibitoren, Bestrahlung und chirurgischer Therapie. Ein vielversprechender Angriffspunkt zur zielgerichteten Therapie des Pankreaskarzinoms eröffnet die tumorspezifische Expression des GnRH-I Rezeptors. In dieser Arbeit konnte der GnRH-IRezeptor durch RT-PCR und immunhistochemisch in 32,5% der duktalen Adenokarzinome des Pankreas nachgewiesen werden. Es wurde gezeigt, dass die Behandlung mit dem Hybridwirksoff AESZ-108 (AN-152), einem zytotoxischen GnRH-Analogon in vitro und in vivo Apoptose in den GnRH-IRezeptor- positiven Pankreaskarzinomzelllinien induziert. Apoptose wurde durch den intrinsischen Signalweg über den Zusammenbruch des mitochondrialen Membranpotentials vermittelt und führte zu DNA-Fragmentierung des Nukleus wie fluoreszenzmikroskopisch gezeigt werden konnte. Das zytotoxische GnRH-Analogon AESZ-108 (AN-152) führt in vivo zu einer signifikanten Inhibition des Tumorwachstums im Vergleich zur Therapie mit dem Anthrazyklin Doxorubicin, welches zu keiner signifikanten Inhibition des Pankreaskarzinomwachstums führt. Die rezeptorvermittelte Aufnahme ermöglicht eine selektive Therapie. Nach rezeptorvermittelter Endozytose wird das an die D-Lys6-Seitenkette gebundene Doxorubicin spezifisch im Nukleus der rezeptorpositiven Karzinomzellen freigesetzt. Die Ergebnisse dieser Arbeiten zeigen, dass AESZ-108 (AN-152) ein geeigneter Ansatz zur selektiven Chemotherapie GnRH-I-Rezeptor positiver humaner duktaler Adenokazinome des Pankreas ist.

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