Die skrotale Kalzinose wird als knotige Ablagerung von Kalziumsalzen im Bereich der Skrotumhaut definiert. Die Erkrankung ist sehr selten und tritt meist im frühen Erwachsenenalter auf. Die Entstehung der lokalisierten skrotalen Kalzinose ist bisher nicht sicher geklärt. Häufig werden klinisch skrotale Zysten vermutet. Ziel der vorliegenden Untersuchung ist die sorgfältige histopathologische Aufarbeitung einer großen Anzahl von skrotalen Kalzinosen. Hierzu wurde archiviertes Gewebsmaterial (54 Fälle) aus verschiedenen pathologischen und dermatopathologischen Instituten zusammengetragen und untersucht. Zur Abklärung der genauen Natur der Zystenauskleidung (in 5 Fälle) wurden immunohistochemische Untersuchungen durchgeführt (Panzytokeratin, GCDFP-15 und CEA). Das Ziel der Untersuchung war, den Zusammenhang zwischen der Zystenauskleidung und den Ausführungsgängen der Schweißdrüsen im Skrotum nachzuweisen. In dieser Studie lassen sich zwei Formen der skrotalen Kalzinose unterscheiden, die eine mit und die andere ohne Epithelauskleidung. Dabei war gemäß ihrer Lokalisation im Korium – beziehungsweise oberflächennah in größeren Kugeln und zur Tiefe hin in kleinen läppchenartig angeordneten Arealen – nachvollziehbar, dass die skrotale Kalzinose nicht idiopathisch ist, sondern eine Folge des Verschlusses des Ausführungsganges von apokrinen beziehungsweise ekkrinen oder auch Mischschweißdrüsen. / Scrotal calcinosis is a rare disorder characterized by multiple papules or nodules of calcification in the scrotal skin. However, the pathogenesis of the calcified nodules has not been fully elucidated: it is still unclear whether the condition is truly idiopathic, or the result of breakdown of calcified epithelial cysts. We examined 54 patients in whom scrotal cysts in varying stages of inflammation coexisted with scrotal calcinosis. Some cysts revealed calcification of their contents with little evidence of active inflammation. Other fife cysts showed rupture of their epithelial walls associated with the presence of calcium. Light microscopy in 5 cysts revealed a large epithelial cyst containing von Kossa-positive material and several small dilated ductal structures beside the cyst. The epithelia of the cyst and ductal structures were connected, showing similar eccrine duct differentiation on immunohistochemical staining (Pancytokeratin, GCDFP-15 and CEA). The pathogenetic mechanism of calcium deposition seemed to be due to excessive production and discharge of matrical debris and sulphated mucopolysaccharides, which derived from luminal cells, and their accumulation in the lumina.

Diss. Universiẗat für Bodenkultur, Wien, 2001.

Thèse--Méd.--Reims, 1973. N°: N° 24. / Bibliogr. ff. I-VII.

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Foram avaliados 507 casos de calcificações quanto as suas características (densidade, morfologia, distribuição, extensão e número) e associação com o câncer de mama.De acordo com os valores preditivos positivos de cada tipo de calcificação elas foram categorizadas pelo sistema BI-RADS em subcategorias 4A (2 a 10%), 4B (10,1 a 30%) e 4C (30,1 a 70,0%) e categoria 5 (acima de 70%). Todas as características se mostraram importantes na diferenciação das calcificações em benignas e malignas, em menor grau a densidade e em maior grau a morfologia e a distribuição. A distribuição linear ou segmentar, e a morfologia pleomorfa ou linear apresentaram as mais altas taxas de malignidade / Five hundred and seven cases of calcificações had been evaluated about its characteristics (density, morphology, distribution, extension and number) and association with the breast cancer. Using the VPP of each type of calcifications they had been categorized by the BI-RADS system in categories 4Â (2 to10%), 4B (10,1 to 30%) and 4C (30,1 to 70.0%) and category 5 (above 70%). All the characteristics had shown importance in the differentiation of the calcificações in benign and malignant, in lesser degree the density and bigger degree the morphology and distribuition. A linear or segmentary distribuition, and the pleomorfic or linear morphology had presented the highest taxes of malignidade

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Foram avaliados 507 casos de calcificações quanto as suas características (densidade, morfologia, distribuição, extensão e número) e associação com o câncer de mama.De acordo com os valores preditivos positivos de cada tipo de calcificação elas foram categorizadas pelo sistema BI-RADS em subcategorias 4A (2 a 10%), 4B (10,1 a 30%) e 4C (30,1 a 70,0%) e categoria 5 (acima de 70%). Todas as características se mostraram importantes na diferenciação das calcificações em benignas e malignas, em menor grau a densidade e em maior grau a morfologia e a distribuição. A distribuição linear ou segmentar, e a morfologia pleomorfa ou linear apresentaram as mais altas taxas de malignidade / Five hundred and seven cases of calcificações had been evaluated about its characteristics (density, morphology, distribution, extension and number) and association with the breast cancer. Using the VPP of each type of calcifications they had been categorized by the BI-RADS system in categories 4Â (2 to10%), 4B (10,1 to 30%) and 4C (30,1 to 70.0%) and category 5 (above 70%). All the characteristics had shown importance in the differentiation of the calcificações in benign and malignant, in lesser degree the density and bigger degree the morphology and distribuition. A linear or segmentary distribuition, and the pleomorfic or linear morphology had presented the highest taxes of malignidade