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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Health in Women of Reproductive Age : A Survey in Rural Zimbabwe

Nilses, Carin January 2000 (has links)
General and reproductive health and reproductive outcome were described in rural women of childbearing age (15-44 years) during 1992-93 in a cross-sectional study in Zimbabwe. Through a two-stage sampling procedure twelve villages were selected at random, and 79% of the women in the villages accepted to participate (n=1213). In a structured interview women¡¯s self-reported morbidity, socio-economic conditions, use of health care and fertility regulation methods, reproductive outcome and infertility problems were assessed. The prevalence rates of anaemia, malaria and syphilis were investigated. Retrospectively, HIV serology was anonymously assessed and associations with socio-economic conditions and morbidity were analysed. The mean age was 28 years. Family planning was currently used by 37%. Primary and secondary infertility was reported by 0.9% and 4.4%, respectively. The perinatal mortality rate for all completed pregnancies (n=3601) was 23/1000. During the latest completed pregnancy 94% had attended antenatal care and 85% had delivered in hospitals or clinics. The self-reported complications during delivery seemed to have been cared for within the health care system. Women perceived their health as being generally good. Mean haemoglobin (Hb) was 13.5 g/dl and only 3.4% were anaemic (Hb ¡Ü11.0 g/dl). Malaria prevalence was 5.4%, but a positive malaria test was not associated with anaemia. Syphilis prevalence was 2.2%, and a positive syphilis test increased the risk of being HIV positive three-fold (OR=3.0; 95% CI: 1.4-6.2). The prevalence of HIV was high (22%). Women aged 15-19 had the lowest prevalence (7.6%), while the highest was found in married women aged 20-29 years (30%). The differences in HIV prevalence between the villages ranged between 8.4% and 33%. HIV positive women reported no more morbidity than HIV negative women. The low morbidity found at the time of the study indicates a fairly short duration of the HIV epidemic.
12

Desarrollo de modelos estadísticos de predicción del ajuste y talla de prendas de ropa a partir de la percepción y características antropométricas del usuario

Alemany Mut, María Sandra 23 January 2024 (has links)
[ES] Los problemas de selección de talla y ajuste en la compra online de ropa son la causa de aproximadamente el 70% de las devoluciones. Esto se debe principalmente a la falta de estandarización del tallaje y al funcionamiento deficiente de los métodos de recomendación de talla. Actualmente, el comercio online de ropa tiene mucho potencial, sin embargo, las elevadas tasas de devolución, suponen costes relevantes en logística y gestión de stocks. En el estado del arte de esta tesis se refleja la complejidad del problema del ajuste de ropa, en el que intervienen múltiples factores tanto objetivos (tipo de tejido, patronaje, número de tallas, moda, morfotipo del usuario, medidas corporales, etc.), como subjetivos (percepción de ajuste y preferencias del usuario). Siendo el ajuste de las prendas uno de los problemas de mayor relevancia en el sector de la confección es de crucial interés avanzar en la generación de un conocimiento que permita relacionar con mayor precisión las dimensiones corporales, el ajuste de las prendas y el tallaje. El objetivo general de esta tesis consiste en establecer los fundamentos para desarrollar un sistema de recomendación del ajuste y talla de prendas de ropa a partir de medidas antropométricas del usuario y valoraciones de ajuste planteando un desarrollo metodológico que sirve de punto de partida para posteriormente escalar el proceso a cualquier tipo de prenda, estilo y sistema de tallaje de ropa. La aproximación propuesta consiste en la predicción del ajuste por zonas de la prenda a partir de medidas antropométricas del usuario y pruebas de ajuste previas utilizando el método estadístico de regresión logística multinomial. A partir de esta predicción de ajuste por zonas, y aplicando de nuevo modelos de regresión logística multinomial, se obtiene la probabilidad de ajuste de la serie de tallas de la prenda analizada. En primer lugar, se ha determinado la fiabilidad de las medidas antropométricas obtenidas a partir de escaneados 3D del cuerpo. Para desarrollar los modelos de predicción, se ha puesto a punto un método de caracterización del ajuste de ropa mediante valoración subjetiva de usurarios y expertos. Además, se han definido los conjuntos de medidas antropométricas relacionadas con el ajuste de la prenda en cada zona. El proceso de entrenamiento de los modelos de predicción de ajuste ha permitido determinar cuáles son las medidas antropométricas más relevantes para el ajuste de cada tipo de prenda, así como las zonas de ajuste que influyen en la selección de la talla. En la fase de validación, se ha demostrado que, con un porcentaje de acierto entre el 80-100%, los modelos de predicción de talla basados en probabilidades de ajuste obtenidas mediante regresión logística multinomial en zonas relevantes de la prenda, ofrecen mayor fiabilidad que los métodos actuales que solo consideran una variable corporal y sus intervalos. Finalmente, se ha propuesto un método para extrapolar los modelos individuales de predicción de talla a toda población objetivo, estimar la cuota de mercado potencial y optimizar la distribución de tallas de cada prenda. / [CA] Els problemes de selecció de talla i ajust en les compres de roba en la xarxa representen aproximadament el 70% de les devolucions. Això es degut principalment a la manca d'estandardització en les talles i al funcionament deficient dels mètodes de recomanació de talles. Actualment, el comerç de roba en la xarxa té molt potencial, no obstant això, les altes taxes de devolució comporten costos rellevants en logística i gestió d'estocs. L'estat de l'art en aquesta tesi reflecteix la complexitat del problema de l'ajust de la roba, que implica múltiples factors, tant objectius (tipus de teixit, patró, nombre de talles, tendències de moda, tipus de cos de l'usuari, mesures corporals, etc.) com subjectius (percepció de l'ajust per part de l'usuari i preferències). Ja que l'ajust de les peces de vestir és un dels problemes més importants en la indústria de la moda, és crucial avançar en la generació de coneixement que permeti establir una relació més precisa entre les dimensions del cos, l'ajust de la roba i les talles. L'objectiu general d'aquesta tesi és establir els fonaments per al desenvolupament d'un sistema de recomanació de l'ajust i la talla de peces de roba basat en les mesures antropomètriques de l'usuari. Això implica un desenvolupament metodològic que serveix com a punt de partida per a posteriorment escalar el procés a qualsevol tipus de peça de roba, estil i sistema de mides. L'aproximació proposada consistix en predir l'ajust per zones de la peça de roba basat en les mesures antropomètriques de l'usuari i proves prèvies d'ajust mitjançant el mètode estadístic de la regressió logística multinomial. A partir d'aquesta predicció d'ajust per zones, i aplicant novament models de regressió logística multinomial, s'obté la probabilitat d'ajust per a la gamma de talles de la peça de roba analitzada. S'ha determinat la fiabilitat de les mesures antropomètriques obtingudes a partir d'escaneigs 3D del cos. Per desenvolupar els models de predicció, s'ha posat a punt un mètode per caracteritzar l'ajust de la roba mitjançant avaluacions subjectives dels usuaris i experts. A més, s'han definit conjunts de mesures antropomètriques relacionades amb l'ajust de la peça a cada zona. El procés de formació dels models de predicció de l'ajust ha permès determinar les mesures antropomètriques més rellevants per a l'ajust de cada tipus de peça, així com les zones d'ajust que influeixen en la selecció de la talla. En la fase de validació, s'ha demostrat que, amb un percentatge d'encert entre el 80-100%, els models de predicció de talla basats en les probabilitats d'ajust obtingudes mitjançant la regressió logística multinomial en zones rellevants de la peça de roba ofereixen una major fiabilitat que els mètodes actuals que només consideren una variable corporal i els seus intervals. Finalment, s'ha proposat un mètode per extrapol·lar els models individuals de predicció de talla a tota la població objectiu, estimar la quota de mercat potencial i optimitzar la distribució de talles per a cada peça. / [EN] The problems of size selection and fit in online clothing purchases account for approximately 70% of returns. This is primarily due to the lack of standardization in sizing and the inefficient performance of current size recommendation methods. Currently, online clothing retail has a lot of potential; however, the high product return rates result in significant costs in logistics and stock management. The state of the art in this thesis reflects the complexity of the clothing fit problem, which involves multiple factors, both objective (fabric type, pattern, number of sizes, fashion trends, user body type, body measurements, etc.) and subjective (user's perception of fit and preferences). Since garment fit is one of the most significant issues in the fashion industry, it is crucial to advance in generating knowledge that allows for a more precise relationship between body dimensions, garment fit, and sizing. The general objective of this thesis is to establish the foundations for developing a recommendation system for clothing fit and size based on user anthropometric measurements and fit evaluations. This involves a methodological development that serves as a starting point for subsequently scaling the process to any type of garment, style, and sizing system. The proposed approach consists of predicting the fit by garment zones based on user anthropometric measurements and previous fit trials using the statistical method of multinomial logistic regression. From this prediction of fit by zones, and by once again applying multinomial logistic regression models, the probability of fit for the range of sizes of the analyzed garment is obtained. The reliability of anthropometric measurements obtained from 3D body scans has been determined. To develop the prediction models, a method for characterizing garment fit through subjective assessments by users and experts has been refined. In addition, sets of anthropometric measurements related to garment fit in each zone have been defined. The training process of the fit prediction models has enabled determining the most relevant anthropometric measurements for the fit of each type of garment, as well as the fit zones that influence size selection. In the validation phase, it has been demonstrated that, with an accuracy rate between 80-100%, size prediction models based on fit probabilities obtained through multinomial logistic regression in relevant garment zones offer greater reliability than current methods that only consider a single body variable and its intervals. Finally, a method has been proposed to extrapolate individual size prediction models to the entire target population, estimate the potential market share, and optimize the distribution of sizes for each garment. / Alemany Mut, MS. (2023). Desarrollo de modelos estadísticos de predicción del ajuste y talla de prendas de ropa a partir de la percepción y características antropométricas del usuario [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/202617
13

Contribution à la validation d’un outil informatique pour l’évaluation des surfaces corporelles brûlées

Matei, Svetlana 08 1900 (has links)
INTRODUCTION L’évaluation de la surface corporelle brûlée, essentielle pour établir la réanimation volémique et statuer sur le pronostic, se base actuellement sur la transposition des brûlures observées sur des diagrammes en papier représentant des mannequins standard. Le but de ce projet est de contribuer à la validation d’un outil pour l’évaluation des ratios brûlés. Deux outils ont été proposés, un numériseur portable et les mesures anthropométriques. MÉTHODES Quatre mannequins commerciaux avec différentes morphologies ont été sélectionnés. Chaque mannequin a été numérisé 10 fois avec un numériseur portable et une fois avec un numériseur de référence. Les surfaces corporelles totales ont été calculées et comparées. Dans un deuxième temps, 14 volontaires ont estimé la surface coporelle brûlée en utilisant les diagrammes papier et en dessinant sur un logiciel. RÉSULTATS Les valeurs des surfaces corporelles totales obtenues avec le numériseur portable sont 0,812; 1,581; 1,711 et 1,916 m2 pour les mannequins enfant, femme I, femme II et homme. Les résultats du numériseur de référence sont 0,815; 1,588; 1,716 et 1,918 m2. Les ratios des surfaces brûlées des mannequins correspondent à 23,33; 22,67, 32,63 et 26,07 % pour les mannequins. Les estimations des surfaces brûlées obtenues avec les diagrammes en papier représentent 29,9; 32,5; 40,4 et 35,7 %. Les résultats obtenus avec le logiciel sont 23,5; 22,6; 32,1 et 25,1 %. CONCLUSION Le numériseur portable reproduit avec précision et exactitude la surface corporelle totale. L’utilisation des données anthropométriques pour le calcul du pourcentage brûlé représente un outil plus précis et exact que les diagrammes papier. / PURPOSE Total body surface area burned assessment is currently based on the transpositon of burns seen on paper charts representing standard models. The purpose of this project is to contribute to the validation of a tool for TBSA assessment. A handheld 3D scanner and anthropometrical measurements have been proposed. METHODS Four commercial mannequins with different body shapes were selected. Each model was scanned 10 times with a handhed, white light scanner and once with a gold standard scanner. The images were transferred to a modelling software allowing to assess the total body surface. Total body surfaces were calculated and compared. Secondly, 14 volunteers estimated the total burned surface using paper charts and drawing on 3D virtual models. RESULTS Values of the total body surface obtained with the handheld scanner are 0.812; 1.581; 1.711 and 1.916 m2 for the child, female I, female II and male mannequins. The results of the gold standard scanner are 0.815 ; 1.588 ; 1.716 and 1.918 m2. Burn extent ratios correspond to 23.33 ; 22.67 ; 32.63 and 26.07 % for the same mannequins. Estimated burned surfaces obtained with paper diagrams are the following : 29.9 ; 32.5 ; 40.4 and 35.7 %. Results obtained with the software are 23.5 ; 22.6 ; 32.1 and 25.1 %. CONCLUSION The handheld scanner is a precise and accurate tool for the assessment of the total surface. Use of anthropometric data for the calculation of the body burned surface is a more accurate tool and less variable than the conventional paper charts.
14

BIRTHWEIGHT AND SUSCEPTIBILITY TO CHRONIC DISEASE

Issa Al Salmi Unknown Date (has links)
The thesis examines the relationship of birthweight to risk factors and markers, such as proteinuria and glomerular filtration rate, for chronic disease in postnatal life. It made use of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). The AusDiab study is a cross sectional study where baseline data on 11,247 participants were collected in 1999-2000. Participants were recruited from a stratified sample of Australians aged ≥ 25 years, residing in 42 randomly selected urban and non-urban areas (Census Collector Districts) of the six states of Australia and the Northern Territory. The AusDiab study collected an enormous amount of clinical and laboratory data. During the 2004-05 follow-up AusDiab survey, questions about birthweight were included. Participants were asked to state their birthweight, the likely accuracy of the stated birthweight and the source of their stated birthweight. Four hundred and twelve chronic kidney disease (CKD) patients were approached, and 339 agreed to participate in the study. The patients completed the same questionnaire. Medical records were reviewed to check the diagnoses, causes of kidney trouble and SCr levels. Two control subjects, matched for gender and age, were selected for each CKD patient from participants in the AusDiab study who reported their birthweight. Among 7,157 AusDiab participants who responded to the questionnaire, 4,502 reported their birthweights, with a mean (standard deviation) of 3.4 (0.7) kg. The benefit and disadvantages of these data are discussed in chapter three. The data were analysed for the relationship between birthweight and adult body size and composition, disorders of glucose regulation, blood pressure, lipid abnormalities, cardiovascular diseases and glomerular filtration rate. Low birthweight was associated with smaller body build and lower lean mass and total body water in both females and males. In addition low birthweight was associated with central obesity and higher body fat percentage in females, even after taking into account current physical activity and socioeconomic status. Fasting plasma glucose, post load glucose and glycosylated haemoglobin were strongly and inversely correlated with birthweight. In those with low birthweight (< 2.5 kg), the risks for having impaired fasting glucose, impaired glucose tolerance, diabetes and all abnormalities combined were increased by 1.75, 2.22, 2.76 and 2.28 for females and by 1.40, 1.32, 1.98 and 1.49 for males compared to those with normal birthweight (≥ 2.5 kg), respectively. Low birthweight individuals were at higher risk for having high blood pressure ≥ 140/90 mmHg and ≥ 130/85 mmHg compared to those with normal birthweight. People with low birthweight showed a trend towards increased risk for high cholesterol (≥ 5.5 mmol/l) compared to those of normal birthweight. Females with low birthweight had increased risk for high low density lipoprotein cholesterol (≥ 3.5 mmol/l) and triglyceride levels (≥ 1.7 mmol/l) when compared to those with normal birthweight. Males with low birthweight exhibited increased risk for low levels of high density lipoprotein cholesterol (<0.9 mmol/l) than those with normal birthweight. Females with low birthweight were at least 1.39, 1.40, 2.30 and 1.47 times more likely to have angina, coronary artery disease, stroke and overall cardiovascular diseases respectively, compared to those ≥ 2.5 kg. Similarly, males with low birthweight were 1.76, 1.48, 3.34 and 1.70 times more likely to have angina, coronary artery disease, stroke and overall cardiovascular diseases compared to those ≥ 2.5 kg, respectively. The estimated glomerular filtration rate was strongly and positively associated with birthweight, with a predicted increase of 2.6 ml/min (CI 2.1, 3.2) and 3.8 (3.0, 4.5) for each kg of birthweight for females and males, respectively. The odd ratio (95% confidence interval) for low glomerular filtration rate (<61.0 ml/min for female and < 87.4 male) in people of low birthweight compared with those of normal birthweight was 2.04 (1.45, 2.88) for female and 3.4 (2.11, 5.36) for male. One hundred and eighty-nineCKD patients reported their birthweight; 106 were male. Their age was 60.3(15) years. Their birthweight was 3.27 (0.62) kg, vs 3.46 (0.6) kg for their AusDiab controls, p<0.001 and the proportions with birthweight<2.5 kg were 12.17% and 4.44%, p<0.001. Among CKD patients, 22.8%, 21.7%, 18% and 37.6% were in CKD stages 2, 3, 4 and 5 respectively. Birthweights by CKD stage and their AusDiab controls were as follows: 3.38 (0.52) vs 3.49 (0.52), p=0.251 for CKD2; 3.28 (0.54) vs 3.44 (0.54), p=0.121 for CKD3; 3.19 (0.72) vs 3.43 (0.56), p= 0.112 for CKD4 and 3.09 (0.65) vs 3.47 (0.67), p<0.001 for CKD5. The results demonstrate that in an affluent Western country with a good adult health profile, low birthweight people were predisposed to higher rates of glycaemic dysregulation, high blood pressure, dyslipidaemia, cardiovascular diseases and lower glomerular filtration rate in adult life. In all instances it would be prudent to adopt policies of intensified whole of life surveillance of lower birthweight people, anticipating this risk. The general public awareness of the effect of low birthweight on development of chronic diseases in later life is of vital importance. The general public, in addition to the awareness of people in medical practice of the role of low birthweight, will lead to a better management of this group of our population that is increasingly surviving into adulthood.
15

BIRTHWEIGHT AND SUSCEPTIBILITY TO CHRONIC DISEASE

Issa Al Salmi Unknown Date (has links)
The thesis examines the relationship of birthweight to risk factors and markers, such as proteinuria and glomerular filtration rate, for chronic disease in postnatal life. It made use of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). The AusDiab study is a cross sectional study where baseline data on 11,247 participants were collected in 1999-2000. Participants were recruited from a stratified sample of Australians aged ≥ 25 years, residing in 42 randomly selected urban and non-urban areas (Census Collector Districts) of the six states of Australia and the Northern Territory. The AusDiab study collected an enormous amount of clinical and laboratory data. During the 2004-05 follow-up AusDiab survey, questions about birthweight were included. Participants were asked to state their birthweight, the likely accuracy of the stated birthweight and the source of their stated birthweight. Four hundred and twelve chronic kidney disease (CKD) patients were approached, and 339 agreed to participate in the study. The patients completed the same questionnaire. Medical records were reviewed to check the diagnoses, causes of kidney trouble and SCr levels. Two control subjects, matched for gender and age, were selected for each CKD patient from participants in the AusDiab study who reported their birthweight. Among 7,157 AusDiab participants who responded to the questionnaire, 4,502 reported their birthweights, with a mean (standard deviation) of 3.4 (0.7) kg. The benefit and disadvantages of these data are discussed in chapter three. The data were analysed for the relationship between birthweight and adult body size and composition, disorders of glucose regulation, blood pressure, lipid abnormalities, cardiovascular diseases and glomerular filtration rate. Low birthweight was associated with smaller body build and lower lean mass and total body water in both females and males. In addition low birthweight was associated with central obesity and higher body fat percentage in females, even after taking into account current physical activity and socioeconomic status. Fasting plasma glucose, post load glucose and glycosylated haemoglobin were strongly and inversely correlated with birthweight. In those with low birthweight (< 2.5 kg), the risks for having impaired fasting glucose, impaired glucose tolerance, diabetes and all abnormalities combined were increased by 1.75, 2.22, 2.76 and 2.28 for females and by 1.40, 1.32, 1.98 and 1.49 for males compared to those with normal birthweight (≥ 2.5 kg), respectively. Low birthweight individuals were at higher risk for having high blood pressure ≥ 140/90 mmHg and ≥ 130/85 mmHg compared to those with normal birthweight. People with low birthweight showed a trend towards increased risk for high cholesterol (≥ 5.5 mmol/l) compared to those of normal birthweight. Females with low birthweight had increased risk for high low density lipoprotein cholesterol (≥ 3.5 mmol/l) and triglyceride levels (≥ 1.7 mmol/l) when compared to those with normal birthweight. Males with low birthweight exhibited increased risk for low levels of high density lipoprotein cholesterol (<0.9 mmol/l) than those with normal birthweight. Females with low birthweight were at least 1.39, 1.40, 2.30 and 1.47 times more likely to have angina, coronary artery disease, stroke and overall cardiovascular diseases respectively, compared to those ≥ 2.5 kg. Similarly, males with low birthweight were 1.76, 1.48, 3.34 and 1.70 times more likely to have angina, coronary artery disease, stroke and overall cardiovascular diseases compared to those ≥ 2.5 kg, respectively. The estimated glomerular filtration rate was strongly and positively associated with birthweight, with a predicted increase of 2.6 ml/min (CI 2.1, 3.2) and 3.8 (3.0, 4.5) for each kg of birthweight for females and males, respectively. The odd ratio (95% confidence interval) for low glomerular filtration rate (<61.0 ml/min for female and < 87.4 male) in people of low birthweight compared with those of normal birthweight was 2.04 (1.45, 2.88) for female and 3.4 (2.11, 5.36) for male. One hundred and eighty-nineCKD patients reported their birthweight; 106 were male. Their age was 60.3(15) years. Their birthweight was 3.27 (0.62) kg, vs 3.46 (0.6) kg for their AusDiab controls, p<0.001 and the proportions with birthweight<2.5 kg were 12.17% and 4.44%, p<0.001. Among CKD patients, 22.8%, 21.7%, 18% and 37.6% were in CKD stages 2, 3, 4 and 5 respectively. Birthweights by CKD stage and their AusDiab controls were as follows: 3.38 (0.52) vs 3.49 (0.52), p=0.251 for CKD2; 3.28 (0.54) vs 3.44 (0.54), p=0.121 for CKD3; 3.19 (0.72) vs 3.43 (0.56), p= 0.112 for CKD4 and 3.09 (0.65) vs 3.47 (0.67), p<0.001 for CKD5. The results demonstrate that in an affluent Western country with a good adult health profile, low birthweight people were predisposed to higher rates of glycaemic dysregulation, high blood pressure, dyslipidaemia, cardiovascular diseases and lower glomerular filtration rate in adult life. In all instances it would be prudent to adopt policies of intensified whole of life surveillance of lower birthweight people, anticipating this risk. The general public awareness of the effect of low birthweight on development of chronic diseases in later life is of vital importance. The general public, in addition to the awareness of people in medical practice of the role of low birthweight, will lead to a better management of this group of our population that is increasingly surviving into adulthood.
16

BIRTHWEIGHT AND SUSCEPTIBILITY TO CHRONIC DISEASE

Issa Al Salmi Unknown Date (has links)
The thesis examines the relationship of birthweight to risk factors and markers, such as proteinuria and glomerular filtration rate, for chronic disease in postnatal life. It made use of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). The AusDiab study is a cross sectional study where baseline data on 11,247 participants were collected in 1999-2000. Participants were recruited from a stratified sample of Australians aged ≥ 25 years, residing in 42 randomly selected urban and non-urban areas (Census Collector Districts) of the six states of Australia and the Northern Territory. The AusDiab study collected an enormous amount of clinical and laboratory data. During the 2004-05 follow-up AusDiab survey, questions about birthweight were included. Participants were asked to state their birthweight, the likely accuracy of the stated birthweight and the source of their stated birthweight. Four hundred and twelve chronic kidney disease (CKD) patients were approached, and 339 agreed to participate in the study. The patients completed the same questionnaire. Medical records were reviewed to check the diagnoses, causes of kidney trouble and SCr levels. Two control subjects, matched for gender and age, were selected for each CKD patient from participants in the AusDiab study who reported their birthweight. Among 7,157 AusDiab participants who responded to the questionnaire, 4,502 reported their birthweights, with a mean (standard deviation) of 3.4 (0.7) kg. The benefit and disadvantages of these data are discussed in chapter three. The data were analysed for the relationship between birthweight and adult body size and composition, disorders of glucose regulation, blood pressure, lipid abnormalities, cardiovascular diseases and glomerular filtration rate. Low birthweight was associated with smaller body build and lower lean mass and total body water in both females and males. In addition low birthweight was associated with central obesity and higher body fat percentage in females, even after taking into account current physical activity and socioeconomic status. Fasting plasma glucose, post load glucose and glycosylated haemoglobin were strongly and inversely correlated with birthweight. In those with low birthweight (< 2.5 kg), the risks for having impaired fasting glucose, impaired glucose tolerance, diabetes and all abnormalities combined were increased by 1.75, 2.22, 2.76 and 2.28 for females and by 1.40, 1.32, 1.98 and 1.49 for males compared to those with normal birthweight (≥ 2.5 kg), respectively. Low birthweight individuals were at higher risk for having high blood pressure ≥ 140/90 mmHg and ≥ 130/85 mmHg compared to those with normal birthweight. People with low birthweight showed a trend towards increased risk for high cholesterol (≥ 5.5 mmol/l) compared to those of normal birthweight. Females with low birthweight had increased risk for high low density lipoprotein cholesterol (≥ 3.5 mmol/l) and triglyceride levels (≥ 1.7 mmol/l) when compared to those with normal birthweight. Males with low birthweight exhibited increased risk for low levels of high density lipoprotein cholesterol (<0.9 mmol/l) than those with normal birthweight. Females with low birthweight were at least 1.39, 1.40, 2.30 and 1.47 times more likely to have angina, coronary artery disease, stroke and overall cardiovascular diseases respectively, compared to those ≥ 2.5 kg. Similarly, males with low birthweight were 1.76, 1.48, 3.34 and 1.70 times more likely to have angina, coronary artery disease, stroke and overall cardiovascular diseases compared to those ≥ 2.5 kg, respectively. The estimated glomerular filtration rate was strongly and positively associated with birthweight, with a predicted increase of 2.6 ml/min (CI 2.1, 3.2) and 3.8 (3.0, 4.5) for each kg of birthweight for females and males, respectively. The odd ratio (95% confidence interval) for low glomerular filtration rate (<61.0 ml/min for female and < 87.4 male) in people of low birthweight compared with those of normal birthweight was 2.04 (1.45, 2.88) for female and 3.4 (2.11, 5.36) for male. One hundred and eighty-nineCKD patients reported their birthweight; 106 were male. Their age was 60.3(15) years. Their birthweight was 3.27 (0.62) kg, vs 3.46 (0.6) kg for their AusDiab controls, p<0.001 and the proportions with birthweight<2.5 kg were 12.17% and 4.44%, p<0.001. Among CKD patients, 22.8%, 21.7%, 18% and 37.6% were in CKD stages 2, 3, 4 and 5 respectively. Birthweights by CKD stage and their AusDiab controls were as follows: 3.38 (0.52) vs 3.49 (0.52), p=0.251 for CKD2; 3.28 (0.54) vs 3.44 (0.54), p=0.121 for CKD3; 3.19 (0.72) vs 3.43 (0.56), p= 0.112 for CKD4 and 3.09 (0.65) vs 3.47 (0.67), p<0.001 for CKD5. The results demonstrate that in an affluent Western country with a good adult health profile, low birthweight people were predisposed to higher rates of glycaemic dysregulation, high blood pressure, dyslipidaemia, cardiovascular diseases and lower glomerular filtration rate in adult life. In all instances it would be prudent to adopt policies of intensified whole of life surveillance of lower birthweight people, anticipating this risk. The general public awareness of the effect of low birthweight on development of chronic diseases in later life is of vital importance. The general public, in addition to the awareness of people in medical practice of the role of low birthweight, will lead to a better management of this group of our population that is increasingly surviving into adulthood.

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