This research investigated the relationship between students’ approaches to second language learning and a specific personality variable. The main research instruments were two questionnaires. One was the Language Learning Orientation Questionnaire (LLOQ), which measures two orientations to language learning, Structure Orientation (SO) and Communication Orientation (CO). The other instrument was the Regulatory Focus Theory Questionnaire (RFTQ), which was extensively modified from the USdesigned Regulatory Focus Theory (RFT: Higgins, 1997) for application in the Chinese cultural background, or Confucian Heritage Cultures (CHC), of Taiwan. The study involved 360 students in four high schools in Taiwan. The quantitative data from the questionnaires were supplemented by qualitative data from interviews and non-participant classroom observations. The analysis of LLOQ results demonstrated a clear distinction between SO and CO among the participants. The results of the CHC RFTQ identified three forms of Regulatory Focus: Obligation-Adherence, Social-Security (which are conflated in standard RFT as PRE) and Goal-Achievement (a specific form of PRO). The analysis of the relationship between the LLOQ and RFTQ data indicates there is a correlation between RF and LLO.

The present thesis describes the development and assessment of two computer-game-like tests designed to measure two cognitive abilities currently of considerable interest to many researchers: processing speed (Gs) and working memory (WM). It is hoped that such tests could provide a unique and important addition to the range of tests currently employed by researchers interested in these constructs. The results of five separate studies are presented across three published papers. In Paper 1-Study 1 (N = 49) a speeded computerized coding test (Symbol Digit) using the mouse as the response device was assessed. Because speeded tests are thought to be highly sensitive to response methods (Mead & Drasgow, 1994) it was deemed important to first assess how a mouse response method might affect the underlying construct validity of a speeded coding test independently of whether it was game-like. Factor analytic results indicated that the computerized coding test loaded strongly on the same factor as paper-andpencil measures of Gs. For Paper 2-Study 1 (N = 68) a more computer-game-like version of Symbol Digit was developed, Space Code. Development of Space Code involved the provision of a cover story, the replacing of code symbols with ‘spaceship’ graphics, the situating of the test within an overall ‘spaceship cockpit’, and numerous other graphical and aural embellishments to the task. Factor analytic results indicated that Space Code loaded strongly on a Gs factor but also on a factor comprised of visuo-spatial (Gv) ability tests. This finding was further investigated in the subsequent study. Paper 2-Study 2 (N = 74) involved a larger battery of ability marker tests and a range of additional computer-game-like elements were added to Space Code. Space Code included a scoring system, a timer with additional voice synthesized countdowns, aversive feedback for errors, and background music. Factor analysis indicated that after a general factor was extracted Space Code loaded on the same factor as paper-and-pencil measures of Gs and did not load on a factor comprised of non-speeded Gv tests. Paper 3-Study 1 (N = 74) was aimed at assessing a computer-game-like test of WM (Space Matrix) and further assessing Space Code within a broader network of tests. Space Matrix used a dual task format combining a simple version of Space Code with a visually presented memory task based on the Dot Matrix test (Miyake, Friedman, Rettinger, Shah, & Hegarty, 2001). The cover story and scoring system for Space Code was expanded to incorporate this additional memory element. Factor analysis indicated that Space Matrix was loaded on the same first order factor as standard WM tests and the Raven’s Advanced Progressive Matrices (Gf). Space Code was substantially loaded on the second order factor but was weakly loaded on each of two first order factors interpreted as Gs and WM/Gf. A final study is presented (Paper 3-Study2) in which Space Code and Space Matrix was administered to a school aged sample (N=94). Space Matrix exhibited construct validity as well as predictive validity (as a predictor of school grades), while results for Space Code were less encouraging. Space Matrix and Raven’s Progressive Matrices showed comparable relationships to school grades for Mathematics, English and Science subjects. It is concluded that the development of computer-game-like tests represents a promising new format for research and applied assessment of known cognitive abilities. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1342350 / Thesis (Ph.D.) -- University of Adelaide, School of Psychology, 2008

The present thesis describes the development and assessment of two computer-game-like tests designed to measure two cognitive abilities currently of considerable interest to many researchers: processing speed (Gs) and working memory (WM). It is hoped that such tests could provide a unique and important addition to the range of tests currently employed by researchers interested in these constructs. The results of five separate studies are presented across three published papers. In Paper 1-Study 1 (N = 49) a speeded computerized coding test (Symbol Digit) using the mouse as the response device was assessed. Because speeded tests are thought to be highly sensitive to response methods (Mead & Drasgow, 1994) it was deemed important to first assess how a mouse response method might affect the underlying construct validity of a speeded coding test independently of whether it was game-like. Factor analytic results indicated that the computerized coding test loaded strongly on the same factor as paper-andpencil measures of Gs. For Paper 2-Study 1 (N = 68) a more computer-game-like version of Symbol Digit was developed, Space Code. Development of Space Code involved the provision of a cover story, the replacing of code symbols with ‘spaceship’ graphics, the situating of the test within an overall ‘spaceship cockpit’, and numerous other graphical and aural embellishments to the task. Factor analytic results indicated that Space Code loaded strongly on a Gs factor but also on a factor comprised of visuo-spatial (Gv) ability tests. This finding was further investigated in the subsequent study. Paper 2-Study 2 (N = 74) involved a larger battery of ability marker tests and a range of additional computer-game-like elements were added to Space Code. Space Code included a scoring system, a timer with additional voice synthesized countdowns, aversive feedback for errors, and background music. Factor analysis indicated that after a general factor was extracted Space Code loaded on the same factor as paper-and-pencil measures of Gs and did not load on a factor comprised of non-speeded Gv tests. Paper 3-Study 1 (N = 74) was aimed at assessing a computer-game-like test of WM (Space Matrix) and further assessing Space Code within a broader network of tests. Space Matrix used a dual task format combining a simple version of Space Code with a visually presented memory task based on the Dot Matrix test (Miyake, Friedman, Rettinger, Shah, & Hegarty, 2001). The cover story and scoring system for Space Code was expanded to incorporate this additional memory element. Factor analysis indicated that Space Matrix was loaded on the same first order factor as standard WM tests and the Raven’s Advanced Progressive Matrices (Gf). Space Code was substantially loaded on the second order factor but was weakly loaded on each of two first order factors interpreted as Gs and WM/Gf. A final study is presented (Paper 3-Study2) in which Space Code and Space Matrix was administered to a school aged sample (N=94). Space Matrix exhibited construct validity as well as predictive validity (as a predictor of school grades), while results for Space Code were less encouraging. Space Matrix and Raven’s Progressive Matrices showed comparable relationships to school grades for Mathematics, English and Science subjects. It is concluded that the development of computer-game-like tests represents a promising new format for research and applied assessment of known cognitive abilities. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1342350 / Thesis (Ph.D.) -- University of Adelaide, School of Psychology, 2008

The present thesis describes the development and assessment of two computer-game-like tests designed to measure two cognitive abilities currently of considerable interest to many researchers: processing speed (Gs) and working memory (WM). It is hoped that such tests could provide a unique and important addition to the range of tests currently employed by researchers interested in these constructs. The results of five separate studies are presented across three published papers. In Paper 1-Study 1 (N = 49) a speeded computerized coding test (Symbol Digit) using the mouse as the response device was assessed. Because speeded tests are thought to be highly sensitive to response methods (Mead & Drasgow, 1994) it was deemed important to first assess how a mouse response method might affect the underlying construct validity of a speeded coding test independently of whether it was game-like. Factor analytic results indicated that the computerized coding test loaded strongly on the same factor as paper-andpencil measures of Gs. For Paper 2-Study 1 (N = 68) a more computer-game-like version of Symbol Digit was developed, Space Code. Development of Space Code involved the provision of a cover story, the replacing of code symbols with ‘spaceship’ graphics, the situating of the test within an overall ‘spaceship cockpit’, and numerous other graphical and aural embellishments to the task. Factor analytic results indicated that Space Code loaded strongly on a Gs factor but also on a factor comprised of visuo-spatial (Gv) ability tests. This finding was further investigated in the subsequent study. Paper 2-Study 2 (N = 74) involved a larger battery of ability marker tests and a range of additional computer-game-like elements were added to Space Code. Space Code included a scoring system, a timer with additional voice synthesized countdowns, aversive feedback for errors, and background music. Factor analysis indicated that after a general factor was extracted Space Code loaded on the same factor as paper-and-pencil measures of Gs and did not load on a factor comprised of non-speeded Gv tests. Paper 3-Study 1 (N = 74) was aimed at assessing a computer-game-like test of WM (Space Matrix) and further assessing Space Code within a broader network of tests. Space Matrix used a dual task format combining a simple version of Space Code with a visually presented memory task based on the Dot Matrix test (Miyake, Friedman, Rettinger, Shah, & Hegarty, 2001). The cover story and scoring system for Space Code was expanded to incorporate this additional memory element. Factor analysis indicated that Space Matrix was loaded on the same first order factor as standard WM tests and the Raven’s Advanced Progressive Matrices (Gf). Space Code was substantially loaded on the second order factor but was weakly loaded on each of two first order factors interpreted as Gs and WM/Gf. A final study is presented (Paper 3-Study2) in which Space Code and Space Matrix was administered to a school aged sample (N=94). Space Matrix exhibited construct validity as well as predictive validity (as a predictor of school grades), while results for Space Code were less encouraging. Space Matrix and Raven’s Progressive Matrices showed comparable relationships to school grades for Mathematics, English and Science subjects. It is concluded that the development of computer-game-like tests represents a promising new format for research and applied assessment of known cognitive abilities. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1342350 / Thesis (Ph.D.) -- University of Adelaide, School of Psychology, 2008

abstract: This study investigated the link between the cognitive clusters from the Woodcock–Johnson III Tests of Cognitive Ability (WJ III COG) and Broad Math, Math Calculation Skills, and Math Reasoning clusters of the Woodcock–Johnson III Tests of Achievement (WJ III ACH) using data collected over seven years by a large elementary school district in the Southwest. The students in this study were all diagnosed with math learning disabilities. Multiple regression analyses were used to predict performance on the Broad Math, Math Calculation Skills, and Math Reasoning clusters from the WJ III ACH. Fluid Reasoning (Gf), Comprehension–Knowledge (Gc), Short–Term Memory (Gsm), and Long–term Retrieval (Glr) demonstrated strong relations with Broad Math and moderate relations with Math Calculation Skills. Auditory Processing (Ga) and Processing Speed (Gs) demonstrated moderate relations with Broad Math and Math Calculation Skills. Visual–Spatial Thinking (Gv) and Processing Speed (Gs) demonstrated moderate to strong relations with the mathematics clusters. The results indicate that the specific cognitive abilities of students with math learning disabilities may differ from their peers. / Dissertation/Thesis / M.A. Educational Psychology 2011

La polarisation des cellules est essentielle à la division cellulaire asymétrique, la migration cellulaire, la fonction neuronale et le développement embryonnaire. Elle peut se faire par le mécanisme de localisation des ARNm dans des compartiments cellulaires spécifiques. Bien que le mécanisme de localisation des ARNm soit assez bien défini dans tous les types cellulaires, son implication dans le développement du cancer n'a pas été caractérisée. Une étude de séquençage direct de l'ARN, réalisée sur des cellules métastatiques (HCCLM3) du carcinome hépatocellulaire (CHC) a déterminé qu'au niveau de leurs protrusions, certains ARNm y sont enrichis, alors qu'aux protrusions des cellules CHC non-métastatiques SMMC7721, ces ARNm n’y sont pas enrichis. L'ARNm qui encode pour le facteur de transcription STAT3 figure parmi ceux identifiés comme étant enrichis. La technique du smiFISH a été utilisée pour valider l'enrichissement de l'ARNm STAT3 au niveau des protrusions des cellules CHC associées à un phénotype métastatique. Les résultats obtenus démontrent que l'essai de déplétion de sérum permet d'induire la migration des cellules SMMC7721, HCCLM3 et MHCC97H, qui forment des protrusions de type lamellipode. En parallèle, l'expression de l'α-actinine-GFP a permis de visualiser les régions protrusives et de les délimiter. Les expériences de smiFISH et les mesures d'expression relative par RT-qPCR ont révélé que les cellules métastatiques HCCLM3 et MHCC97H expriment peu d'ARNm STAT3, comparativement aux cellules non-métastatiques SMMC7721. De plus, les quantifications absolues de l'enrichissement démontrent que dans toutes les lignées CHC, les molécules d'ARNm STAT3 uniques localisent majoritairement au niveau des corps cellulaires, et très peu dans les protrusions. Le ratio du nombre de molécules d'ARNm STAT3 uniques localisées dans les protrusions sur le nombre de molécules uniques localisées dans les corps cellulaires est nettement plus petit pour les cellules HCCLM3 et MHCC97H que pour les cellules SMMC7721. La densité de l'ARNm STAT3 / unité de surface dans les protrusions des cellules HCCLM3 et MHCC97H est inférieure à celle des cellules SMMC7721. Ensemble, ces résultats confirment qu'il n'y a pas d'enrichissement de l'ARNm STAT3 aux protrusions des cellules CHC associées à un phénotype métastatique. / Subcellular mRNA localization regulates cell polarization. Asymmetric distribution of transcripts is important in cell division, cell migration, neuronal function and embryonic development. In all cell types, the mechanisms of mRNA localization are well defined, but their involvement in cancer development is still unknown. A recent study has identified protrusion-localized STAT3 mRNA in metastatic hepatocarcinoma cells (HCCLM3). In comparison, the STAT3 mRNA was not found to be enriched in the non-metastatic cells (SMMC7721) protrusions. The enrichment of the STAT3 mRNA at the protrusions of HCC cells associated with a metastatic phenotype was studied by smiFISH. Our results showed that the serum starvation assay induced lamellipodia-based migration in SMMC7721, HCCLM3 and MHCC97H cells. Also, expression of GFP-α-actinin allowed to mark the protrusive regions of migrating HCC cells. The smiFISH results and RT-qPCR quantification revealed that the metastatic cells (HCCLM3 and MHCC97H) express lower levels of STAT3 mRNA compared to the non-metastatic cells (SMMC7721). Absolute quantification of localization and enrichment revealed that STAT3 mRNA mainly localizes in the cell bodies of all HCC cell lines. The ratio of the number of single molecules of STAT3 mRNA localized in the protrusions on the number of single molecules localized in the cell bodies is smaller for the metastatic cells than the non-metastatic cells. In the metastatic cells protrusions, the density of STAT3 mRNA / unit of surface was found the be lower than the non-metastatic cells. Altogether, these results confirm that there is no enrichment of STAT3 mRNA at the protrusions of metastatic HCC cells.

Bakgrund: Sverige har en hög vaccinationstäckning men allt fler föräldrar ifrågasätter att vaccinera sina barn. Barnhälsovårdssjuksköterskor (BVC-sjuksköterskor) har en viktig och komplex roll i sitt uppdrag gällande att arbeta för en fortsatt hög vaccinationstäckning i Sverige. Syfte: Att undersöka barnhälsovårdsjuksköterskors upplevelser gällande föräldrar som är tveksamma till att följa barnvaccinationsprogrammet. Metod: En kvalitativ intervjustudie med induktiv ansats genomfördes. Nio intervjuer utfördes och analyserades sedan utifrån en kvalitativ manifest innehållsanalys. Resultat: I studien framkom fyra kategorier och elva underkategorier. De fyra kategorierna som presenteras i resultatet är: (i) BVC-sjuksköterskans erfarenheter av hinder för vaccination, (ii) Utmaning för BVC-sjuksköterskan att bemöta individuella behov hos föräldrar, (iii) Olika tillvägagångssätt för att främja vaccination och (iv) Behov av kunskapsstöd för BVC-sjuksköterskor. Sammanfattning: Allt fler föräldrar ifrågasätter barnvaccinationer bland annat på grund av tidigare händelser i form av vaccinationsbiverkningar och falsk vaccinationspropaganda via sociala nätverk och media. Det är en utmaning för BVC-sjuksköterskan att bemöta föräldrars oro och tveksamhet samtidigt som att arbeta för en fortsatt hög vaccinationstäckning och bibehålla en god vårdrelation för barnets bästa. BVC-sjuksköterskan behöver ha förmåga att möta föräldrars individuella behov genom att i sin profession informera, vara lyhörd och ha en god kommunikation. / Background: Sweden has a high vaccination coverage but more and more parents are questioning vaccinating their children. Child Health Care nurses (CHC-nurses) have an important and complex role in their assignment regarding working for a continued high level of vaccination coverage in Sweden. Purpose: To investigate the experiences of CHC-nurses regarding parents who are hesitant to follow the child vaccination program. Method: A qualitative interview study with an inductive approach was conducted. Nine interviews were conducted and then analysed based on a qualitative manifest content analysis. Results: In the study four categories and eleven subcategories emerged. The four categories presented in the results are: (i) The CHC-nurses experiences of barriers to vaccination, (ii) Challenges for the CHC-nurse to meet the individual needs of the parents, (iii) Different approaches to promote vaccination and (iv) Need for knowledge support for CHC-nurses. Summary: More and more parents question child vaccinations, among other things due to previous events in form of vaccination side effects and false vaccinations propaganda from social networks and the media. It is a challenge for the CHC-nurse to address parents´concerns and hesitations and at the same time working for a continued high level of vaccination coverage and maintaining a good care relationship for the child. The CHC-nurse needs to be able to meet parents´ individual needs by informing, being sensitive and having good communication in their profession.

Demonstration videos can be found on fr.linkedin.com/in/doriangomez/ / Cette thèse porte sur la modélisation procédurale de mondes virtuels étendus dans le domaine de l’informatique graphique. Nous proposons d’exploiter les propriétés de visibilité entre régions élémentaires de la scène, que nous appelons tuiles, pour contrôler sa construction par pavage rectangulaire. Deux objectifs distincts sont visés par nos travaux : (1) fournir aux infographistes un moyen efficace pour générer du contenu 3D pour ces scènes virtuelles de très grande taille, et (2) garantir, dès la création du monde, des performances de rendu et de visualisation efficace. Pour cela, nous proposons plusieurs méthodes de détermination de la visibilité en 2D et en 3D. Ces méthodes permettent l’évaluation d’ensembles potentiellement visibles (PVS) en temps interactif ou en temps réel. Elles sont basées sur les calculs de lignes séparatrices et de lignes de support des objets, mais aussi sur l’organisation hiérarchique des objets associés aux tuiles. La première technique (2D) garantit l’occultation complète du champ visuel à partir d’une distance fixe, spécifiée par le concepteur de la scène, depuis n’importe quel endroit sur le pavage. La seconde permet d’estimer et de localiser les tuiles où se propage la visibilité, et de construire le monde en conséquence. Afin de pouvoir générer des mondes variés, nous présentons ensuite l’extension de cette dernière méthode à la 3D. Enfin, nous proposons deux méthodes d’optimisation du placement des objets sur les tuiles permettant d’améliorer leurs propriétés d’occultation et leurs impacts sur les performances de rendu tout en conservant l’atmosphère créée par l’infographiste par ses choix de placement initiaux. / This thesis deals with procedural modeling applied to extended worlds for computer graphics.We study visibility applied to tiling patterns, aiming at two distinct objectives : (1) providing artists with efficient tools to generate 3D content for very extended virtual scenes, and (2) guaranteeing that this content improves performance of subsequent renderings, during its construction. We propose several methods for 2D and 3D visibility determination, in order to achieve interactive or real-time evaluation of potentially visible sets (PVS). They are based on the concepts of separating and supporting lines/planes, as well as objects hierarchies over tiles. Our first 2D method guarantees full occlusion of the visual field (view frustum) beyond a fixed distance, regardless of the observer’s location on a tiling. The second method enables fast estimation and localization of visible tiles, and builds up a virtual world accordingly. We also extend this method to 3D. Finally, we present two methods to optimize objects locations on tiles, and show how to improve rendering performance for scenes generated on the fly.

No description available.

Le Carcinome Hépatocellulaire a une incidence mondiale élevée et est associé à un mauvais pronostic. Les traitements curatifs existants ne sont applicables qu’à une minorité de patients. La radiothérapie sélective interne (SIRT) est un traitement palliatif de plus en plus utilisé. Elle consiste à l’injection sélective intra-tumorale de microsphères d’yttrium-90 par infusion intra-artérielle, et repose sur deux étapes : une étape pré-thérapeutique de simulation du traitement avec l’injection de macroagrégats d’albumines marqués au 99mTc et le traitement en lui-même. Cependant les caractéristiques de ces deux vecteurs diffèrent et peuvent conduire à des variations de biodistribution et à une dosimétrie approximative. Ce travail a pour but de développer un vecteur radiothéranostique unique pour la SIRT : les microparticules à base d’amidon (SBMP), afin de pallier aux différents problèmes rencontrés en clinique. L’optimisation du radiomarquage par le 68Ga et le 188Re sous forme de kits lyophilisés prêts-à-l’emploi, a permis d’obtenir une pureté radiochimique > 98 % et > 95 % respectivement. Une étude préliminaire par imagerie TEP/TDM in vivo chez le rat, suite à l’injection intraartérielle des 68Ga-SBMP a montré une biodistribution spécifique des microparticules avec plus de 95 % de l’activité retrouvée dans le foie et plus particulièrement dans les tumeurs. Les SBMP offrent plusieurs avantages répondant à différents problèmes actuels et constituent un agent théranostique prometteur pour la SIRT. Une présentation de la SIRT, des différentes microparticules en développement pour la SIRT et des modèles animaux de tumeur hépatique existants seront également développées dans ce travail. / The Hepatocellular Carcinoma has a high incidence worldwide and is associated with a bad prognostic. The existing curative treatments can only be apply in a minority of cases. The selective internal radiation therapy (SIRT) is a palliative treatment that is increasingly used. This technique is define by the selective intratumoral injection of yttrium-90microspheres via intra-arterial infusion. It involves two steps : a pre-therapeutic one for treatment simulation purpose with the injection of serum albumin macroaggregates radiolabeled with 99mTc and the treatment itself. However the characteristics of these two vectors are different and can lead to variations in biodistribution and approximate dosimetry. This works aims to develop a unique radiotheranostic vector for the SIRT: the starch-basedmicroparticles (SBMP), in order to overcome the different currents clinical problems. The optimization of the radiolabeling by the 68Ga and the 188Re in the form of ready-to-use radiolabeling kits allowed to obtain a radiochemical purity > 98 % and > 95 % respectively. A preliminary in vivo study by PET/CT imaging in rat, following the intra-arterial injection of 68Ga-SBMP displayed a specific biodistribution of the microparticles with more than 95 % of the activity found in the liver and mostly in the tumors. The SBMP offer several advantages that answer different current issues and area promising theranostic agent for the SIRT. A presentation of the SIRT, the different microparticles in development and the existing animal models of hepatic tumor will also be developed in this work.