A microbubble dispersion (MBD) was used to supply oxygen for an aerobic fermentation of Baker's yeast. The 1-liter microbubble dispersion generator supplied bubbles for 20-liter and 50-liter working volume fermentations in a 72-liter pilot scale fermenter. The microbubbles were stabilized by the surfactants naturally present in the culturing broth medium. The growth patterns of yeast Saccharomyces cerevisiae, cultured at agitation speeds of 150 rpm and 500 rpm, were compared for oxygen supplied by ordinary air sparging and by MBD sparging. Both air sparged and MBD systems were supplied air at equivalent volumetric flow rates. The volumetric oxygen transfer coefficients (KLa) were estimated by the yield coefficient method. The KLa values increased from 142.5 to 458.3 h-1 and from 136.1 to 473.3 h-1 for 20- and 50- liter runs, respectively, as the agitation speed was increased from 150 to 500 rpm in the ordinary air sparged fermentations. The oxygen transfer coefficients in the MBD sparged fermentations were found to be independent of the fermenter agitation speed at approximately 480 h-1 for 20-liter runs and 340 h-1 for 50-liter runs. The growth rates for MBD at 150 rpm were essentially equivalent with air sparged fermentations at 500 rpm. The total power consumption per unit volume of broth for the 150 rpm, MBD fermentation was 68% lower than the 500 rpm, air sparged run for the 20-liter fermentations and was 55% lower for the 50-liter fermentations. / Master of Science

Avec la construction et le développement de la ville intelligente, la façon de construire le modèle 3D réaliste des grands bâtiments de la ville rapidement et efficacement devient le hotspot de recherche. Dans cette thèse, une méthode procédurale de modélisation intelligente est proposée pour construire rapidement et efficacement un modèle de construction de ville 3D à grande échelle basé sur la modélisation de la forme de la façade et de la grammaire de forme. La technologie de l'information du bâtiment (BIM) est un moyen technique important pour améliorer l'industrie de la construction, pour la conception du bâtiment de la ville et la construction de la meilleure recherche et l'application de la technologie BIM est la clé, de gérer efficacement les informations du cycle de vie du bâtiment et de réaliser le partage et l'échange. Cette thèse a étudié l'acquisition et le traitement des données de modélisation. Google Earth et le logiciel ArcGIS sont principalement utilisés pour acquérir et traiter des données d'images-cartes et des données de cartes d'élévation de la zone cible, ces deux types de correspondance et de superposition de données, qui peuvent générer des données de terrain urbain 3D avec des informations de localisation géographique. Ensuite OpenStreetMap est utilisé pour acquérir les données routières de la zone cible, et il peut être optimisé pour le réseau routier nécessaire par le logiciel JOSM. La technologie de balayage laser 3D est utilisée pour collecter des images de texture de surface de bâtiment et pour créer le modèle de nuages de points de la modélisation d'architecture cible afin d'obtenir les dimensions de modélisation par mesure. Sur cette base, cette thèse a principalement étudié le principe et le processus de la règle CGA pour créer des modèles de construction, et étudié la méthode qui peut séparer les éléments architecturaux en utilisant la segmentation d'image pour générer automatiquement la règle CGA et de créer ensuite le modèle de construction. Ainsi, des modèles de construction 3D ont été établis dans le logiciel CityEngine en utilisant les règles CGA et la technologie de segmentation des façades. Cette thèse a construit le modèle d'information intégré au bâtiment urbain (CBIIM) basé sur BIM. L'information sur la construction de la ville est classée et intégrée, et le bâtiment et la composante ont été décrits avec la norme IFC, afin de gérer efficacement les informations du cycle de vie du bâtiment. Cette thèse étudie la technologie du modèle d'association d'information intégrée, qui permet de réaliser une conception standardisée des composants avec des caractéristiques associées et une conception intelligente des bâtiments avec des paramètres associés dans les règles de connaissances combinées avec l'IFC. La technologie de simulation de la construction de visualisation est étudiée. Les règles de connaissance dans le modèle d'information intégré fournissent une référence fiable pour la simulation de construction, et la scène de simulation est créée en invoquant le modèle d'information intégré, ainsi le processus de simulation est terminé. En prenant le campus Baoshan de l'Université de Shanghai comme exemple, le processus de modélisation de la scène entière est illustré, et les étapes de modélisation de toutes sortes d'objets 3D sont décrites en détail pour résoudre les problèmes spécifiques dans le processus de modélisation réelle. Ainsi, la faisabilité et la validité de la méthode de modélisation intelligente procédurale sont vérifiées. Prenant comme exemple le dortoir de l'Université de Shanghai, une simulation et le modèle de simulation ont été créés par les informations intégrées, combinées aux informations de construction pertinentes, la simulation de construction a été complétée par le programme. Ainsi, la faisabilité et la validité du CBIIM sont vérifiées. / With the construction and development of the smart city, how to construct the realistic 3D model of the large-scale city buildings quickly and efficiently which becomes the research hotspot. In this thesis, a novel 3D modeling approach is proposed to quickly and efficiently build 3D model of large-scale city buildings based on shape grammar and facade rule modeling. Building Information Model (BIM) is an important technical means to enhance the construction industry, for the city building design and construction, how to better research and application of BIM technology which is the key, in this thesis City Building Integrated Information Model (CBIIM) is specified to manage the information of building lifecycle effectively and realize the information sharing and exchanging. This thesis has studied the acquisition and processing of the modeling data. Google Earth and ArcGIS software are mainly used to acquire and process image-maps data and elevation-maps data of the target area, these two kinds of data match and overlay, which can generate 3D city terrain data with geographic location information. Then OpenStreetMap is used to acquire road data of the target area, and it can be optimal processed to the necessary road network by JOSM software. 3D laser scanning technology is used to collect building surface texture images and create the point clouds model of the target architecture modeling so as to get the modeling dimensions by measurement. On this basis, this thesis mainly has studied the principle and the process of CGA rule to create building models, and studied the method that can separate architectural elements using image segmentation to generate CGA rule automatically and to create building model furtherly. Thus 3D building models have been established in the CityEngine software using CGA rules and facade modeling technology. This thesis has specified the City Building Integrated Information Model (CBIIM) based on BIM. The city building information are classified and integrated, and the building and component was described with the IFC standard, in order to manage the informations of building lifecycle effectively. This thesis studies the integrated information association model technology, that it can realize standardized component design with associated features and intelligent building design with associated parameters in knowledge rules combined with IFC. The construction simulation technology is studied. The knowledge rules in the integrated information model provide a reliable reference for the construction simulation, and the simulation scene is created through the invoking the integrated information model, thus the construction simulation process is completed by the program. Taking Baoshan Campus of Shanghai University as an example, the modeling process of the whole scene is illustrated, and the modeling steps of all kinds of 3D objects are described in detail to solve the specific problems in the actual modeling process. Thus the feasibility and validity of the procedural intelligent modeling approach are verified. Taking the dormitory of Shanghai University as an example, a simulation scene and the simulation model were created by the integrated informations, combined with the relevant construction information the construction simulation was completed by the program. Thus the feasibility and validity of the CBIIM are verified.

海洋是國家發展的利基，亦是我們賴以生存最重要的憑藉，更是捍衛國家安全的第一道防線。臺灣地處西太平洋第一島鏈中央地帶，戰略地位極為重要，從臺灣的地理特性和地緣位置來看，臺灣的國家安全與海洋是密切相關的，海洋不僅是國家安全的重要緩衝空間，也是維護國家安全的屏障和門戶，控制了海洋即可加大安全縱深，遏止來自於海洋方面的威脅。 臺灣是一個海洋國家，海洋權益的確保、藍色國土的經略乃政府施政的重大目標。今日我們面對海域主權權利、海洋資源、海洋環境等各項層面的威脅及挑戰，需站在戰略及國安的高度展開多面向的海洋戰略(包括尋求國際合作、爭取國際地位等)，並制定國家海洋政策，有效經營海洋資源，方能增進全方位的國家利益，以落實海洋國家發展願景。 行政院海岸巡防署為中華民國開國以來第一個依法定程序設立且律屬於行政院二級部會層級的海域執法專責機關，除海軍以外，為我國第二大擁有海上執法能量的武裝團隊，肩負起維護國家安全、海上治安及救災救難等重責大任；其擁有獨立運作且強而有力的海域司法管轄權，並代表國家執行公權力、伸張海權，以維護國家海洋權益及確保國家安全。 關鍵詞：國家安全、國安戰略、海權、海洋戰略、海洋政策、海軍戰略、地緣戰略、海巡署、海軍、海關 / The sea is the gateway for national development, the most important reliance for our survival, and the first line of defense for national security. Taiwan locates in the middle of the first island chain in the west Pacific with strategic significance. From the geographical points of view, Taiwan's national security closely relates to the sea, which not only acts as important buffer zone for national security, but also safeguards barriers and portals of national security. Controlling the sea deepens the depth of security and deterring threats from the sea. Taiwan is a maritime country. To ensure maritime rights and interests, the governance of Blue Territory is a major goal to the government. Today we are faced with issues such as the sovereign rights of the sea, marine resources, marine environment and other aspects of threats and challenges. It is necessary to take strategic vantage point of national security and expand multi-faceted maritime strategies (including international cooperation and international status, etc.). In order to effectively manage marine resources for all the spectrum of the national interests, national policies and visions of the sea should be developed and fullfilled. The Coast Guard Administration of the Executive Yuan (CGA) is the first ministerial agency of the Republic of China specifically for maritime law enforcement. In addition to the Navy, the CGA has become the country's second largest armed forces responsible for national security, maritime peace and search and rescue, etc. at sea. Representing national authority and sovereignty, it operates independently and holds strongly jurisdiction in sea territories to preserve national maritime rights and interests and to ensure national security. Keywords: national security, national security strategy, sea power, maritime strategy, sea policy, naval strategy, geostrategic, Coast Guard(CGA), Navy, Customs

IPv6, protocole succédant à IPv4, est en cours de déploiement dans l'Internet. Il repose fortement sur le mécanisme Neighbor Discovery Protocol (NDP). Celui-ci permet non seulement à deux nœuds IPv6 de pouvoir communiquer, à l'instar du mécanisme Address Resolution Protocol (ARP) en IPv4, mais il apporte aussi de nouvelles fonctionnalités, telles que l'autoconfiguration d'adresse IPv6. Aussi, sa sécurisation pour le bon fonctionnement de l'Internet en IPv6 est critique. Son mécanisme de sécurité standardisée à l'Internet Engineering Task Force (IETF) se nomme Secure Neighbor Discovery (SEND). Il s'appuie à la fois sur l'utilisation d'identifiants cryptographiques, adresses IPv6 appelées Cryptographically Generated Addresses (CGA) et qui sont générées à partir d'une paire de clés publique/privée, et de certificats électroniques X.509. L'objet de cette thèse est l'étude de ces identifiants cryptographiques, les adresses CGA, ainsi que le mécanisme SEND les employant, et leurs réutilisations potentielles pour la sécurisation IPv6. Dans une première partie de cette thèse, tout d'abord, nous posons l'état de l'art. Dans une deuxième partie de cette thèse, nous nous intéressons à la fiabilité du principal mécanisme connu employant les adresses CGA, le mécanisme SEND. Dans une troisième et dernière partie de cette thèse, nous présentons des utilisations des identifiants cryptographiques pour la sécurisation IPv6

The master thesis deals with a block subdivision into parcels using procedural modeling. The main goal focuses on improving of the existing method called OBB-based Subdivision that uses auxiliary envelopes of rectangle shape for splitting. It is required to adapt the method to Czech conditions as well. The first part focuses on the analysis of scientific publications, which describes the development and current situation of procedural modeling issues. Then the methodology of suggested algorithm is described that tests a change of the envelope to the trapezium shape, respectively to the quadrangle shape. In conclusion, the proposed algorithms are tested on the real data in CityEngine, which offered the possibility of using procedural approach to automatically generate 3D parcels. The whole process is controlled by the limitations of development plans of the selected urban areas. Powered by TCPDF (www.tcpdf.org)

Host sensors that recognize pathogen associated molecular patterns and the mechanisms of innate immune response to mouse polyomavirus (MPyV) infection were the main topics of current work. We found that MPyV did not induce interferon (IFN) production during early events of infection, but induced interleukin-6 (IL-6) and other cytokine production without inhibiting virus multiplication. Cytokine microenvironment changed the phenotype of adjacent non infected fibroblasts toward the cancer-associated fibroblast (CAF)-like phenotype. We identified Toll-like receptor 4, a sensor of the innate immunity system, to be responsible for infection dependent IL-6 production. In an effort to determine whether and where virions are released from endosomal compartments into the cytosol, we found that the hydrophobic domains of minor capsid proteins, exposed on the surface of virions after their partial disassembly in the ER, play an important role in effective escape of virions from the lumen part of endoplasmic reticulum into the cytosol, Although naked, partially disassembled virions appear before translocation to the nucleus in the cytosol, viral DNA is not recognized by cytosolic sensors at this phase of infection Sensing of MPyV resulting in IFN production occurs first during viral replication. Mutant virus,...

<p>This thesis reports on the effects of stress management on long-term pain patients and on a healthy sample from IT and media companies; two groups that are commonly exposed to high stress levels. Even if there are important differences between these two groups, there are similarities such as the necessity for effective stress management. Stress-related and musculoskeletal disorders are major public health issues in most industrialized countries and are expected to become increasingly common during the coming decades. The pathogenic plastic changes in the CNS and immune system caused by long-term stress pose severe burdens to individuals, organizations as well as society in general. Thus, stress management may be essential to maintain and improve long-term health and wellbeing and to proactively counteract stress-related ill-health.</p><p>This thesis is based on four papers: Paper I assessed the effects of massage as compared to relaxation tapes in long-term pain patients. Paper II validated some of the Visual Analogue Scale questions that were to be used in paper III and IV. Paper III assessed the effects on mental and physical wellbeing and biological stress markers from a web-based stress management and health promotion tool. Paper IV aimed at mapping out predictors for trends (improvement vs. worsening) in self-rated health (SRH) over a period of one year.</p><p>The overall results indicate that individually focused stress management interventions in long-term pain patients as well as on a healthy, working population may have short-term beneficial effects on psychological and physiological stress, health and wellbeing. On a long-term basis the beneficial changes seem to revert. In paper four, it is indicated that the stress management intervention is not a significant predictor of long-term changes in SRH. Rather, other factors such as health perception, sleep quality and sense of coherence predicted improvement in SRH over time.</p>

This thesis reports on the effects of stress management on long-term pain patients and on a healthy sample from IT and media companies; two groups that are commonly exposed to high stress levels. Even if there are important differences between these two groups, there are similarities such as the necessity for effective stress management. Stress-related and musculoskeletal disorders are major public health issues in most industrialized countries and are expected to become increasingly common during the coming decades. The pathogenic plastic changes in the CNS and immune system caused by long-term stress pose severe burdens to individuals, organizations as well as society in general. Thus, stress management may be essential to maintain and improve long-term health and wellbeing and to proactively counteract stress-related ill-health. This thesis is based on four papers: Paper I assessed the effects of massage as compared to relaxation tapes in long-term pain patients. Paper II validated some of the Visual Analogue Scale questions that were to be used in paper III and IV. Paper III assessed the effects on mental and physical wellbeing and biological stress markers from a web-based stress management and health promotion tool. Paper IV aimed at mapping out predictors for trends (improvement vs. worsening) in self-rated health (SRH) over a period of one year. The overall results indicate that individually focused stress management interventions in long-term pain patients as well as on a healthy, working population may have short-term beneficial effects on psychological and physiological stress, health and wellbeing. On a long-term basis the beneficial changes seem to revert. In paper four, it is indicated that the stress management intervention is not a significant predictor of long-term changes in SRH. Rather, other factors such as health perception, sleep quality and sense of coherence predicted improvement in SRH over time.

海巡署於2000年成立是我國海域的專責機關，其中分為兩套體系即「海洋巡防」、「海岸巡防」，組織成員背景來自軍職、警職、文職人員。海岸巡防下轄之各地區巡防局在各縣市設機動查緝隊，主要內容為海域海岸的犯罪偵防、查緝走私、防止非法入出國以及安全情報蒐報等事項。 跟隨著性別主流化、性別工作平等法的推動，海巡特考招考於2006年取消男女名額限制，越來越多女性查緝員加入陽剛職場。本研究欲探討女性查緝人員進入陽剛職場之工作壓力及工作滿足感，研究對象以海岸巡防總局下轄的各地區機動查緝隊內文職女性人員，以Hellriegel , Slocum& Woodman的工作壓力因子探討，分別從工作本身、組織角色、人際關係、生涯發展、組織結構與氣氛及組織外部六大構面，工作滿足感之研究係依據Vroom所提出的組織本身、工作環境、工作內容三大構面，對於女性查緝人員之工作壓力及滿足感進行探討與分析。 本研究採用深度訪談法，依據地區、年齡、婚姻狀況等不同的樣本特性的基本資料進行抽樣，找出對本研究具有代表性方能提供最豐富的資訊、經驗得以反映出研究的真實情況，以提高研究之可信度。海巡署查緝隊中截至104年底共有28位女性查緝員，本研究從其中挑選了7位受訪者，分別於北、中、南東以及離島地區之女性查緝人員。 研究結果發現，女性在陽剛職場的工作壓力及滿足感深受以下因素影響： 一、個人內在因素：地緣因素、婚姻狀況、教育程度以及生理心理狀態。 二、外在環境因素：人際關係、工作性質、組織文化以及組織結構。 最後，本研究根據上述研究結論，提出具體建議，提供公務機關及未來相關研究之參考。 關鍵詞：海巡署、陽剛職場、工作滿足感、工作壓力、查緝員 / The Coast Guard Administration of the Executive Yuan was established in 2000 and it is charged with maintaining law and order, protecting the resources of the territorial waters of the Republic of China. The CGA combined the Coast Guard Command and the Marine Police Bureau. The CGA is organized by military, police officer and government officer. The CGA set up coast guard in every city in Taiwan to provide a first line of defense along coastal areas against smugglers, illegal immigrants and State's Internal Security Investigation. With stimulating Gender mainstreaming, Act of Gender Equality in Employment and canceling gender restriction on civil service special examination for coast guard personnel, more and more women work in masculine occupational fields. The purpose of this study is to explore the job stress and the job satisfaction of the women who work in masculine occupational fields. The main research objects are the women who work as coast guard under Coastal Patrol Directorate General control. Based on the data of work stress risk factors of Hellriegel and Slocum& Woodman discusses six themes, including the work itself, organization role, interpersonal relation, career development, organization structure, organization climate and organizational external factors. The study of job satisfaction bases on the work itself, working environment and the content of the job which are advanced by Vroom to analysis job pressure and job satisfaction of the female detectives. This research was conducted via depth interview method. According to different area, age and marital status I conducted the random sampling to find out the representative cases. In the end of 2014 there are 28 female detectives in The CGA. The study selected seven of them from eastern, western, southern, northern and outley island of Taiwan. The research results reveal that the job stress and the job satisfaction of the women who work in masculine occupational fields are affected by the following factors: 1. Immanent factors：geological factor, marital status, educational background, physiological condition and mentality. 2. External factors：interpersonal relations, job, organizational culture and organization structure. Based on the study results, some suggestions were proposed for the reference of government institutions and future researchers. Key words : CGA, masculine workplace, job satisfaction, job pressure, reconnaissance officer