No description available.

No description available.

No description available.

No description available.

No description available.

No description available.

Bakgrund: Den 1 december 2016 trädde Lag (2016:947) om ändring i årsredovisningslagen (1995:1554) i kraft. Syftet är att göra hållbarhetsredovisningen mer transparent och jämförbar. Vissa bolag ska enligt denna lag upprätta en hållbarhetsrapport där hållbarhetsfrågor som mänskliga rättigheter, miljö, sociala förhållanden och information om dess personal presenteras. Ungefär 1600 företag påverkas av den nya lagen och kommer således tvingas hållbarhetsredovisa från och med årsredovisningen som avser 2017. Syfte: Denna uppsats syftar till att undersöka hur nya lagkrav kring hållbarhetsredovisning har påverkat hållbarhetsredovisningen för företag noterade på Small Cap inom konfektion- och finansbranschen. Metod: Studien tillämpar en deduktiv ansats med induktiva inslag och utför en kvalitativ innehållsanalys. Studien använder sig av en longitudinell fallstudie där empiri hämtas från Odd Molly och Venue Retail Group från konfektionsbranschen samt Midway och MedCap från finansbranschen. Insamlingen av data består av årsredovisningar från samtliga bolag och mellan åren 2014–2017. Slutsats: Studien visar att hållbarhetsredovisningen för företag noterade på Small Caps har påverkats av Lag (2016:947) om ändring i årsredovisningslagen (1995:1554). Den finner mönster av att studiens fyra bolag har gått från en allmän till en mer företagsspecifik hållbarhetsredovisning. Vidare så tillför studien branschspecifika insikter om hur utvecklingen av konfektions- och finansbranschens hållbarhetsredovisning sett ut mellan 2014–2017. / Introduction: On December 1, 2016, Act (2016: 947) amending the Annual Accounts Act (1995: 1554) entered into force. The purpose is to make the sustainability report more transparent and comparable. Large Companies now have to establish a sustainability report under which sustainability issues such as human rights, the environment, social conditions and information about its personnel are reported. About 1600 companies are affected by the new law and will therefore be required to report on sustainability from the annual report relating to 2017. Purpose: This paper aims to investigate how new regulations for sustainability reporting have affected the sustainability reports for companies listed on Small Cap in the clothing and finance industry. Method: The study applies a deductive approach with inductive elements and conducts a qualitative content analysis. The study uses a longitudinal case study where the empirical data is collected from Odd Molly and Venue Retail Group from the clothing industry, as well as Midway and MedCap from the finance industry. The collection of data consists of annual reports from these companies between 2014-2017. Conclusion: The study shows that sustainability reporting for companies listed on Small Cap has been affected by Law (2016: 947) as amended in the Annual Accounts Act (1995: 1554). It finds that the four companies of the study have gone from a general to a more company-specific sustainability report. Furthermore, the study provides insights on the development of the clothing and finance industry's sustainability report expires between 2014-2017.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O número de mulheres jovens infectadas pelo HIV-1 vem crescendo desde o início da epidemia da aids, principalmente nos países em desenvolvimento, onde a frequência de gravidez é elevada. O desenvolvimento de estratégias para evitar a transmissão vertical tem aumentado o número de recém-nascidos não infectados nascidos de gestantes portadora do vírus. O objetivo da presente tese foi avaliar, in vivo e in vitro, o perfil de citocinas de neonatos não infectados, porém nascidos de mulheres infectadas pelo HIV-1. Os resultados demonstraram elevados níveis de citocinas pró-inflamatórias relacionadas ao fenótipo Th17, associadas à baixa produção de IL-10, tanto nos plasmas quanto nos sobrenadantes das culturas de células T ativadas obtidas do sangue do cordão umbilical de neonatos nascidos de gestantes infectadas pelo HIV-1 com cargas virais plasmáticas(PVL) detectáveis. De modo interessante, um perfil similar pró-inflamatório foi observado em amostras de sangue periférico de suas respectivas mães. Por outro lado, níveis elevados de IL-10, associados à reduzida produção de citocinas inflamatórias, foram dosados no sangue e nos sobrenadantes das culturas de células T ativadas de gestantes que controlavam a PVL, assim como de seus neonatos. Com relação à caracterização fenotípica das células T maternas produtoras de IL-10, a análise por citometria de fluxo demonstrou que essa citocina é majoritariamente produzida por células T CD4+Foxp3-. Curiosamente, a replicação viral in vitro do HIV-1 foi inferior nas culturas das gestantes infectadas pelo HIV-1 e foi relacionada aos efeitos inibitórios da IL-10 sobre a produção de TNF-α. Por fim, os neonatos não infectados expostosin utero à terapia antirretroviral (ART) apresentaram um menor peso ao nascer, e este achado foi inversamente correlacionado com os níveis periféricos maternos de TNF-α. Em conclusão, nossos achados sugerem que gestantes que conseguem controlar a PVL, e o incremento na produção de IL-10 materna possam favorecer a expansão das células Tr-1, as quais podem auxiliar em reduzir o risco de transmissão vertical do HIV-1 por reduzir a taxa de replicação viral. Por outro lado, outros resultados também apresentados aqui, apesar de preliminares, revelaram efeitos adversos da replicação viral e da ART em gestantes infectadas pelo HIV-1 no desenvolvimento funcional das células T de neonatos não infectados. Esses dados podem ajudar a explicar por que algumas dessas crianças apresentam elevado risco à morbidade e mortalidade devido a um estado basal de hipersensibilidade patológica. / The number of HIV-1-infected young women has been increasing since the beginning of the AIDS epidemic, mainly in developing countries, where the frequency of pregnancy among them is also elevated. The development of strategies for vertical transmission avoidance has enhanced the number of uninfected neonates born from infected mothers. The objective of the present study was to evaluate, in vivo and in vitro, the cytokine profile of uninfected neonates born from pregnant women infected with HIV-1.The results demonstrated high levels of proinflammatory cytokines related to Th17 phenotype associated with low IL-10 production, in plasma as well as in culture supernatants of activated T cells obtained from umbilical cord blood of neonates born from mothers infected with HIV -1 with plasma viral load (PVL) detectable.Interestingly, a similar pro-inflammatory cytokine profile was observed in peripheral blood samples from their respective mothers.On the other hand, high levels of IL-10 associated to reduced production of inflammatory cytokines were measured in blood and in the supernatants of activated T cells culturesfrom women that controlled the PVL, as well as their neonates.Regarding the phenotypic profile of pregnant women infected of HIV-1, the main T lymphocyte subset involved in producing IL-10 was CD4+Foxp3-. Interestingly, the in vitro HIV-1 replication was lower in cell cultures from pregnant patients, and it was related to the inhibitory effects of IL-10 on the production of TNF-α. Finally, ART-in utero-exposed neonates showed to be born with lower weight, and it was inversely correlated with maternal peripheral TNF-α level. In conclusion, the results suggest that pregnant women that are able to control the PVL, and the increment in the production of IL-10 may favor maternal Tr-1 cell expansion, which could help to reduce the risk of vertical transmission of HIV-1 by reducing the rate of viral replication.However, other results also presented here, although preliminary, have revealed adverse effects of viral replication, as well as the use of ART by pregnant women infected with HIV-1 in the development of functional T cells from uninfected newborns.These data may help to explain why some of these children have elevated risk of clinical morbidity and mortality due to a baseline state of pathological hypersensitivity.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O número de mulheres jovens infectadas pelo HIV-1 vem crescendo desde o início da epidemia da aids, principalmente nos países em desenvolvimento, onde a frequência de gravidez é elevada. O desenvolvimento de estratégias para evitar a transmissão vertical tem aumentado o número de recém-nascidos não infectados nascidos de gestantes portadora do vírus. O objetivo da presente tese foi avaliar, in vivo e in vitro, o perfil de citocinas de neonatos não infectados, porém nascidos de mulheres infectadas pelo HIV-1. Os resultados demonstraram elevados níveis de citocinas pró-inflamatórias relacionadas ao fenótipo Th17, associadas à baixa produção de IL-10, tanto nos plasmas quanto nos sobrenadantes das culturas de células T ativadas obtidas do sangue do cordão umbilical de neonatos nascidos de gestantes infectadas pelo HIV-1 com cargas virais plasmáticas(PVL) detectáveis. De modo interessante, um perfil similar pró-inflamatório foi observado em amostras de sangue periférico de suas respectivas mães. Por outro lado, níveis elevados de IL-10, associados à reduzida produção de citocinas inflamatórias, foram dosados no sangue e nos sobrenadantes das culturas de células T ativadas de gestantes que controlavam a PVL, assim como de seus neonatos. Com relação à caracterização fenotípica das células T maternas produtoras de IL-10, a análise por citometria de fluxo demonstrou que essa citocina é majoritariamente produzida por células T CD4+Foxp3-. Curiosamente, a replicação viral in vitro do HIV-1 foi inferior nas culturas das gestantes infectadas pelo HIV-1 e foi relacionada aos efeitos inibitórios da IL-10 sobre a produção de TNF-α. Por fim, os neonatos não infectados expostosin utero à terapia antirretroviral (ART) apresentaram um menor peso ao nascer, e este achado foi inversamente correlacionado com os níveis periféricos maternos de TNF-α. Em conclusão, nossos achados sugerem que gestantes que conseguem controlar a PVL, e o incremento na produção de IL-10 materna possam favorecer a expansão das células Tr-1, as quais podem auxiliar em reduzir o risco de transmissão vertical do HIV-1 por reduzir a taxa de replicação viral. Por outro lado, outros resultados também apresentados aqui, apesar de preliminares, revelaram efeitos adversos da replicação viral e da ART em gestantes infectadas pelo HIV-1 no desenvolvimento funcional das células T de neonatos não infectados. Esses dados podem ajudar a explicar por que algumas dessas crianças apresentam elevado risco à morbidade e mortalidade devido a um estado basal de hipersensibilidade patológica. / The number of HIV-1-infected young women has been increasing since the beginning of the AIDS epidemic, mainly in developing countries, where the frequency of pregnancy among them is also elevated. The development of strategies for vertical transmission avoidance has enhanced the number of uninfected neonates born from infected mothers. The objective of the present study was to evaluate, in vivo and in vitro, the cytokine profile of uninfected neonates born from pregnant women infected with HIV-1.The results demonstrated high levels of proinflammatory cytokines related to Th17 phenotype associated with low IL-10 production, in plasma as well as in culture supernatants of activated T cells obtained from umbilical cord blood of neonates born from mothers infected with HIV -1 with plasma viral load (PVL) detectable.Interestingly, a similar pro-inflammatory cytokine profile was observed in peripheral blood samples from their respective mothers.On the other hand, high levels of IL-10 associated to reduced production of inflammatory cytokines were measured in blood and in the supernatants of activated T cells culturesfrom women that controlled the PVL, as well as their neonates.Regarding the phenotypic profile of pregnant women infected of HIV-1, the main T lymphocyte subset involved in producing IL-10 was CD4+Foxp3-. Interestingly, the in vitro HIV-1 replication was lower in cell cultures from pregnant patients, and it was related to the inhibitory effects of IL-10 on the production of TNF-α. Finally, ART-in utero-exposed neonates showed to be born with lower weight, and it was inversely correlated with maternal peripheral TNF-α level. In conclusion, the results suggest that pregnant women that are able to control the PVL, and the increment in the production of IL-10 may favor maternal Tr-1 cell expansion, which could help to reduce the risk of vertical transmission of HIV-1 by reducing the rate of viral replication.However, other results also presented here, although preliminary, have revealed adverse effects of viral replication, as well as the use of ART by pregnant women infected with HIV-1 in the development of functional T cells from uninfected newborns.These data may help to explain why some of these children have elevated risk of clinical morbidity and mortality due to a baseline state of pathological hypersensitivity.

Diese Dissertation befasst sich mit räumlichen Wahrnehmungen und Diskursen, mit denen man den Raum und seine Bestandteile behandelte. Die Eroberung Sibiriens im 17. Jahrhundert bewirkte einen tiefgreifenden Wandel in den russischen Vorstellungen über die weit entfernte Peripherie sowie deren Ressourcen. Die neuen Denkweisen kristallisierten sich in einer diskursiven Formation heraus, die Macht über Raum und Rohstoffe Sibiriens symbolisierte und organisierte. Dieser „Berg-Diskurs“ trug moderne Züge, denn er bedurfte sich neuer Formen der Kontrolle über die Raumsproduktion. Diese Einstellung wurde allmählich zu einer erstaunlich überlebensfähigen räumlichen Ideologie und zum festen Bestandteil des russischen Bodenschätzediskurses der Zukunft. Die Rolle der Wissensproduzenten wechselte zwischen den zentralen und regionalen Institutionen und Netzwerken. Der „Altai“, der den kaiserlichen Bergbau-Bezirk und die Gebirgslandschaft umfasste, wurde auf Grund seines Rohstoffreichtums von Repräsentanten des russischen Staates als Region erfunden. Die Dissertation stellt die imaginären und realen Geographien des Altai in drei unterschiedlichen Dimensionen dar. Dabei geht es um den Wandel der Repräsentationen von geographischen Räumen und der Berglandschaften in Russland insgesamt (Makroebene), die Mehrschichtigkeit des russischen Diskurses über Bergregionen und Gebirgslandschaften (Mesoebene) und den Altai als facettenreiches Konzept einer komplexen imperialen geographischen Imagination (Mikroebene). Die Beschreibung des Altai faßte in sich zahlreiche inkohärente Bilder verschiedener sozialer Gruppen. Der Ort wurde durch mentale Geographien erfolgreich instrumentalisiert, z.B. „die Goldenen Gebirge“ und „die sibirische Schweiz“. Diese Bilder machten die Region sichtbar, sowohl für nationalistisch gesinnte Gruppen als auch die breiteren Bervölkerungsschichten. / This dissertation focuses on the production of imperial space with a particular emphasis on the role of power discourses concerning mineral resources. By relying on published materials, it aims to establish a new conceptual framework for the examining of cultural patterns and practices of imagining of space and mineral wealth. For that purpose, it introduces a concept of the ”Berg-Discourse” that expands our understanding of the Russian engagement with geographical space. It begins by exploring Russian exposure to the mountains and mineral resources of Siberia in terms of the spatial knowledge production. It then examines how Russian imperial strategies and aspirations were embedded in the making of the Altai, a vast mining territory in West Siberia that once formed a private domain of the Russian rulers. The dissertation argues that the making of the Altai was in many ways part of the same imperial impulse towards mineral exploitation. It explores the ways in which the Altai was imagined through its enormous mineral endowment; how the imagined place became real; and how this real place became imagined from various vantage points. As the study shows, the region acquired multiple mental representations, enjoying a near mythological presence across imperial culture. Finally, the dissertation concludes by showing how this landscape was incorporated into imperial and national myths in the course of production and consumption of spatial knowledge about the remote location.