This study sought to determine whether a recently isolated slow-growing nonstarter lactic acid bacterium, Lactobacillus wasatchii sp. nov., could be implicated in late gassy defect in Cheddar cheese. I demonstrated that Lb. wasatchii grows readily in the laboratory under cheese-like stress conditions of 5% salt and pH 5.2, and has the potential to survive pasteurization. Lactobacillus wasatchii can co-utilize ribose and galactose to maximize its growth. Due to being an obligatory heterofermentative, Lb. wasatchii produces CO2 whenever it ferments a hexose such as galactose. A second investigation extended these findings by examining the growth and gas forming characteristics of Lb. wasatchii in Cheddar cheese. The optimum growth of Lb. wasatchii and highest levels of gas production were observed in cheese supplemented with ribose plus galactose, and stored at 12°C rather than 6°C. Lactobacillus wasatchii also grew readily and produced gas in Cheddar cheese even without added ribose and galactose, which corresponds with the ability of Lb. wasatchii to grow on starter cell lysate. A challenge still remains of how to easily enumerate Lb. wasatchii in cheese with a higher background population of other nonstarter lactic acid bacteria. The third set of experiments explored the consequences on growth and gas production of Lb. wasatchii in Cheddar cheese made with Streptococcus thermophilus. Using St. thermophilus in cheesemaking results in galactose accumulation, which Lb. wasatchii then can utilize for growth, causing release of CO2 with the end result of having blown Cheddar cheese. Results showed Lb. wasatchii or similar nonstarter lactic acid bacteria are likely to be particularly problematic in cheesemaking involving starter or adventitious St. thermophilus. From these observations, it was concluded that Lb. wasatchii is a contributor to late gassy defect in Cheddar cheese and may be widely present as part of the nonstarter lactic bacteria population but has been undetected up until now. The late gassy defect is more pronounced at temperatures used for accelerated ripening of cheese and when there are substantial residual levels of galactose in the cheese. Thus, researchers and cheese manufacturers now must consider slow-growing obligatory heterofermentative nonstarter lactic acid bacteria when dealing with late gassy defect in cheese.

Gardner's syndrome is an autosomal dominant disease presenting multiple colonic polyps with a predisposition for malignant change. In addition to colonic polyp formation by early adolescence, extracolonic lesions appear often prior to polyp formation. One theoretical mechanism for the origin of polyps and malignancies in Gardner's syndrome is a genetic defect in the natural killer cell activity of patients with this disease. Natural killer cells are a of lymphocytes that spontaneously lyse tumor cells subpopulation and virally transformed cells. A study was undertaken to determine the natural killer activity of patients with Gardner's syndrome .

The Internet has revolutionized the way users share and acquire knowledge. As important and popular Web-based applications, online discussion forums provide interactive platforms for users to exchange information and report problems. With the rapid growth of social networks and an ever increasing number of Internet users, online forums have accumulated a huge amount of valuable user-generated data and have accordingly become a major information source for business intelligence. This study focuses specifically on product defects, which are one of the central concerns of manufacturing companies and service providers, and proposes a machine learning method to automatically detect product defects in the context of online forums. To complement the detection of product defects , we also present a product feature extraction method to summarize defect threads and a thread ranking method to search for troubleshooting solutions. To this end, we collected different data sets to test these methods experimentally and the results of the tests show that our methods are very promising: in fact, in most cases, they outperformed the current state-of-the-art methods. / Ph. D.

The diploma thesis deals with inspection and construction technical survey of the reinforced concrete bridge structure and final evaluation of the condition of the selected reinforced concrete bridge object. This bridge structure is located on the road 4794 and overcomes the Olešná stream in the town of Paskov.

This diploma thesis focuses on diagnostics of bridge structures. First part of this diploma thesis will focus on theoretical knowledge about bridge structures and common diagnostic techniques suited for examining material priperties of samples taken from structure. Second part of this thesis will focus on practical use of experiments used in diagnostic branch. I will be doing visual observation of concrete structure followed by experiments on core samples. End of thesis will be evaluating structure from global perspective and will deliver specific sugestions for renovation.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第18494号 / 理博第4009号 / 新制||理||1578(附属図書館) / 31380 / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)准教授 中 暢子, 教授 田中 耕一郎, 教授 金光 義彦 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第18982号 / 工博第4024号 / 新制||工||1620(附属図書館) / 31933 / 京都大学大学院工学研究科材料工学専攻 / (主査)教授 田中 功, 教授 酒井 明, 教授 邑瀬 邦明 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第19185号 / 工博第4062号 / 新制||工||1627(附属図書館) / 32177 / 京都大学大学院工学研究科航空宇宙工学専攻 / (主査)教授 斧 髙一, 教授 木村 健二, 教授 立花 明知 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20563号 / 医博第4248号 / 新制||医||1022(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 生田 宏一, 教授 髙折 晃史, 教授 前川 平 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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