abstract: Every year, 3 million older people are treated for fall injuries, and nearly 800,000 are hospitalized, many of which due to head injuries or hip fractures. In 2015 alone, Medicare and Medicaid paid nearly 75% of the $50 Billion in medical costs generated by falls. As the US population continues to age, more adults are beginning to deal with movement related disorders, and the need to be able to detect and mitigate these risks is becoming more necessary. Classical metrics of fall risk can capture static stability, but recent advancements have yielded new metrics to analyze balance and stability during movement, such as the Maximum Lyapunov Exponent (MLE). Much work has been devoted to characterizing gait, but little has explored novel way to reduce fall risk with interventional therapy. Targeting certain cranial nerves using electrical stimulation has shown potential for treatment of movement disorders such as Parkinson’s Disease (PD) in certain animal models. For human models, based on ease of access, connection to afferents leading to the lower lumber region and key brain regions, as well as general parasympathetic response, targeting the cervical nerves may have a more significant effect on balance and posture. This project explored the effects of transcutaneous Cervical Nerve Stimulation (CNS) on posture stability and gait with the practical application of ultimately applying this treatment to fall risk populations. Data was collected on each of the 31 healthy adults (22.3 ± 6.3 yrs) both pre and post stimulation for metrics representative of fall risk such as postural stability both eyes open and closed, Timed-Up-and-Go (TUG) time, gait velocity, and MLE. Significant differences manifested in the postural stability sub-metric of sway area with subject eyes open in the active stimulation group. The additional 8 metrics and sub-metrics did not show statistically significant differences among the active or sham groups. It is reasonable to conclude that transcutaneous CNS does not significantly affect fall risk metrics in healthy adults. This can potentially be attributed to either the stimulation method chosen, internal brain control mechanisms of posture and balance, analysis methods, and the Yerkes-Dodson law of optimal arousal. However, no adverse events were reported in the active group and thus is a safe therapy option for future experimentation. / Dissertation/Thesis / Masters Thesis Biomedical Engineering 2019

abstract: This thesis presents the design and testing of a soft robotic device for water utility pipeline inspection. The preliminary findings of this new approach to conventional methods of pipe inspection demonstrate that a soft inflatable robot can successfully traverse the interior space of a range of diameter pipes using pneumatic and without the need to adjust rigid, mechanical components. The robot utilizes inflatable soft actuators with an adjustable radius which, when pressurized, can provide a radial force, effectively anchoring the device in place. Additional soft inflatable actuators translate forces along the center axis of the device which creates forward locomotion when used in conjunction with the radial actuation. Furthermore, a bio-inspired control algorithm for locomotion allows the robot to maneuver through a pipe by mimicking the peristaltic gait of an inchworm. This thesis provides an examination and evaluation of the structure and behavior of the inflatable actuators through computational modeling of the material and design, as well as the experimental data of the forces and displacements generated by the actuators. The theoretical results are contrasted with/against experimental data utilizing a physical prototype of the soft robot. The design is anticipated to enable compliant robots to conform to the space offered to them and overcome occlusions from accumulated solids found in pipes. The intent of the device is to be used for inspecting existing pipelines owned and operated by Salt River Project, a Phoenix-area water and electricity utility provider. / Dissertation/Thesis / Masters Thesis Engineering 2019

abstract: Basilisk lizards are often studied for their unique ability to run across the surface of water. Due to the complicated fluid dynamics of this process, the forces applied on the water’s surface cannot be measured using traditional methods. This thesis presents a novel technique of measuring the forces using a fluid dynamic force platform (FDFP), a light, rigid box immersed in water. This platform, along with a motion capture system, can be used to characterize the kinematics and dynamics of a basilisk lizard running on water. This could ultimately lead to robots that can run on water in a similar manner. / Dissertation/Thesis / Masters Thesis Mechanical Engineering 2019

The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung function and mechanics. In this thesis, we present a technique that uses multiple respiratory-gated CT images of the lung acquired at different levels of inflation with both breath-hold static scans and retrospectively reconstructed 4D dynamic scans, along with non-rigid 3D image registration, to make local estimates of lung tissue function and mechanics. We validate our technique using anatomical landmarks and functional Xe-CT estimated specific ventilation. The major contributions of this thesis include: 1) developing the registration derived regional expansion estimation approach in breath-hold static scans and dynamic 4DCT scans, 2) developing a method to quantify lobar sliding from image registration derived displacement field, 3) developing a method for measurement of radiation-induced pulmonary function change following a course of radiation therapy, 4) developing and validating different ventilation measures in 4DCT. The ability of our technique to estimate regional lung mechanics and function as a surrogate of the Xe-CT ventilation imaging for the entire lung from quickly and easily obtained respiratory-gated images, is a significant contribution to functional lung imaging because of the potential increase in resolution, and large reductions in imaging time, radiation, and contrast agent exposure. Our technique may be useful to detect and follow the progression of lung disease such as COPD, may be useful as a planning tool during RT planning, may be useful for tracking the progression of toxicity to nearby normal tissue during RT, and can be used to evaluate the effectiveness of a treatment post-therapy.

Low back problems are among the most common nonfatal occupational injuries reported in the United States, and account for substantial healthcare expenditures (e.g., medical care costs) and losses to worker productivity. A strong association has been well-documented between occupational exposure to repetitive trunk motion and low back problems, particularly among workers performing manual material handling (i.e., lifting) activities. A feature of repetitive motion believed important to the development of work-related musculoskeletal disorders (MSDs), including low back problems, is a lack of within-individual, between-cycle variation of physical exposure summary measures, e.g., when observed visually, the cycle-to-cycle motion pattern appears consistent. An active literature has emerged using concepts of motor control to improve ergonomists’ understanding of physical exposure variation (i.e., motor variability) arising from individual-level mechanisms during repetitive work. Fundamentally, for any particular individual, the onset of exposure to a repetitive physical activity (i.e., task training) involves a learning process during which motor control strategies are developed to accomplish the task effectively. The cycle-to-cycle variability of motor learning metrics, such as postural and task performance summary measures, has been observed to exponentially decay during task training. From an ergonomics perspective, a temporal reduction in postural variability may lead to greater cumulative loading and physiological fatiguing of the underlying muscle tissues (due to more consistent cycle-to-cycle movements), thus increasing MSD risk over time. However, it is not known if, or to what extent, physical task characteristics (e.g., work pace) modify the temporal behavior of motor variability during training of a repetitive occupational activity. Moreover, the relationships between motor variability, task performance, and muscle fatigue during occupational task training are not well understood. The goal of this dissertation was to present new information concerning occupationally relevant metrics of motor learning during training of a laboratory-simulated, repetitive lifting activity. In this study, participants performed 100 repetitions (i.e., cycles) of the lifting task in each of four experimental sessions (i.e., visits) at different combinations of box load (low or high) and work pace (slow or fast). Three main observations were discussed in this dissertation: (i) participants exhibited a greater temporal reduction in the cycle-to-cycle variability of trunk postural summary measures during training of a heavier-weighted and faster-paced lifting activity (Chapter 3), which may have facilitated increases in the efficiency and repeatability of box movements (Chapter 4), (ii) the cycle-to-cycle variability of the erector spinae (back) muscle activity summary measures increased, but the variability of the multifidus muscle activity summary measures decreased, over time during faster-paced lifting (Chapter 3), and (iii) a greater temporal increase in trunk postural variability (i.e., a more “flexible” trunk movement strategy) was generally associated with lesser electromyographic back muscle fatigue during training of the lifting task (Chapter 5). Collectively, these research findings may open pathways to the development of new task design criteria and ergonomic guidelines to promote motor variability in the workplace and, ultimately, improve workers’ musculoskeletal health.

Obesity is a severe concern worldwide and its prevalence is expected to continue to increase. Linked to diabetes, kidney disease, heart disease, and high blood pressure among other things, obesity has been identified as the forthcoming, largest preventable cause of mortality. Osteoarthritis, surgical consequences, distribution of subcutaneous adipose tissue, and alteration of joint biomechanics have vast implications in total joint repair (TJR). Previous studies have linked obesity to increased forces through weight-bearing lower extremities, alterations in gait, and risk of implant failure. The objectives of this study were to (1) provide a tool to predict lower extremity dimensions and shape variations of subcutaneous adipose tissue, (2) identify the degree to which obesity influences shape variation of the osseous anatomy of the knee joint, and (3) lay a foundation to compare the knee contact force of obese patients in activities of daily living. Long-leg EOS films were obtained, retrospectively over 5 years, from 232 patients that were being seen at the Adult Reconstruction Clinic at the University of Iowa. Using custom Matlab algorithms, measurements of soft tissue distribution and lower extremity osseous anatomy were obtained and analyzed. Additionally knee contact force measurements were obtained through motion capture analysis and modeling in Anybody Technology. Males and females had similar lower extremity shapes, with females having greater knee circumferences than males. The variability of PPT and PTT tended to be greater in females and increased with increasing BMI. Although similar in the anteroposterior direction, males tended to have on average 12mm wider proximal tibias in the mediolateral direction. Clinical observations of increased post-operative complications trend with these findings. The future of research into biomechanics of obesity will rely heavily on anatomic models of the obese lower extremities, which until this work did not exist.

As a comparison to the suction feeding mechanics in aquatic environments, I investigated buccal pumping in an ontogenetic series of suspension feeding Xenopus laevis tadpoles (4-18 mm snout-vent length) by examining the morphology, kinematics, fluid flow, pressure generated in the buccal cavity, and effects of viscosity manipulation. Investigation of the dimensions of the feeding apparatus of Xenopus revealed that the feeding muscles exhibited strong negative allometry, indicating that larger tadpoles had relatively smaller muscles, while the mechanical advantage of those muscles did not change across the size range examined. Buccal volume and head width also exhibited negative allometry: smaller tadpoles had relatively wider heads and larger volumes. Tadpoles were imaged during buccal pumping to obtain kinematics of jaw and hyoid movements as well as fluid velocity. Scaling patterns were inconsistent with models of geometric growth, which predict that durations of movements are proportional to body length. Only scaling of maximum hyoid distance, duration of mouth closing, and duration of hyoid elevation could not be distinguished from isometry. The only negatively allometric variable was maximum gape distance. No effect of size was found for duration of mouth opening, duration of hyoid depression, and velocity of hyoid elevation. Velocity of mouth opening, velocity of mouth closing, and velocity of hyoid depression decreased with increasing size. Fluid velocity increased with size, and is best predicted by a piston model that includes head width and hyoid depression velocity. Reynolds number increased with size and spanned two flow regimes (laminar and intermediate) ranging from 2 to over 100. Pressure was found to be greatest in the smallest tadpoles and decreased as size increased, ranging from 2 kPa to 80 kPa. The viscosity of the water was altered to explore changes in body size, independent of development (higher viscosity mimicked smaller tadpole size). Viscosity manipulations had a significant effect on the kinematics. Xenopus initially increased velocity and distance of movements as viscosity increased, but these values declined as viscosity increased further. These results suggest that abiotic factors such as fluid viscosity may set a lower size limit on suspension feeding.

Variable Resistance Training (VRT), loading elastic band tension on a barbell, has shown improvements in force, power, and velocity. Studied extensively in the squat and bench press, VRT is less researched in the context of the deadlift. Additionally, while no acute VRT deadlift studies exist where intensity was ≥ 90% 1- RM, some heavy VRT studies suggest that at approximately 90% 1-RM, less band tension (BT) is required to enhance force and power than seen at lower intensities in existing research. Therefore, the purpose of this study was to determine the effects of VRT on peak relative vertical ground reaction force (VGRF), average and peak velocity, and time of peak force (VGRF time), in heavy, traditional deadlifts. METHODS: Seven resistance trained, college-aged males were recruited for this study. Over the course of approximately eight weeks, subjects completed five training sessions including familiarization, and testing the deadlift at 90% 1-RM with no bands (NB), 10%BT, 20%BT, or 30%BT. All training sessions were performed on dual force plates and with a linear position transducer to determine kinetic and kinematic outcomes. RESULTS: There were significant differences between conditions for both peak [F (3,18) = 13.607, p < 0.001] and average velocity [F (3, 18) = 14.077, p < 0.001]. No significant differences were detected between conditions for peak relative VGRF [F (3, 12) = 2.41, p= 0.118], or VGRF time [F (3, 12) = 1.843, p= 0.193]. PRACTICAL APPLICATIONS: The results of this study suggest velocity is improved with 20% to 30%BT when deadlifting approximately 90% 1-RM. For maximum force, traditional, NB deadlifts might be optimal considering the lack of improvement with the addition of bands. Despite the lack of significance between conditions, the large relative percent decrease in VGRF time from NB to 10%BT suggests that this small amount of BT may be advantageous for rapid force development with heavy loads

Heavy backpacks have been suggested to have a pathogenic role in experience of low back pain among children. We have conducted a repeated-measure study to investigate the backpack-induced changes in lumbo-pelvic coordination of forty gender-balanced college age students when they walked and jogged on a treadmill with two different types of backpacks: normal and ergonomically modified. The backpack-induced changes in lumbo-pelvic coordination were larger when carrying an ergonomically modified vs. a normal backpack as well as when jogging versus walking. The larger changes in lumbo-pelvic coordination when carrying an ergonomically modified backpack were likely due to kinematic restraints imposed by rigidity and enhanced attachments devised in the backpack for increased comfort. Given the role of lower back biomechanics in low back pain, the effects of such larger mechanical abnormalities in the lower back when carrying an ergonomically-modified backpack on risk of low back pain among children requires further investigation.

Human red blood cells (RBCs) must undergo severe deformation to pass through narrow capillaries and submicronic splenic slits for several hundred thousand times in their normal lifespan. Studies of RBC biomechanics have been mainly focused on cell deformability measured from a single application of stress using classical biomechanical techniques, such as optical tweezers and micropipette aspiration. Mechanical fatigue effect on RBCs under cyclic loadings of stress that contributes to the membrane failure in blood circulation is not fully understood. This research developed a new experimental method for mechanical fatigue testing of RBCs using amplitude-modulated electro-deformation technique. Biomechanical parameters of individually tracked RBCs show strong correlations with the number of the loading cycles. Effects of loading configurations on the cellular fatigue behavior of RBCs is further studied. The results uniquely establish the important role of mechanical fatigue in influencing physical properties of biological cells. They further provide insights into the accumulated membrane damage during blood circulation, paving the way for further investigations of the eventual failure of RBCs in various hemolytic pathologies. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2019. / FAU Electronic Theses and Dissertations Collection