The effects of feed processing, pea cultivar and their interaction on the nutritional value of field pea (Pisum sativum L.) for poultry were evaluated in regard to its apparent metabolizable energy (AMEn), apparent protein digestibility (APD), and rate and extent of starch digestion. Amino acid sparing as affected by the rate of starch digestion was studied in laying hens and broiler chickens. Also, the effects of feeding a slowly digested starch (SDS) from pea on performance and metabolism of broiler–breeder pullets were investigated. The first objective of this research was to evaluate the effects of screen–hole size, cold pelleting, and pre–pelleting conditioning temperature on nutrient digestibility of pea. There was no interaction between dietary treatments on all studied parameters. Small hammer–mill screen–hole size (3.2–mm) increased AMEn, APD, and extent of starch digestion values compared with coarse screen–hole size (6.4–mm). The AMEn and extent of protein digestion were not affected by cold pelleting, but the site of protein digestion was affected. In contrast, cold pelleting increased the rate and extent of starch digestion. Pre–pelleting conditioning temperature affected AMEn of pea in a quadratic fashion but had no positive effect on starch digestibility. The 70°C of pre–pelleting conditioning temperature maximized pea AMEn. Increasing pre–pelleting conditioning temperature decreased APD in a linear fashion. The second objective of this research was to study the effects of feed processing, pea cultivar and their interaction on AMEn, APD, and rate and extent of starch digestion. In vitro and in vivo experiments were conducted. An in vitro procedure simulating the gastric and small intestine conditions of chickens was developed to predict the rate and extent of starch digestion as affected by pea cultivar and sieve–hole size (0.5–, 1.0–, 2.0–mm). The rate and extent of starch digestion of cereal grain samples (barley, corn, and wheat) was also compared to pea starch. No interactions were found between pea cultivar and sieve–hole size on the kinetics of starch digestion. Pea cultivar affected the rate and extent of starch digestion. The small sieve–hole size in the in vitro assay resulted in a higher rate and extent of starch digestion. Pea starch was slowly digested in comparison with cereal grains. The in vivo experiment confirmed that fine grinding and pelleting improves AMEn and APD. Cultivar effects on AMEn and APD were observed, but no interaction was found between pea cultivar and feed processing. The third objective of this research was to investigate whether feeding SDS from pea would have sparing effect on amino acid utilization in chickens. In the first experiment, the effects of three levels of pea inclusion 0, 150, 300 g/kg on the response of laying hens to three levels of lysine intake (700, 780, and 860 mg per day) were evaluated using performance and production criteria. This experiment revealed that pea inclusion up to 300 g/kg in laying hen diets was well tolerated by laying hens and improved energy retention as indicated by increased body weight and egg weight. However, this experiment did not confirm the hypothesis that SDS from pea spared amino acids for laying hens. The second experiment investigated the interaction between SDS derived from pea and amino acid levels on the performance and carcass quality of broiler chickens. Six levels of pea inclusion (0, 150, 300, 450, 600, and 750 g/kg) and two levels of amino acids (100 and 85% of Ross × Ross 308 requirement) were examined in a broiler trial (0 – 35 d). The maximum level of pea inclusion recommended in diets increased with broiler age, but the effect of SDS from pea on amino acid sparing could not be confirmed. In the third experiment, the effects of feeding SDS from pea on growth performance and metabolism of broiler breeder pullets were investigated. Body weight and uniformity of pullets fed pea–based diet were similar to that of a wheat–based diet. Target body weight and uniformity of pullets were not affected by feeding a diet containing 890 g/kg of pea. Mean blood glucose levels and relative liver weight were markedly lower in broiler pullets fed pea–based diet compared with those fed a wheat–based diet. In conclusion, feed processing independently had a significant effect on the availability of pea nutrients. Pea is a good source of both energy and protein and that it can be partially or completely included to replace wheat and soybean meal in poultry diets. However, the effect of SDS on amino acid sparing could not be confirmed. Further research is needed to examine other feed processing techniques, pea cultivars, level of inclusion, and to understand other metabolism responses to feeding SDS from pea.

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<p>Many English teachers see British English as the standard variety and teach this variety in the classroom. Their students are, however, also exposed to a great deal of American English in today’s media. As a result, there are a lot of students who use a mixture of these varieties because of the double input, both from media and from the teachers in school. In this paper, I interviewed teachers from Swedish secondary and upper secondary schools to find out what their attitudes towards British and American English were and whether these attitudes were reflected in their teaching. I also examined whether the teachers actually spoke the variety of English they thought they did as well as what their views were on students using a mixture of varieties. The focus of this essay will be on American English and British English.</p>

Many English teachers see British English as the standard variety and teach this variety in the classroom. Their students are, however, also exposed to a great deal of American English in today’s media. As a result, there are a lot of students who use a mixture of these varieties because of the double input, both from media and from the teachers in school. In this paper, I interviewed teachers from Swedish secondary and upper secondary schools to find out what their attitudes towards British and American English were and whether these attitudes were reflected in their teaching. I also examined whether the teachers actually spoke the variety of English they thought they did as well as what their views were on students using a mixture of varieties. The focus of this essay will be on American English and British English.

L’évaluation des masses atomiques (Ame), commencée dans les années 1960, est la source la plus fiable d’informations complètes sur les masses atomiques. Elle fournit les meilleures valeurs pour les masses atomiques et les incertitudes associées en évaluant les données expérimentales de désintégration, de réactions et de la spectrométrie de masse. Dans cette thèse, la philosophie et les caractéristiques les plus importantes de l’Ame seront discutées en détail. Les développements les plus récents de l’évaluation, AME2016, tels que l’énergie de liaison moléculaire, la correction d’énergie des mesures par implantation, et la formule relativiste pour le processus de décroissance alpha, seront présentés. Une autre partie de cette thèse concerne l’analyse des données du spectromètre à piège de Penning ISOLTRAP au ISOLDE/CERN. Les nouveaux résultats sont inclus dans l’ajustement global et leurs influences sur les masses existantes sont discutées. La dernière partie de cette thèse porte sur les études des erreurs systématiques du spectromètre de masse à multi-réflexion à temps de vol d’ISOLTRAP, utilisant une source d’ions hors ligne et le faisceau de protons en ligne. A partir de l’analyse des mesures sélectionnées, j’ai trouvé que l’erreur systématique est beaucoup plus faible que les incertitudes statistiques obtenues jusqu’à présent. / The Atomic Mass Evaluation (AME), started in the 1960s, is the most reliable source for comprehensive information related to atomic masses. It provides the best values for the atomic masses and their associated uncertainties by evaluating experimental data from decay, reactions, and mass spectrometry. In this thesis, the philosophy and the most important features of the Ame will be discussed in detail. The most recent developments of the latest mass table (AME2016), such as molecular binding energy, energy correction of the implantation measurements, and the relativistic formula for the alpha-decay process, will be presented. Another part of this thesis concerns the data analysis from the Penning-trap spectrometer ISOLTRAP at ISOLDE/CERN. The new results are included in the global adjustment and their influences on the existing masses are discussed. The last part of this thesis is related to the systematic error studies of the ISOLTRAP multi-reflection time-of-flight mass spectrometer, using an off-line ion source and the on-line proton beam. From the analysis of the selected measurements, I found that the systematic error is much smaller than the statistical uncertainties obtained up to now.

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Cette thèse voudrait faire connaître la pensée de Francisco Canals, philosophe catalan qui s’inscrit dans la tradition de la philosophie thomiste mais avec beaucoup de particularités. L’œuvre de Canals est principalement un effort de fondation de la métaphysique, dans le sillage de Joseph Maréchal.Nous présentons un élément qui transperce toute l’œuvre de Canals: l’auto-connaissance de l’âme. Nous allons voir si la doctrine de Canals sur la cognitio de anima secundum quod habet esse, un des fondements de la métaphysique selon lui, peut être considérée comme un élément central et structurant de toute sa pensée. Nous pensons, en effet, que cet élément permet à Canals d’avoir une vocation systématique et une compréhension unitaire de toute la philosophie.Une présentation unitaire et systématique de la pensée originale de Canals constitue une invitation à considérer plus cet auteur et sans doute un apport à l’Académie. / The aim of my thesis is for the reader to become acquainted with the thought of Francisco Canals, a Catalan philosopher whose work builds on the tradition of thomistic philosophy yet with many specific particularities. Canals’ work is mainly an attempt to lay the ground for metaphysics, building on Joseph Maréchal’s work. In this thesis I will focus on one aspect underlying the whole of Canals’ work : the soul’s knowledge of itself. My aim is to assess the extent to which Canals’ theory on cognitio de anima secundum quod habet esse, which is, according to him, one of the fundamental bases of metaphysics, may be considered a core element and a driving principle for the whole of his thought. Indeed my view is that this one point is what enables Canals to develop a systematic and comprehensive understanding of the whole of philosophy. This unified and systematic approach to Canals’ original thought should be taken as an invitation to give greater importance that author and shall hopefully be considered helpful in the academic field.

O objetivo do presente estudo foi avaliar o desempenho, saúde intestinal e metabolizabilidade de dietas para frangos de corte alimentados com o uso contínuo ou mudança brusca de diferentes rações à base de milho e sorgo moído ou inteiro. No Exp. 1 foi estudada a mudança no tipo de grão com as dietas: M100% (ração à base de milho); S100% (ração à base de sorgo); M:S50% (ração à base de 50% milho e 50% sorgo); PS-M (ração à base de sorgo na fase pré-inicial e milho nas demais fases); PM-S (ração à base de milho na fase pré-inicial e sorgo nas demais fases). No Exp. 2 foi estudada a mudança na forma do grão de sorgo: Sm100% (ração à base de sorgo moído); Si100% (ação à base de sorgo inteiro); PSm-Si (ração à base de sorgo moído na fase pré-inicial e inteiro nas demais fases) e PSi- Sm (ração à base de sorgo inteiro na fase pré-inicial e moído nas demais fases). Os experimentos foram conduzidos em um delineamento em blocos casualizados (blocos no tempo) para avaliar o desempenho e epitélio jejunal (r=8), microbiota intestinal (r=4) e metabolizabilidade das dietas (r=10). As mudanças entre milho e sorgo não alteraram o desempenho, epitélio jejunal nem a metabolizabilidade das rações, mas influenciaram a porcentagem de Clostridium, Weissella, Bacillus e Alkaliphilus no intestino delgado e Lactobacillus e Desulfotomaculum nos cecos. O uso de sorgo inteiro piorou o desempenho aos sete dias. Aos 40 dias, Sm100% e PSm-Si apresentaram desempenhos semelhantes, PSi-Sm apresentou menor ganho de peso, mas melhor conversão alimentar e Si100% apresentou o pior desempenho. Si100% e PSm-Si apresentaram aumento no peso relativo da moela e na metabolizabilidade das rações, assim como diminuição de Clostridium e aumento de bactérias das famílias Actinomycetales e Bacillales no intestino delgado, Si100% resultou em menor porcentagem de Alkaliphilus e Enterococcus que Sm100% nos cecos. Conclui-se que a melhor estratégia de uso do sorgo é a substituição total de milho por sorgo moído ao alojamento com posterior mudança para sorgo inteiro, pois não afeta o desempenho e epitélio jejunal das aves, melhora a metabolizabilidade das rações e potencializa a redução de Clostridium no intestino delgado de frangos de corte. / The aim of this study was to evaluate performance, intestinal health and metabolizability of diets in broilers fed different corn- or sorghum (ground or whole)- based diets, continuously or with abrupt change between the diets. Exp. 1 - Change in the type of grain: C100% (corn-based diet); S100% (sorghum-based diet); C:S50% (50% corn and 50% sorghum-based diet); PC-S (corn-based diet in pre-starter phase and sorghum-based diet in other phases); PS-C (sorghum-based diet in pre-starter phase and corn-based diet in other phases). Exp. 2 - Change in the form of sorghum grain: Gs100% (ground sorghum-based diet); Ws100% (whole sorghum-based diet); PGs-Ws (ground sorghum-based diet in pre-starter phase and whole sorghum-based diet in other phases); PWs-Gs (whole sorghum-based diet in pre-starter phase and ground sorghum-based diet in other phases). Experiments were conducted in a randomized block design for to evaluate performance and jejunal epithelium (r=8), intestinal microbiota (r=4) and metabolizabilty of diets (r=10). The changes between corn and sorghum did not affect performance, jejunal epithelium or metabolizability of the diets, but influenced the genera Clostridium, Weissella, Bacillus and Alkaliphilus in the small intestine, and Lactobacillus and Desulfotomaculum in the caecum. Whole sorghum resulted in decreased performance at seven days of age. At 40 days, Gs100% and PGs-Ws showed similar performance, PWs-Gs showed lower weight gain and the best feed conversion rate, and Ws100% showed the worst performance. Ws100% and PGs-Ws resulted in the biggest gizzard relative weight and the highest diet metabolizability values, as well as the lowest level of Clostridium and highest level of Actinomycetales and Bacillales in the small intestine. Ws100% showed lower level of Alkaliphilus and Enterococcus than Gs100% in the caecum. The best strategy to use sorghum in broilers diets is replacing 100% of corn for ground sorghum since the first day followed by change to whole sorghum, because this diet did not affect performance or jejunal epithelium, improved diet metabolizability values, and reduced Clostridium in the small intestine of broilers.

The Spemann organizer in amphibians gives rise to the anterior mesendoderm (AME) and is capable of inducing neural tissues. This inductive activity is thought to occur largely via the antagonism of Bone Morphogenetic Protein (BMP) signaling in the organizer. In the mouse, BMP antagonists Chordin and Noggin function redundantly in the AME and are required during forebrain maintenance. However, the timing of forebrain initiation and the function of BMP antagonism in forebrain initiation remained unclear prior to this study. In addition, the Transforming Growth Factor β (TGFβ) ligand Nodal patterns the forebrain via its function in the anterior primitive streak (APS), the precursor tissue of the AME. Whether BMP and Nodal signaling pathways interact has not been previously investigated. The goal of this dissertation was to investigate the cellular and molecular mechanisms involved in early mammalian forebrain establishment by embryonic and genetic manipulations. This study determined that forebrain initiation occurs during early gastrulation and requires signals from the AVE and AME. The AVE was identified as a source of active BMP antagonism in vivo, and the BMP antagonism supplied by exogenous tissues was capable to promote forebrain initiation and maintenance in the murine ectoderm. It is likely that BMP antagonism enhances forebrain gene expression via inhibiting posteriorization. This study further identified a possible crosstalk between BMP and Nodal signaling. Loss of Chordin or Noggin in combination with heterozygosity for Nodal or Smad3 results in holoprosencephaly. Molecular analyses suggest that the BMP-Nodal interaction occurs in the APS and/or the AME. Failure of this interaction results in an imbalance of BMP and Nodal signal levels that devastate APS and AME patterning during early forebrain establishment, ultimately leading to holoprosencephaly in mid-gestation. This interaction is likely to occur extracellularly, possibly by formation of a BMP-Nodal heteromeric complex. Furthermore, the spatiotemporal expression of phospho-Smad1/5/8, an effector of BMP signaling pathway, was characterized during early mouse embryogenesis. Distribution of phospho-Smad1/5/8 serves as a faithful readout of BMP signaling activity and helps to better understand how BMPs are involved in patterning early embryos. The implication of phospho-Smad1/5/8 expression in both wildtype and mutant embryos is also discussed. / Dissertation

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