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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Immune mediated inflammatory responses in the central nervous system

Matyszak, M. K. January 1993 (has links)
No description available.
2

CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010. / Clinical and epidemiological characteristics of 146 patients with multiple sclerosis followed up in the city of Fortaleza, CE, Brazil, between 1979 and 2010.

Carlos Augusto Ciarlini Teixeira 28 December 2011 (has links)
nÃo hà / Para analisar a histÃria natural da Esclerose MÃltipla (EM) no estado do CearÃ, Brasil, o autor estuda retrospectivamente 146 pacientes diagnosticados por critÃrios de Poser e / ou McDonald-2010. CasuÃstica e mÃtodos: dados biogrÃficos, clÃnicos e para-clÃnicos obtidos em visitas ambulatoriais e nos surtos. Considera como desfechos de incapacidade os marcos EDSS 4, 6 e 7. Com software estatÃstico R ( RKWard 0.5.3 ) faz anÃlise descritiva, teste exato de Fisher (p < 0,05) e curvas de anÃlise de tempo atà o evento ( Kaplan-Meier). Mais de 75 % dos pacientes sÃo acompanhados durante atà 15 anos. Resultados: EM predomina no sexo feminino (80,82 %); tem inÃcio antes dos 30 anos de idade em 47,9 % dos casos. Pacientes com educaÃÃo de nÃvel superior (33,5 %) representam mais do dobro do esperado na populaÃÃo em geral. Nas avaliaÃÃes inicial e evolutiva predominam os sintomas sensitivos, motores e esfincterianos. Pacientes mais jovens e com evoluÃÃo recorrente â remitente atingem EDSS 4 apÃs maior intervalo de tempo. A proporÃÃo de casos de EM benigna à de 4,7 %. A taxa anualizada de surtos à 0,6. Os dois primeiros surtos da maioria dos pacientes ocorreram nos primeiros 3 anos. O tempo entre 1 e 2 surtos tem relaÃÃo positiva com o tempo para atingir EDSS 4, 6 e 7. A duraÃÃo da doenÃa atà o Ãbito (8 casos, 5,4 %) foi em mÃdia de 14,4 anos. PrevalÃncia de EM no estado do Cearà à estimada em 2,9 / 100.000 habitantes. ConclusÃo: As caracterÃsticas clÃnicas e evolutivas da EM, no estado do Cearà (latitude sul entre 2o 46â e 7o 52â), sÃo semelhantes Ãs observadas mundialmente. / In order to study the natural history of Multiple Sclerosis (MS) in the state of CearÃ, Brazil, the author retrospectively analyzes 146 patients diagnosed according to Poser and/or McDonald-2010 criteria. Cases and methods: biographical, clinical and para-clinical data collected on outpatient visits and at relapses. EDSS scores 4, 6 and 7 used as disability outcomes. Statistical software R (RKWard 0.5.3) used to perform descriptive analysis, Fisher exact test (p< 0,05) and time-to-the-event curves (Kaplan-Meier). Results: over 75 % of the patients followed for as long as 15 years; disease onset before 30 years of age in 47,9 %, with female sex preponderance (80.82 %). Patients with university education (33,5 %) are in high proportion when compared to the general population. Sensory, motor and sphincter complaints are the most common, in both initial and final examinations. Younger patients with relapsing-remitting MS took a longer time to reach EDSS 4. The proportion of benign MS cases was 4, 7 %. Annualized relapse rate was 0,6 . For most patients, the first two relapses took place in the initial three years of illness.Time between 1st. and 2nd relapses bears a positive relationship with time to reach EDSS 4, 6 and 7. Disease duration until death (8 cases , 5,4 %) was an average of 14,4 years. The prevalence of MS in the state of CearÃ, Brazil, is estimated as 2,9 / 100.000 inhabitants. Conclusion: Clinical course of MS in the state of CearÃ, Brazil (south latitudes between 2o 46â and 7o 52â ) is similar to that observed worldwide.
3

Measurement of brain atrophy in pediatric patients with clinically isolated demyelinating syndromes and multiple sclerosis

Belzycki, Sari E. January 2007 (has links)
Brain atrophy has been used as a marker for disease progression in Multiple Sclerosis (MS). SIENA, an automated tool for measuring brain volume change, was tested to see whether MRI slice thickness and gap presence affect longitudinal atrophy measures. Isotropic global scan-rescan images were used to simulate 3 mm and 5 mm axial slice thicknesses with 1 and 2mm gaps, respectively. SIENA remained accurate and precise with increasing slice thickness and gap presence. Furthermore, symmetric pre-registration was crucial for scans with larger slice-thickness and gaps. / SIENA was used to observe atrophy in children who have experienced a Clinically Isolated Syndrome (CIS) of the type leading to MS (CIS-MS). Brain atrophy was present within the first three months after a CIS event, and then subsided over the rest of the year. If the first acute episode was excluded, there was no significant difference in atrophy rates between the CIS-MS group and the CIS group, and no significant difference between those with T2-weighted brain lesions versus those who had none.
4

Protein aggregation in peripheral myelin protein 22 (pmp22)-associated neuropathies

Fortun, Jenny, January 2005 (has links)
Thesis (Ph.D.)--University of Florida, 2005. / Typescript. Title from title page of source document. Document formatted into pages; contains 123 pages. Includes Vita. Includes bibliographical references.
5

The oligodendrocyte progenitor response to demyelination /

Vana, Adam C January 2006 (has links) (PDF)
Thesis (Ph.D.)--Uniformed Services University of the Health Sciences, 2006 / Typescript (photocopy)
6

Measurement of brain atrophy in pediatric patients with clinically isolated demyelinating syndromes and multiple sclerosis

Belzycki, Sari E. January 2007 (has links)
No description available.
7

Radiological studies of LMNB1-related autosomal dominant leukodystrophy and Marinesco-Sjögren syndrome

Finnsson, Johannes January 2016 (has links)
There are approximately 6000 to 8000 rare diseases, each with a prevalence of less than 1 / 10 000, but in aggregate affecting 6 to 8% of the population. It is important to evaluate disease development and progression to know the natural course of any disease. This information can be utilized in diagnostics and in assessing effects of therapeutic interventions as they become available. This thesis describes the natural clinical history and evolution of imaging findings of two rare diseases over approximately two decades. Papers I, II and III present clinical, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) findings in LMNB1-related autosomal dominant leukodystrophy (ADLD). MRI was found to be very sensitive in finding pathology in patients with LMNB1-related ADLD, even before the onset of clinical symptoms. However, even patients with widespread MRI changes can have a relatively mild symptomatology and present only slight disturbances in metabolic examinations such as MRS and FDG-PET. This is compatible with relatively intact axons, even as myelin impairment is widespread. Paper IV presents clinical and MRI findings in the brain and musculature in SIL1-positive Marinesco-Sjögren syndrome (MSS), and describes a new, mild phenotype of the disease with no intellectual disabilities and only slight motor disabilities. With a 19-year-long radiological follow-up, a slow progressive atrophic process in the cerebellum and brainstem could be demonstrated. MRI of the musculature shows early involvement of the quadriceps and gastrocnemii but not the tibialis anterior, progressing to widespread atrophy in the back and upper and lower limbs at the age of 20 years. In the mildest phenotype, the most severely affected muscles were the m gluteus maximus, m sartorius, m peroneus longus, and the lateral head of the m gastrocnemius.
8

Úloha střevního mikrobiomu v imunitních onemocněních centrálního nervového systému / The role of the gut microbiome in immune-mediated CNS disorders

Zedníková, Barbora January 2016 (has links)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Barbora Zedníková Supervisor: Doc. MUDr. Josef Herink, DrSc. Title of diploma thesis: The role of the gut microbiome in immune-mediated CNS disorders Human body hosts a large number of microorganisms - i.e. Archea, Eukarya, Bacteria and viruses. These microorganisms form microbiome, the total number of the microorganisms is ten times higher than the number of all human cells. Largest part of the microbiome is located in the intestine. The current development of molecular genetics revealed the close relationship between intestinal microbiome and health. Recent studies the most recent studies have pointed to a connection with the pathogenesis of various diseases. This dissertation is focused on the connection between intestinal microbiome and autoimmune diseases of the central nervous system. Research shows that the key factor are the ongoing changes in the composition of microbiome. These changes lead to increased immune stimulation and thereby to inflammatory proliferation.
9

Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida / Voiding dysfunction in patients with neuromyelitis optica spectrum disorder and its association with neurological impairment and quality of life

Carvalho, Fabricio Leite de 14 March 2014 (has links)
INTRODUÇÃO: Neuromielite óptica (NMO) e suas formas limitadas são doenças desmielinizantes autoimunes do sistema nervoso central que acometem preferencialmente a medula espinhal e o nervo óptico. Várias formas clínicas do espectro da NMO (NMO-SD) tem sido descritas e incluem desde um evento único de mielite transversa longitudinalmente extensa (MTLE) à NMO recorrente. O comprometimento neurológico destes pacientes pode levar a diversas disfunções autonômicas, incluindo disfunção miccional. OBJETIVOS: Determinar a prevalência e as características dos sintomas do trato urinário inferior (STUI) e dos achados urodinâmicos em pacientes portadores de NMO-SD, e analisar suas associações com o grau de comprometimento neurológico e qualidade de vida (QV). MÉTODOS: Avaliamos 30 pacientes (23 mulheres e 7 homens) com diagnóstico estabelecido de NMO-SD, que foram convidados a participar do estudo a despeito de apresentarem ou não STUI. A avaliação neurológica foi realizada por meio da Escala Expandida do Estado de Incapacidade (EDSS), ressonância magnética de crânio e coluna vertebral, e dosagem de NMOIgG. Os STUI foram avaliados pelo Questionário de Avaliação da Bexiga Hiperativa (OAB-V8) e pelo Escore Internacional de Sintomas Prostáticos (IPSS). A qualidade de vida de forma geral foi avaliada pelo questionário de Satisfação com a Vida (LiSat-9). Todos os pacientes foram submetidos ao estudo videourodinâmico. RESULTADOS: A idade média dos pacientes foi de 41,1 ± 13,5 anos (intervalo de 13 a 70) e o tempo médio de duração da doença neurológica foi de 33,8 ± 30,8 meses (intervalo de 3 a 135). A avaliação neurológica mostrou pacientes com EDSS médio de 5,3 ± 1,8 (intervalo de 1 a 8,5). O escore médio do OAB-V8 foi de 17,5 ± 14,0 (intervalo de 0 a 40) e de 14,3 ± 10,6 (intervalo de 0 a 35) para o I-PSS. A média da QV geral medida pelo Lisat-9 foi de 38,9 ± 6,8 (intervalo de 26 a 49). Os STUI mais comuns foram urgência em 15 (50%) pacientes, noctúria em 15 (50%), jato urinário fraco em 15 (50%), intermitência em 14 (46,6%), esvaziamento incompleto em 13 (43,3%), hesitação em 13 (43,3%), aumento da frequência urinária em 13 (43,3%) e urge-incontinência em 5 (16%). Os achados urodinâmicos mais comuns foram hiperatividade detrusora (HD) com dissinergia detrusor-esfincteriana (DDE) em 11 (36,6%) pacientes, DDE sem HD em 7 (23,3%), HD sem DDE em 6 (20%), e incontinência urinária de esforço em 1 (3,3%). Cinco (16,6%) pacientes apresentaram estudo videourodinâmico sem anormalidades. Sintomas urinários medidos pelo IPSS e pelo OAB-V8 correlacionaram-se com maior comprometimento neurológico (r=0,42; p=0,018 e r=0,48; p=0,006 respectivamente). Pacientes portadores de DDE foram aqueles que mostraram maior comprometimento neurológico (p=0,027). Da mesma forma, pacientes dissinérgicos apresentaram maiores escores ao I-PSS (p=0,029) e ao OAB-V8 (p=0,008). Pacientes com maior comprometimento neurológico foram aqueles que apresentaram pior QV (r=-0,410; p=0,022). CONCLUSÃO: Encontramos alta prevalência de STUI e disfunção miccional em portadores de NMO, sendo DDE e a HD as anormalidades urodinâmicas mais frequentes. Dissinergia detrusor-esfincteriana e STUI se correlacionam com a gravidade da doença neurológica. A severidade da doença neurológica correlaciona-se com a qualidade de vida geral / INTRODUCTION: Neuromyelitis optica (NMO) and its limited forms are demyelinating autoimmune diseases of the central nervous system that preferentially affects the spinal cord and optic nerve. Several clinical forms of NMO spectrum disorders (NMO-SD) have been described and range from a limited event of longitudinally extensive transverse myelitis (LETM) to relapsing NMO. The neurological damage in these patients may lead to a range of autonomic dysfunctions, including voiding dysfunction. OBJECTIVES: To determine the prevalence and characteristics of the lower urinary tract symptoms (LUTS) and the urodynamic findings in patients with NMO-SD and analyze their correlations with the level of neurological damage and quality of life (QoL). METHODS: We evaluated 30 patients (23 women and 7 men) with an established diagnosis of NMO-SD based on stringent criteria. All patients were invited to participate irrespective of the presence of LUTS. Neurological impairment was assessed with the Expanded Disability Status Scale (EDSS), magnetic resonance imaging of the brain and spinal cord and NMO-IgG status. LUTS were evaluated with the Overactive Bladder V8 (OAB-V8) questionnaire and by the International Prostate Symptom Score (I-PSS). Quality of Life was evaluated using the Life Satisfaction questionnaire (LiSat-9). All patients underwent videourodynamics, transabdominal urinary tract sonography, urine culture and serum creatinine levels. RESULTS: The mean age of the patients was 41.1 ± 13.5 years (range 13 to 70) and the mean time of neurological disease duration was 33.8 ± 30.8 months (range 3 to 135). Neurological evaluation showed a mean EDSS score of 5.3 ± 1.8 (range 1 to 8.5). The mean OAB-V8 score was 17.5 ± 14.0 (range 0 to 40) and the mean I-PSS score was 14.3 ± 10.6 (range of 0 to 35). Mean general QoL measured by the Lisat-9 was 38.9 ± 6.8 (range 26 to 49). The most common urinary symptoms were urgency in 15 (50%) patients, nocturia in 15 (50%), weak urinary stream in 15 (50%), intermittence in 14 (46.6%), incomplete emptying in 13 (43.3%), hesitation in 13 (43.3%), increased urinary frequency in 13 (43.3%) and urge-incontinence in 5 (16,6%). The most frequent urodynamic findings were detrusor overactivity (DO) with sphincter dyssinergia (DSD) in 11 (36.6%) patients, DSD alone in 7 (23.3%), DO without DSD in 6 (20%) and stress urinary incontinence (SUI) in 1 (3.3%). Five (16.6%) patients had normal findings. Voiding dysfunction assessed by I-PSS and OAB-V8 increased with the degree of neurological impairment (r=0.42; p=0.018 and r=0.48; p=0.006 respectively). Patients with DSD had significantly higher symptoms based in the I-PSS (p=0.029) as well as the OAB- V8 scores (p=0.008) and greater neurological impairment (p=0.027). Patients with more severe neurological impairment were associated with worse Qol (r=-0.410; p=0.022). CONCLUSION: We have shown a high prevalence of LUTS and voiding dysfunction, with DSD and DO as the main urodynamic findings. Detrusor-sphincter dyssinergia and LUTS correlates with more severe neurological impairment. The severity of neurological impairment correlates with QoL
10

Mechanisms in inflammatory demyelinating diseases of the nervous system : immunological and methodological aspects /

Kvarnström, Maria, January 2005 (has links) (PDF)
Diss. (sammanfattning) Linköping : Linköpings universitet, 2005. / Härtill 4 uppsatser.

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