The South African pharmaceutical market is seen as part of the so called "pharmerging" markets, together with countries like India, China and Brazil. These "pharmerging" markets are the fastest growing markets within the global pharmaceutical industry. The distribution of chronic medicine in South Africa is a growing market, as the disease burden in South Africa continues to escalate, with the incidence of chronic conditions growing at a rapid rate. The study will focus on one of South Africa’s pioneer courier medication service providers, with more than twenty years’ experience in the healthcare industry. The company will be referred to as Pharmacy X. The mission of Pharmacy X is to provide the right chronic medication, to the right patient, at the right place, at the right time. It is imperative to ensure that a patient receives his/her chronic medication on the scheduled date of delivery to ensure compliance and customer satisfaction. To achieve a competitive advantage, companies increasingly depend on their supply chain partners to minimize cost and improve business processes. The core value chain activity of outbound logistics has been outsourced by Pharmacy X to several courier companies. This study will aim to understand the importance of the outbound logistics function within the value chain of the company and the costs involved with the outsourcing of the function. The primary objective of this study was to determine the feasibility of an in-house courier operation in the Bloemfontein area versus the current outsourced courier model. In order to achieve the primary objective of the study, several secondary objectives were set and reached throughout the four chapters of this study. The study applied cost benefit analysis techniques to determine the feasibility of the Bloemfontein courier investment project. All the cost benefit analysis techniques concluded that the Bloemfontein courier investment will be a financial viable operation. The Bloemfontein courier investment will increase shareholder value over the period of the project compared to the current outsourced model. The contribution of this case study to determine the feasibility of a courier operation investment can be of value to Pharmacy X. The current projected total courier cost of Pharmacy X for the 2013 financial year amounts to more than a third of the total operational cost. The findings within the case study can lead to a greater national roll out of courier operations in order to reduce costs and increase profit margins for Pharmacy X. / MBA, North-West University, Potchefstroom Campus, 2014

Tillage erosion is the dominant soil erosion process in hummocky landscapes. The topsoil lost from the convex upper slope positions (i.e., hilltops knolls, ridges) gradually makes its way to the concave lower slope positions (i.e., foot slopes, toe slopes/depressions), while reducing yield capability in the knolls. The accumulation of topsoil in the concave lower slope positions does not increase yield potential. Landscape restoration is a process by which organic-rich topsoil is removed from lower slope positions and is moved to the knoll positions where it is applied and incorporated as additional topsoil. Field studies on this matter have shown increases in crop yield productivity due to land restoration on the convex upper slope positions. Using a model developed in STELLA ®, this research examines the net monetary benefit of landscape restoration in specific landscape scenarios modeled after areas in Manitoba which are prone to tillage erosion. This study demonstrates that farming operations in hummocky landscapes, experiencing topsoil loss at knolls benefit from landscape restoration as it can lead to positive net returns. In this study, the research shows that landscape restoration, in the Rural Municipality of Lorne (South Western Manitoba), led to revenues greater than restoration costs for arable land used for agricultural purposes. Depending on soil conditions and tillage choices the payback period for landscape restoration ranged from 8 to 18 years.

The purpose of this research was to understand an indigenous perspective on the development and commercialization of non-timber forest products, such as medicines and foods, in Pikangikum First Nation, Northwestern Ontario, Canada. Framed by a research agreement between Pikangikum First Nation and the University of Manitoba, this collaborative research was based on participant observation, field trips, semi-structured interviews, and community workshops. The appropriate development and commercialization of Anishinaabe mushkeekeeh (medicine) and meecheem (food) requires the guidance of community Elders, Anishinaabe knowledge, and traditional teachings. The community is cautiously interested in developing collaborative, diligent, and culturally respectful partnerships that interface knowledge systems. Benefit sharing means the joint ownership of intellectual property and financial benefits, developing employment and capacity-building opportunities for community members, and planning products for community use. This thesis offers a community perspective on how NTFPs might be researched, developed and commercialized in joint and mutually beneficial partnerships with a First Nation.

Diese Dissertation setzt sich mit der Effizienz von Maßnahmen mit Gewichtsauswirkung in der PKW-Entwicklung auseinander. Sie vermittelt eine andere Sichtweise zur Ermittlung und Beurteilung der Effizienz von Maßnahmen. Maßnahmeneffizienz bedeutet heute, bezogen auf die Fahrzeugentwicklung, nicht mehr unbedingt nur die Kosten zu senken, schwere Werkstoffe durch leichtere zu ersetzen oder gesetzte Ziele zu erreichen. Vielmehr geht es darum, durch die Einbeziehung verschiedener Betrachtungsgruppen z. B. Gewicht, Kosten, Emission, Sensitivitäten, Nutzen von Zielerreichungen etc. eine gesamtheitliche Effizienzaussage zu treffen und ggf. die Effizienz verbessernde Handlungen einzuleiten, um dadurch einen deutlichen Fortschritt in der Gesamteffizienz der Maßnahmen zu erreichen. Die entscheidende Zielsetzung dabei ist, die wirkungsintensiven technischen und wirtschaftlichen Eingangsgrößen zu dieser Maßnahme zu erfassen, diese Vielzahl von Größen in thematisierte Module zu ordnen und aus diesen Bewertungsmodulen unter Zuhilfenahme erweiterter Bewertungsmethoden und neuer Ansätze die Einzel- und Gesamteffizienzwerte abzuleiten. Diese Ergebnisse bilden die Grundlage für einen sich anschließenden Iterationsprozess, der einen Beitrag zur Verbesserung der Maßnahmeneffizienz (Qualität) und Nachhaltigkeit im Sinne von Ressourcenverbrauch (Materialeinsatz) sowie Wettbewerbsfähigkeit leistet. Die bestmögliche Effizienz leistet einen Teilbeitrag zur langfristigen Überlebensfähigkeit einer Unternehmung (vgl. Keuper, F. und Brösel, G. (2005), S. 214). / This dissertation deals with the efficiency of measures regarding the impact of weight in passenger car development. It conveys a different perspective concerning the determination and evaluation of the efficiency of measures. The efficiency of measures today regarding vehicle development doesn ́t necessarily mean just lowering costs, replacing heavy materials with lighter ones, or reaching targets. Even more it has to do with making an all inclusive statement about efficiency and where applicable to take action to improve efficiency by the inclusion of groups of influencing factors, for example, weight, cost, emission, sensitivities between input and output variables, benefits of reaching targets, etc., in order to achieve considerable progress in the total efficiency of the measure. The key objective in doing this is to determine extremely effective technical and economic input parameters for this measure, to organize this large number of parameters into topic-based modules and to derive single and total efficiency values from these assessment modules with the help of advanced assessment methods and new approaches. These results form the foundation for a subsequent iteration process which contributes to the improvement of the efficiency of the measure (quality) and sustainability in the sense of consumption of resources (material usage) as well as competitiveness. The best possible efficiency contributes to the long term competitiveness and viability of a company (compare Keuper, F. and Brösel, G. (2005), p 214).

Managed honey bee colonies face severe winter losses in northern climates. In my studies, interactions between genotypes of bees (genetically selected stock and unselected stock) with different levels of resistance and tolerance to varroa mites were assessed under a variety of treatment combinations to quantify effects of queen pheromone, acaricide treatment, wintering method, ventilation condition and pathogen infection on the costs and benefits associated with mite removal and mite-tolerance behaviors. In most of the experiments, mite-resistance caused greater varroa mite mortality within selected stock relative to unselected stock. Artificial and natural sources of queen pheromone caused greater varroa mite mortality within honey bee colonies relative to queenless colonies. While mite resistance had significant benefits, I showed that when producers selected colonies containing some mite resistance traits, it was traits associated with mite-tolerance and not mite-resistance were maintained and contributed to wintering success. Tolerance was effective at two levels of mites as obtained by late autumn treatment of colonies with oxalic but treatment did not improve wintering performance of either stock. Selected stock showed greater colony size, survival and resulted in more viable colonies in spring in comparison to unselected stock with similar initial mite levels (0.16 mites per bee). Selected stock showed greater relative wintering success than unselected stock when wintered indoors than when wintered outdoors but indoor wintering improved colony survival in both stocks relative to outdoor wintering. Carbon dioxide level increased within the winter bee cluster when colonies were maintained under restricted-ventilation (mean 3.82±0.031%, range 0.43-8.44%) and restricted ventilation increased mite mortality by 138% relative to standard-ventilation (mean 1.29±0.031%, range 0.09-5.26%), but restricted-ventilation did not affect bee mortality in comparison to standard-ventilation. In a laboratory study, I showed that Nosema inoculation (with co-infections of N. ceranae and N. apis) suppressed the effectiveness of mite removal behavior within selected bees relative to unselected bees. N. ceranae was more abundant than N. apis. Bees with greater mite removal capacities had higher costs associated with varroa-resistance as indicated by greater bee mortality rates when inoculated with varroa but bee mortality was not affected in Nosema inoculated bees.

Usability testing is a branch of usability engineering that focuses on analyzing and improving user interactions with computer systems. This testing technique has been used in different industries for years and has proven to be very useful in determining major issues with applications before they are released, however the use of this technique has been slow to gain widespread acceptance in testing health information systems. This study was designed to determine if a specific form of usability testing, Low-Cost Rapid Usability Testing, can be introduced as a standard part of the system development lifecycle (SDLC) for health information systems in a cost effective manner. To determine if this was possible a full cost-benefit analysis of Low-Cost Rapid Usability Testing was performed on a health information system, the BC Chronic Disease Management (CDM) Toolkit, tracking all of the costs involved in the testing process and comparing them against the possible costs that may have been incurred if this testing was not performed. It was found that by introducing this technique into the system development lifecycle to allow for earlier detection of errors in a health information system it is possible to achieve an estimated 36.5% to 78.5% cost saving compared to the impact of errors going undetected and causing a technology-induced error. Overall it was found that Low-Cost Rapid Usability Testing can be implemented in conjunction with other testing techniques in a cost effective manner to develop health information systems, and computer systems in general, which will have a lower incidence of technology-induced errors. / Graduate

Die vorliegende Arbeit behandelt die Anlage von Pensionsvermögen im Rahmen von Contractual Trust Arrangements. Es wird untersucht, welche Anlagestrategien sich unter Berücksichtigung bilanzieller, verpflichtungs- und vermögensseitiger Rahmenbedingungen zur Anlage von Pensionsvermögen eignen. Anhand eines geeigneten Anlagemodells für Pensionsvermögen und der Durchführung einer stochastischen Simulation wird analysiert, welchen Einfluss unterschiedliche Anlagestrategien auf die Entwicklung des Pensionsvermögens haben. Die Arbeit geht zunächst den Hintergrund der betrieblichen Altersversorgung und Contractual Trust Arrangements in Deutschland ein. Zur Abbildung der Verpflichtungsseite und der Mitarbeiterstruktur des Unternehmens wird unter Einbezug aktuarischer Ansätze ein Mitarbeitermodell entwickelt. Das in der Arbeit entwickelte Portfoliomodell integriert die Verpflichtungs- und Vermögensseite und zeigt, wie das Vermögen zur Deckung leistungsorientierter Zusagen zur betrieblichen Altersversorgung unter Einbezug der Unternehmensperspektive mit Hilfe dynamischer Risikonebenbedingungen geeignet angelegt werden kann.

Die vorliegende Arbeit behandelt die Anlage von Pensionsvermögen im Rahmen von Contractual Trust Arrangements. Es wird untersucht, welche Anlagestrategien sich unter Berücksichtigung bilanzieller, verpflichtungs- und vermögensseitiger Rahmenbedingungen zur Anlage von Pensionsvermögen eignen. Anhand eines geeigneten Anlagemodells für Pensionsvermögen und der Durchführung einer stochastischen Simulation wird analysiert, welchen Einfluss unterschiedliche Anlagestrategien auf die Entwicklung des Pensionsvermögens haben. Die Arbeit geht zunächst auf den Hintergrund der betrieblichen Altersversorgung und Contractual Trust Arrangements in Deutschland ein. Zur Abbildung der Verpflichtungsseite und der Mitarbeiterstruktur des Unternehmens wird unter Einbezug aktuarischer Ansätze ein Mitarbeitermodell entwickelt. Das in der Arbeit entwickelte Portfoliomodell integriert die Verpflichtungs- und Vermögensseite und zeigt, wie das Vermögen zur Deckung leistungsorientierter Zusagen zur betrieblichen Altersversorgung unter Einbezug der Unternehmensperspektive mit Hilfe dynamischer Risikonebenbedingungen geeignet angelegt werden kann.

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