Os dados de clientes nas empresas são coletados e armazenados em um Banco de Dados e sua administração requer o uso de uma ferramenta computacional. A construção de um modelo de Perfil de Cliente a partir de um banco de dados requer o processo descoberta de conhecimento em uma base de dados. Essa busca de conhecimento e extração de padrões das bases de dados demanda a utilização de um aplicativo com capacidade analítica para extrair informações que estão implícitas e desconhecidas, porém, potencialmente úteis. Um Banco de Dados por meio do processo de recuperação é capaz de obter informações dos clientes, mas a dificuldade é de que esses sistemas não geram padrões. Estes Bancos de dados contêm uma quantidade expressiva de atributos, os quais podem prejudicar o processo de extração de padrões. Assim, métodos de redução de dimensionalidade são empregados para eliminar atributos redundantes e melhorar o desempenho do processo de aprendizagem tanto na velocidade quanto na taxa de acerto. Também identificam um subconjunto de atributos relevantes e ideal para uma determinada base de dados. Os dois métodos de redução utilizados nesta pesquisa foram: Seleção de Atributos e Conceitos de Framework, até então não aplicados no domínio de Clientes. O Método de Seleção de Atributos tem o intuito de identificar os atributos relevantes para uma tarefa alvo na Mineração de Dados, levando em conta os atributos originais. Já os Conceitos de Framework promovem sucessivos refinamentos nos atributos que podem levar a construção de um modelo mais consistente em um domínio de aplicação. A presente pesquisa aplicou esses dois métodos para comparação destes no domínio Clientes,usando três bases de dados chamadas: Stalog, Customere Insurance. Identificaram-se cinco etapas principais para a comparação dos dois métodos de redução: Preparação das Bases de Dados, Escolha das Bases de Dados, Aplicação dos Métodos de Seleção de Atributos e dos Conceitos de Framework, Execução dos Algoritmos de Classificação e Avaliação dos Resultados. Com a operacionalização das cinco etapas, compostas por vários processos, foi possível comparar os dois métodos e identificar os melhores algoritmos que aumentam a taxa de acerto dos algoritmos classificadores e consequentemente gerar os atributos mais relevantes para uma base de dados, aumentando o desempenho do processo de aprendizagem. Desta forma, com os melhores subconjuntos identificados é possível submetê-los a aplicação de tarefas da Mineração de Dados as quais permitem a construção de regras que ajudam na Gestão do Conhecimento do Perfil do Cliente. / Information related to the Customers at companies are collected and stored in databases. The administration of these data often requires the use of a computational tool. The building of a Customer Profile model from the database requires the process of knowledge discovery in databases. This search of knowledge and extraction patterns of the databases demands the use of a tool with analytics capability to extract information that are implicit, and are previously unknown, but, potentially useful. A data base through of the recovery of date, obtain information of the Customers, but the difficulty is in the fact of these systems do not generate patterns. However, these databases have an expressive amount of data, where redundant information it prejudices this process of patterns extraction. Thus, dimensionality reduction methods are employed to remove redundant information and improve the performance of the learning processes the speed as in the performance of classifier. Furthermore, it identifies a subset of relevant and ideal attributes for a determinate database. The two methods of dimensionality reduction used in this search were: Attribute Selection and Framework Concepts which theretofore were not applied in Customer domain. The Attribute Selection Method has as goal to identify the relevant attributes for a target task, taking into account the original attributes. Considering the Framework Concepts it promotes successive refinements on the attributes where can tale he building of a model more consistent application domain. The present search applied these two methods in order to comparison of these in the Customer domain, using three databases called: Stalog, Customer e Insurance. This paper identified five main steps in order to comparison of the two methods: Preparation of Database, Choice of Database, Application of the Attributes Selection and Framework Concepts Methods, Execution of the Algorithms of the Classification and Evaluation of the Results. With the implementation of theses five steps composed of several processes, it was possible to compare the two methods and identify the best classifiers algorithms and consequently to create the attributes more relevant for a database, increasingthe performance of the learning process. Of this way, with the best subset identified is possible submit them to the application of the Data Mining Tasks which allow the building of rules that help the Knowledge Management of Customer Profile.

A produção científica gerada e publicada por docentes das Faculdades de Odontologia pertencentes ao SIEO e vinculados aos Programas de pós-graduação credenciados pela CAPES, é analisada neste trabalho com vistas à verificação da rede colaborativa entre autores. Objetivos: Identificar a visibilidade da produção brasileira de artigos científicos da área de Odontologia, indexada em bases de dados internacionais no período de 2000 a 2008, de autoria dos docentes dos programas de pós-graduação, atuando nas faculdades que integram o SIEO; Traçar a rede colaborativa entre os autores que publicaram artigos em co-autoria; Analisar o tipo de autoria (única ou múltipla) para publicação de artigos científicos publicados em revistas brasileiras e estrangeiras indexadas nas fontes internacionais: Medline, Web of Science e Embase; Verificar os autores que mais colaboraram entre si, a partir da rede dos autores mais produtivos de cada programa de pós-graduação e identificar a afiliação destes colaboradores. Método: a produção científica dos docentes credenciados pela CAPES, foi verificada em três bases de dados internacionais: Medline, Web of Science e Embase, no período de 2000 a 2008. Identificou-se em cada programa, o docente com maior número de trabalhos publicados neste período. A partir da sua produção foram identificados os artigos de autoria única e múltipla. As coautorias permitiram elaborar a rede colaborativa entre autores caracterizando os mais produtivos como autores nó de cada Programa. Resultados: de um total de 29 Programas de pós-graduação na área de Odontologia, das Instituições que compõe o SIEO, estão vinculados 492 docentes credenciados. De acordo com a sua produção científica, 24 deles foram selecionados como docentes nó da rede colaborativa. Do total de 1.422 artigos publicados por esses autores, a rede mostrou que apenas 8 dos trabalhos (0,5%) foram escritos por autoria única. Conclusões: as bases de dados internacionais Medline, Web of Science e Embase indexam e dão visibilidade à produção científica indexada, dos artigos de autoria dos docentes da área de Odontologia, pertencentes ao SIEO; a autoria única mostrou estar, na área Odontológica, cada vez menos frequente, dando espaço para a colaboração entre autores; foi confirmada a autoria múltipla como predominante ente docentes brasileiros dessa área; a análise das redes colaborativas entre autores mostrou ser adequada para identificar as relações existentes entre eles; quanto à distribuição geográfica, foi confirmada a maior concentração de Programas e de docentes de pós-graduação na região Sudeste; a predominância de colaboração foi identificada entre os autores dos departamentos da mesma instituição, e com menor frequência entre faculdades, universidades e outros tipos de instituição; a rede colaborativa não se estabeleceu entre autores de Programas credenciados em Faculdades diferentes. / The scientific production generated and published by professors of the Dentistry Colleges belonging to SIEO and linked to the Post Graduation programme accredited by CAPES, is analyzed in this study with the aim to verify the collaborative network between authors. Objectives: To identify the perceptibility of the Brazilian production of scientific articles in the field of Dentistry, indexed in international databases from 2000 to 2008, authored by professors of post-graduation programme, working in the colleges of the SIEO; To plot the collaborative network between the authors who published co-authored articles; to analyze the type of authorship (single or multiple) for the publication of scientific articles published in Brazilian and foreign journals indexed in international sources: MEDLINE, Web of Science and Embase; to check the most cooperating authors among each other, from the network of the most productive authors of each post graduation program and to identify the affiliation of these collaborators. Method: the scientific production of accredited CAPES professors was verified in three international databases: MEDLINE, Web of Science and Embase from 2000 to 2008. We identified in each program the professor with the highest number of papers published in this period and from this production, the publications of single or multiple authorship were identified. Through the collaborative network, it was able to verify the major collaborators of the authors \"knots\" of each program as well as the form of authorship of articles: single or multiple. Results: In 29 post graduation programme in the Dentistry major area, and from the Institutions composing the SIEO, there are 492 certified professors. According to their scientific production, 24 were selected as teachers \"knots\" of the collaborative network. Out of 1,422 published articles, the network showed that only 8 (0.5%) were written as single authorship. Conclusions: The international databases MEDLINE, Web of Science and Embase index and provide visibility to the indexed scientific production, from the articles authored by members in the field of Dentistry, belonging to SIEO; the single authorship showed to be, in Dentistry, less frequent, giving rise to co-operation among authors; collaboration resulting in multiple authorship is prevalent among Brazilian professors in the field of dentistry, where the development and dissemination of their research analysis of collaborative networks among authors, is adequate to identify the relationship between them: There is a greater concentration of programme and post graduation professors in the Southeast; the predominance of collaboration was identified among authors of the departments within the same institution, and less frequently, between colleges, universities and other institutions, the strong endogenous showed in 16.6% of the authors (the same department). A collaborative network is not established between authors of accredited programs in different faculties.

Os insetos são os mais numerosos animais encontrados no mundo, com mais de 675 mil espécies conhecidas. Pertencentes à ordem Hymenoptera, da superfamília Apoidea, as abelhas são encontradas distribuídas em aproximadamente 20 mil espécies. No Brasil estima-se que existam 1.700 espécies. Uma das principais espécies é a Apis mellifera, com ocorrência cosmopolita. A Apis mellifera, popularmente conhecida como abelha africanizada, é agressiva, enxameia várias vezes ao ano e utiliza uma grande variedade de locais para nidificar. Esse comportamento aumenta o contato direto entre o inseto e a população, aumentando o número de acidentes. Os acidentes com abelhas representam um problema de saúde pública em diversos países do mundo pela freqüência com que ocorrem e pela mortalidade que ocasionam. O presente estudo propõe a busca por inibidores naturais contra o veneno de abelhas. Um sistema e uma base de dados foram desenvolvidos para a integração entre dados de plantas medicinais antivenenos e os venenos de abelhas. As atividades anti-hemorrágica, anti-proteolítica, anti-miotóxica, antifosfolipase e anti-edema de plantas medicinais antiveneno foram analisadas por meio de ensaios farmacológicos. As possíveis interações entre as toxinas Melitina e Fosfolipase A2 com inibidores foram avaliadas, através do docking virtual. O banco de dados, denominado Bee Venom, foi implementado e os dados de bancos de dados públicos foram inseridos no sistema. O sistema foi liberado para acesso público no endereço eletrônico http://gbi.fmrp.usp.br/beevenom/. Durante a análise da proteína Melitina foram encontradas as regiões da proteína em que os possíveis inibidores devem interagir e identificadas as propriedades químicas que os inibidores devem possuir para interagir corretamente com a Melitina. Nas análises in silico foi possível identificar 10 possíveis inibidores que interagiram corretamente com o sítio ativo da Fosfolipase A2. Algumas espécies do Banco de Germoplasma da FMRP/USP foram obtidas e utilizadas nos experimentos de atividade fosfolipásica indireta e de Edema, sendo possível observar inibição do veneno total e da proteína Fosfolipase A2. Os compostos sintéticos e inibidores avaliados não causaram inibição em todos os experimentos avaliados. Já as plantas obtidas no laboratório de Toxinas Animais e Inibidores Naturais e Sintéticos causaram inibição do veneno total e da proteína Fosfolipase A2. / Insects are the most numerous animals worldwide, with more than 675 thousand known species. Belonging to Hymenoptera order, Apoidea, superfamily, bees are found distributed in approximately 20 thousand species. In Brazil there are about 1,700 species. One of the major species is Apis mellifera, with cosmopolitan occurrence. Apis mellifera, popularly known as Africanized bee, is aggressive, swarm several times per year and uses a great variety of locals to nidificate. This behavior raises the contact between the insect and the population, increasing the accidents numbers. Bee accidents represent a public health problem in many countries because of their frequency and mortality. The present study proposes to search for natural inhibitors of bee venom. A system and a data base have been developed to integrate anti-venom medicinal plants data and bee venoms. Plants activities against venom have been evaluated by farmacological assays, such as anti-hemorraghic, anti-proteolitic, anti-myotoxicity, anti-Phospholipase and anti-edema. The possible interactions between Melittin and Phospholipase A2 toxins with inhibitors have been evaluated by virtual docking. The data base, denominated Bee Venom, was implemented and the data from public data bases have been inserted in the system. The system was released to public access in the following address http://gbi.fmrp.usp.br/beevenom/. In Melittin analysis the protein regions which the inhibitors may act have been found and also the chemical properties that the inhibitors must have to interact with Melitina have been identified. During in silico analysis it was possible to identify 10 possible inhibitors that interacted well with Phospholipase A2 active site. Some plants species from FMRP/USP Germoplam Bank have been obtained and used in the indirect Phospholipase activity and edema, being possible to observe inhibitions of total venom and Phospholipase A2 protein. The synthetic compounds and inhibitors evaluated did not cause inhibition in any experiments. However, the plants obtained on Animals Toxins and Natural and synthetic Inhibitors laboratory have caused inhibition of total venom and Phospholipase A2 protein.

Esse trabalho propõe uma solução de um Data Warehouse distribuído para implementação de um sistema de CRM, Customer Relationship Management, com o objetivo de uso no ambiente bancário possibilitando que ações de relacionamento com clientes sejam planejadas e implementadas. É proposta uma arquitetura para implementação de um Data Warehouse em ambiente distribuído, utilizando programação paralela. Com o aumento no volume de dados armazenados nos Data Warehouse, as arquiteturas tradicionais exigem processadores e sistemas de entrada e saída cada vez mais robustos em termos de desempenho. Isso fica mais bem caracterizado quando são executadas procuras complexas (Ad hoc). A utilização de ambientes distribuídos em conjunto com programação paralela é uma alternativa para redução de custo e aumento de desempenho. É apresentada, aqui, uma proposta de arquitetura de Data Warehouse distribuído, integrado ao uso de programação paralela. / This lecture proposes a solution for Data Warehouse in an distributed environment for implementation of a CRM, Customer Relationship Management in a banking system. It\'s possible to create, plan and implement relationship actions with clients. Architecture is proposed for implementation of a Data Warehouse in a distributed environment, using parallel programming. With the increase of volume of data stored in Data Warehouse, the traditional architectures needs high performance in terms of processors and input and output systems. This kind of problem is well characterized when high complex queries (Ad hoc) is performed. Using distributed environment, together with parallel programming is a good choice to increase the performance and reduce cost. It\'s presented, here, a proposal for architecture of distributed Data Warehouse, integrated with the use of parallel programming.

A produção científica gerada e publicada por docentes das Faculdades de Odontologia pertencentes ao SIEO e vinculados aos Programas de pós-graduação credenciados pela CAPES, é analisada neste trabalho com vistas à verificação da rede colaborativa entre autores. Objetivos: Identificar a visibilidade da produção brasileira de artigos científicos da área de Odontologia, indexada em bases de dados internacionais no período de 2000 a 2008, de autoria dos docentes dos programas de pós-graduação, atuando nas faculdades que integram o SIEO; Traçar a rede colaborativa entre os autores que publicaram artigos em co-autoria; Analisar o tipo de autoria (única ou múltipla) para publicação de artigos científicos publicados em revistas brasileiras e estrangeiras indexadas nas fontes internacionais: Medline, Web of Science e Embase; Verificar os autores que mais colaboraram entre si, a partir da rede dos autores mais produtivos de cada programa de pós-graduação e identificar a afiliação destes colaboradores. Método: a produção científica dos docentes credenciados pela CAPES, foi verificada em três bases de dados internacionais: Medline, Web of Science e Embase, no período de 2000 a 2008. Identificou-se em cada programa, o docente com maior número de trabalhos publicados neste período. A partir da sua produção foram identificados os artigos de autoria única e múltipla. As coautorias permitiram elaborar a rede colaborativa entre autores caracterizando os mais produtivos como autores nó de cada Programa. Resultados: de um total de 29 Programas de pós-graduação na área de Odontologia, das Instituições que compõe o SIEO, estão vinculados 492 docentes credenciados. De acordo com a sua produção científica, 24 deles foram selecionados como docentes nó da rede colaborativa. Do total de 1.422 artigos publicados por esses autores, a rede mostrou que apenas 8 dos trabalhos (0,5%) foram escritos por autoria única. Conclusões: as bases de dados internacionais Medline, Web of Science e Embase indexam e dão visibilidade à produção científica indexada, dos artigos de autoria dos docentes da área de Odontologia, pertencentes ao SIEO; a autoria única mostrou estar, na área Odontológica, cada vez menos frequente, dando espaço para a colaboração entre autores; foi confirmada a autoria múltipla como predominante ente docentes brasileiros dessa área; a análise das redes colaborativas entre autores mostrou ser adequada para identificar as relações existentes entre eles; quanto à distribuição geográfica, foi confirmada a maior concentração de Programas e de docentes de pós-graduação na região Sudeste; a predominância de colaboração foi identificada entre os autores dos departamentos da mesma instituição, e com menor frequência entre faculdades, universidades e outros tipos de instituição; a rede colaborativa não se estabeleceu entre autores de Programas credenciados em Faculdades diferentes. / The scientific production generated and published by professors of the Dentistry Colleges belonging to SIEO and linked to the Post Graduation programme accredited by CAPES, is analyzed in this study with the aim to verify the collaborative network between authors. Objectives: To identify the perceptibility of the Brazilian production of scientific articles in the field of Dentistry, indexed in international databases from 2000 to 2008, authored by professors of post-graduation programme, working in the colleges of the SIEO; To plot the collaborative network between the authors who published co-authored articles; to analyze the type of authorship (single or multiple) for the publication of scientific articles published in Brazilian and foreign journals indexed in international sources: MEDLINE, Web of Science and Embase; to check the most cooperating authors among each other, from the network of the most productive authors of each post graduation program and to identify the affiliation of these collaborators. Method: the scientific production of accredited CAPES professors was verified in three international databases: MEDLINE, Web of Science and Embase from 2000 to 2008. We identified in each program the professor with the highest number of papers published in this period and from this production, the publications of single or multiple authorship were identified. Through the collaborative network, it was able to verify the major collaborators of the authors \"knots\" of each program as well as the form of authorship of articles: single or multiple. Results: In 29 post graduation programme in the Dentistry major area, and from the Institutions composing the SIEO, there are 492 certified professors. According to their scientific production, 24 were selected as teachers \"knots\" of the collaborative network. Out of 1,422 published articles, the network showed that only 8 (0.5%) were written as single authorship. Conclusions: The international databases MEDLINE, Web of Science and Embase index and provide visibility to the indexed scientific production, from the articles authored by members in the field of Dentistry, belonging to SIEO; the single authorship showed to be, in Dentistry, less frequent, giving rise to co-operation among authors; collaboration resulting in multiple authorship is prevalent among Brazilian professors in the field of dentistry, where the development and dissemination of their research analysis of collaborative networks among authors, is adequate to identify the relationship between them: There is a greater concentration of programme and post graduation professors in the Southeast; the predominance of collaboration was identified among authors of the departments within the same institution, and less frequently, between colleges, universities and other institutions, the strong endogenous showed in 16.6% of the authors (the same department). A collaborative network is not established between authors of accredited programs in different faculties.

Esse trabalho propõe uma solução de um Data Warehouse distribuído para implementação de um sistema de CRM, Customer Relationship Management, com o objetivo de uso no ambiente bancário possibilitando que ações de relacionamento com clientes sejam planejadas e implementadas. É proposta uma arquitetura para implementação de um Data Warehouse em ambiente distribuído, utilizando programação paralela. Com o aumento no volume de dados armazenados nos Data Warehouse, as arquiteturas tradicionais exigem processadores e sistemas de entrada e saída cada vez mais robustos em termos de desempenho. Isso fica mais bem caracterizado quando são executadas procuras complexas (Ad hoc). A utilização de ambientes distribuídos em conjunto com programação paralela é uma alternativa para redução de custo e aumento de desempenho. É apresentada, aqui, uma proposta de arquitetura de Data Warehouse distribuído, integrado ao uso de programação paralela. / This lecture proposes a solution for Data Warehouse in an distributed environment for implementation of a CRM, Customer Relationship Management in a banking system. It\'s possible to create, plan and implement relationship actions with clients. Architecture is proposed for implementation of a Data Warehouse in a distributed environment, using parallel programming. With the increase of volume of data stored in Data Warehouse, the traditional architectures needs high performance in terms of processors and input and output systems. This kind of problem is well characterized when high complex queries (Ad hoc) is performed. Using distributed environment, together with parallel programming is a good choice to increase the performance and reduce cost. It\'s presented, here, a proposal for architecture of distributed Data Warehouse, integrated with the use of parallel programming.

Engineering complex systems and New Product Development (NPD) are major challenges for contemporary engineering design and must be studied at three levels of: Products, Processes and Organizations (PPO). The science of complexity indicates that complex systems share a common characteristic: they are robust yet fragile. Complex and large scale systems are robust in the face of many uncertainties and variations; however, they can collapse, when facing certain conditions. This is so since complex systems embody many subtle, intricate and nonlinear interactions. If formal modelling exercises with available computational approaches are not able to assist designers to arrive at accurate predictions, then how can we immunize our large scale and complex systems against sudden catastrophic collapse? This thesis is an investigation into complex product design. We tackle the issue first by introducing a template and/or design methodology for complex product design. This template is an integrated product design scheme which embodies and combines elements of both design theory and organization theory; in particular distributed (spatial and temporal) problem solving and adaptive team formation are brought together. This design methodology harnesses emergence and innovation through the incorporation of massive amount of numerical simulations which determines the problem structure as well as the solution space characteristics. Within the context of this design methodology three design methods based on measures of complexity are presented. Complexity measures generally reflect holistic structural characteristics of systems. At the levels of PPO, correspondingly, the Immunity Index (global modal robustness) as an objective function for solutions, the real complexity of decompositions, and the cognitive complexity of a design system are introduced These three measures are helpful in immunizing the complex PPO from chaos and catastrophic failure. In the end, a conceptual decision support system (DSS) for complex NPD based on the presented design template and the complexity measures is introduced. This support system (IMMUNE) is represented by a Multi Agent Blackboard System, and has the dual characteristic of the distributed problem solving environments and yet reflecting the centralized viewpoint to process monitoring. In other words IMMUNE advocates autonomous problem solving (design) agents that is the necessary attribute of innovative design organizations and/or innovation networks; and at the same time it promotes coherence in the design system that is usually seen in centralized systems.

Interest in more accurate assignment of overhead costs to establish credible product/service cost profiles has assumed substantial prominence in much of the recent debates on management accounting practices. While the promotion of new cost management systems and in particular Activity Based Costing (ABC) has promised to address many of the perceived shortcomings of more traditional and long established techniques, the lack of its implementation success raises some concern as to the validity and value of these new system designs. A major purpose of this thesis is the development of a mathematical model that is capable of computing overhead allocations on the basis of organisational specific dimensions other than DLH.While almost all data bases suffer from data entry and omission errors, the information content contained in the data bases often forms the basis for management decisions without first confirming the accuracy of the data base content. The model has been successfully applied and tested to detect internal consistency and data element detail accuracy. Future research may test the applicability of the model with more diverse data bases to confirm its generalisability as an investigative as well as predictive model. / Doctor of Philosophy (PhD)

The environmental assessment system Miljöbyggnad is a Swedish system initiated by Bygga-Bo-Dialogen to assess buildings with regards to three main areas; “Energy”, “Indoor climate” and “Materials”. A building can obtain three different classifications depending on how well it manages to meet the demands. GOLD is the highest classification and is followed by SILVER and BRONZE. The majority of the measures needed to comply with the demands are done during the design phase. During the production phase a considerable amount of work is required to make sure to document the built in products and make sure they do not contain any dangerous substances. The thesis is based on the experiences retrieved by working with Miljöbyggnad in Skanska’s project Sickla Udde skola which is aiming for the highest classification GOLD. Interviews have been conducted with employees of Skanska working with the system in order to take part of their experiences. The thesis identifies difficulties linked to working with the main area “Materials” during the production phase. It also describes the available product data bases used to simplify the work with the system. Furthermore the thesis gives suggestions on how to work with Miljöbyggnad during the production phase.

Engineering complex systems and New Product Development (NPD) are major challenges for contemporary engineering design and must be studied at three levels of: Products, Processes and Organizations (PPO). The science of complexity indicates that complex systems share a common characteristic: they are robust yet fragile. Complex and large scale systems are robust in the face of many uncertainties and variations; however, they can collapse, when facing certain conditions. This is so since complex systems embody many subtle, intricate and nonlinear interactions. If formal modelling exercises with available computational approaches are not able to assist designers to arrive at accurate predictions, then how can we immunize our large scale and complex systems against sudden catastrophic collapse? This thesis is an investigation into complex product design. We tackle the issue first by introducing a template and/or design methodology for complex product design. This template is an integrated product design scheme which embodies and combines elements of both design theory and organization theory; in particular distributed (spatial and temporal) problem solving and adaptive team formation are brought together. This design methodology harnesses emergence and innovation through the incorporation of massive amount of numerical simulations which determines the problem structure as well as the solution space characteristics. Within the context of this design methodology three design methods based on measures of complexity are presented. Complexity measures generally reflect holistic structural characteristics of systems. At the levels of PPO, correspondingly, the Immunity Index (global modal robustness) as an objective function for solutions, the real complexity of decompositions, and the cognitive complexity of a design system are introduced These three measures are helpful in immunizing the complex PPO from chaos and catastrophic failure. In the end, a conceptual decision support system (DSS) for complex NPD based on the presented design template and the complexity measures is introduced. This support system (IMMUNE) is represented by a Multi Agent Blackboard System, and has the dual characteristic of the distributed problem solving environments and yet reflecting the centralized viewpoint to process monitoring. In other words IMMUNE advocates autonomous problem solving (design) agents that is the necessary attribute of innovative design organizations and/or innovation networks; and at the same time it promotes coherence in the design system that is usually seen in centralized systems.