The aim of this study was to evaluate the therapeutic effect of rehabilitation in patients with carpal tunnel syndrome. The study focused on a comparison between electromyographic findings, the findings of physioterapist-led clinical examinations and the patient's subjective feelings, illustrated by a visual analogue scale of pain intensity. These three types of examinations were carried out prior to the commencement of rehabilitation and following 8 rehabilitation sessions (within a period of 2 months) in a cohort of 15 patients, and correlations between them were described. Given the high prevalence of the disease, an effort was made to find objective examination criteria without the need to resort to electromyography. Powered by TCPDF (www.tcpdf.org)

Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-04-12T11:42:16Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE DIGITAL COM FICHA SEM ASSINAT.pdf: 7130468 bytes, checksum: 91f192851345cb3030b04950f2f04c1e (MD5) / Made available in DSpace on 2016-04-12T11:42:17Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE DIGITAL COM FICHA SEM ASSINAT.pdf: 7130468 bytes, checksum: 91f192851345cb3030b04950f2f04c1e (MD5) Previous issue date: 2015-07-03 / INTRODUÇÃO: A avaliação dos limiares dolorosos em pacientes com neuropatias compressivas é de grande utilidade quando se tenta explicar a presença de sintomas generalizados. Sabe-se que no processo de sensibilização periférica a liberação de prostaglandina e bradicinina altera receptores específicos TRPV1 levando a redução do limiar de disparo da fibra nervosa. Essa repetição leva a uma ampliação no campo receptivo cerebral com consequente sensibilização central. A síndrome do túnel do carpo (STC) é a mononeuropatia mais frequentemente diagnosticada, porém os estudos de limiares dolorosos são escassos e não avaliam segundo o grau de comprometimento do nervo. MÉTODOS: Foram avaliadas 160 mulheres divididas em Grupo A) Controle (n=40) e grupo B) pacientes com quadro clínico de síndrome do túnel do carpo (n=120) subdivididas de acordo com o grau de comprometimento neurofisiológico do nervo mediano no punho seguindo a classificação de Pádua em Grupo I (n=20): pacientes com sintomas sugestivos, porém sem confirmação da neuropatia do nervo mediano no punho (NNMP); Grupo II (n=20): NNMP discreta; Grupo III (n=20): NNMP leve; Grupo IV (n= 20): NNMP moderada; Grupo V (n=20): NNMP acentuada; Grupo VI (n=20): NNMP extrema. Realizaram-se algometria de pressão, estudo de condução nervosa, sensibilidade discriminatória entre dois pontos e foi aplicado o questionário de gravidade de sintomas de Boston. A algometria foi realizada em território inervado pelo nervo mediano após a passagem através do túnel do carpo, na região inervada pelo nervo cutâneo palmar, em território inervado pelo nervo ulnar e em áreas proximais ao túnel do carpo. Os valores algométricos em um mesmo grupo seguiram padrão de normalidade (Kolmogorov-Smirnov p <0.05). As comparações entre os grupos foram não-paramétricos (Shapiro- Wilk p= 0.1955) e, portanto, o teste de Kruskal-Wallis foi utilizado e o poshoc de Dunn quando houve diferença significativa. RESULTADOS: Houve diferença extremamente significativa entre o grupo controle e os grupos com NNMP discreta, NNMP leve, NNMP moderada e NNMP acentuada (p<0,0001). Porém, não houve diferença significativa em alguns pontos tanto na presença dos sintomas sem NNMP como na NNMP extrema. Portanto, os limiares reduzem à medida que a patologia se inicia e progride até certo ponto. Quando já não são mais obtidos potenciais sensitivos ou motores nos estudos de condução nervosa, os limiares dolorosos retornam aos valores próximos da normalidade. Sugere-se esse resultado à provável destruição de fibras finas, na qual já pode haver hipoestesia em substituição da hiperalgesia. Quanto à sensibilidade discriminatória entre dois pontos foi observado que quanto mais acentuada a NNMP maiores os valores da sensibilidade discriminatória, havendo diferença significativa entre o controle e os grupos III, IV, V e VI (p<0,0001). Quanto à escala de gravidade de sintomas, as queixas relacionadas à dor e dormência ou formigamento foram mais evidentes nos grupos I, III, IV e V. Enquanto a incapacidade de realizar atividades cotidianas predominou nos grupos III, IV e V. CONCLUSÃO: O limiar para sensação dolorosa é menor em pacientes com síndrome do túnel do carpo, tanto em território inervado pelo nervo mediano como em outras áreas. / INTRODUCTION: Pain threshold evaluation in compressive neuropathy is very useful for explain generalized symptoms. About peripheral sensitization process in the release of bradykinin and prostaglandin alters specific TRPV1 receptors leading to reduction of nerve fiber firing threshold. This repetition leads to a brain receptive field expansion with consequent central sensitization. Carpal tunnel syndrome (CTS) is the most frequently diagnosed mononeuropathy, but painful thresholds studies are scarce and not evaluate according to nerve impairment degree. METHODS: We have evaluated 160 female divided into Group A) Control (n = 40), B) patients with symptoms suggestive of CTS (n = 120) subdivided according to the neurophysiologic impairment of median nerve at the wrist according to Padua classification into Group I (n = 20): patients with symptoms suggestive, but without confirmated wrist median nerve neuropathy (WMNN); Group II (n = 20): Discrete MNNW; Group III (n = 20): Light MNNW; Group IV (n = 20): Moderate MNNW; Group V (n = 20): Severe MNNW; Group VI (n = 20): Extreme MNNW. METHODS: Pressure algometry was held in 320 hands, as well as nerve conduction study and discriminatory sensitivity between two points. The Boston symptom severity questionnaire were applied to the patients. The algometry was held on areas innervated by the median nerve after crossing through the carpal tunnel, palmar cutaneous territory, ulnar cutaneous territory and proximal areas to the carpal tunnel. RESULTS: The algometry values within the same group were normal (Kolmogorov-Smirnov p <0.05). Comparisons between groups were non-parametric (Shapiro-Wilk p = 0.1955) and thus, the Kruskal-Wallis test was used and when there the significant difference pairwise comparisons were performed whit the Dunn test (poshoc). RESULTS: The comparison of algometry data showed extremely significant differences between control group and groups with discrete MNNW, light MNNW, moderate MNNW and severe MNNW (p <0.0001). However, there was no significant difference at some points both in the presence of symptoms without MNNW as in MNNW extreme. Therefore, pain thresholds showed direct relation to MNNW severity to a certain point. When sensory or motor potential were no longer obtained, painful thresholds returned close to normal values. We suggest this result could be due to small fibers destruction, when hyperalgesia would be replaced by hypoesthesia. As for discriminatory sensitivity between two points has been observed higher values were obtained as most affected by MNNW with a significant difference between control group and III, IV, V and VI groups (p <0.0001). As for the scale of severity of symptoms, the complaints with pain and numbness or tingling were more evident in I, III, IV and V groups. About the inability to perform daily activities predominated in III, IV and V groups. CONCLUSION: Pain threshold is lower in patients with carpal tunnel syndrome, either the median nerve innervated area or another areas.

Median Nerve Ultrasonography Examination Correlates for the Diagnosis of Moderate to Severe Carpal Tunnel Syndrome Objective: The aim of the study was to investigate the associations of cross-sectional area (CSA) of the median nerve measured by ultrasonography (US), the median to ulnar nerve ratio (MUR), the median to ulnar nerve difference (MUD) and the ratio of CSA of the median nerve to height squared (MHS) in relation to electrodiagnostic classification of moderate and severe carpal tunnel syndrome (CTS) and thus to identify patients suitable for surgical treatment. Materials and Methods: A prospective study was conducted in patients aged ≥ 18 years who underwent both median and ulnar nerve US and electrodiagnostic studies (EDS). 124 wrists of 62 patients were examined. The patients' characteristics were acquired through a questionnaire. CTS was diagnosed using EDS and classified according to the guidelines of the Czech Republic Association of Electrodiagnostic Medicine. The CSA of the median nerve and of the ulnar nerve were measured at the carpal tunnel inlet, i.e. at the level of the pisiform bone. Results: The median nerve swells at the wrist in CTS. Median nerve CSA at the tunnel inlet ≥ 12mm2 correlates with electrodiagnostic classification of moderate to severe carpal tunnel syndrome. At...

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<p>Carpal tunnel syndrome (CTS) is one of the most prevalent work-related musculoskeletal disorders of the upper extremity yet its etiology remains elusive. Nerve hypervascularization has been proposed as a pathophysiological change in CTS and can be measured using high resolution sonography of intraneural blood flow. The purpose of this study was to determine the effects of deviated wrist postures and fingertip force on the intraneural blood flow velocity of the median nerve proximal to the wrist crease. Ten participants experiencing the classic symptoms of CTS and nine healthy volunteers were recruited and underwent qualitative assessments (Phalen’s test, Katz hand diagram, Levine’s CTS questionnaire). Intraneural blood flow velocity was measured in five wrist postures (flexion 30°, flexion 15°, neutral, extension 15°, extension 30°) with and without a middle digit fingertip press (0N, 6N). A control (N=9) group and a CTS symptomatic (N=9) group were determined, in addition to a CTS individual (N=1) that required a separate analysis. A significant main effect of force was found (F_1,16= 28.039, p < 0.0005) with the mean peak velocity being greater with force (3.56 cm/s) than without force (2.81 cm/s). Wrist posture had a main effect (F_4,64= 3.163, p < 0.020) with flow velocity as neutral (2.87 cm/s) was significantly lower than flexion 30° (3.37 cm/s), flexion 15°(3.27 cm/s) and extension 30° (3.29 cm/s). There was no significant difference in peak blood flow velocity between the two experimental groups, CTS symptomatic (3.34 cm/s) and control (3.03 cm/s) (F_1,16= 4.121, p < 0.059). The results suggest that both force and non-neutral wrist postures may acutely induce vascular changes previously associated with CTS. The quantification of reactive median nerve hypervascularity should be investigated further as it has potential to be both a reliable diagnostic technique and a non-invasive assessment of CTS risk.</p> / Master of Science in Kinesiology

Made available in DSpace on 2016-12-06T17:07:25Z (GMT). No. of bitstreams: 1 Daniela.pdf: 2419593 bytes, checksum: 894152ce479aae16445a360b52fda72a (MD5) Previous issue date: 2010-03-03 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This study investigated the effect of Carpal Tunnel Syndrome (CTS) on hand function. It was analyzed the parameters of the grip force and their associations with the characteristics of CTS; and also, the control of the grip force in individuals with CTS during functional tasks and the effect of muscle fatigue and the object&#8223;s weight. It was evaluated 13 women with CTS (GE) and 13 without STC (GC) aged 43.54 ± 7.70 and 43.23 ± 7.89, respectively. The GE was assessed by the symptoms severity and functional status (Boston Questionnaire for CTS), the threshold of tactile sensibility and the manual dexterity (Moberg test). The maximal voluntary grip force was evaluated using a dynamometer. The parameters of the grip force analyzed were: maximal grip force (Fmax), time do reach the maximal grip force (TFmax), force rate (TDF) and area under the curve force-time (AFmax). To analyze the grip force control, the subjects performed two functional tasks while an object (instrumented with force sensor and triaxial accelerometer) was manipulated: i) drinking to bring the object close to the mouth and ii) "transition" - to lift the object 11 times sequentially and to leave it on the table after 5 s; in the trials 6-8, the object&#8223;s weight was increased; therefore, the trials without object&#8223;s additional load (average of 1-5, OBJP1) and the second lift with object&#8223;s additional load (OBP2) were compared. The parameters analyzed were: peak of the velocity (Pvel), time lag (DT), peak of the grip force (PFP), mean of the grip force in movement&#8223;s acceleration (Fac) and deceleration (Fdc) and safety margin (MS). The subjects performed the functional tasks before the fatigue protocol (FAD1) and with the muscles fatigued (FAD2). At group&#8223;s comparison, the GE showed lower values of Fmax, TDF and AFmax and higher TFmax. There were high and moderate associations between TFmax and the characteristics of the GE and a moderate association between manual dexterity and the parameters of the grip force. The temporal parameters (Pvel and DT) were not affected by the CTS, fatigue and object&#8223;s weight. Before the fatigue protocol, the GE applied higher PFP than the GC (drinking task); furthermore, both groups increased the PFP and the MS (transition task) while lifting the object with additional load. When the subjects performed the tasks with fatigued muscles, it was found a decreased of Fdc for the GE (drinking task) and also of PFP and MS for both groups (transition task); there was no difference on PFP between OBJP1 and OBJP2 for the GE. The analysis of the parameters of the grip force was useful to detect the muscle function impairments in CTS. It was identified that the TFmax might be the best parameter to indicate these changes. Moreover, it is suggested that the sensibility of the fingertips is important to avoid the excessive grip forces in functional tasks and that the manipulation of the objects with muscles of prehension fatigued may increase the likelihood of accidental slips, especially in individuals with CTS. / Este estudo investigou efeito da Síndrome do Túnel do Carpo (STC) na função manual. Foram analisados os parâmetros da força de preensão e suas associações com as características da STC, bem como o controle da força de preensão de indivíduos com STC em tarefas funcionais e o efeito causado pela fadiga e peso do objeto. Foram avaliadas 13 mulheres com STC (GE) e 13 sem STC (GC) com idade de 43,54 ± 7,70 e 43,23 ± 7,89 anos, respectivamente. O GE foi classificado quando à gravidade dos sintomas e estado funcional (Questionário de Boston para STC), o limiar de sensibilidade tátil e a destreza manual (Teste de Moberg). Foi realizado teste de força de preensão voluntária máxima em um dinamômetro. Os parâmetros da força de preensão analisados foram: força de preensão máxima (Fmax), tempo para atingir a força de preensão máxima (TFmax), taxa de desenvolvimento da força de preensão (TDF) e área sob a curva força-tempo (AFmax). Para análise do controle da força de preensão os indivíduos manipularam um objeto (instrumentado com sensor de força e acelerômetro triaxial) em duas tarefas funcionais: i) beber - levar o objeto até próximo à boca e ii) transição - realizar 11 levantamentos seqüenciais do objeto e reposicioná-lo sobre a mesa após 5 s, sendo que seu peso era aumentado nas repetições 6-8; foram comparadas as tentativas sem peso adicional do objeto (média 1-5, OBJP1) e o segundo levantamento com peso adicional (OBJP2). Os parâmetros analisados foram: pico da velocidade (Pvel), diferença temporal (DT), pico da força de preensão (PFP), média de força de preensão na aceleração (Fac) e desaceleração (Fdc) do movimento e margem de segurança (MS). Os indivíduos realizaram as tarefas funcionais antes de um protocolo de fadiga (FAD1) e com os músculos da preensão fadigados (FAD2). Os parâmetros da força de preensão foram diferentes entre grupos. GE mostrou menores valores de Fmax, TDF e AFmax e maior TFmax do que o GC. Foram encontradas associações moderadas e altas entre o TFmax e características do GE e moderada entre destreza manual e os parâmetros da força de preensão. Os parâmetros Pvel e DT não foram alterados pela STC, fadiga e peso do objeto. Antes do protocolo de fadiga, o GE aplicou maior PFP do que o GC (tarefa beber); ao levantar o objeto com peso adicional, ambos os grupos aumentaram o PFP e a MS (tarefa transição). Com os músculos fadigados, houve decréscimo da Fdc para GE (tarefa beber) e do PFP e da MS (tarefa transição) para ambos os grupos; o GE não mostrou diferença do PFP entre OBJP1 e OBJP2. A análise dos parâmetros da preensão apresentou-se útil para detectar prejuízo da função muscular na STC. Foi identificado que o TFmax pode ser o melhor parâmetro para indicar este comprometimento. Além disso, sugere-se que a sensibilidade é importante para evitar forças de preensão excessivas em tarefas funcionais e que a manipulação de objetos com músculos da preensão fadigados pode aumentar a probabilidade de deslizes acidentais, especialmente em indivíduos com STC.

Karpaltunnelsyndrom är den vanligaste formen av infångningsneuropati hos den vuxna befolkningen. Kända riskfaktorer för karpaltunnelsyndrom inkluderar arbetsskador som upprepad och repetitiv användning av handen och handleden, men även andra orsaker som graviditet, kön, eventuella frakturer med mera. Elektroneurografi (neurografi) är en klinisk undersökningsmetod som används för att diagnostisera och gradera nervskadan av karpaltunnelsyndrom. Syftet med studien var att jämföra motorisk och sensorisk nervledningshastighet och amplitud mellan arbetsrelaterade skador och andra orsaker vid bekräftad karpaltunnelsyndrom. Patienter rekryterades från avledningen för klinisk neurofysiologi på Gävle sjukhus som var kallade för en neurografiundersökning med frågeställning karpaltunnelsyndrom. Inklusionskriterier i studien var patienter, kvinnor och män i åldern 18–65 år med bekräftad karpaltunnelsyndrom. Neurografi utfördes motorisk och sensoriskt på n. medianus och n. ulnaris bilateralt. Vidare undersöktes n. medianus bilateralt med 14–7 metoden. Ingen signifikant skillnad hittades mellan arbetsskador och andra orsaker för karpaltunnelsyndrom vid jämförelse mellan motorisk och sensorisk nervledningshastighet samt amplitud. Ingen skillnad hittades i 14–7 metoden vid registrering av n. medianus mellan grupperna. Inget samband hittades mellan kroppslängd och motorisk nervledningshastighet. / Carpal tunnel syndrome is the most common form of entrapment neuropathy in the adult population. Known risk factors for carpal tunnel syndrome include work related injuries such as repeated and repetitive use of hand and wrist, but also other causes such as pregnancy, gender, possible fractures and more. Electroneurography (neurography) is a clinical examination method used to diagnose and grade the nerve damage of carpal tunnel syndrome. The purpose of this study is to compare motor and sensory nerve conduction velocity and amplitude between work related injuries and other causes when confirmed carpal tunnel syndrome. Patients were recruited from the neurophysiology department at Gävle hospital who were called for a neurography examination with a question of carpal tunnel syndrome. Inclusion criteria in the study were patients, women, and men between the age 18-65 years with confirmed carpal tunnel syndrome. Neurography were performed bilaterally for both motor and sensory function of the median and ulnar nerve. The median nerve was also examined bilaterally with the 14-7 method. No difference was found between work related injuries and other causes in carpal tunnel syndrome when comparing motor and sensory nerve conduction velocity and amplitude. No difference was found in the 14-7 method when registering the n. medianus between the groups. No correlation was found between body height and motor nerve conduction velocity.

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