Verksamheten Spindeln i Västerås vänder sig till personer med så kallad dubbeldiagnos, människor med psykisk sjukdom och samtida missbruksproblematik. Syfte med denna studie var att söka kunskap om vad klienterna med så kallad dubbeldiagnos på verksamheten Spindeln upplevde som meningsfull sysselsättning, samt om verksamheten Spindeln bidrog till att klienterna upplevde sig inneha någon form av meningsfull sysselsättning. Empirin insamlades genom kvalitativa semistrukturerade intervjuer med fem klienter från Spindeln. De teorier som behandlades var känslan av sammanhang (KASAM), stigma samt socialt kapital. Dessa teorier användes till att tolka empirin tillsammans med tidigare forskning inom området psykisk sjukdom och meningsfull sysselsättning. Studiens resultat visade på betydelsen av att ha något att göra om dagarna, att meningsfull sysselsättning innebar en sorts trygghet i vardagen som medförde struktur och mening. Att ha ett socialt sammanhang att delta i var även det av mycket stor vikt enligt studiens deltagare samt en strategi för att undvika att hamna i psykos. Meningsfull sysselsättning var mycket individuellt och varierade beroende på respondenternas livssituation i relation till ålder, sjukdom, erfarenhet och visioner. Resultatet visade att Spindelns verksamhet upplevdes som meningsfull av deltagarna. / The activity Spindeln in Västerås is a project that attempts to deliver daily occupation for clients with dual diagnosis, people diagnosed with a mental disorder and a contemporary substance abuse. The purpose of this bachelor thesis was to gain knowledge about what Spindeln's dual diagnosis clients experience as meaningful occupation. The purpose was also to examine if Spindeln contributes to making its clients experience meaningful occupation.  The empirical material was based on qualitative and semi-structured interviews with five clients of Spindeln. The conceptual framework was based on concepts such as sense of coherence (SOC), stigma and social capital. This theories was used mainly to interpret empirical material together with earlier research regarding mental disorder and meaningful occupation. The findings of the study indicated that meaningful daily occupation was very important for dual diagnosis patients because it provides them with a feeling of safety which led to structured and meaningful days. Also the study indicated that having social connection to participate in, and a strategy to avoid a state of psychosis, was of great importance to the clients at Spindeln. Meaningful occupation turned out to be highly individual depending on variables such as age, disease, experiences and visions. The findings also indicated that Spindeln was meaningful according the clients.

War inevitably impacts on the lives of soldiers who participate in them. The impact often suggests a negative nature, leaving some soldiers with permanent physical and emotional scars. Some soldiers will return from war suffering from several psychological disorders as the result of their exposure to combat trauma. Pathologies such as post-traumatic stress disorders, anxiety and mood disorders are not uncommon. Yet, for others war has provided them with numerous positive experiences from which they can find meaning for themselves. It was Aaron Antonovsky who developed the idea of salutogenesis, mainly focussing on the psychological factors that allow individuals to find meaning in their adversity. This study attempts to investigate the impact of service rendered in the South African Special Forces during the Angolan war on current levels of well-being and sense of coherence amongst former Special Forces members. It is commonly known that these soldiers were exposed to severe battle related conditions, often working behind enemy lines for unknown periods of time whilst being self-reliant. It would seem that most of these soldiers have adapted adequately to society 15 years after their participation in the Angolan war (South Africa’s “Border War”). Some of these soldiers have achieved success in many different ways after leaving Special Forces. Some have embarked into the world of business and others chose professional careers and then there are those who became successful entrepreneurs. A sample of 32 respondents was collected. All of the respondents were members of the South African Special Forces during the Angolan war but have resigned since. The respondents were requested to complete a questionnaire consisting of a biographical information section, Antonovsky’s 13-item Orientation to Life Questionnaire (OLQ) and Diener’s Satisfaction With Life Scale (SWLS). The purpose was to determine the respondents’ current sense of coherence and level of well-being and to determine to what extent service in Special Forces has contributed to these levels. Descriptive and inferential statistics were used to analyse the data. Inferential statistics included Chi-square, Fisher’s exact test, Spearman correlation coefficient and the t-test. Analysis of data suggests that the sample currently measures high on both levels of sense of coherence and well-being. The means of both OLQ and SWLS of this sample compare higher to any other samples they were administered to. However, statistically no clear correlation could be determined between service rendered in Special Forces and current levels of well-being. Respondents did however indicate that they feel that their service in Special Forces did have a positive impact on their lives and their current levels of functioning. / Dissertation (MA (Clinical Psychology))--University of Pretoria, 2007. / Psychology / unrestricted

Chronic diseases are usually the result of complex interactions between various lifestyle factors, physiological processes and societal factors. While some of these factors are not modifiable, modification of several of these factors have, to a large extent, demonstrated preventative properties against the development or further development of various chronic diseases. Health-related behaviours are modifiable factors. Behaviour plays an important role in both the development and the management of chronic diseases. One way of investigating this role is to evaluate the impact of health-related behaviours on health. Positive health-related behaviours include eating a healthy diet, regularly engaging in physical exercise, having regular screenings and checkups, not smoking, moderate alcohol use, getting vaccinations and seat belt use. Negative health-related behaviours include eating an unhealthy diet, leading a sedentary life style, not having regular screenings and checkups, smoking, excessive alcohol use and irresponsible driving. Various models of health-related behaviour use social cognitive factors as proximal determinants of health-related behaviours. A social cognitive factor that has received little attention in relation to health-related behaviour, that is sense of coherence (SOC), was used in this study. Although personality factors tend to be only distally associated with health-related behaviour, they do however seem to contribute to a better understanding of these behaviours. Trait emotional intelligence (EI) as a lower order personality trait was used in this study. The purpose of this study was to investigate the nature of the relationships between SOC, trait EI and health-related behaviours. A cross-sectional, correlational research design was used. Participants were selected based on convenient and easy access. Participants completed an online questionnaire that consisted of a health behaviour survey as well as the short form of the Orientation to Life Questionnaire and the Trait Emotional Intelligence Questionnaire. The health behaviour survey assessed some aspects of people's health-related behaviour, including diet, sleep and preventive behaviours, alcohol use, exercise and smoking. Health behaviour correlated significantly with both SOC and Trait EI. SOC and Trait EI were also significantly correlated. When controlling for a third variable, neither SOC nor trait EI correlated significantly with health behaviour. Although none of the predictors made significant contributions to the prediction of health behaviour, the basic regression model reached statistical significance. Trait EI made a significant contribution to the prediction of health behaviour in a more parsimonious regression model, which also reached statistical significance. / Dissertation (MA (Research Psychology))--University of Pretoria, 2008. / Psychology / unrestricted

La diffusion Brillouin est la diffusion inélastique de la lumière par les ondes acoustiques d'un milieu. Dans une fibre optique, la diffusion Brillouin stimulée (DBS) se manifeste, à partir d'une certaine intensité lumineuse incidente (Pompe), par la génération d'une onde Stokes rétrodiffusée dont la fréquence est décalée de celle de la Pompe d'une valeur directement proportionnelle à la vitesse de propagation des ondes acoustiques. Le décalage Brillouin présente une grande sensibilité à tous les effets qui peuvent modifier la vitesse de l'onde acoustique. Cette propriété permet d'étudier la composition des fibres et confère à la DBS la potentialité pour la réalisation de capteurs à fibres optiques. Le processus de DBS s'accompagne aussi d'un gain pour l'onde Stokes rétrodiffusée, puisque presque toute la puissance de l'onde Pompe y est transférée. Il peut donc être utilisé pour la réalisation d'amplificateurs et de lasers à fibres optiques. Dans le cadre de ce travail de thèse, nous avons étudié expérimentalement les propriétés statiques et dynamiques du laser à fibre Brillouin (LFB). Dépendamment du taux d'amortissement de l'onde acoustique et du taux de pertes de la cavité, le LFB peut être très cohérent et très peu bruité, favorisant ainsi son utilisation dans de multiples domaines comme la défense, la métrologie et les télécommunications. Lorsque la Pompe ne fait qu'un tour dans la cavité Brillouin, le LFB étudié présente un bruit de fréquence 10 000 fois plus faible que celui du laser de Pompe tout en gardant un bruit d'intensité similaire. Lorsque la Pompe est résonante, il est possible d'obtenir un LFB à multiples ondes Stokes en cascadant l'effet non-linéaire Brillouin dans la fibre optique. Limités par nos bancs de mesures, nous avons mesuré un bruit de fréquence 1 000 fois plus faible que celui de la Pompe et un bruit d'intensité plus de 100 fois plus faible. / Brillouin scattering is the inelastic scattering of light by the acoustic waves of a medium. In an optical fiber, stimulated Brillouin scattering occurs, from a certain incident light intensity (pump), for generating a backscattered "Stokes" wave, whose frequency is shifted from that of the pump by a value directly proportional to the acoustic wave propagation velocity in the fiber. The Brillouin shift has a high sensitivity to all effects that can change the speed of the acoustic wave. This property makes it possible to study the composition of the fibers and gives to the SBS the potential for the production of optical fiber sensors. The SBS process is also accompanied by a gain for the backscattered Stokes wave since almost all the power of the Pump wave is transferred there. It can, therefore, be used for the production of optical fiber amplifiers and lasers. As part of this thesis work, we experimentally studied static and dynamic properties of the Brillouin fiber lasers (BFLs). Depending on the damping rate of the acoustic wave and the loss rate of the cavity, the BFL can be very coherent and less noisy, thus promoting its use in multiple fields such as defense, metrology, and telecommunications. When the Pump makes only one turn in the Brillouin cavity, the studied BFL has a frequency noise 10,000 times lower than that of the Pump laser while keeping a similar intensity noise. When the Pump is resonant, it is possible to obtain a BFL with multiple Stokes waves by cascading the Brillouin non-linear effect in the optical fiber. Restricted by our measurement benches, we measured a frequency noise 1000 times lower than that of the Pump and an intensity noise more than 100 times lower.

Aim: The overall aim of this thesis was to gain a deeper understanding of older people's view of health and care while dependent on community care. Furthermore to describe and compare formal caregivers' perceptions of quality of care, working conditions, competence, general health, and factors associated with quality of care from the caregivers' perspective. Method: Qualitative interviews were conducted with 19 older people in community care who were asked to describe what health and ill health((I), good and bad care meant for them (II). Data were analyzed using content analysis (I) and a phenomenological analysis (II). The formal caregivers; 70 nursing assistants (NAs) 163 enrolled nurses (ENs) and 198 registered nurses (RNs), answered a questionnaire consisting of five instruments: quality of care from the patient's perspective modified to formal caregivers, creative climate questionnaire, stress of conscience, health index, sense of coherence and items on education and competence (III). Statistical analyses were performed containing descriptive statistics, and comparisons between the occupational groups were made using Kruskal-Wallis ANOVA, Mann-Whitney U-test and Pearson's Chi-square test (III). Pearson's  product moment correlation analysis and multiple regression analysis were performed studying the associations between organizational climate, stress of conscience, competence, general health and sense of coherence with quality of care (IV). Results: The older people's health and well-being were related to their own ability to adapt to and compensate for their disabilities and was described as negative and positive poles of autonomy vs. dependence, togetherness vs. being an onlooker, security vs. insecurity and tranquility vs. disturbance (I).  The meaning of good care (II) was that the formal caregivers respected the older people as unique individuals, having the opportunity to live their lives as usual and receiving a safe and secure care. Good care could be experienced when the formal caregivers had adequate knowledge and competence in caring for older people, adequate time and continuity in the care organization (II). Formal caregivers reported higher perceived quality of care in the dimensions medical-technical competence and physical-technical conditions than in identity-oriented approach and socio-cultural atmosphere (III). In the organizational climate three of the dimensions were close to the value of a creative climate and in seven near a stagnant climate. The formal caregivers reported low rate of stress of conscience. The RNs reported to a higher degree than the NAs/ENs a need to gain more knowledge, but the NAs and the ENs more often received training during working hours. The RNs reported lower emotional well-being than the NAs/ENs (III). The formal caregivers' occupation, organizational climate and stress of conscience were associated with perceived quality of care (IV). Implications: The formal caregivers should have an awareness of the importance of kindness and respect, supporting the older people to retain control over their lives. The nursing managers should employ highly competent and adequate numbers of skilled formal caregivers, organize formal caregivers having round the clock continuity. Improvements of organizational climate and stress of conscience are of importance for good quality of care.

The work presented in the thesis focuses on systematically documenting the multi scale nature of the temporal persistence and spatial coherence of tropical rainfall. There are three parts to the thesis: The first two parts utilize satellite-retrieved rainfall at multiple observational resolutions to characterize the space-time organization of rain; the third part assesses the ability of state-of-the-art coupled models to reproduce some of the observed features. In the first part of the study, which focuses on the temporal persistence of rain, we analyze the Tropical Rainfall Measurement Mission (TRMM) satellite-based observations to compare and contrast wet and dry spell characteristics over the tropics (30 S-30 N). Defining a wet (dry) spell as the number of consecutive rainy (nonrainy) days, we find that the distributions of wet spells (independent of spatial resolution) exhibit universality in the following sense. While both ocean and land regions with high seasonal rainfall accumulation (humid regions) show a predominance of 2-4 day wet spells, those regions with low seasonal rainfall accumulation (arid regions) exhibit a wet spell duration distribution that is essentially exponential in nature, with a peak at 1 day. The behaviour that we observed for wet spells is reversed for dry spell distributions. The total rainfall accumulated in each wet spell has also been analyzed, and we find that the major contribution to seasonal rainfall for arid regions comes from very short length wet spells; however, for humid regions, this contribution comes from wet spells of duration as long as 30 days. An exhaustive sensitivity study of factors that can potentially affect the wet and dry spell characteristics (e.g., resolution) shows that our findings are robust. We also explore the role of chance in determining the 2-4 day mode, as well as the inuence of organized convection in separating reality from chance. The second part deals with the spatial coherence of tropical rain. We take two different approaches, namely, a global and local view. The global view attempts to quantify the con-ventional view of rain, i.e., the dominance of the intertropical convergence zone (ITCZ), while the local view tries to answer the question: if it rains, how far is the influence felt in zonal and meridional directions? In both approaches, the classical e-folding length for spatial decorrelation is used as a measure of spatial coherence. The major finding in the global view approach is that, at short timescales of accumulation (daily to pentad to even monthly), rain over the Equator shows the most dominant zonal scale. It is only at larger timescales of accumulation (seasonal or annual) that the dominance of ITCZ around 7 N is evident. In addition, we also find a semi-log linearity between the spatial scales, seen from afar, and timescale of accumulation, with a break in linearity around typical synoptic timescales of 5-10 days. The local view quantifies the dominance of the zonal scale in the tropical ocean convergence zones, with an anisotropy value (ratio of zonal to meridional scales) of 3-4. Over land, on the other hand, the zonal and meridional scales are comparable in magnitude, suggesting that rain tends to be mostly isotropic over continental regions. This latter finding holds true, irrespective of the spatial and temporal resolutions at which rain is observed. Interestingly, the anisotropy over ocean, while invariant with spatial resolution, is found to be a function of temporal resolution: from a value of 3-4 at daily timescale, it decreases to around 1.5 at 3-hourly resolution, suggesting that perhaps rain fundamentally might be isotropic in nature at an event scale. The final part analyses a few models from the suite of Coupled Model Intercomparison Project (CMIP5) models, to evaluate their ability to reproduce some of these aforementioned features. For all the strong biases that models are known to have, some of the observed features are captured well by the models. Specifically, on the temporal persistence front, the observed 2-4 day mode of wet (dry) spells of rain over humid (arid) regions is also seen in models. The overestimation of longer duration wet spells appears to be the primary cause of a positive bias in the number of rainy days from the models. In general, the tendency of models to not stop raining results in lower and higher number of shorter and longer duration wet spells, respectively, and consequently an overall reduction in dry spells of all durations. On the spatial coherence front, the main finding from the global view approach is that the observed semi-log linearity of the zonal spatial scale of rainfall as a function of timescale of accumulation is strikingly well-reproduced by the models. Even more remarkable is that the models are able to mimic the break in this linearity around 5 days (typical synoptic scale). What the models fail to do prominently is the transition of the dominance of equatorial rain at smaller timescales of accumulation to the dominance of ITCZ at around 7 N at higher timescales of accumulation. Based on the local view approach, we find that, in general, even though the zonal and meridional scales are overestimated, the observed isotropy of continental rain is captured very well by the models. Over the oceans, the success is less prominent, especially with the core of the ITCZ showing much larger ratios than those observed. Thus, the models seem to be able to reproduce the anisotropy for the wrong reasons, and the proposed anisotropy ratio could be a useful metric in further diagnosis of climate models.

Ce travail présente une méthodologie efficace pour mesurer le champ de déformation total en 3-D des tissus mous semi-transparents et diffusant la lumière, tels que la cornée de l'œil vertébré. Cela a été obtenu en utilisant la tomographie par cohérence optique couplée avec la corrélation volumique numérique sur des fantômes en caoutchouc de silicone et de la cornée porcine. Des tests de traction et des tests d'inflation postérieure ont été étudiés. Avant ces tests, l'effet du bruit et la décorrélation des speckles due à la déformation sont d'abord étudiés en utilisant des méthodes expérimentales et numériques. Le biais d'interpolation dans les résultats de déformation a été analysé. Deux approches efficaces ont été prises pour réduire le biais d'interpolation. Pour extraire les paramètres constitutifs des mesures de déformation 3-D, la méthode des champs virtuels a été étendue en 3-D. Les champs virtuels définis manuellement et les champs virtuels optimisés par morceaux ont été développés et comparés entre eux. Des efforts ont également été déployés pour corriger les distorsions induites par réfraction dans les reconstructions de la tomographie par cohérence optique. Des tests d'inclinaison des différents fantômes de silicone ont été introduits afin d’évaluer la performance de la méthode pour corriger les reconstructions distordues / This work presents an effective methodology for measuring the depth-resolved 3-D full-field deformation of semitransparent, light scattering soft tissues such as vertebrate eye cornea. This was obtained by performing digital volume correlation on optical coherence tomography volume reconstructions of silicone rubber phantoms and porcine cornea samples. Both the strip tensile tests and the posterior inflation tests have been studied. Prior to these tests, noise effect and strain induced speckle decorrelation were first studied using experimental and simulation methods. The interpolation bias in the strain results has also been analyzed. Two effective approaches have been introduced to reduce the interpolation bias. To extract material constitutive parameters from the 3-D full-field deformation measurements, the virtual fields method has been extended into 3-D. Both manually defined virtual fields and the optimized piecewise virtual fields have been developed and compared with each other. Efforts have also been made in developing a method to correct the refraction induced distortions in the optical coherence tomography reconstructions. Tilt tests of different silicone rubber phantoms have been implemented to evaluate the performance of the refraction correction method in correcting the distorted reconstructions

La plus grande partie de l’Afrique orientale présente un climat aride à semi-aride, et une forte variabilité spatio-temporelle des pluies. Les sécheresses sont courantes dans cette région, et persistent souvent sur plusieurs années consécutives, précédées ou suivies par des inondations majeures. La plupart des modes de vie et des activités socio-économiques restent néanmoins dépendants des précipitations, avec des effets extrêmement dommageables en périodes d’extrêmes climatiques. Il a été montré qu’un seul événement extrême suffisait à inverser la croissance économique nationale plusieurs années d’affilée. Aucun développement durable ne peut donc être réalisé en Afrique de l’Est sans une prise en compte effective de l’information climatique dans les politiques, les plans et les programmes de développement. De nombreuses études antérieures sur la région ont été consacrées à la variabilité des pluies aux échelles saisonnière, annuelle et décadaire. Peu de recherches ont porté sur l’échelle intra-saisonnière, qui est déterminante pour la plupart des applications agricoles. Cette étude vise à combler cette lacune, en examinant la structure de la saison des pluies en termes de répartition des épisodes secs et pluvieux, et la façon dont cette répartition varie dans l’espace et le temps, à l’échelle interannuelle à travers l’Afrique est-équatoriale. Des modèles de prévision destinés à être utilisés dans des systèmes d’alerte précoce, en vue d’atténuer les risques liés au climat, sont en outre développés. Les objectifs spécifiques de l’étude incluent : un diagnostic des différents aspects de la répartition des épisodes secs et pluvieux, dans leur variation interannuelle ; une analyse des relations entre les aspects de cette répartition ainsi identifiés et les principaux champs climatiques d’échelle large qui gouvernent le climat global ; une évaluation de la prévisibilité des différents aspects des épisodes secs et pluvieux pour l’amélioration des systèmes d’alerte précoce de la région.Plusieurs bases de données couvrant une période de 40 ans (1961-2000) ont été utilisées. Elles comprennent des séries de précipitations journalières mesurées par pluviomètre dans les trois pays d’Afrique orientale (Kenya, Ouganda, Tanzanie) ; les températures de surface marine (SST) du Hadley Centre ; des données de réanalyses et des stations de radiosondages de Nairobi (Kenya) et de Bangui (République Centrafricaine). Des indices d’El Niño-Oscillation Australe (ENSO), du Dipôle de l’Océan Indien et de gradients de SST, constituant des prédicteurs SST prédéfinis, ont été également utilisés [...] / Most of Eastern Africa has arid and semi-arid climate with high space-time variability in rainfall. The droughts are very common in this region, and often persist for several years, preceded or followed by extreme floods. Most of the livelihoods and socio-economic activities however remain rain-dependent leading to severe negative impacts during the periods of occurrence of climate extremes. It has been noted that one extreme event was capable of reversing national economic growth made over a period of several years. Thus no sustainable development can be attained in eastern Africa without effective mainstreaming of climate information in the development policies, plans and programmes. Many past studies in the region have focused on rainfall variability at seasonal, annual and decadal scales. Very little work has been done at intraseasonal timescale that is paramount to most agricultural applications. This study aims at filling this research gap, by investigating the structure of rainfall season in terms of the distribution of wet and dry spells and how this distribution varies in space and time at interannual time scale over Equatorial Eastern Africa. Prediction models for use in the early warning systems aimed at climate risk reduction were finally developed. The specific objectives of the study include, delineate and diagnose the some aspects of the distribution of the wet and dry spells at interannual timescale; investigate the linkages between the aspects of the distribution of wet and dry spells identified and dominant large scale climate fields that drive the global climate; and assess the predictability of the various aspects of wet and dry spells for the improvement of the use in the early warning systems of the region.Several datasets spanning a period of 40 years (1961 – 2000) were used. The data included gauged daily rainfall amount for the three Eastern Africa countries namely Kenya, Uganda, and Tanzania; Hadley Centre Sea Surface Temperature (SST); re-analysis data and radiosonde observations from Nairobi (Kenya) and Bangui (Central Africa Republic) upper air stations. The indices of El Niño-Southern Oscillation (ENSO), Indian Ocean Dipole and SST gradients which constituted the predefined predictors were also used [...]

Syfte: Pröva en integrerad metod av den transteoretiska modellen och begreppet känsla av sammanhang hos ungdomar gällande munhygienbeteende och upplevelse av intervention och reflektioner kring oral hälsa. Metod: Studien utfördes med en mixad metod. Urvalet bestod av 20 ungdomar där 11 valde att delta. Deltagarna randomiserades till två grupper där experimentgrupp vid base-line fick ta del av den beteendevetenskapliga interventionen och kontrollgrupp av en mer traditionell tandvårdsbehandling. Plack och gingivit mättes vid base-line och efter en månad. Experimentgrupp intervjuades vid uppföljning om upplevelse av att ha fått ta del av intervention och inställningar till oral hälsa. Statistiska analyser av kvantitativa data gjordes för att räkna ut skillnader inom respektive grupper samt mellan dem gällande plack och gingivit. Dataanalysen utfördes med deskriptiv statistik och icke-parametriska test. En kvalitativ innehållsanalys gjordes av intervjuerna och sedan jämfördes kvantitativa och kvalitativa resultat och presenterades i en metaslutsats. Resultat: Mellan base-line och en-månads uppföljning minskade plack och gingivit signifikant hos experimentgruppen. I jämförelse mellan grupperna minskade plack och gingivit mer hos experimentgrupp än kontrollgrupp. Frågeställningen kring deltagarnas upplevelse av interventionen resulterade i huvudkategorierna ”positivt bemötande” och ”begriplig och motiverande kunskap”, med fyra underkategorier. Frågeställningen om reflektioner kring oral hälsa resulterade i ”oral hälsa ur en social kontext” och ”munnens betydelse för att fungera och se bra ut” också med fyra underkategorier. Slutsats: Den integrerade beteendevetenskapliga interventionen gav ett bättre resultat på munhygienbeteende hos deltagarna än den mer traditionella tandvårdsbehandlingen. Upplevelsen av att ha tagit del av interventionen var positiv vilket stärker interventionens användbarhet. Mer forskning behövs för att utreda nyttan och användbarheten av interventionen inom tandvården.

L’OCT plein champ est une technique d’imagerie permettant de faire de la microscopie des milieux diffusants à une profondeur donné à l’aide d’un système interférométrique. L’un des principaux objectifs qui ont motivé le développement de l’OCT plein champ ces dernières années a été de pouvoir fournir au chirurgien, durant les opérations des images similaires aux coupes histologiques mais en temps réel. Actuellement, les diagnostiques effectué à partir des images d’OCT plein champs donne de bon résultats, notamment dans le cas de certaine pathologie mammaire. Cependant, la différence majeure entre les coupes histologiques et les images d’OCT plein champs est qu’en OCT plein champ le contraste est uniquement un contraste morphologique et que dans certain cas, ce contraste seul ne suffit pas pour faire le diagnostic. Au cours des travaux de recherche décrits dans cette thèse nous nous sommes attachés à développer de nouvelles approches tomographiques, conduisant à de nouvelles formes de contraste susceptible d’enrichir les images d’OCT plein champ pour une meilleure qualité du diagnostic. Plus précisément, nous avons travaillé sur la détection optique et photo-thermique de nanoparticules d’or par OCT plein champ et la cartographie des propriétés mécaniques par trois méthodes dans le but de développer de nouveaux types de contrastes qui pourront permettre d’améliorer le diagnostic. / Full Field OCT (FF-OCT) is an imaging technic use to do microscopy inside scattering media at a given depth using an interferometric setup. One of the main objectives that motivated the development of FF-OCT was to provide during surgery to the surgeon images similar to histological slices but in real time. Currently, diagnostic made from FF-OCT images gives good results, especially in the case of some breast disease. However, the major difference between the histological and FF-OCT is that FF-OCT has only a morphological contrast and in some cases, this contrast is not enough to make the diagnosis. In the research described in this thesis we are committed to developing new tomographic approaches, leading to new forms of contrast may enhance images of FF- OCT for a better quality of diagnosis. Specifically, we worked on the optical and photothermal detection of gold nanoparticles by FF-OCT and the mechanical properties mapping by three methods in order to develop new types of contrasts that will help improve the diagnosis.