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Major depression disorder (MDD) is a complex and chronic disease that ranks fourth as cause of disability worldwide. About 14 million adults in the USA are believed to have MDD, and an estimated 75 % attempt suicide making MDD a major public health problem. Neuroticism has been recognized as an endophenotype of MDD; however, few genome-wide association (GWA) analyses of neuroticism as a quantitative trait have been reported to date. The aim of this study is to identify genome-wide genetic variants affecting neuroticism using a European sample. A linear regression model was used to analyze the association with neuroticism as a continuous trait in the Netherlands Study of Depression and Anxiety and Netherlands Twin Registry population-based sample of 2,748 individuals with Perlegen 600K single nucleotide polymorphisms (SNPs). In addition, the neuroticism-associated genes/loci of the top 20 SNPs (p < 10-4) were examined with anti-social personality disorder (ASPD) in an Australian twin family study. Through GWA analysis, 32 neuroticism-associated SNPs (p < 10-4) were identified. The most significant association was observed with SNP rs4806846 within the TMPRSS9 gene (p = 7.79 × 10-6) at 19p13.3. The next best signal was in GRIN2B gene (rs220549, p = 1.05 × 10-5) at 12p12. In addition, several SNPs within GRIN2B showed borderline associations with ASPD in the Australian sample. In conclusion, these results provide a possible genetic basis for the association with neuroticism. Our findings provide a basis for replication in other populations to elucidate the potential role of these genetic variants in neuroticism and MDD along with a possible relationship between ASPD and neuroticism.

Major depression disorder (MDD) is a complex and chronic disease that ranks fourth as cause of disability worldwide. About 14 million adults in the USA are believed to have MDD, and an estimated 75 % attempt suicide making MDD a major public health problem. Neuroticism has been recognized as an endophenotype of MDD; however, few genome-wide association (GWA) analyses of neuroticism as a quantitative trait have been reported to date. The aim of this study is to identify genome-wide genetic variants affecting neuroticism using a European sample. A linear regression model was used to analyze the association with neuroticism as a continuous trait in the Netherlands Study of Depression and Anxiety and Netherlands Twin Registry population-based sample of 2,748 individuals with Perlegen 600K single nucleotide polymorphisms (SNPs). In addition, the neuroticism-associated genes/loci of the top 20 SNPs (p < 10-4) were examined with anti-social personality disorder (ASPD) in an Australian twin family study. Through GWA analysis, 32 neuroticism-associated SNPs (p < 10-4) were identified. The most significant association was observed with SNP rs4806846 within the TMPRSS9 gene (p = 7.79 × 10-6) at 19p13.3. The next best signal was in GRIN2B gene (rs220549, p = 1.05 × 10-5) at 12p12. In addition, several SNPs within GRIN2B showed borderline associations with ASPD in the Australian sample. In conclusion, these results provide a possible genetic basis for the association with neuroticism. Our findings provide a basis for replication in other populations to elucidate the potential role of these genetic variants in neuroticism and MDD along with a possible relationship between ASPD and neuroticism.

O presente estudo versa sobre os discursos policial, jurídico, psiquiátrico e jornalístico produzidos acerca de um jovem, autor de um quíntuplo homicídio em família (patri-matri-fratricídio). O dossier sobre o caso, e ainda mais três explicações para a conduta violenta, oriundas do campo psi, foram analisados a partir da arqueologia, genealogia e ética foucaultianas visando esclarecer os motivos e os modos de construção destes discursos. O estudo permitiu constatar que as diferentes instâncias sociais solidarizaram-se para forjar uma representação do homicida compatível com o consagrado modelo da psicopatia - a ausência de remorsos, a incapacidade para a empatia, a frieza afetiva e a insensibilidade moral; também, que produções do campo psi prestam-se a dar referendo científico às conclusões sociais que retratam os homicidas como seres malignos, portadores de aberrações biológicas que os incapacitam a desenvolver adequadamente a afetividade e a moralidade, condenando-os aos atos criminosos violentos. Estas constatações, discutidas pelo prisma das contradições da sociedade contemporânea, deixam vislumbrar parte daquilo que se obnubila por estes discursos: remetendo ao plano biológico as determinações da conduta irracional e violenta, poupa-se de crítica o ordenamento sistemático das relações sócio-econômicas. Em conclusão, apresenta-se como imperativo derivar para a ciência psi a injunção de conhecer e denunciar as interveniências dos planos individual e coletivo em toda e qualquer conduta humana - o mais irracional e violento dos crimes cometido por um homem, guarda obrigatoriamente os traços da irracionalidade e violência do sistema social que o envolve; aperceber-se deles é condição de transformá-los. / This present study considers the police, legal, psychiatric and journalistic speeches about a young man who is the author of a quintuplet family homicide (patricide-matricide-fraticide). The dossier about the case, and three explanations else for the violent behaviour from the psy area, were analysed from the archaeological, genealogical and ethical foucaultian considering to clear up the cause and way these speeches were constructed.The study has allowed to show up the different social resort to join forces to forging a representation of the murderer with the stablished model of psychopath - no remorses, the incapacity for empathy, coolness affection and moral insensibility; it is also to show that productions of the psy area are suitable for giving scientific endorsement to the social agreement that show the murderer as evil beings who are owners a such of biological aberrations that make them incapable of developing the affecting and morality and to sentence them to criminal violent actions. All these observations were talked about by the point of view of the contemporany society contradictions and they let to glimpse part of that are hided by those speeches: the systematic order of social economical relations indulgences itself of criticism when it sends the determinations of irrational and violent behaviour to the biological area. As conclusion, it shows the necessity to deduce to the psy science the obligation to knowing and denouncing the interference between individual and collective plans in all human behaviour - the most of irrational and violent crimes commited by a man hides traces of irrationality and violence of social system that involves it. The capacity of see the traces is the conditions to be able to change them.

O presente estudo versa sobre os discursos policial, jurídico, psiquiátrico e jornalístico produzidos acerca de um jovem, autor de um quíntuplo homicídio em família (patri-matri-fratricídio). O dossier sobre o caso, e ainda mais três explicações para a conduta violenta, oriundas do campo psi, foram analisados a partir da arqueologia, genealogia e ética foucaultianas visando esclarecer os motivos e os modos de construção destes discursos. O estudo permitiu constatar que as diferentes instâncias sociais solidarizaram-se para forjar uma representação do homicida compatível com o consagrado modelo da psicopatia - a ausência de remorsos, a incapacidade para a empatia, a frieza afetiva e a insensibilidade moral; também, que produções do campo psi prestam-se a dar referendo científico às conclusões sociais que retratam os homicidas como seres malignos, portadores de aberrações biológicas que os incapacitam a desenvolver adequadamente a afetividade e a moralidade, condenando-os aos atos criminosos violentos. Estas constatações, discutidas pelo prisma das contradições da sociedade contemporânea, deixam vislumbrar parte daquilo que se obnubila por estes discursos: remetendo ao plano biológico as determinações da conduta irracional e violenta, poupa-se de crítica o ordenamento sistemático das relações sócio-econômicas. Em conclusão, apresenta-se como imperativo derivar para a ciência psi a injunção de conhecer e denunciar as interveniências dos planos individual e coletivo em toda e qualquer conduta humana - o mais irracional e violento dos crimes cometido por um homem, guarda obrigatoriamente os traços da irracionalidade e violência do sistema social que o envolve; aperceber-se deles é condição de transformá-los. / This present study considers the police, legal, psychiatric and journalistic speeches about a young man who is the author of a quintuplet family homicide (patricide-matricide-fraticide). The dossier about the case, and three explanations else for the violent behaviour from the psy area, were analysed from the archaeological, genealogical and ethical foucaultian considering to clear up the cause and way these speeches were constructed.The study has allowed to show up the different social resort to join forces to forging a representation of the murderer with the stablished model of psychopath - no remorses, the incapacity for empathy, coolness affection and moral insensibility; it is also to show that productions of the psy area are suitable for giving scientific endorsement to the social agreement that show the murderer as evil beings who are owners a such of biological aberrations that make them incapable of developing the affecting and morality and to sentence them to criminal violent actions. All these observations were talked about by the point of view of the contemporany society contradictions and they let to glimpse part of that are hided by those speeches: the systematic order of social economical relations indulgences itself of criticism when it sends the determinations of irrational and violent behaviour to the biological area. As conclusion, it shows the necessity to deduce to the psy science the obligation to knowing and denouncing the interference between individual and collective plans in all human behaviour - the most of irrational and violent crimes commited by a man hides traces of irrationality and violence of social system that involves it. The capacity of see the traces is the conditions to be able to change them.