Resumo: O tratamento de não união e união retardada é um desafio constante na rotina do ortopedista veterinário. A dificuldade de se conseguir repouso adequado dos pacientes submetidos à osteossíntese, frequentemente, resulta em consolidações mal sucedidas. Com o objetivo de se avaliar o comportamento do cimento de aluminato de cálcio, foram induzidos defeitos ósseos de 3,57mm de diâmetro nos fêmures de 12 coelhos, sendo os do lado direito preenchidos com o referido biomaterial e os do esquerdo permaneceram vazios. Aos 15, 30 e 60 dias de pós-operatório, realizaram-se avaliações clínico-cirúrgicas, radiográficas e histológicas, a fim de se observar o potencial osteoindutor e osteocondutor do biomaterial no defeito ósseo, e se houve osteointegração. Os resultados evidenciaram que o cimento aluminoso, nesta formulação, não possui esses potenciais e nem poder de osteointegração, possivelmente por possuir porosidade reduzida / Abstract: The treatment of non union and delayed union is a constant challenge for veterinary orthopedists. The difficulty in achieving adequate rest for patients which have undergone osteosynthesis results in unsuccessful bone consolidations. With the aim of evaluating the behavior of a calcium aluminate cement, bone defects of 3,57 mm of diameter were induced in femurs of 12 rabbits. The defects on the right side were filled with the biomaterial and the ones on the left side remained unfilled. The evaluation periods occurred at 15, 30 and 60 days after surgery. Clinical, surgical, radiographic and histological evaluations were performed in order to observe the osteoinductive and osteocondoctive potential of the biomaterial on the bone defects, as well to verify if there was osteointegration. The results showed that the aluminate cement does not have these potencial and nor cause osteointegration in the formulation used in this study / Orientador: Cíntia Lucia Maniscalco / Coorientadora: Paola Castro Moraes / Banca: Julio Carlos Canola / Banca: Gustavo Garkalns de Souza Oliveira / Mestre

Resumo: Objetivou-se avaliar, por meio de exames radiográficos e histológicos, a função da resina de poliuretana derivada do óleo de mamona (Ricinus communis), na forma de grânulos, no tratamento de defeito ósseo segmentar induzido no rádio de coelhos, tendo como padrão comparativo o enxerto ósseo esponjoso autólogo. Foram utilizados 20 coelhos da raça Norfolk, fêmeas, com idade entre 12 e 14 meses e peso entre 4 e 5kg. Uma falha óssea segmentar de 1,0 cm de comprimento foi induzida na diáfise de ambos os rádios pela excisão de fragmento osteoperiosteal. No rádio esquerdo o defeito foi tratado com a resina de poliuretana e no direito com auto-enxerto esponjoso colhido do úmero proximal esquerdo. Para realização dos exames histológicos foram eutanaziados cinco animais aos 15 dias, 30 dias, 60 dias e 120 dias de pós-operatório. A regeneração óssea foi maior no defeito tratado com auto-enxerto esponjoso em todos os períodos de observação, sendo que, aos 120 dias de pós-operatório, estes estavam totalmente reconstituídos. Pela avaliação histológica o polímero de mamona atuou como preenchedor de espaço, minimizando a produção de tecido fibroso no local, além de não apresentar sinais de reabsorção em nenhum dos momentos de avaliação. Foi possível concluir que o polímero de mamona na forma de grânulos é biocompatível e osteointegrável, porém não apresenta a mesma capacidade de regeneração óssea do auto-enxerto esponjoso. / Abstract: The aim of the present study was to compare, by radiographic and histological analyses, the castor oil plant polyurethane in granules presentation, applied to a segmental bone defect, created in both radial diaphyses, to the cancellous bone autograft, in order to evaluate an alternative to bone defect healing. Norfolk adult female rabbits, with approximately 13 months of age and a mean body weight of 4.5kg were used. Thus, a one-cm segmental defect was created in both radial diaphyses. The defect in the left radius was filled with the castor oil plant polyurethane, and the right one, filled with cancellous bone autograft, collected from the left proximal humerus. The rabbits were euthanased at 15, 30, 60 and 120 days post-surgery (5 animals/period), in order to proceed the histological analysis. New bone formation was increased and accelerated in the defect treated with cancellous bone autograft along all periods of observation. In the last moment (120 days), the defects were totally reconstituted and remodeled. The polyurethane acted as a space filler, minimizing the local production of fibrous tissue. No granules degradation or reabsorb were detected, as well as any inflammatory reaction. Thus, it was possible to conclude that the castor oil plant polyurethane, in granules presentation, was biocompatible and osteointegrated, but did not show the same bone regeneration capacity of the cancellous bone autograft. / Orientador: Paulo Iamaguti / Coorientador: Sheila Canavese Rahal / Mestre

Esta dissertação apresenta a modelagem e o monitoramento de características de qualidade do tipo taxa, que apresentam valores restritos ao intervalo [0,∞). A motivação inicial é que a característica de qualidade do tipo taxa pode ser modelada pela distribuição Poisson e, geralmente, a modelagem e o monitoramento não utilizam tal distribuição. Os objetivos desta dissertação são: (i) Propor uma nova carta de controle (CC), Carta Poisson, para monitorar características de qualidade do tipo taxa, com adaptação no cálculo dos limites de controle utilizando a distribuição Poisson; (ii) Propor uma CC baseada em modelo de regressão utilizando a distribuição de Poisson para monitorar características de qualidade do tipo taxa em função das variáveis de controle do processo e (iii) Propor índices de capacidade MRPOISSON Cp e MRPOISSON Cpk para avaliar processos monitorados por CCs baseadas em modelos de regressão utilizando a distribuição de Poisson. As cartas de controle e os índices de capacidade propostos foram avaliados aplicando exemplos retirados da literatura. As cartas de controle foram comparadas através do número médio de amostras (NMA) via simulação de Monte Carlo. Concluiu-se que as cartas de controle propostas são adequadas para a modelagem e o monitoramento de características de qualidade do tipo taxa pois detectaram mais rapidamente todas as alterações induzidas, apresentando melhor desempenho em comparação com outras cartas similares encontradas na literatura. / This paper presents the modeling and monitoring of quality features like rate, which have values restricted to the interval [0, ∞). The initial motivation is that the quality characteristic of the type rate can be modeled by the Poisson distribution, and generally, modeling and monitoring do not use such a distribution. The objectives of this dissertation are: (i) to propose a new control chart (CC), Poisson Charter, to monitor quality characteristics of the type rate, adapted to calculate the control limits using a Poisson distribution, (ii) propose a CC based on regression model using the Poisson distribution to monitor quality characteristics like rate as a function of the control variables of the process and (iii) Propose capability indices MRPOISSON Cp and MRPOISSON Cpk to evaluate processes and monitored by CCs based on regression models using the distribution of Poisson. The control charts and capability indices were estimated by applying the proposed examples from the literature. The control charts were compared using the average number of samples (NMA) via Monte Carlo simulation. It was concluded that the proposed control charts are suitable for modeling and monitoring of quality characteristics of the type detected faster rate because all the changes induced, showing better performance in comparison with other similar letters found in the literature.

Esta dissertação apresenta a modelagem e o monitoramento de características de qualidade do tipo taxa, que apresentam valores restritos ao intervalo [0,∞). A motivação inicial é que a característica de qualidade do tipo taxa pode ser modelada pela distribuição Poisson e, geralmente, a modelagem e o monitoramento não utilizam tal distribuição. Os objetivos desta dissertação são: (i) Propor uma nova carta de controle (CC), Carta Poisson, para monitorar características de qualidade do tipo taxa, com adaptação no cálculo dos limites de controle utilizando a distribuição Poisson; (ii) Propor uma CC baseada em modelo de regressão utilizando a distribuição de Poisson para monitorar características de qualidade do tipo taxa em função das variáveis de controle do processo e (iii) Propor índices de capacidade MRPOISSON Cp e MRPOISSON Cpk para avaliar processos monitorados por CCs baseadas em modelos de regressão utilizando a distribuição de Poisson. As cartas de controle e os índices de capacidade propostos foram avaliados aplicando exemplos retirados da literatura. As cartas de controle foram comparadas através do número médio de amostras (NMA) via simulação de Monte Carlo. Concluiu-se que as cartas de controle propostas são adequadas para a modelagem e o monitoramento de características de qualidade do tipo taxa pois detectaram mais rapidamente todas as alterações induzidas, apresentando melhor desempenho em comparação com outras cartas similares encontradas na literatura. / This paper presents the modeling and monitoring of quality features like rate, which have values restricted to the interval [0, ∞). The initial motivation is that the quality characteristic of the type rate can be modeled by the Poisson distribution, and generally, modeling and monitoring do not use such a distribution. The objectives of this dissertation are: (i) to propose a new control chart (CC), Poisson Charter, to monitor quality characteristics of the type rate, adapted to calculate the control limits using a Poisson distribution, (ii) propose a CC based on regression model using the Poisson distribution to monitor quality characteristics like rate as a function of the control variables of the process and (iii) Propose capability indices MRPOISSON Cp and MRPOISSON Cpk to evaluate processes and monitored by CCs based on regression models using the distribution of Poisson. The control charts and capability indices were estimated by applying the proposed examples from the literature. The control charts were compared using the average number of samples (NMA) via Monte Carlo simulation. It was concluded that the proposed control charts are suitable for modeling and monitoring of quality characteristics of the type detected faster rate because all the changes induced, showing better performance in comparison with other similar letters found in the literature.

Os estudos na área de engenharia de tecidos aplicada à reparação da cartilagem articular estão voltados ao desenvolvimento de uma matriz biocompatível que permita a diferenciação, proliferação e manutenção de células para produção de cartilagem hialina. A quitosana é um biomaterial e vem sendo estudada como suporte para condrócitos e para liberação controlada de substâncias. O objetivo deste trabalho foi estudar a biocompatibilidade do gel de quitosana associada ao fosfato de glicerol para reparação de defeitos osteocondrais induzidos experimentalmente na tróclea do talus de eqüinos. Foram utilizados cinco cavalos da raça Mangalarga, de três anos de idade, e por artroscopia foi criado um defeito osteocondral na tróclea lateral do talus de cada articulação. De forma aleatória um defeito foi escolhido para implante do gel de quitosana - fosfato de glicerol, e o defeito da articulação contralateral foi mantido vazio, servindo como controle. Para acompanhamento da evolução do processo de reparação da cartilagem articular foram realizados os exames físico, radiográfico e ultrassonográfico; análise do líquido sinovial (física, celularidade, quantificação de proteína, condroitim sulfato e ácido hialurônico); e análise da cartilagem articular (histológica e produção de proteoglicanos). Os resultados obtidos de todas as avaliações realizadas foram semelhantes entre os defeitos tratados e controle. O gel de quitosana fosfato de glicerol é biocompatível com o ambiente articular e pode ser indicado para futuras aplicações como suporte de células e para liberação controlada de medicamentos. / The tissue engineering studies applied to articular cartilage repair are focused on the development of scaffold biocompatibility allowing the differentiation, proliferation and cells maintenance providing production of the hyaline cartilage. Chitosan is a biomaterial that has been evaluated as a scaffold for chondrocyts implant and also as a drug-delivery control material. The aim of this work was to evaluate the chitosan glycerol phosphate gel biocompatibility in experimentally induced equine talus osteochondral defect. Five three years old Mangalarga breed horses were submitted to arthroscopy for osteochondral defect production on the lateral troclea of the talus in both tibiotarsal joints by arthroscopy. In a random form one defect was chosen for chitosan-glycerol phosphate gel implant, and the defect of the opposed joint was kept empty and used as a control. For the assessment of the articular cartilage repair process was performed the physic, radiographic and ultrassonographic exams; the synovial fluid analyze (physic, cellularity, protein quantification, chondroitin sulphate and hialuronan); and the articular cartilage analyze (hystologic and proteoglicans production). The results obtained in all evaluations performed were similar between the treated and control defects. The chitosan glycerol phosphate gel is biocompatible with the articular environment and can be indicate for future applications as an scaffold for cells support and drug-delivery control system.

This thesis describes work on the theoretical modelling and experimental measurement of the complex permittivity of dielectrics. The main focus of research has been into the characterisation of permittivity of planar and layered samples within the millimetre wave band. The measurement method is based on the free-space measurement of the transmission and reflection coefficients of samples. A novel analytical method of determining the transmission and reflection coefficients as functions of frequency arising from a generalised structure of planar dielectric layers is also described and validated. The analytical method is based on signal flow techniques. The measurement and analytical techniques have been applied in two main areas: firstly, the acquisition of new data on human skin in the band 57 to 100GHz and secondly, the detection and location of defects in composite materials for which a band of 90 to 100GHz was used. Measurements have been made on the complex permittivity of a single sample of excised human skin fixed in formaldehyde. The experimental results have been corrected to account for the fixing process in formaldehyde and are projected to body temperature. This data is, to the best of the author’s knowledge, the first of its kind to be published. Predicted skin permittivity based on various relaxation models varies widely and only partially fits the measured data. The experimental results have been used to determine the parameters of a Cole-Cole function which gives the best fit to the measured data. The measured skin data has also been used to calculate power deposition in skin exposed to millimetre wave radiation. This work concludes that a skin surface temperature rise of only 0.20C results from a thirty second exposure to signals of 100W/m2. Experimental work with fibreglass composite samples has shown that defects such as delaminations, voids, matrix cracks and improper cure result in resolvable differences in the dielectric properties of the samples at 90 – 100GHz. The measurement technique is particularly sensitive to the detection of cracks and its spatial resolution is 20mm or better. Whilst confirming the general conclusions of previously published work, the specific findings of this study are novel.

Software security has always been an afterthought in software development which results into insecure software. Companies rely on penetration testing for detecting security vulnerabilities in their software. However, incorporating security at early stage of development reduces cost and overhead. Static code analysis can be applied at implementation phase of software development life cycle. Applying machine learning and visualization for static code analysis is a novel idea. Technique can learn patterns by normalized compression distance NCD and classify source code into correct or faulty usage on the basis of training instances. Visualization also helps to classify code fragments according to their associated colors. A prototype was developed to implement this technique called Code Distance Visualizer CDV. In order test the efficiency of this technique empirical validation is required. In this research we conduct series of experiments to test its efficiency. We use real life open source software as our test subjects. We also collected bugs from their corresponding bug reporting repositories as well as faulty and correct version of source code. We train CDV by marking correct and faulty version of code fragments. On the basis of these trainings CDV classifies other code fragments as correct or faulty. We measured its fault detection ratio, false negative and false positive ratio. The outcome shows that this technique is efficient in defect detection and has low number of false alarms. / Software trygghet har alltid varit en i efterhand inom mjukvaruutveckling som leder till osäker mjukvara. Företagen är beroende av penetrationstester för att upptäcka säkerhetsproblem i deras programvara. Att införliva säkerheten vid tidigt utvecklingsskede minskar kostnaderna och overhead. Statisk kod analys kan tillämpas vid genomförandet av mjukvaruutveckling livscykel. Tillämpa maskininlärning och visualisering för statisk kod är en ny idé. Teknik kan lära mönster av normaliserade kompressionständning avstånd NCD och klassificera källkoden till rätta eller felaktig användning på grundval av utbildning fall. Visualisering bidrar också till att klassificera code fragment utifrån deras associerade färger. En prototyp har utvecklats för att genomföra denna teknik som kallas Code Avstånd VISUALISERARE CDV. För att testa effektiviteten hos denna teknik empirisk validering krävs. I denna forskning vi bedriver serie experiment för att testa dess effektivitet. Vi använder verkliga livet öppen källkod som vår test ämnen. Vi har också samlats in fel från deras motsvarande felrapportering förråd samt fel och rätt version av källkoden. Vi utbildar CDV genom att markera rätt och fel version av koden fragment. På grundval av dessa träningar CDV klassificerar andra nummer fragment som korrekta eller felaktiga. Vi mätt sina fel upptäckt förhållandet falska negativa och falska positiva förhållandet. Resultatet visar att den här tekniken är effektiv i fel upptäckt och har låga antalet falsklarm. / waqasmah@gmail.com +46762316108

Context: Defects occurred in the SRS may cause problems in project due to implementation of poor requirements which require extra time, effort, resources and budget to complete it. Reading techniques i.e., checklist based reading (CBR) helps to guide reviewers in identifying defects in software requirement specification (SRS) during individual requirement inspections. Checklists contain potential defects/problems to look for, but often lack clear definitions with examples of the problem, and also their abstractions are different. Therefore, there is a need for identifying existing defects and classifiers and to create a consolidated version of taxonomy. Objectives: We developed taxonomy for requirement defects that are in requirement specifications and compared it with the checklist based approach. The main objective was to investigate and compare the effectiveness and efficiency of inspection techniques (checklist and taxonomy) with M.Sc. software engineering students and industry practitioners by performing a both controlled student and industry experiment. Methods: Literature review, controlled student experiment and controlled industry experiment were the research methods utilized to fulfill the objectives of this study. INSPEC and Google scholar database was used to find the articles from the literature. Controlled student experiment was conducted with the M.Sc. software engineering students and controlled industry experiment was performed with the industry practitioners to evaluate the effectiveness and efficiency of the two treatments that are checklist and taxonomy. Results: An extensive literature review helped us to identify several types of defects with their definitions and examples. In this study, we studied various defect classifiers, checklists, requirement defects and inspection techniques and then built taxonomy for requirement defects. We evaluated whether the taxonomy performed better with respect to checklist using controlled experiments with students and practitioners. Moreover, the results of student experiment (p= 0.90 for effectiveness and p=0.10 for efficiency) and practitioner experiment (p=1.0 for effectiveness and p=0.70 for efficiency) did not show significant values with respect to effectiveness and efficiency. But because of less number of practitioners it is not possible to apply a statistical test since we also have used standard formulas to calculate effectiveness and efficiency. 2 out of the 3 reviewers using taxonomy found more defect types compared to 3 reviewers using checklist. 10-15% more defects have been found by reviewers using taxonomy. 2 out of the 3 reviewers using taxonomy are more productive (measuring in hours) compared to reviewers of checklist. Although the results are quite better than the student experiment but it is hard to claim that reviewers using taxonomy are more effective and efficient than the reviewers using checklist because of less subjects in number. The results of the post experiment questionnaire revealed that the taxonomy is easy to use and easy to understand but hard to remember while inspecting SRS than the checklist technique. Conclusions: Previously researchers created taxonomies for their own purpose or on industry demand. These taxonomies lack clear and understandable definitions. To overcome this problem, we built taxonomy with requirement defects which consists of definitions and examples. No claims are made based on student experiment because of insignificant values with respect to effectiveness and efficiency. Although the controlled industry experiment results showed that taxonomy performed slightly better than the checklist in efficiency i.e., in defect detection rate and effectiveness i.e., number of defect found. From this we can conclude that taxonomy helps guiding the reviewers to indentify defects from SRS but not quite much so it is recommended to perform a further study with practitioners in a large scale for effective results. / skarimuddin@yahoo.com, hassanshah357@gmail.com

Context: Software testing is an integral part of software development life cycle. To improve the quality of software there are different testing approaches practiced over the years. Traditionally software testing is carried out by following approach focusing on prior test design. While exploratory testing is an approach to test software where the tester does not require to follow a specific test design. But rather, exploratory testing should facilitate the tester in testing the complete system comprehensively. Exploratory testing is seen by some, as a way to conduct simultaneous learning, test design and execution of tests simultaneously. While others point to exploratory testing enabling constant evolution of tests in an easy manner. Objectives: In this study we have investigated the field of exploratory testing in literature and industry to understand its perception and application. Further among the stated claims by practitioners, we selected defect detection efficiency and effectiveness claim for empirical validation through an experiment and survey. Methods: In this study, a systematic literature review, interview, experiment and survey are conducted. In the systematic review a number of article sources are used, including IEEE Xplore, ACM Digital Library, Engineering village, Springer Link, Google Scholar and Books database. The systematic review also includes the gray literature published by the practitioners. The selection of studies was done using two-phase and tollgate approach. A total of 47 references were selected as primary studies. Eight semi-structures interviews were conducted with industry practitioners. Experiment had total 4 iterations and 70 subjects. The subjects were selected from industry and academia. The experimental design used was one factor with two interventions and one response variable. Results: Based on our findings from literature review and interviews, the understanding of exploratory testing has improved over the period but still lacks empirical investigation. The results drawn from experimental and survey data shows that exploratory testing proved effective and efficient in finding more critical bugs in limited time. Conclusions: We conclude that exploratory testing has a lot of potential and much more to offer to testing industry. But more empirical investigation and true facts and figures are required to motivate the testing industry to adapt it. We have reported a number of advantages, disadvantages, challenges and factors in this study. We further investigated the claims stated by the ET practitioners through an experiment and survey. The statistical tests were conducted on the collected data to draw meaningful results. We found statistical significance difference in number of true defects found. Using exploratory testing approach testers found far more defects than test case based testing. Although, there was no statistical significance difference between the two approaches for false defects. / Slutsatser: Vi anser att det experimentella tester har stor potential och mycket mer att erbjuda testning industrin. Men mer empirisk undersökning och sann fakta och siffror är skyldiga att motivera testning industrin att anpassa den. Vi har rapporterat en rad fördelar, nackdelar, utmaningar och faktorer i denna studie. Vi undersökte vidare fordringar anges av ET utövare genom ett experiment och undersökning. De statistiska test genomfördes på insamlade data för att dra meningsfulla resultat. Vi fann statistisk signifikans skillnaden i antalet sann fel som upptäcks. Använda utforskande testning strategi testare fann långt fler fel än testfall baserat testning. Även om det inte fanns någon statistisk signifikans skillnad mellan de två synsätten för falska defekter. / 0046 73 651 8048

Context. Software testing is the process of finding faults in software while executing it. The results of the testing are used to find and correct faults. Software defect prediction estimates where faults are likely to occur in source code. The results from the defect prediction can be used to opti- mize testing and ultimately improve software quality. Machine learning, that concerns computer programs learning from data, is used to build pre- diction models which then can be used to classify data. Objectives. In this study we, in collaboration with Ericsson, investigated whether software metrics from source code files combined with metrics from their respective tests predicts faults with better prediction perfor- mance compared to using only metrics from the source code files. Methods. A literature review was conducted to identify inputs for an ex- periment. The experiment was applied on one repository from Ericsson to identify the best performing set of metrics. Results. The prediction performance results of three metric sets are pre- sented and compared with each other. Wilcoxon’s signed rank tests are performed on four different performance measures for each metric set and each machine learning algorithm to demonstrate significant differences of the results. Conclusions. We conclude that metrics from tests can be used to predict faults. However, the combination of source code metrics and test metrics do not outperform using only source code metrics. Moreover, we conclude that models built with metrics from the test metric set with minimal infor- mation of the source code can in fact predict faults in the source code.