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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Synthèse de surfactifs à base de polyoxazoline : propriétés physicochimiques et formulation / Synthesis, properties and formulation of surfactants based on Polyoxazoline

Giardi, Chloé 30 November 2011 (has links)
Nous décrivons dans ce manuscrit la synthèse et l'étude de surfactifs à base de poly(2-méthyl-2-oxazoline) et de corps gras. Pour cela, deux voies de synthèse ont été réalisées. La première qui consiste à amorcer la polymérisation avec un alcool gras tosylé. La deuxième voie de synthèse a été réalisée en amorçant la polymérisation par un alcane iodé. Les surfactifs ainsi obtenus ont une chaîne grasse saturée ayant douze ou dix-huit atomes de carbone et des longueurs de chaînes polymères variables.Ces surfactifs sont examinés afin d'évaluer leur aptitude à la formulation. Ainsi, la valeur de leur concentration micellaire critique a été déterminée par tensiométrie et spectrofluorimétrie. Ensuite, l'évaluation de leurs pouvoirs mouillant et moussant, de leur HLB, de leur température de point de trouble… ont été déterminés afin de les comparer avec leurs homologues POE, les Brij®. Dans l'optique d'une application à la formulation, des tests d'évaluation de leur toxicité ont également été réalisés. Enfin, des préparations cosmétiques ont été formulées, à base de ces surfactifs et des Brij®. Parallèlement, une étude a été menée démontrant l'intérêt du carbonate de glycérol tosylé comme amorceur de la polymérisation de la 2-méthyl-2-oxazoline. Cet amorceur a permis de fonctionnaliser les polyoxazolines en extrémité de chaîne par des fonctions terminales (hydroxy)uréthane. / In this manuscript, we describe the synthesis and the study of surfactants based on poly(2-methyl-2-oxazoline) and vegetable oil derivatives. Two ways for the synthesis are realized. The first path consists to initiate the polymerization with a tosylate fatty alcohol. The second synthetic route was realized by initiating the polymerization by an iodoalkane. The obtained surfactants have au saturated fatty chain with twelve or eighteen carbon atoms and various lengths of polymeric chain. This surfactants are reviewed to assess their suitability for the formulation. Thus, the value of their critical micelle concentration was determined by tensiometry and spectrofluorimetry. After, the evaluation of their wetting and foaming powers, their HLB, their cloud point temperature… was determinded in order to compare with their homologous POE, the Brij®. In the context of an application in the formulation, evaluation tests of toxicity were also made. Next, cosmetic preparations were realized, based on this surfactants and Brij®. In parallel, a study was conducted to demonstrate the tosylate gycerol carbonate interest as initiator in the 2-methyl-2-oxazoline polymerization. This initiator enable to fonctionalize the polyoxazoline in the chain end with (hydroxy)uréthane terminal function.
2

Estudo da Solubilização da Griseofulvina em Micelas dos Brijs 78, 98, 700 / Study of the Solubilization of Griseofulvin in Brijs Micelles 78, 98, 700

Moura, Carolina de Lima e January 2013 (has links)
MOURA, Carolina de Lima e. Estudo da Solubilização da Griseofulvina em Micelas dos Brijs 78, 98, 700. 2013. 74 f. Dissertação (Mestrado em Química)-Universidade Federal do Ceará, Fortaleza, 2013. / Submitted by Anderson Silva Pereira (anderson.pereiraaa@gmail.com) on 2017-04-19T18:56:31Z No. of bitstreams: 1 2013_dis_clmoura.pdf: 1755226 bytes, checksum: 6ce2cc79a9e05f85d842d0251210cef5 (MD5) / Approved for entry into archive by Jairo Viana (jairo@ufc.br) on 2017-04-19T19:27:07Z (GMT) No. of bitstreams: 1 2013_dis_clmoura.pdf: 1755226 bytes, checksum: 6ce2cc79a9e05f85d842d0251210cef5 (MD5) / Made available in DSpace on 2017-04-19T19:27:07Z (GMT). No. of bitstreams: 1 2013_dis_clmoura.pdf: 1755226 bytes, checksum: 6ce2cc79a9e05f85d842d0251210cef5 (MD5) Previous issue date: 2013 / The preparation of drug solutions with low solubility in water is one of the main problems found in the preparation of such medicines in aqueous medium. The study about the use of surfactant micellar solutions in the solubilisation of drugs with low solubility in water has been increasingly practiced, mainly due to the low toxicity of these carriers, to the efficiency of the dissolution process and to the additional protection provided to the drug. The objective of this work is to encapsulate the antifungic griseofulvin in poly(ethylene oxide) (Em) hydrophilic block copolymers and poly(methylene) (Cn) hydrophobic block. The copolymers (Brij® 700, Brij® 78, Brij® 98) and the griseofulvin were obtained from Aldrich. The Brijs critical micelle concentration (cmc) was reached through dye solubilisation method (fluorescence). The griseofulvin encapsulates were obtained through the method of direct dissolution and quantified by UV/Vis and 1H NMR and characterized by particle size through light scattering and X-Ray. The controlled release of the drug was carried out. The cmc values found for Brij® 78 and 98 are lower than those for Brij® 700. The size of the Brij® 700 particle, provided by the hydrodynamic radius (rh) is higher than those from Brijs® 78 e 98. The reason is that the hydrophilic portion of the Brij® 700 has 80 units more than Brijs® 78 e 98. The drug did not affect the size of the particle of the polymers. The solubilisation results for griseofulvin obtained through 1H NMR confirm the values obtained through UV/Vis. The griseofulvin had an increase in solubility up to 6.9 times, which makes the use of Brijs® feasible in the encapsulation of this drug. / A preparação de soluções de fármacos pouco solúveis em água é um dos principais problemas encontrados na formulação de tais medicamentos em formas farmacêuticas líquidas. O estudo sobre a utilização de soluções micelares de surfactantes na dissolução de fármacos pouco solúveis em água vem sendo cada vez mais praticado, devido, principalmente, à baixa toxicidade desses carreadores, da eficiência no processo de dissolução e da proteção adicional fornecida ao fármaco. Este trabalho visou encapsular o antifúngico griseofulvina em copolímeros de bloco hidrofílico de poli(óxido de etileno) (Em) e bloco hidrofóbico de poli(metileno)(Cn). Os surfactantes (Brij® 700, Brij® 78, Brij® 98) e a griseofulvina foram obtidos da Aldrich. A concentração micelar crítica (cmc) dos Brijs foi obtida pelo método de solubilização do corante (fluorescência). Os encapsulados da griseofulvina foram obtidos pelo método de dissolução direta e quantificados por UV/Vis e RMN de 1H e caracterizados por tamanho de partícula, espalhamento de luz e raio – X. Foi realizada a liberação controlada de fármaco. Os valores das cmc´s encontrados para o Brij® 78 e 98 são menores que os cmc do Brij® 700. O tamanho de partícula do Brij® 700, fornecido pelo raio hidrodinâmico (rh), é maior que o dos Brijs® 78 e 98, uma vez que o Brij® 700 possui uma porção hidrofílica com 80 unidades a mais que os outros Brijs®. O fármaco não afetou o tamanho de partícula dos polímeros estudados. Os resultados de solubilização da griseofulvina obtidos por RMN de 1H corroboram com os obtidos por UV/Vis. A griseofulvina teve um aumento da solubilidade de até 6,9 vezes o que viabiliza o uso dos Brijs® na encapsulação deste fármaco.
3

Mesoporous materials

Tan, Yu-May January 2001 (has links)
No description available.
4

Effect of Brij 97 in the presence and absence of carrageenan on the transdermal delivery of 5-Fluorouracil / Carli Neethling

Neethling, Catharina Elizabeth January 2006 (has links)
The skin is the largest and most easily accessible organ of the human body thus making it the ideal route for systemic drug delivery. The transdermal route of drug delivery offers several advantages compared to the traditional routes including elimination of first pass metabolism and higher patient compliance. However, many drugs are topically and systemically ineffective when applied onto the skin, due to their almost complete failure to penetrate the skin. The main limitation lies in the stratum corneum, the barrier of the skin, which prevent the drug from reaching the deeper skin strata. 5-Fluorouracil is a polar hydrophilic drug and is therefore not a good penetrant through skin. A popular technique to increase transdermal permeation is to use a penetration enhancer, which reversibly reduce the permeability barrier of the stratum corneum. The primary aim of this study was to determine the effect of Brij 97 in the presence and absence of carrageenan on the transdermal delivery of 5-fluorouracil. The formulations were identified by means of confocal laser scanning microscopy and measurement of the particle size. The zeta-potential was measured to determine whether the formulations were stable and the pH was measured to determine if the internal structures of the formulations were affected by the drug. The drug released from the formulations was measured with a VanKel dissolution apparatus. In vitro transdermal diffusion studies were performed using vertical Franz diffusion cells with human epidermal skin. Histopathological studies were carried out on human epidermis skin to determine if the surfactant, Brij 97, had any effect on the skin. Through confocal laser scanning microscopy and particle size measurements, the 4 and 8% Brij 97 formulations without carrageenan could be identified as emulsions while the 15 and 25% Brij 97 formulations without carrageenan could be identified as microemulsions. The 4, 8, 15 and 25% Brij 97 formulations containing carrageenan could be identified as gels. The results obtained from the zeta-potential analysis indicated that the 4 and 8% Brij 97 formulations without carrageenan and 4% Brij 97 formulation with carrageenan are the most electronegative and thus the most stable. The pH measurements confirmed that the internal structure of the formulations was not influenced by the drug. 5-Fluorouracil was released from the formulations. The 4 and 8% Brij 97 formulations without carrageenan had an enhancing effect on the penetration of 5-fluorouracil while the 4, 8, 15 and 25% Brij 97 formulations with carrageenan and the 15 and 25% Brij 97 formulations without carrageenan had an hindering effect on the penetration of 5-fluorouracil. Although carrageenan led to good adhesiveness of the formulation on the skin, it did not lead to the enhancement of the penetration of 5-fluorouracil through the skin. When histopathological studies were carried out on female human abdominal skin, Brij 97, the surfactant, was found to have no damaging effect on the skin structure. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2006.
5

Effect of Brij 97 in the presence and absence of carrageenan on the transdermal delivery of 5-Fluorouracil / Carli Neethling

Neethling, Catharina Elizabeth January 2006 (has links)
The skin is the largest and most easily accessible organ of the human body thus making it the ideal route for systemic drug delivery. The transdermal route of drug delivery offers several advantages compared to the traditional routes including elimination of first pass metabolism and higher patient compliance. However, many drugs are topically and systemically ineffective when applied onto the skin, due to their almost complete failure to penetrate the skin. The main limitation lies in the stratum corneum, the barrier of the skin, which prevent the drug from reaching the deeper skin strata. 5-Fluorouracil is a polar hydrophilic drug and is therefore not a good penetrant through skin. A popular technique to increase transdermal permeation is to use a penetration enhancer, which reversibly reduce the permeability barrier of the stratum corneum. The primary aim of this study was to determine the effect of Brij 97 in the presence and absence of carrageenan on the transdermal delivery of 5-fluorouracil. The formulations were identified by means of confocal laser scanning microscopy and measurement of the particle size. The zeta-potential was measured to determine whether the formulations were stable and the pH was measured to determine if the internal structures of the formulations were affected by the drug. The drug released from the formulations was measured with a VanKel dissolution apparatus. In vitro transdermal diffusion studies were performed using vertical Franz diffusion cells with human epidermal skin. Histopathological studies were carried out on human epidermis skin to determine if the surfactant, Brij 97, had any effect on the skin. Through confocal laser scanning microscopy and particle size measurements, the 4 and 8% Brij 97 formulations without carrageenan could be identified as emulsions while the 15 and 25% Brij 97 formulations without carrageenan could be identified as microemulsions. The 4, 8, 15 and 25% Brij 97 formulations containing carrageenan could be identified as gels. The results obtained from the zeta-potential analysis indicated that the 4 and 8% Brij 97 formulations without carrageenan and 4% Brij 97 formulation with carrageenan are the most electronegative and thus the most stable. The pH measurements confirmed that the internal structure of the formulations was not influenced by the drug. 5-Fluorouracil was released from the formulations. The 4 and 8% Brij 97 formulations without carrageenan had an enhancing effect on the penetration of 5-fluorouracil while the 4, 8, 15 and 25% Brij 97 formulations with carrageenan and the 15 and 25% Brij 97 formulations without carrageenan had an hindering effect on the penetration of 5-fluorouracil. Although carrageenan led to good adhesiveness of the formulation on the skin, it did not lead to the enhancement of the penetration of 5-fluorouracil through the skin. When histopathological studies were carried out on female human abdominal skin, Brij 97, the surfactant, was found to have no damaging effect on the skin structure. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2006.
6

The effect of Brij 97 and carrageenan on the transdermal delivery of acyclovir / Maderi Roestorf

Roestorf, Maderi January 2006 (has links)
The skin, by weight, is the largest organ of the body. Human skin serves to provide several important functions that may be classified. in a general context, as protective, maintaining homeostasis and sensing. The outermost layer of the skin, the stratum corneum, has an essential role as a barrier against the transport of water and of chemical and biological agents. In this study acyclovir (ACV), an antiviral used for treating the varicella zoster virus, was used. It is sensible to say that a hydrophilic drug like acyclovir needs a delivery vehicle or penetration enhancer to permeate the skin with more ease. In an attempt to enhance the permeation of acyclovir, it was formulated in a delivery vehicle with the same formulation as for a micro-emulsion. Increasing percentages of the surfactant, Brij 97, were incorporated in the formulation to determine which of the four formulations is indeed a micro-emulsion. A gelating agent. carrageenan, was used to make the emulsion transdermally more applicable; the influence of this component on the transdermal delivery of acyclovir was also determined. Therefore the aim of this study was to determine: -The effect of a drug delivery vehicle on the transdermal delivery of acyclovir; -The specific formulation of a micro-emulsion and -The influence of a gelating agent on the transdermal delivery of acyclovir. Diffusion studies were performed in vertically mounted glass Franz diffusion cells. The epidermis of female abdominal skin, obtained after abdomeoplasty, was heat separated from the dermis. One millilitre of emulsion (0.1%: 1mg/ml ACV) was added to the skin sample in the donor side of the diffusion cell. The control solution had an equivalent amount of active in water and was added to the donor compartment in a separate experiment. The receptor phase was PBS (phosphate buffered solution). The entire receptor phase of the cells was removed every second hour and was replaced with fresh receptor phase at 37°C. The amount of acyclovir in the receptor phase was determined by HPLC analysis. The cumulative amounts of the active that permeated the skin over the 24 hour period were plotted with the slope of the graphs representing the flux in ng/cm²/h. The average flux values of the experimental cells and control cells were compared. Results of the diffusion studies without carrageenan showed that increasing the concentration of the surfactant increased the diffusion of acyclovir. Permeation studies with carrageenan had a totally different outcome. The enhancement ratio of the experimental cells was much lower than that of the control cells. However the experimental cells showed a small increase as the concentration of the surfactant increased. From VanKel dissolution studies it could be seen that release of acyclovir from the emulsion was not a problem and that the active was available for absorption. Confocal studies were done to determine whether there were any vesicles in the emulsions. Vesicles were expected in the 25% Brij 97 emulsion because it was the same formulation as a micro-emulsion, but vesicles could only be found in the 4% and 8% Brij 97 emulsion. A previous study with acyclovir and three different delivery vehicles gave enhancement ratios between 0.32 to 2.92. Values obtained in this study of the 4% and 8% Brij 97 emulsion without carrageenan were more or less the same but the 15% and 25% Brij 97 emulsion had a much higher enhancement ratio. For the emulsions with carrageenan not one exceeded an enhancement ratio of 0.57. More studies still have to be done on micro-emulsions to determine which specific concentration of surfactant forms a micro-emulsion. The active itself and its physicochemical properties also play an important role in the diffusion studies with the specific delivery vehicle and further research has to be done with different model drugs. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2006.
7

The effect of Brij 97 and carrageenan on the transdermal delivery of acyclovir / Maderi Roestorf

Roestorf, Maderi January 2006 (has links)
The skin, by weight, is the largest organ of the body. Human skin serves to provide several important functions that may be classified. in a general context, as protective, maintaining homeostasis and sensing. The outermost layer of the skin, the stratum corneum, has an essential role as a barrier against the transport of water and of chemical and biological agents. In this study acyclovir (ACV), an antiviral used for treating the varicella zoster virus, was used. It is sensible to say that a hydrophilic drug like acyclovir needs a delivery vehicle or penetration enhancer to permeate the skin with more ease. In an attempt to enhance the permeation of acyclovir, it was formulated in a delivery vehicle with the same formulation as for a micro-emulsion. Increasing percentages of the surfactant, Brij 97, were incorporated in the formulation to determine which of the four formulations is indeed a micro-emulsion. A gelating agent. carrageenan, was used to make the emulsion transdermally more applicable; the influence of this component on the transdermal delivery of acyclovir was also determined. Therefore the aim of this study was to determine: -The effect of a drug delivery vehicle on the transdermal delivery of acyclovir; -The specific formulation of a micro-emulsion and -The influence of a gelating agent on the transdermal delivery of acyclovir. Diffusion studies were performed in vertically mounted glass Franz diffusion cells. The epidermis of female abdominal skin, obtained after abdomeoplasty, was heat separated from the dermis. One millilitre of emulsion (0.1%: 1mg/ml ACV) was added to the skin sample in the donor side of the diffusion cell. The control solution had an equivalent amount of active in water and was added to the donor compartment in a separate experiment. The receptor phase was PBS (phosphate buffered solution). The entire receptor phase of the cells was removed every second hour and was replaced with fresh receptor phase at 37°C. The amount of acyclovir in the receptor phase was determined by HPLC analysis. The cumulative amounts of the active that permeated the skin over the 24 hour period were plotted with the slope of the graphs representing the flux in ng/cm²/h. The average flux values of the experimental cells and control cells were compared. Results of the diffusion studies without carrageenan showed that increasing the concentration of the surfactant increased the diffusion of acyclovir. Permeation studies with carrageenan had a totally different outcome. The enhancement ratio of the experimental cells was much lower than that of the control cells. However the experimental cells showed a small increase as the concentration of the surfactant increased. From VanKel dissolution studies it could be seen that release of acyclovir from the emulsion was not a problem and that the active was available for absorption. Confocal studies were done to determine whether there were any vesicles in the emulsions. Vesicles were expected in the 25% Brij 97 emulsion because it was the same formulation as a micro-emulsion, but vesicles could only be found in the 4% and 8% Brij 97 emulsion. A previous study with acyclovir and three different delivery vehicles gave enhancement ratios between 0.32 to 2.92. Values obtained in this study of the 4% and 8% Brij 97 emulsion without carrageenan were more or less the same but the 15% and 25% Brij 97 emulsion had a much higher enhancement ratio. For the emulsions with carrageenan not one exceeded an enhancement ratio of 0.57. More studies still have to be done on micro-emulsions to determine which specific concentration of surfactant forms a micro-emulsion. The active itself and its physicochemical properties also play an important role in the diffusion studies with the specific delivery vehicle and further research has to be done with different model drugs. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2006.
8

Chemical study of two Xylopia species and resolution of natural products by matrix assisted diffusion ordered spectroscopy (MAD) / Estudo QuÃmico de duas espÃcies de xylopia (Annonaceae) e resoluÃÃo de misturas de produtos naturais por espectroscopia ordenada por difusÃo assistida por matriz (MAD)

Mariano George Sousa Vieira 05 September 2014 (has links)
CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico / Xylopia nitida and Xylopia sericea are commonly known as âembira-brancaâ and âpimenta do sertÃoâ, respectively, belonging to Annonaceae family. The chromatographic analysis of X. nitida roots allowed isolation of a trachlyobane diterpene, ent-trachlyoban-18,19-diol and its acetylated product, ent-18,19-diacetoxy-trachylobane, a kaurene diterpene, ent-kaur-16-en-18,19-diol, two aporphinic alkaloids, 5,6,6a,7-tetrahydro-1-methoxy-(6aS)-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline e xylopine, and a glucoside, named 1-O-ethyl-β-D-glucopiranose. Also using chromatographic analysis of X. sericea fruits were obtained a kaurane diterpene, kauran-16β-ol and a diterpenes mixture, ent-kaur-16-en-19-oic acid and beyer-15-19-oic acid. The structures of these compounds were elucidated by spectroscopic studies (IR, MS and NMR). In the second part of this work, has been showed the diffusion-ordered spectroscopy (DOSY) as a powerful tool in natural product mixture analysis. The assignment of NMR signals to specific components in a mixture is a challenging task. DOSY has provided important progress in this area, allowing the signals originating from individual components of different molecular sizes to be distinguished. However, when the sizes of the compounds are similar and/or the spectra are overlapped, signal assignment can easily become intractable. The use of a co-solute in a matrix-assisted DOSY (MAD) experiment can be a useful solution, improving diffusional (and sometimes spectral) resolution by exploiting selective binding to the matrix. The challenge is to apply MAD to molecules with high structural similarity, for example in natural product mixtures. Various surfactants, including SDS, AOT and CTAB have previously been shown to be effective in MAD analysis. Here we present an important addition, the Brij family of nonionic surfactants. We demonstrate the use of Brij micelles and other systems in mixed solvents with a variety of mixtures relevant to natural products. / Xylopia nitida e X. sericea, conhecidas popularmente como embira-branca e pimenta do sertÃo, respectivamente, sÃo espÃcies pertencentes à famÃlia Annonaceae. A anÃlise cromatogrÃfica dos extratos hexÃnico e etanÃlico das raÃzes de X. nitida possibilitou o isolamento de um diterpeno de esqueleto traquilobano, ent-traquiloban-18,19-diol e seu derivado acetilado, ent-18,19-diacetÃxi-traquilobano, um diterpeno de esqueleto caureno, ent-caur-16-en-18,19-diol, dois alcalÃides aporfÃnicos, 5,6,6a,7-tetraidro-1-metoxi-(6aS)-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinolina e xylopina e um glicosÃdeo, 1-O-etil-β-D-glicopiranose, todos de carÃter inÃdito na literatura, exceto os dois Ãltimos. AtravÃs da anÃlise cromatogrÃfica do extrato hexÃnico dos frutos de X. sericea foi possÃvel obter um diterpeno de esqueleto caurano denominado cauran-16β-ol e uma mistura de diterpenos, Ãcido ent-caur-16-en-19-Ãico e Ãcido beier-15-en-19-Ãico. O isolamento dos constituintes quÃmicos presentes nos extratos da raiz e frutos de X. nitida e X. sericea, respectivamente, foi realizada por mÃtodos cromatogrÃficos convencionais e a determinaÃÃo estrutural das substÃncias isoladas foi realizada a partir de mÃtodos espectromÃtricos como: IV, EM, RMN 1H, 13C e DEPT 135 incluindo tÃcnicas bidimensionais como, COSY, HSQC e HMBC. A primeira parte deste trabalho relata o estudo quÃmico das raÃzes de X. nitida e dos frutos de X. sericea. A espectroscopia ordenada por difusÃo ou DOSY (Diffusion Ordered Spectroscopy) provà um meio para uma âseparaÃÃo virtualâ de compostos, atravÃs de um mapa bidimensional onde em um eixo temos o deslocamento quÃmico e em outro observamos o coeficiente de difusÃo (D) das molÃculas na mistura. A separaÃÃo de sinais somente à possÃvel quando espÃcies difundem a diferentes velocidades. Na quÃmica de produtos naturais, frequentemente nos deparamos com misturas de compostos quimicamente semelhantes e de tamanhos muito similares, o que torna limitado o experimento DOSY tradicional. Entretanto, o coeficiente de difusÃo das substÃncias pode ser modificado pela adiÃÃo de co-solutos e/ou co-solventes, surgindo a partir daà a espectroscopia ordenada por difusÃo assistida por matriz (matrix-assisted DOSY ou MAD). VÃrios surfactantes, incluindo SDS, AOT e CTAB tÃm se mostrado efetivos em anÃlises por MAD. Neste trabalho, experimentos MAD foram realizados com algumas misturas de produtos naturais com similaridades estruturais utilizando o Ãcido perfluoro-octanÃico (PFOA), polivinilpirrolidona (PVP) e os surfactantes Brij 78 e 98, que por sua vez, ainda nÃo haviam sido utilizados para esse propÃsito. NÃs tambÃm demonstramos a formaÃÃo de micelas de Brij 78 e 98 em misturas dos solventes DMSO-d6 e D2O.

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