Thesis (Ph. D.)--Lund University, 1995. / Summary in Swedish. Errata sheet inserted. Includes bibliographical references.

Thesis (Ph. D.)--Lund University, 1995. / Summary in Swedish. Errata sheet inserted. Includes bibliographical references.

Sleep deprivation is defined as an individual sleeping less than 6 hours per night. It is a common behavior amongst individuals who live in industrialized nations.Along with industrialization, its prevalence is also expected to rise with age. Despite this, there has been a shift in recent years with sleep deprivation increasing in the youth, likely related to the increased use of technology during the nighttime. Sleep deprivation and chronic sleep disruption are behaviors commonly observed amongst patients suffering from neurological and psychiatric disorders, like Alzheimer’s disease, Parkinson’s disease, depression, and anxiety. Many of these patients suffer from sleep disorders like insomnia, hypersomnia, and rapid eye movement sleep behavior disorder. It has long been thought that lack of sleep was caused by these disorders, yet there may be evidence to support a bidirectional relation between the two. We searched the literature to determine if there is a link between sleep disorders and sleep deprivation causing the exacerbation of these neurological and psychiatric disorders. Some studies support this hypothesis, for example, linking β-amyloid plaque buildup to lack of sleep, therefore increasing the risk of Alzheimer’s disease among chronically sleep deprived individuals. In this presentation we will take a closer look into the possible reasons as to why poor sleep may negatively impact cognitive health.

Non-monetary deprivation indicators are now widely used for studying and measuring poverty in Europe. However, despite their prevalence, the empirical performance of existing deprivation scales has rarely been examined. This thesis i) identifies possible conceptual problems of existing deprivation scales such as indexing, missing dimensions and threshold; ii) empirically assesses the extent of possible error in measurement related to these conceptual problems; and iii) offer an alternative way for constructing deprivation measures to mitigate the identified conceptual problems. The thesis consists of four stand-alone papers, accompanied by an overarching introduction and conclusion. The first three papers provide empirical evidence on the empirical consequences of the missing dimensions and threshold problems for the measurement and analysis of poverty, while the fourth paper exemplifies a concept-led multidimensional design that can reduce the error introduced by these conceptual problems. The analysis is generally held for 25 EU countries using European Survey of Income and Living Conditions (EU-SILC); only in the second paper, the analysis is done for the UK using British Household Panel Survey (BHPS).

The abstract on the file is incorrect, use the the one in the system as it summerizes the full text. / This attempted to describe factors contributing to sleep deprivation in the a multidisciplinary intensive care unit in KwaZulu-Natal Province. A quantitative, descriptive research design was adopted and structured interviews were conducted with 34 adult patients. Most factors contributing to these patients' sleep deprivation are basic physiological needs. Much can be done to enhance patients' abilities to sleep if noise (from alarms, monitors, televisions, telephones and footsteps) could be controlled, patients' pain would be managed effectively, doctors would visit the patients regularly, doctors and nurses use lay terms when talking to patients. Visible clocks and windows will help patients to maintain time orientation. Friendly, approachable and respectful nurses who introduce themselves to the patients help' to reduce patients' stress levels and improve their abilities to sleep. / Health Sciences / M.A. (Health Studies)

The abstract on the file is incorrect, use the the one in the system as it summerizes the full text. / This attempted to describe factors contributing to sleep deprivation in the a multidisciplinary intensive care unit in KwaZulu-Natal Province. A quantitative, descriptive research design was adopted and structured interviews were conducted with 34 adult patients. Most factors contributing to these patients' sleep deprivation are basic physiological needs. Much can be done to enhance patients' abilities to sleep if noise (from alarms, monitors, televisions, telephones and footsteps) could be controlled, patients' pain would be managed effectively, doctors would visit the patients regularly, doctors and nurses use lay terms when talking to patients. Visible clocks and windows will help patients to maintain time orientation. Friendly, approachable and respectful nurses who introduce themselves to the patients help' to reduce patients' stress levels and improve their abilities to sleep. / Health Sciences / M.A. (Health Studies)

The issue of diagnosed children has been heavily debated in the media over the past decade. This study deals with the issue of diagnosis from a family perspective and utilizes a method of thematic analysis trough a literature review of four autobiographies that describes the parents experience of the diagnosis issue regarding attitudes and responses towards their children and family. The purpose is to create a greater understanding of the family situation and to explore new approaches and strategies to counter psychological affliction and exclusion in society. The results show a widespread exclusion based on the main themes, internal and external influences. These themes represent exclusion factors like for example inexperience in dealing with power bearing institutions such as schools and health facilities and creates few opportunities for socialization processes due to the child's disability, stigma. Both of these themes can be seen as a result of sensory deprivation. The attitudes and responses of society towards the stigma bearing child has a great negative impact on the families with diagnosed children. / Diagnosfrågan har varit starkt omdebatterad i media under det senaste decenniet. Dennas studie behandlar diagnosfrågan ur ett familjeperspektiv genom en kvalitativ ansats via en litteraturstudie och tematisk analys av fyra självbiografier. Syftet med studien är att belysa diagnosbärande barns föräldrars erfarenheter kring omgivningens attityder och bemötande samt skapa en ökad förståelse för familjernas livssituation. Vidare menar den kommande analysen till att kunna utröna nya förhållningssätt och strategier för att motverka psykisk ohälsa i dessa familjer. Resultatet visar på ett utbrett utanförskap som redovisas i två huvudteman, inre och yttre påverkan. Dessa teman representerar faktorer som okunskap i bemötande och attityder inom maktbärande institutioner men även i ett fördomsfullt och toleranslöst bemötande från den närmaste omgivningen. Resultatet visar även att utanförskapet skapar få möjligheter till socialiseringsprocesser på grund av de negativa attityderna kring barnets funktionsnedsättning och beteende, detta kan ses som en följd av sensorisk deprivation.

Life course literature states that early childhood development (ECD) can influence most aspects of health throughout the life-cycle. Canada ranked last among 25 wealthy nations in meeting ECD objectives. Fewer than 5% of children born have clinically detectable shortcomings in developmental health, increasing to 26% by school age with emerging socioeconomic associations. Understanding how social determinants of health (SDH) influence ECD at the household and neighbourhood scales would help identify conditions for optimal developmental outcomes. The effects of SDH on ECD in the Kingston, Ontario area were studied. SDH were classified via marginalization (ONMarg) and deprivation (Pampalon) indices. ECD was measured via 2006 Early Development Instrument (EDI) scores for children most at risk upon school entry (Grade One). The basic spatial unit of analysis was 2006 Census of Canada Dissemination Areas, subdivided into quintiles of deprivation (Q1 being the least deprived and Q5 the most). EDI results from each of the quintiles within the two indices were compared and then combined. The socioeconomic health gradient assumes that EDI scores will directly correlate to material and social deprivation. Social deprivation had a slightly greater impact than material deprivation on children’s developmental vulnerability, with Q5 being the most vulnerable in all competencies. Surprisingly, emotional health and social competence were significant areas of vulnerability for children in Q1 and Q2. “Village effects” – when social determinants at the neighbourhood level have protective effects on ECD despite material deprivation at the household level – were present within the Q3 and Q4 groups for the domains of social competency and emotional health. While the highest proportions of early childhood developmental vulnerability are found within the most deprived households, the largest numbers of vulnerable children are spread throughout the middle-class in a variety of neighbourhoods. Canadian policy should focus on mediating avoidable risks within this critical time to avoid future deleterious health effects and costs. Mapping the effects of SDH at the neighbourhood level generates knowledge that informs intersectoral action by policy makers to provide the supports needed to foster healthy children. / Thesis (Master, Geography) -- Queen's University, 2013-05-04 10:36:25.165

Alcoholism is a persistent substance abuse disorder that is associated with negative health, social, and economic outcomes. Treatment strategies for alcohol use disorders are limited, and only three drugs have been approved by the FDA for treatment. Although behavioral therapy and drug combination strategies improve abstinence outcomes, the majority of those in treatment will not achieve long-term abstinence. Therefore, better treatment strategies are needed. While much progress has been made toward understanding the neurobiology of alcoholism, this knowledge has not been effectively translated into treatment strategies. Animal models of alcohol drinking have been crucial to this research effort, but until recently there have been few procedures that effectively model alcoholism by producing binge-like drinking, withdrawal, and relapse behavior. In the last five years the intermittent alcohol access (IAA) model, which uses repeated cycles of scheduled alcohol deprivation and reinstatement to elevate drinking, has been established as such a procedure, with substantial evidence that escalation of drinking produced by IAA is mediated by similar mechanisms as in human alcoholics, which include transcriptional regulation that alters functioning of mesolimbocortical reward pathways. The IAA model. The studies reported herein characterize changes in gene expression in mesolimbocortical brain regions associated with development of maladaptive binge-like alcohol drinking due to scheduled abstinence, particularly in the nucleus accumbens, which regulates motivated behavior. Furthermore the IAA model is characterized with regard to effectiveness in 2 ethanol-preferring C57BL/6 inbred mouse strains, and the influence of concurrent access to multiple alcohol concentrations is examined. Finally, the potential of naltrexone and novel mu-opioid receptor-selective antagonist NAQ to modulate alcohol drinking under continuous access and intermittent access procedures is reported. Microarray analysis is used to analyze the transcriptome in prefrontal cortex, nucleus accumbens, and ventral midbrain of C57BL/6NCrl mice after alcohol deprivation, and to identify differentially expressed genes and gene co-expression networks in C57BL/6J mice during continuous access, as well as after six cycles of IAA. Differentially expressed genes, network hub genes, and regulation mechanisms represent high priority targets for further study in binge-like drinking behavior, with the goal of translating this knowledge to treatment strategies for alcoholism.

The objective and main task of this thesis is to ascertain, in the individual case studies of users of illicit addictive substances who underwent institutional care, what risk factors occurred in the examined persons, which of them were represented by the greatest number and what life event or events were associated with the beginning of drug abuse career of the examined persons. The theoretical part of the thesis first describes the institutional care with regard to its function, legislative and statutory regulations applicable in the Czech Republic and the reasons for placing children into institutional care. The thesis further deals with institutional care with regard to formation of human personality and describes the individual risk factors of institutional care in relation to development of personality which follow from the current theoretical knowledge of this phenomenon where the main attention is paid to psychological deprivation in childhood in connection with institutional care. This thesis is concerned with qualitative research in the form of case studies and the data for the purposes of this thesis were collected using the method of semi-structured interview. The results of this thesis indicate that the examined persons manifested, to a certain degree, all the described risk factors of...