There is an epidemic of chronic kidney disease of unknown origin (CKDu) primarily affecting younger men in Central America, especially El Salvador and Nicaragua. The primary hypothesis has included heat stress and dehydration. Although medication usage is widely viewed as a likely contributor to kidney damage, the association with chronic kidney disease in Central America has not been fully explored. This study investigated medication usage, symptom presentation, and kidney function among 524 outdoor workers in agricultural and non-agricultural industries enrolled in the Mesoamerican Nephropathy Occupational Study (MANOS) led by Boston University researchers. An overview of the literature on the adverse effects of medication on renal function and thermoregulation, with a focus on medications considered in MANOS, was conducted. Medication usage and symptom presentation on both a short- and long-term timeframe were explored in relation to kidney function measured by estimated glomerular filtration rate. Long-term usage of NSAIDS and potassium supplements was significantly associated with kidney function. Neither short- or long-term uses of acetaminophen, the most commonly used medication, were associated with kidney function. While several self-reported health symptoms were significantly associated with lower kidney function in crude models, the associations’ significance levels lessened after adjusting for age, country, and industry. In contrast, symptoms of chistata (a local term for painful urination) and lower abdominal pain three months prior to data collection each significantly predicted higher kidney function. The results of this exploratory, cross-sectional study present an opportunity for further study on how medications and symptoms, related to both nephrotoxicity and heat stress, could be associated with kidney function.

Orientador: Amanda Martins Baviera / Resumo: No Brasil, o número de indivíduos com doença renal crônica (DRC) em terapia dialítica no ano de 2017 foi de aproximadamente 127 mil indivíduos; dentre estes, 92% realizavam hemodiálise (HD). A HD tem como principal objetivo a remoção dos solutos urêmicos e assim a redução dos sintomas relacionados à síndrome urêmica, melhorando a qualidade de vida do indivíduo com DRC. No entanto, aumentam as evidências de que a HD seja um fator exacerbante do estresse oxidativo, via aumento na produção de espécies reativas de oxigênio devido à ativação de leucócitos estimulada pela diálise ou pelo tipo de membrana utilizada, bem como via remoção dialítica de compostos antioxidantes solúveis em água e de baixo peso molecular. No entanto, a literatura reporta resultados contraditórios em relação às alterações em biomarcadores de lesão oxidativa e atividade antioxidante em indivíduos submetidos à HD. O objetivo deste trabalho foi avaliar as alterações na capacidade antioxidante total, nas atividades de enzimas antioxidantes e nos níveis de biomarcadores de danos oxidativos no soro de indivíduos saudáveis e de indivíduos com DRC, antes (pré-HD) e após (pós-HD) uma sessão de HD. Foram selecionados 40 indivíduos saudáveis, sem DRC ou qualquer outra patologia, doadores de sangue do Hemonúcleo Regional de Araraquara para compor o grupo controle, e 40 indivíduos com DRC que realizam HD no Centro Regional de Hemodiálise de Araraquara. Amostras de soro foram utilizadas para determinação dos marcadores ... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

Orientador: José Eduardo Corrente / Resumo: Introdução: Doença renal crônica (DRC) é uma enfermidade de relevância para a saúde pública, cursando com prevalência crescente. Estudos confirmam associação da hipertensão arterial, diabetes mellitus e proteinúria com desenvolvimento da DRC, progressão e mortalidade. Intervenções nutricionais podem prevenir ou atenuar essas complicações da doença, além de manter o estado nutricional e levar à maior sobrevida e qualidade de vida aos pacientes. Objetivo: Avaliar os benefícios do aconselhamento nutricional em pacientes portadores de DRC. Metodologia: Estudo quase-experimental, controlado e em dois momentos (inicial e após três meses), com indivíduos nos estadios 3 e 4 da doença, divididos em dois grupos: controle, composto por indivíduos que nunca receberam aconselhamento nutricional por recusa, e intervenção, caracterizado por pacientes em acompanhamento com nutricionista. Foi realizada a comparação entre os parâmetros: antropometria, exames bioquímicos e avaliação do consumo alimentar através da análise dos R24h através do programa Nutrition Data System for Research. Para análise estatística, ANOVA seguido do teste de Tukey ou teste de Wald de acordo com a distribuição dos dados, adotando nível de significância de 5%. Resultados: Foram incluídos 50 pacientes, sendo: controle (n=23) e intervenção (n=27). Os grupos foram homogêneos. Observou-se diferenças em relação à pressão arterial, reduzida após aconselhamento nutricional. Não ocorreram alterações consideráveis nos bioquími... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Chronic kidney disease (CKD) is a condition of increasing prevalence, considered relevant to public health. Studies confirm an association of arterial hypertension, diabetes mellitus and proteinuria with the development of CKD, progression and mortality. Dietary interventions can prevent or mitigate these complications of the disease, in addition to maintaining nutritional status and leading to greater survival and quality of life for patients. Objective: To evaluate the benefits of nutritional counseling in patients with CKD. Methodology: Quasi-experimental study, controlled and two-stage (initial and after three months), with individuals in stages 3 and 4 of the disease, separated into two groups: control, composed of individuals who never received nutritional advice for refusal, and intervention, characterized by patients being followed up with a nutritionist. A comparison was between the parameters: anthropometry, biochemical tests and evaluation of food consumption by the analysis of R24h using the Nutrition Data System for Research program. For statistical analysis, ANOVA followed by the Tukey test or Wald test according to the data distribution, adopting a significance level of 5%. Results: 50 patients were included in the groups control (n = 23) and intervention (n = 27). The groups were homogeneous. Differences were observed in blood pressure that reduced after nutritional counseling. There were no changes in biochemicals exams, however in the evaluatio... (Complete abstract click electronic access below) / Mestre

Bakgrund: Kronisk njursjukdom drabbar mer än var 10:e människa världen över. Sjukdomen är komplex och kan ses i samband med andra sjukdomar. Individer behöver utföra en livslång och krävande egenvård av denna progressiva sjukdom. I dagens hälso- och sjukvård vårdas vanligtvis en sjukdom i taget vilket kan få vården att brista i individanpassat egenvårdsstöd. Syfte: Syftet med litteraturstudien är att beskriva erfarenheter av egenvård för individer med kronisk njursjukdom. Metod: En kvalitativ litteraturstudie baserad på åtta empiriska studier. Artiklarna hämtades från databaserna PubMed och Cinahl. Innehållsanalysen gjordes utifrån Fribergs femstegsmodell. Resultat: Två kategorier och sju underkategorier skapades utifrån resultatet. Kategorierna; 1) Hälsorelaterade värderingar och upplevelser påverkar egenvården 2) Behov av stöd för att utföra egenvård. Konklusion: Litteraturstudien visar att individer kan uppleva ångest och oro över sitt hälsotillstånd vilket försvårar utförandet av egenvård. Hälso- och sjukvården behöver ha ett personcentrerat bemötande och beakta individens beteenden och värderingar för att kunna ge en individanpassad information och ett kontinuerligt egenvårdsstöd. Därefter kan individen få en god förutsättning att ta till sig kunskap om sin hälsa. Sjuksköterskan har ett ansvar i att möta det egenvårdsbehov individen har genom att ge egenvårdsstöd för att leva ett mer hälsosamt liv. / Background: Chronic kidney disease affects more than every 10th person worldwide. The disease is complex and can be seen with other diseases. Individs need to perform a lifelong and demanding self-management of this progressive disease. In today's health care, one illness is usually cared for at a time, which can cause the care to fail in individualized self-management support. Aim: The aim of this study was to describe experiences of self-management for individs with chronic kidney disease. Methods: A qualitative literature study based on eight empirical articles. The articles were retrieved from the databases PubMed and Cinahl. The content analysis was based on Friberg's five-step model. Results: Two categories and seven subcategories were created based on the result. The two categories were: 1) Health-related values and experiences affect self-management 2) Need for support to perform self-management. Conclusion: The study shows that participants may experience anxiety about their state of health, which makes it difficult to perform self-management. Healthcare needs to have a person-centered approach and take into account the individ's behaviors and values in order to be able to provide individualized information and continuous self-management support. After that, individs can have a good chance of absorbing knowledge about their health. The nurse has a responsibility to meet the individs self-management needs by providing support to live a healthier life.

El documento ¨Formulación técnica, económica, financiera y social en la implementación de Clínicas de Hemodiálisis” definirá la viabilidad del funcionamiento de una clínica privada que presta servicio de tercerización de la hemodiálisis a Essalud – Seguro Social de Salud y cuyo servicio de hemodiálisis es diferente del resto de las clínicas privadas del país por su calidad de productos y tecnología de equipos que propenden a mejorar la calidad de vida del paciente renal crónico. Para determinar esta viabilidad, este documento nos mostrará las características y planes económico financiero y estratégicos que generen respuesta a la siguiente pregunta: ¿El proyecto de clínicas de hemodiálisis para tercerización con Essalud genera valor al inversionista y es económicamente rentable? La Enfermedad Renal Crónica Terminal (ERCT) es una enfermedad progresiva que evoluciona en las personas en diferentes estadios y que da inicio a un tratamiento sustitutivo de la función mediante diálisis o trasplante de riñón con unas tasas de incidencia y prevalencia crecientes en las dos últimas décadas. Nuestro enfoque va direccionado al servicio de hemodiálisis que se ofrecerá en tercerización al Seguro Social de Salud que actualmente cobertura al 66.66% de pacientes asegurados a nivel nacional en Perú. Las tercerizaciones se realizan mediante un Concurso Público para la Contratación del Servicio. / The document "Technical, economic, financial and social formulation in the implementation of Hemodialysis Clinics" will define the feasibility of operating a network of private clinic that provide outsourcing of hemodialysis to Essalud - Social Health Insurance and whose hemodialysis service It is different from the rest of the private clinics in the country because of its quality of products and equipment technology that tend to improve the quality of life of the chronic renal patient. To determine this viability, this document will show us the economic and strategic economic characteristics and plans that generate an answer to the following question: Does the hemodialysis clinic project for outsourcing with Essalud generate value for the investor and is it economically profitable? Terminal Chronic Kidney Disease (ERCT) is a progressive disease that evolves in people at different stages and that begins a substitute treatment of function by dialysis or kidney transplant with increasing incidence and prevalence rates in the last two decades. Our approach is directed to the hemodialysis service that will be offered in outsourcing to the Social Health Insurance that currently covers 66.66% of insured patients nationwide in Peru. Outsourcing is carried out through a Public Tender for the Service Hiring. / Trabajo de investigación

Background: Chronic Kidney Disease (CKD) can be described as the loss of the kidney function over time. Symptoms usually develop slowly and it may not appear in early stages. Lab tests can confirm a CKD diagnosis. The approximate number of incidents per year is more than 200,000 cases and approximately 30 million people are living with CKD today in the United States. This long-standing disease ultimately leads to renal failure at the end. At this present time, there are no known cures for CKD and the only treatment available is dialysis. Objectives: The purpose of this study is to determine the association between CKD and further with Hemodialysis (HD) and medical condition such as cardiac complications, cardiogenic shock, hemorrhage, anemia, vascular complication, postop respiratory failure, post op infarct hemorrhage, acute renal failure, new temporary pacemaker, new permanent pacemaker, pericardial complications, and death. Methods: The study employed secondary data in a cross-sectional design. A sample of 106,969 was drawn from the population. The outcome variables were a diagnosis of CKD and/or CKD with HD. The predictor variables were cardiac complications, cardiogenic shock, hemorrhage, anemia, vascular complication, postop respiratory failure, post op infarct hemorrhage, acute renal failure, new temporary pacemaker, new permanent pacemaker, pericardial complications and death. Logistic regression was conducted to analyze the relationship between outcome variable and each independent variable. Variables with a p-value <0.05 were considered significant. Odds Ratio (OR) and 95% Confidence Intervals (CI) were reported and discussed. The statistical analysis was performed using SAS version 9.4. Results: Analysis shows that subjects with cardiac complications were 17% less likely to have CKD as compared to those who did not have cardiac complications (OR: 0.83, 95% CI: 0.78-0.88). CKD patients who had cardiac complications were 18% more likely to have HD than the subjects who did not have cardiac complications (OR: 1.18, 95% CI: 1.01-1.39). Patients with cardiogenic shock were 86% more likely to have CKD than the subjects who did not have cardiogenic shock (OR: 1.86, 95% CI: 1.82-1.91). CKD patients who had cardiogenic shock were also 18% more likely to have HD than the subjects who did not have cardiogenic shock (OR: 1.18, 95% CI: 1.11-1.25). Similar results have been reported if a patient had other conditions. Conclusion: Chronic kidney disease with hemodialysis is significantly associated by the other medical conditions such as cardiac complications cardiogenic shock, hemorrhage, anemia, vascular complication, postop respiratory failure, post op infarct hemorrhage, acute renal failure, new temporary pacemaker, new permanent pacemaker, pericardial complications and death in the United States. Further studies are needed to confirm the results and to understand the prognosis.

The prevalence of pregnancies complicated by chronic kidney disease (CKD) is increasing. Yet, CKD in pregnancy tends to be under-diagnosed, as women of childbearing age are not regularly screened for renal dysfunction, nor is screening incorporated into routine pregnancy follow up. Further, renal dysfunction has significant implications for maternal and fetal outcomes, with degree of renal dysfunction at conception being the most important prognostic factor. It is established that the risk for poorer renal, maternal and fetal outcomes, increases incrementally with severity of CKD, with intrauterine death and progression to end-stage renal disease (ESDR) associated with severe CKD. However, it is difficult to predict which CKD pregnancies will lead to poor outcomes as the definition of CKD in pregnancy is not uniform between studies, nor are measurement parameters. This paucity of data prevents the establishment of a standard of care protocol and leaves clinicians ill-equipped to care for and manage this complex patient cohort. This review discusses renal, maternal and fetal outcomes in CKD pregnancies as presented by the literature, in order to demonstrate the contradictions in data and gaps in knowledge surrounding this topic, as well as the need for a general management algorithm.

The incidence of chronic kidney disease (CKD) is increasing. CKD is characterized by a gradual decrease in renal function leading to end stage renal disease (ESRD). Damage to the glomerular podocytes, is one of the first hallmarks of CKD. We hypothesized that podocyte prostaglandin E2 (PGE2) receptors contribute to the progression of glomerular injury in models of CKD. To test this hypothesis, transgenic mice were generated with either podocyte-specific overexpression or deletion of the PGE2 EP4 receptor (EP4pod+and EP4pod-/- respectively). Mice were next tested in the 5/6 nephrectomy (5/6 Nx) or angiotensin II (Ang II) models of CKD. These studies revealed increased proteinuria and decreased survival for EP4pod+ mice while EP4pod-/- mice were protected against the development of glomerular injury. Furthermore, our findings were supported by in vitro studies using cultured mouse podocytes where an adhesion defect was uncovered for cells overexpressing the EP4 receptor. Additionally, our investigations have demonstrated a novel synergy between angiotensin II AT1 receptors and prostaglandin E2 EP4 receptors. This was revealed by in vitro studies using isolated mouse glomeruli. There we were able to show that Ang II stimulation leads to increased expression of cyclooxygenase 2 (COX-2), the enzyme responsible for synthesis of PGE2, in a p38 mitogen activated protein kinase (MAPK) dependent fashion. Moreover increased PGE2 synthesis was measured in response to Ang II stimulation. We confirmed the presence of this synergy in our cultured mouse podocytes and showed an adhesion defect in response to Ang II stimulation which was COX-2 and EP4 dependent. These findings suggest that Ang II AT1 receptors and PGE2 EP4 receptors act in concert to exacerbate glomerulopathies. Studies using mice with either podocyte-specific overexpression of a dominant negative p38 MAPK or mice with global deletion of the EP1 receptor did not provide conclusive results as to their respective signaling involvement in podocyte injury. Altogether our findings provide novel insight for podocyte PGE2 EP4 and Ang II AT1 receptor signaling in models of CKD. These studies provide novel avenues for pursuing therapeutic interventions for individuals with progressive kidney disease.

No description available.

Impairments in insulin sensitivity can occur in patients with chronic kidney disease (CKD). Correction of metabolic acidosis has been associated with improved insulin sensitivity in CKD, suggesting that metabolic acidosis may directly promote insulin resistance. Despite this, the effect of acid or alkali loading on insulin sensitivity in a rodent model of CKD (remnant kidney) has not been directly investigated. Such studies could better define the relationship between blood pH and insulin sensitivity. We hypothesized that in remnant kidney rats, acid or alkali loading would promote loss of pH homeostasis and consequently decrease insulin sensitivity. To test this hypothesis, we determined the impact of alkali (2 wk) or acid (5-7 days) loading on plasma electrolytes, acid-base balance, and insulin sensitivity in either sham control rats, 2/3 nephrectomized rats, or 5/6 nephrectomized rats. Rats with 5/6 nephrectomy had the greatest response to insulin followed by rats with 2/3 nephrectomy and sham control rats. We found that treatment with 0.1 M sodium bicarbonate solution in drinking water had no effect on insulin sensitivity. Acid loading with 0.1 M ammonium chloride resulted in significant reductions in pH and plasma bicarbonate. However, acidosis did not significantly impair insulin sensitivity. Similar effects were observed in Zucker obese rats with 5/6 nephrectomy. The effect of renal mass reduction on insulin sensitivity could not be explained by reduced insulin clearance or increased plasma insulin levels. We found that renal mass reduction alone increases sensitivity to exogenous insulin in rats and that this is not acutely reversed by the development of acidosis.