Edward I's Jewish policy attempted to curb usury and transform the lives and financial practices of the Jews. Historians have claimed that the policy, which is embodied in the Statutum de Judeismo of 1275, was a failure and resulted in the Expulsion of 1290. Although the Expulsion has received some attention from historians, very little work has been done on Edwardian Jewry as a whole and therefore it has not been possible to discern the exact effect of the Statutum within a general context. The best account and examination of the source material for the Expulsion still remains that of B.L.Abrahams. In the light of his work, the majority of historians have seen the Statute as an end to Jewish moneylending, a curtailing of Jewish livelihoods and an anti-semitic prelude to the Expulsion. It has not, however, always been clear how such historians have reached such conclusions. This thesis re-examines the Statutum de Judeismo and analyses, from the records of over 2000 bonds, the shift in Jewish financial interests that it brought about. In doing so, it highlights the way in which, in Edward's reign, certain Jews tempered their moneylending activities with commercial concerns. The method used to illustrate this change is tripartite. Firstly, Anglo-Jewish society and its relationship with the host community in the late thirteenth century is examined. Secondly, the specific histories of the three Jewish communities of Canterbury, Hereford and Lincoln are scrutinised. Finally, a discussion of Jewish financial practices after 1275 attempts to identify the changes brought about by the Edwardian Experiment.

At the cellular level, the stress response involves the synthesis of a highly conserved family of heat shock proteins (Hsps). These proteins are essential for maintenance of cellular homeostasis, both in times of stress and in normal cell functioning. Some of the most abundant forms of Hsps in the cell are members of the 70 kDa family. Intracellular heat shock protein 70 (Hsp70) expression in response to proteotoxicity is a highly conserved cellular stress response, but little is known about the role of extracellular Hsp70 (eHsp70) in fish. In order to begin characterizing eHsp70 in fish, the hypothesis that an acute stressor will elevate plasma Hsp70 levels in rainbow trout (Oncorhynchus mykiss) was tested. Subsequent in vitro studies examined whether eHsp70 level was modulated by cortisol and if this involved the action of the glucocorticoid receptor (GR), a ligand-activated transcription factor. The effect of cortisol on the eHsp70 response is important to consider because this steroid is elevated as a result of stressor exposure to allow for short-term allocation of energy stores to cope with stress. Cortisol is the primary corticosteroid in fish and exerts its main effects by binding to either GR or mineralocorticoid receptors (MR). Furthermore, eHsp70 has been previously implicated as having important immunoregulatory roles in mammalian models, but nothing has yet been reported in fish. To this end, a hypothesis tested here was that eHsp70 levels will increase after exposure to the bacterial endotoxin lipopolysaccharide (LPS), and that this response is modulated by cortisol. Finally, research on the effects of exogenous Hsp70 has not been reported in lower vertebrates; however, the relevance of this protein in intercellular signaling, especially in regards to immune regulation, is gaining increasing importance in mammalian models. Therefore, an experiment to determine whether Hsp70 would elicit upregulation of key immunoregulatory cytokines was also conducted. To accurately measure the low levels of Hsp70 in the plasma, a competitive antibody-capture enzyme-linked immunosorbent assay (ELISA) was developed. In the in vivo study, fish exposed to an acute heat shock (1h at 10°C above ambient temperature) exhibited a significant elevation in red blood cell Hsp70 levels over a 24 h period. There was also a significant increase in plasma Hsp70 levels at 4 h, but not at 24 h post-heat shock. To more specifically determine how cortisol affected the release of Hsp70, in vitro studies using primary cultures of hepatocytes demonstrated that cortisol significantly decreased eHsp70 levels in the medium at 24 h when compared with untreated controls, and this response was abolished in the presence of a GR antagonist, mifepristone (RU486). This result for the first time established a link between cortisol signaling and eHsp70 release in any animal model. When hepatocytes were exposed to LPS in vitro, eHsp70 levels were significantly lower in the LPS (30 µg/ml) group; however, heat shock abolished this effect at 24 h. Though eHsp70 levels in the heat shocked hepatocytes treated with low-dose LPS (10 µg/ml) was similar to untreated control levels, high-dose LPS treated hepatocytes showed significant elevation of eHsp70 levels above the low dose group. The ability of LPS to modulate eHsp70 release was not observed to be further regulated by cortisol. While this work suggests the modulation of eHsp70 by LPS, the physiological role remains to be elucidated. Finally when hepatocytes were exposed to exogenous Hsp70, there was no effect on key immunoregulatory genes (IL-1β and IL-8) transcript levels; however, the effect of this protein remains to be tested using other cell systems, including immune cells in fish. Overall, eHsp70 concentration was measured in trout plasma using a competitive ELISA and demonstrates for the first time that stressor exposure affects plasma eHsp70 levels in fish. Furthermore, cortisol, the primary corticosteroid in teleosts, modulates eHsp70 release in trout hepatocytes and this is action is mediated by GR signaling. Also, while trout hepatocytes secrete eHsp70 in response to endotoxin shock, a role for eHsp70 in eliciting an immune response is not clear in lower vertebrates. Taken together the results from this study suggest a role for eHsp70 in acute stress adaptation in fish, but the target tissues involved and the physiological responses remain to be elucidated. Further work on the effects of eHsp70 on target tissues effects, and the mechanisms involved, may have important implications in our understanding of the role of this stress protein in cell signaling and stress adaptation in fish.

Zweite Studienarbeit Hochschule für Angewandte Psychologie Zürich, 2006.

Thèse (Ph. D.)--Université Laval, 2004. / Bibliogr.: f. [130]-146. Publié aussi en version électronique.

Freiburg (Breisgau), Universiẗat, Diss., 2001.

No description available.

The aim of this thesis is to study furniture production in Czechoslovakia during 60s-80s of 20th century, evaluate the benefits of this time period and specify progressive trends for current generation. Thesis is describing history and operation of the Spojene UP Zavody thorough the chosen period and particular changes of sector furniture lines. This work is further focused on contemporary furniture production inspired by this time period. In the second part of the thesis analysis has been made for proposal of furnishing element which continues in own proposal of selected sector line. In the end of the work creative solutions are described, followed by discussion and conclusion. Attachments, containing constructive solution of one furnishing element in designed sector line, list of material, calculation of technical-economic standard consumption of material and list of used hardware, are enclosed to the thesis.

This thesis is focused on and is summarizing events in ballet of the National Theatre in Prague in 1970's and 1980's, specifically between 1969 and 1989. It's dedicated to personalities on positions as directors of ballets - Jiří Němeček, Emerich Gabzdyl and Miroslav Kůra, who, besides managing the ballet, worked as choreographers too. There were also other choreographers in the theatre aside from the above mentioned, namely Jiří Blažek, Antonín Landa, Vlastimil Jílek, or Daniel Wiesner. I describe individual seasons and specific works, which were introduced in premiere. Furthermore in my thesis I deal with extraordinary generation of interprets who were performing here, for example Michaela Černá, Marta Drottnerová, Vlastimil Harapes, Jan Kadlec, Lubomír Kafka, Jaromír Petřík, Michaela Vítková, Hana Vláčilová, Aneta Voleská, Pavel Ždichynec and many others. I put everything in the context of the political era known as „normalization“. Foreign groups and individuals, who gave guest performances in the theatre are also described. My primary sources of information were mainly: “Archiv Národního divadla” (the National Theatre's archive), “Ročenky Národního divadla” (the National Theatre’s yearbooks) and contemporary periodical „Taneční listy” (Letters of dance), from which I used mainly critiques and reviews for premieres. Another valuable source were personal testimonies of artists, who performed in the National Theatre at that time: Mahulena Křenková, Jiří Němeček ml., Astrid Štúrová, Hana Vláčilová and Daniel Wiesner.

O presente trabalho tem como objetivo avaliar o comportamento da chapa de latão 70/30 para o processo de Estampagem Incremental de Chapas (ISF - Incremental Sheet Forming), baseado nos parâmetros: ângulo de parede (ψ), passo vertical ( Z) e estratégia do caminho da ferramenta. Os experimentos baseiam-se na variante da Estampagem Incremental denominada Estampagem Incremental com Ponto Simples (SPIF - Single Point Incremental Forming). Foram realizados 18 ensaios usando uma ferramenta de estampar com raio (RT) de 5 mm. Para execução dos testes práticos, foram utilizados os recursos: softwares CAD/CAM, centro de usinagem CNC com três eixos, matriz incremental, ferramenta de estampagem incremental e um dispositivo prensa chapas. Além disso, o acabamento da superfície conformada foi medido através do parâmetro de rugosidade RZ nos principais ensaios, bem como a medição das deformações verdadeiras (j) e da espessura (s1). Os testes práticos demonstraram que a estratégia de usinagem espiral proporcionou um maior ângulo de parede, comparado à estratégia paralela de contorno. / This study aims to evaluate the behavior of 70/30 brass plate to the process of Incremental Sheet Forming - ISF, based on the parameters: wall angle (ψ), vertical step ( Z) and tool path strategy. The experiments were based on a variation of the ISF process, called SPIF (Single Point Incremental Forming). Eighteen tests were conducted using a punching tool with a radius (RT) of 5 mm. For the execution of practical tests, the resources were used: CAD / CAM software, CNC machining center with three axis. It was also used an incremental matrix, a tool for incremental forming and a sheet-press device. In addition, the surface finish was measured by RZ roughness parameter in the main tests, the same way the measurement of true strains (φ) and thickness (s1). The practice tests showed that the spiral machining strategy has provided a greater wall angle, compared to the parallel strategy contour.

Biblical and Ancient Studies / M.Th. (Old Testament)