The Saccharomyces cerevisiae iron-responsive transcription factor, Aft1p, has a well established role in regulating iron homeostasis through the transcriptional induction of iron-regulon genes. However, recent studies have implicated Aft1p in other cellular processes independent of iron-regulation such as chromosome stability. In addition, chromosome spreads and two-hybrid data suggest that Aft1p interacts with and co-localizes with kinetochore proteins, however the cellular implications of this have not been established. Here, we demonstrate that Aft1p associates with the kinetochore complex through Iml3p. Furthermore, we show that Aft1p, like Iml3p, is required for the increased association of cohesin with the pericentromere and that aft1Δ cells display sister chromatid cohesion defects in both mitosis and meiosis. Our work defines a new role for Aft1p in the sister chromatid cohesion pathway.

Religion has had an ambiguous role in Ontario public education, having provided both the common language for social cohesion and for resistance by religious groups to what they have perceived to be a dominant, exclusive and coercive ethos. In similar ways, religious freedom and diversity have been highly prized and protected in Ontario while at the same time being sources of anxiety and social disruption. Using critical discourse analysis and critical genealogical analysis I examine the conflicted role of religion in Ontario public education through competing discourses in political rhetoric, selected government documents formulating ways of conceptualizing the role of religion in public education from 1950 to 2003 and case law between 1985 and 1997. More precisely, I examine ways in which educational, social and political goals of education have been intertwined throughout the history of Ontario public education. I show that the public school system has been a state instrument privileged to deliver public education as a way to resolve the tension between social cohesion and social diversity by delivering common civic values. One result is that challenges to the public school system are often interpreted as attacks on public education and on Ontario society, particularly when those challenges are launched by religious groups. This has meant that debates about the role of religion in public education tend to be volatile making serious dialogue about this important social issue difficult to achieve while restricting the space for religious diversity in public education.

Although different studies have been conducted on various aspects of the National Solidarity Program (NSP) in Afghanistan, research on strengthening solidarity and social cohesion through its participatory approach has received little attention. This research used development communication as a theoretical framework to understand the role of participatory communication in strengthening solidarity and social cohesion in Afghanistan. The study employed a qualitative case study. To this end, the study used semi-structured interviews via email and telephone with 10 participants. Thematic analysis was used to code and categorize the data. The study findings show that the NSP appears to promote participation and increase collectiveness among the Afghan people, which, in turn, seem to strengthen solidarity and social cohesion. Finally, future research areas are discussed in the light of these findings.

Les relations entre l'utilisation, l'origine et les propriétés des matériaux de construction peuvent être définies comme des éléments de cohésion territoriale. Elles sont en outre des questions inhérentes à la conservation et restauration du patrimoine culturel. L'objectif de ce travail est d'évaluer cette relation dans le Pays rémois (Bassin Parisien, France). Ce dernier est un exemple concret de zone d'étude limitée (1 400 km², 140 communes) mais dotée d'une géologie et d'un patrimoine très variés. 26 matériaux de construction différents (craie, grès, calcaires, meulière et briques etc.) ont été décrits macroscopiquement et recensés afin de construire une base de données géoréférencées (via ArGis®). Leurs répartitions spatiales ont été analysées à l'aide d'outils de distribution et d'autocorrélation. Par ailleurs, des caractérisations pétrophysiques ont été réalisées en laboratoire sur une sélection de calcaires lutétiens. Les résultats montrent une cohésion territoriale d'utilisation des matériaux répartie selon 6 microrégions et une évolution de leur utilisation du XIe au XXe siècle. La diversité pétrophysique des matériaux du Lutétien est importante, avec différents niveaux de sensibilité aux sels et au gel. L'étude apporte des clefs pour comprendre les critères de choix des matériaux et des conseils pour la gestion du patrimoine dans le territoire d‘étude. / The relationship between uses, origins and properties of building materials can be defined as an element of territorial cohesion of. This is an inherent matter of the preservation and restoration of the cultural heritage. The aim of the study was to highlight this relationship in The Pays rémois (Paris Basin, France). This is a specific zone of 1400 km² with around 140 villages, with an important geological and historical background. Twenty-six building materials (chalk, sandstones, limestones, cherts and bricks) were macroscopically described and field observations werecompiled in a GIS-database (via Arcgis®). Repartition analyses were made with distribution and spatial autocorrelation tools. Petrophysical characterizations were realized on selected lutetian limestones. Results showed 6 areas of building material uses and temporal tendencies use from XIe to XXe centuries. Petrophysical datas were very different between and inside these four limestone groups. Their salt and freeze durability were variable too. The study highlighted some clues to understand choice criteria of building stones and provided guidance for the management and restoration in the Pays rémois.

This thesis offers a complex view on the Integrated Operational Programme from the point of view of its structure, focus, supported areas and also its implementation structure. Further it offers evaluation of actual situation of implementation and realization activities of this operational programme.

Most studies of 'cohesion' between urban residents focus separately on either social network structure or ideations with very little attention given to the intersection between spatial, structural and ideational dimensions of networks. This is problematic on two levels: firstly because attitudes and practices are formed in the context of personal social networks; and secondly because social interactions between residents are physically embodied and therefore spatially constrained. This thesis explores empirically the relationship between spatial cohesion (the extent to which a network is geographically localised or dispersed), structural cohesion (the extent to which a network is tight-knit or fragmented) and ideational cohesion (the extent to which residents have similar attitudes and practices). The social networks, attitudes and practices of white-British residents living in deprived urban localities of North Manchester are studied (survey, n=409; interview, n=53). Variances in forms of cohesion were found to have consequences for residents and localities. At the individual level, the spatial and structural shape of a resident's network was linked to their attitudes and behaviours. Attitudes and practices were 'framed' in the context of personal network structure exhibited through a set of resident 'roles'. This matters for urban cohesion because a person's social network structure influenced whether they liked their neighbourhood, trusted other residents, felt a sense of community or had found jobs through contacts. Previous studies have argued that contemporary urban networks have become fluid, dynamic and spatially dispersed. Yet this research found that although some people had networks that were geographically spread, most resident networks were made of localised, tight-knit, stable, long-term relations. Moreover, people with these cohesive, localised networks framed their experiences of urban cohesion differently to those with geographically spread and/or disconnected social networks. Particularly because the attitudes and practices of residents with localised, cohesive networks were very often habitual and socially reproduced. Social networks focus people's activities in such a way that not only constrains or enables current attitudes and practices but can also affect an individual's ability to change their future behaviour. At the locality level, the type of 'deprived' locality seemed to influence network structure. The structural, spatial and ideational distribution of cohesion at locality level provided neighbourhoods with different portfolios of social capital. Qualitative differences were observed between homogeneous-deprived (very low income, white areas) and socially mixed-deprived (white deprived areas with some class/ethnic mix) localities. People living in deprived-homogenous localities concentrated their networks within the local area and had few ties to residents of bordering areas, a sign of social distance. Conversely, residents of socially mixed-deprived localities had more potential to bridge ties to other neighbourhoods because their networks were not overly focused within the local area. Given that attitudes and practices are framed in the context of social network structure, it was argued that residents of deprived-homogeneous and socially mixed-deprived areas may experience and interpret urban cohesion differently and this has implications for universal policies of cohesion in deprived neighbourhoods. The thesis illustrates the interplay between spatial, structural and ideational forms of cohesion and highlights consequences for individual action and the generation of neighbourhood social capital. The originality of analysis and data synthesis are used to advance a relational and contextualised theory of urban cohesion and contribute to wider academic and policy debates on urban social networks and neighbourhood deprivation.

The diploma thesis deals with cohesion funding in the Czech Republic. The main focus is put on risk factors of cohesion funding in Czech Republic in the programming period of 2007 -- 2013. The main output of this thesis is the analysis of factors that could cause possible financial corrections of the amount stated for the Czech Republic in the programming period of 2007 -- 2013. The theoretical part is focused on description of Cohesion policy of European Union and funding. The practical part analyzes the main risk factors of drawing funds from European resources in the Czech Republic -- additionality, amount of drawn funds and system of management and control.

Promue au même titre que la cohésion sociale et économique dans le Traité de Lisbonne, la cohésion territoriale est devenue un enjeu essentiel dans la définition d‟une politique commune d‟aménagement du territoire pour les pays membres de l‟Union européenne. La thèse vise comprendre dans quelle mesure la cohésion territoriale influence les politiques nationales d‟aménagement du territoire dans un pays candidat. Après avoir rappelé la lente construction d‟une politique territoriale commune au sein de l‟UE, les dynamiques territoriales de la Turquie contemporaine ont été confrontées aux exigences de la cohésion territoriale. Les plus grands défis identifiés sont la permanence de grandes inégalités régionales et l‟absence de structures territoriales pouvant favoriser l‟émergence d‟une gouvernance multi-niveaux. Alors que la Turquie est un pays fortement centralisé, l‟innovation majeure dans ce domaine réside dans la création de 26 agences de développement à l‟échelle régionale NUTS 2 qui n‟existait pas auparavant. En s‟appuyant sur trois exemples régionaux (Istanbul, Izmir, Diyarbakır-ġanlıurfa), la thèse analyse le découpage de ces nouvelles régions, le processus de constitution de ces agences, leur fonctionnement, leur intégration dans le contexte institutionnel local et les politiques spatiales qu‟elles entendent mettre en oeuvre. Trois grandes idées peuvent en être retenues. Elles marquent tout d‟abord une nouvelle étape dans les politiques nationales d‟aménagement du territoire, en introduisant des principes nouveaux, en vigueur également dans l‟Union européenne (appel à projets, co-financement, etc.). Elles contribuent ensuite à la transformation de l‟échelle régionale, en dotant des institutions nouvelles de moyens importants, leur permettant de construire petit à petit leur propre territoire d‟intervention. Enfin, l‟objectif de cohésion territoriale est dépassé par l‟articulation entre l‟échelle régionale et l‟échelle métropolitaine, la grande majorité des politiques publiques d‟aménagement visant à renforcer la compétitivité de cette dernière / Territorial cohesion, at the same level than social cohesion and economic cohesion, lies at the core of the European model of society. This thesis intends to understand how far is a national spatial planning policy modified by the europeanisation process. It appears that the main issues at stake in Turkey are the huge regional disparities between the East and the West of the country, but also at a regional scale between metropolitan major cities and declining rural areas, and the lack of regional adminisrative units fostering multi-level governance. The creation of regional development agencies at regional scale in Turkey introduces new actors within the centralised development process of the country. Established at the NUTS 2 level, they are supposed to be the first step on the adaptation of the territorial system to EU standards, and to anticipate the European funds management in case of full membership. The thesis analyses the creation process of these RDAs, their internal organisation, their funding and their spatial policies through strategic planning. They lie at the core of the creation of regional growth coalitions by supporting regional business communities, which are supposed to enhance endogenous capital and promote regional capacities in order to promote economic growth and social well-being. This thesis shows that the creation of a new territorialised actor does not necessary mean apparition of a new territorial administrative level: the new institutions are not a piece of evidence of a devolution process. On the contrary, they appear as new bodies of the centralised spatial planning process. The so called regionalisation process under europeanisation pressure is actually a new way of territorial management, closer to international neoliberal standards than to regional policy implementation demands. Moreover, the territorial cohesion policy is challenged by the mismatch between regional and metropolitan scale, the latter being the main frame of implementation for the national policies of innovation

No description available.

abstract: This study is a qualitative exploration into the roles and social identities that Research Engineering Undergraduates (REU) enacted while engaging the public through designing serious games. At present, the science communication field is searching for ways to train the next generation of scientists to practice public engagement with science in a way that fosters dialogue with the public, however, little research has been done on training undergraduates in this regard. This exploratory study seeks to determine what opportunities a game design project in a summer program in solar energy engineering research provides undergraduates to that end. The project includes REUs designing games through a facilitated design process and then sharing them with the public at arts festivals. Through discourse analysis, data was analyzed through the lens of cohesion in order to interpret what roles and social identities REUs enacted as well as members of the public who play the games. Based on the analysis of 12 REUs and 39 player participants, findings indicate REUs most often enacted the science game designer social identity and science educator role during the public event. Less often, REUs enacted a sociotechnical role to determine the player's relationship to science/solar energy. Also, less often did they position themselves directly as scientists. For the most part, REUs reproduced the dissemination model of science communication in an interactive way and with an element of reflexivity. However, during public engagement events, dialogue with the public occurred when REUs enacted open-ended roles that enabled members of the public to contribute to the conversation by assuming a range of roles and social identities rather than positioning them into a single role. Dialogue was also supported when REUs were responsive and shifted their role/ social identity to correspond with the public’s enactment. Some players enacted a local Arizonan social identity in response to the open-ended role and game content about Arizona’s solar energy. The project afforded REUs the opportunity to learn illustration and reformulation to communicate science concepts. Also, REUs referenced their game during illustration and reformulation, using it as a tool to teach science, be a science game designer, and other enactments. More research is needed to determine how science, technology, engineering, and math (STEM) undergraduates learning science communication can design serious games and conduct player reflections in such a way to promote dialogue to a greater degree than observed in this study. / Dissertation/Thesis / Doctoral Dissertation Educational Technology 2020