This diploma thesis was made to evaluate the influence of body condition change in Czech Fleckvieh cattle to their milk production in one-year monitoring of 214 dairy cows. Their body condition was individually valued with 5-point system named Body Condition Scoring (BCS) with accuracy to 0,5 point. Body condition of these dairy cows was written down between 1 up to 2 months before calving and then between 40 up to 70 days after calving. The change in body condition between these two terms was subsequently evaluated to milk yield and the composition of milk. There was also evaluated the influence of body condition change to phase of lactation, parity and somatic cell count. Relationship between body condition change and milk yield was highly positive. Relationship between body condition change and the amount of milk fat, milk protein, fat to protein ratio, phase of lactation and somatic cell count was not proved.

The aim of the final thesis was to control the management of dairy cows breeding, nutrition, health and milk production in the chosen company. The next aim was to recommend measures in the order to improve the business situation, to realize some of them and compare results. Literary part is focused on the characteristic of nutrition of calves, heifers and dairy cattle. Methods how to control nutrition and metabolism with using feed mixture, excrements, ruminant, body condition, control of milk production and a content of milk components analysis are described. Practical part includes a description of the company, an analysis of the situation in April 2018 and recommended improvement measures. The implemented measures on the farm in summer 2018 are also described. The breed is characterized by data such as number of cattle, results of reproduction and health, average yields in last years and milk components. Furthermore, the changes that took place on the farm during the reporting period are described. The weights of two groups of calves with different nutrition were compared and evaluated (the group of calves fed with milk and starter from the birth vs. the group of calves fed only with milk). At the age of three months, calves fed with milk and starter had significantly higher weight compared to the group of calves which were fed with starter during weaning period. The milk yield was inconclusive (p = 0.06) after the realization of the measures. However, there were significant changes in milk components — protein, fat and urea content increased. The comparision of milk yield and milk components of the Czech Fleckvieh’s and Holstein’s breed was evaluated. Holstein dairy cows had a higher milk yield with lower somatic cells. On the other hand milk of Czech Fleckvieh’s cows contained more protein and fat. Other analyses showed, that cows are getting fat at the end of lactation and during dry period. Suspicions of acidosis and insufficient homogeneity of feed mixture were evaluated (because of the different consistency of feces of dairy cows in the same group, the content of the raw elements was high in feed ration, the problem of separation of feed mixture components during transport by belt conveyors was proven).

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20166号 / 理博第4251号 / 新制||理||1611(附属図書館) / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 松田 祐司, 教授 川上 則雄, 教授 前野 悦輝 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第21247号 / 理博第4417号 / 新制||理||1634(附属図書館) / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 石田 憲二, 教授 前野 悦輝, 教授 松田 祐司 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

No description available.

On considère généralement que la fonction d’onde macroscopique décrivant un condensat de paires de fermions possède une phase parfaitement définie et immuable. En réalité, il n’existe que des systèmes de taille finie, préparés à température non nulle ; le condensat possède alors un temps de cohérence fini, même lorsque le système est isolé. Cet effet fondamental, crucial pour les applications qui exploitent la cohérence macroscopique, restait très peu étudié.Dans cette thèse, nous relions le temps de cohérence à la dynamique de phase du condensat, et nous montrons par une approche microscopique que la dérivée temporelle de l’opérateur phase ˆθ0 est proportionnelle à un opérateur potentiel chimique qui inclut les deux branches d’excitations du gaz : celle, fermionique, de brisure des paires et celle, bosonique, de mise en mouvement de leur centre de masse. Pour une réalisation donnée de l’énergie E et du nombre de particules N, la phase évolue aux temps longs comme −2μmc(E,N)t/~ où μmc(E,N) est le potentiel chimique microcanonique ; les fluctuations de E et de N d’une réalisation à l’autre conduisent alors à un brouillage balistique de la phase, et à une décroissance gaussienne de la fonction de cohérence temporelle avec un temps caractéristique ∝ N1/2. En l’absence de telles fluctuations, la décroissance est au contraire exponentielle avec un temps de cohérence qui diverge linéairement en N à cause du mouvement diffusif de ˆθ0 dans l’environnement des modes excités. Nous donnons une expression explicite de ce temps caractéristique à bassetempérature dans le cas d’une branche d’excitation bosonique convexe lorsque les phonons interagissent via les processus 2 ↔ 1 de Beliaev-Landau. Enfin, nous proposons des méthodes permettant de mesurer avec un gaz d’atomes froids chaque contribution au temps de cohérence / It is generally assumed that a condensate of paired fermions at equilibrium is characterized by a macroscopic wavefunction with a well-defined, immutable phase. In reality, all systems have a finite size and are prepared at non-zero temperature ; the condensate has then a finite coherence time, even when the system is isolated. This fundamental effect, crucial for applicationsusing macroscopic coherence, was scarcely studied. Here, we link the coherence time to the condensate phase dynamics, and show using a microscopic theory that the time derivative of the condensate phase operator ˆθ0 is proportional to a chemical potential operator which includes both the fermionic pair-breaking and the bosonic pair-motion excitation branches.For a given realization of the number of particle N and of the energy E, the phase evolves at long times as −2μmc(E,N)t/~ where μmc(E,N) is the microcanonical chemical potential ; fluctuations of N and E from one realization to the other then lead to a ballistic spreading of the phase and to a Gaussian decay of the temporal coherence function with a characteristictime ∝ N1/2. On the contrary, in the absence of energy and number fluctuations, the decay of the temporal coherence function is exponential with a characteristic time scaling as N due to the diffusive motion of ˆθ0 in the environnement created by the excited modes. We give an explict expression of this characteristic time at low temperature in the case where the bosonicbranch is convex and the phonons undergo 2 ↔ 1 Beliaev-Landau process. Finally, we propose methods to measure each contribution to the coherence time using ultracold atoms.

The phenomenon of pairing in atomic and nuclear many-body systems gives rise to a great number of different physical properties of matter, from areas as seemingly diverse as the shape of stable nuclei to superconductivity in metals and superfluidity in neutron stars. With the experimental realisation of the long sought BCS-BEC crossover observed in trapped atomic gases - where it is possible to fine tune the s-wave scattering length a of a many-fermion system between a dilute, correlated BCS-like superfluid of Cooper pairs and a densely packed BEC of composite bosons - pairing problems in atomic physics have found renewed interest in recent years. Given the high precision techniques involved in producing these trapped gas condensates, we would like to employ a suitably accurate many-body method to study such systems, preferably one which goes beyond the simple mean-field picture.The Coupled Cluster Method (CCM) is a widely applied and highly successful ab initio method in the realm of quantum many-body physics and quantum chemistry, known to be capable of producing extremely accurate results for a wide variety of different many-body systems. It has not found many applications in pairing problems however, at least not in a general sense. Our aim, therefore, is to study various models of pairing using a variety of CCM techniques - we are interested in studying the generic features of pairing problems and in particular, we are especially interested in probing the collective modes of a system which exhibits the BCS-BEC crossover, in either the BCS or BEC limit. The CCM seems a rather good candidate for the job, given the high precision results it can produce.

Ericssons Business Communication Suite (BCS) är en Unified Communication-lösning, och är avsedd för större företag och teleoperatörer. BCS erbjuder tjänster som snabbmeddelanden, videosamtal, lägga till kontakter i grupper samt grupphantering mm. Syftet med detta projekt var tvåfaldigt; att utveckla och integrera ett program som kan kommunicera med Ericssons BCS, samt att dokumentera denna integration genom de erhållna kunskaperna från utvecklingen. Applikationen utvecklades för Windows Sidebar widget miljön och BCS miljön simulerades med hjälp av flera program och applikationer som tillhandahölls av Ericsson. Det första resultatet är en steg-för-steg integrationsguide, som innehåller installationsintruktioner för BCS-miljön samt riktlinjer för denna integration. Det andra resultatet är en widget som kan söka efter personer på sökmotorn www.eniro.se och utnyttja tjänster som tillhandahålls från BCS, som kontakt-och grupphantering samt videosamtal. Detta projekt visar att en tredjepartsutvecklad applikation kan integreras med BCS, och att tredjepartsutvecklare samt anställda på Ericsson kan använda steg-för-steg integrationsguiden för att sätta upp test- och utvecklingsmiljö för BCS. / Ericsson Business Communication Suite (BCS) is a Unified Communication solution destined for larger companies and telecommunication operators. BCS offers services such as instant messaging, video calls, contact group management and much more. The purpose of this project was twofold; developing and integrating an application that could communicate with Ericsson's Business Communication Suite, but also to document this integration through the knowledge acquired from the development. The application was developed for the Windows Sidebar widget engine and a BCS environment was simulated with the help of several programs and applications provided by Ericsson. The results of the project are a step-by-step integration guide, which contains environment setup as well as integration guidelines, and also a widget application that can search for people on the search engine www.eniro.se and utilize services provided by BCS such as contact and group management and video calls. This project demonstrates that a third party developed application can be integrated with Ericsson BCS, and that third party developers and people at Ericsson can use the step-by-step integration guide to easily setup the necessary BCS test environments.

No description available.

A avaliação da classe biofarmacêutica dos fármacos assume importância na política de medicamentos genéricos, já que as características de solubilidade e permeabilidade de um fármaco, conforme definidas pelo Sistema de Classificação Biofarmacêutica (SCB), constituem critério essencial para bioisenção na obtenção de registro de genéricos. O propósito do trabalho foi o de determinar a classe biofarmacêutica dos fármacos benzilato de anlodipino, fluconazol e cloridrato de fluoxetina, por meio da determinação de seus parâmetros de solubilidade e permeabilidade. Para o teste de solubilidade, foram desenvolvidos e validados métodos para a quantificação do benzilato de anlodipino, fluconazol e cloridrato de fluoxetina em água e nos tampões farmacopéicos pH 1,2; pH 4,5;pH 6,8 e 7,5. O estudo de solubilidade foi realizado pelo método shake flask num período de 72 horas de agitação a 37°C. A maior dose comercializada no mercado é de 10 mg, 200 mg e 20 mg respectivamente para o besilato de anlodipino, fluconazol e cloridrato de fluoxetina. Os valores de solubilidade para o besilato de anlodipino nos meios avaliados foram de 0,88 a 2,35 mg/mL enquanto intervalo da razão dose: solubilidade (D: S) foi de 4,24 mL a 11,36 mL. Para o fluconazol os valores de solubilidade foram: 8,22 a 14,4 mg/mL, e o intervalo da razão D: S foram de 13,38 mL a 24,33 mL. Já para o cloridrato de fluoxetina a solubilidade foi de 5,12 a 44,36 mg/mL, e o intervalo razão D: S foram de 0,45 a 3,91 mL. De acordo com o SCB, para classifacar um fármaco como de alta solubilidade a dose mais alta cormecializada do fármaco deve ser solúvel em 250 mL de meio aquoso na faixa de pH de 1 a 7,5 a 37º C e um fármaco é considerado como de alta permeabilidade quando a sua fração absorvida seja ≥ 90%. De acordo com esse critério, ambos os fármacos apresentam alta solubilidade. A avaliação da permeabilidade dos fármacos foi realizada por meio da determinação do fluxo de fármaco através de segmentos intestinais de ratos, isolados e contidos em câmaras de difusão vertical da plataforma manual para testes de permeabilidade. Os valores de permeabilidade aparente (Papp) obtidos nos experimentos indicam que o besilato de anlodipino e o fluconazol são fármacos de baixa permeabilidade, portanto, classe III e o cloridrato de fluoxetina alta permeabilidade, classe I. / The Biopharmaceutical Classification System (BCS) concept was established by Amidon and co-workers (1995) and BCS allows expectations regarding correlation between in vitro dissolution data and in vivo bioavailability data. According to the BCS, three major factors govern drug bioavailability: the drug aqueous solubility, the ability of the drug molecules to permeate biologic membranes and drug dissolution from the dosage form. Solubility criteria defined by the FDA to classify a drug as highly soluble requires the highest dose strength to be soluble in 250 mL of aqueous media over the pH range of 1-7.5 at 37°C and a drug is considered with high permeability when its fraction absorbed is ≥ 90%. The purpose of this study was to evaluate the solubility and permeability of amlodipine benzylate, fluconazole and fluoxetine hidrochoride in order to determine them BCS class. The solubility study was performed using the drug over a 72 hours period of agitation as the shake flask method at 37 °C. The results from solubility values are given in mg/mL and dose: solubility ratio is given in mL. The highest dose marketed is 10 mg, 200 mg and 20 mg, respectively for the amlodipine besylate, fluconazole and fluoxetine hydrochloride. The solubility values for the amlodipine besylate in the tested aqueous media range from 0.88 to 2.35 mg/mL, while dose solubility ratio (D: S) values range from 4.24 to 11.36 mL. The values for fluconazole solubility were 8.22 to 14.4 mg/mL, and the D: S was 13.38 to 24.33 mL. The fluoxetine hydrochloride solubility is range from 5.12 to 44.36 mg/mL, and the ratio D: S from 0.45 to 3.91 mL. According to BCS all the drugs have high solubility. The evaluation of the drugs permeability was performed by determining the drug flow through the rat intestinal segments, isolated and contained in vertical diffusion chambers platform for manual testing permeability. The apparent permeability values (Papp) obtained in the experiments indicate that the amlodipine besylate and fluconazole are low permeability drugs and fluoxetine hydrochloride high permeability. Considering Solubility and permeability assay, amlodipine besylate and fluconazole are Class III and fluoxetine hydrochloride is Class I.