Esta dissertação apresenta um estudo desenvolvido com o intuito de consolidar uma metodologia para a otimização de projeto de porta-sedes de uma válvula de esfera trunnion. Este trabalho está dividido em dois artigos. Primeiramente, é apresentado um estudo comparativo entre diferentes modelos de porta-sedes, realizado com o apoio do método dos elementos finitos (FEA). O porta-sede de melhor desempenho foi determinado utilizando a Função de Perda Quadrática Multivariada. O objetivo principal deste primeiro artigo é identificar os principais parâmetros da geometria de um porta-sede, que possam garantir o desempenho funcional da válvula e correspondente atendimento dos requisitos de qualidade. O segundo artigo descreve uma aplicação da metodologia de Projeto de Experimentos (DOE), conduzida com o intuito de identificar a configuração geométrica da válvula que conduza a condição ótima de funcionamento, fornecendo, desta forma, subsídio para a área de Desenvolvimento de Produtos na elaboração de válvulas mais robustas. Uma das principais contribuições deste trabalho é a constatação que os quatro fatores controláveis incluídos no estudo exercem efeito significativos sobre as variáveis de resposta utilizadas (pressão de contato e força de reação). Excetuando-se o fator “pressão de operação da válvula”, que caracteriza a condição operação, mas não é um parâmetro de projeto, o fator que revelou efeito mais pronunciado sobre as variáveis resposta foi a “área da pista de vedação”. / This thesis presents a study conducted in order to consolidate a methodology for seat-retainer design optimization of a trunnion ball valve. This work is divided in two papers. Initially a comparative study between different seat-retainer models, developed with the support of the finite element analysis (FEA), is presented. The best performance seat-retainer was determined using the Multivariate Quadratic Loss Function. The main purpose of this first article is to identify the main parameters of the seat-retainer geometry, which could ensure the functional performance of the valve and corresponding quality requirements. The second paper describes an application of Design of Experiments (DOE) methodology, conducted in order to identify the geometric configuration of the valve that leads to the optimal operating condition, providing thereby, contribution to the Product Development area in designing more robust valves. The main contribution of this work is the finding that the four control factors included in the study exert significant effect on the response variables used (contact pressure and reaction force). Except for the factor "valve operating pressure" that characterizes the operation condition, but is not a design parameter, the factor that showed more pronounced effect on the response variables was the “seat sealing area”.

O silverskin é um resíduo, rico em compostos antioxidantes, como o ácido 5-cafeoilquínico (5-CQA) e a cafeína (CAF), produzido durante a torrefação dos grãos de café. O objetivo deste estudo foi desenvolver uma metodologia de extração, aliando a extração assistida por ultrassom e o planejamento de experimentos, para a recuperação simultânea do 5-CQA e da CAF da silverskin. Os extratos gerados foram caracterizados e tiveram a capacidade antioxidante e a toxicidade investigadas. A metodologia de superfície de resposta e a função Desejabilidade foram empregadas na otimização da extração. A LC-DAD/MSn foi utilizada para a caracterização dos extratos, os métodos de sequestro do radical DPPH e de redução do ferro (FRAP), para avaliar a capacidade antioxidante; enquanto o ensaio da Artemia salina foi usando para avaliar a toxicidade. As condições ótimas de extração foram: 45 % de etanol em água como solvente de extração, razão amostra-solvente 1/20, extração por 7 min a 59 °C, com rendimentos de 5-ACQ e CAF de respectivamente 2,00 e 6,26 mg g-1. No total, 9 derivados clorogênicos foram tentativamente identificados. Os teores de teofilina, ácido cafeico e derivados clorogênicos foram respectivamente: 0,53, 0,06 e 4,40 mg g-1. O extrato demonstrou considerável capacidade antioxidante, com concentração eficiente de 46,87 mg L-1 e capacidade redutora de ferro de 152,71 μM de FeSO4 g-1, além de alta toxicidade. O método desenvolvido obteve rendimento similar ao da extração sólido-líquido para o 5-ACQ. / Silverskin is a waste generated during the coffee beans roasting. This residue has been showing antioxidant compounds, mainly 5-caffeoylquinic acid (5-CQA) and caffeine (CAF). The aim of this study was used the design of experiments and ultrasound-assisted extraction to develop an extraction method for the efficient recovery of 5-CQA and CAF from silverskin, simultaneously. In addition, the optimized extract was characterized, and its antioxidant capacity and acute toxicity were investigated. The response surface methodology and Desirability function were employed to optimize the extraction. The chemical characterization was carry out by LC-DAD/ESI-MSn. Antioxidant capacity was evaluated by DPPH (2, 2-diphenyl-1 picryl hydrazyl) and FRAP (ferric reducing antioxidant power) methods and the acute toxicity by Artemia salina assay. The optimal extraction conditions were 45.0 % ethanol in water, the solid-to-liquid ratio was 1:20, and extraction for 7.0 min at 59 °C. Under optimal conditions, the yield of 5-CQA and CAF were 2.00 and 6.26 mg g-1, respectively. Theophylline, caffeic acid, and total chlorogenic acid concentrations were 0.53, 0.06 e 4.40 mg g-1, respectively and 9 chlorogenic acids were identified in the extract. The extract showed considerable antioxidant capacity, with efficient concentration value of 46,87 mg L-1 in the DPPH assay and 152,71 μM FeSO4 g-1 (FRAP) and high toxicity. The developed extraction methodology showed similar performance as solid-liquid extraction to 5-CQA yield.

京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第21808号 / 農博第2321号 / 新制||農||1066(附属図書館) / 学位論文||H31||N5180(農学部図書室) / 京都大学大学院農学研究科応用生命科学専攻 / (主査)教授 植田 充美, 教授 渡邊 隆司, 教授 栗原 達夫 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DFAM

The diploma thesis deals with the processing of digestate, which is the remaining material after biogas production. It aims to experimentally prove how chosen operational parameters of antifoaming agents influence digestate foaming associated with the vacuum evaporating technology. Based on the research of available antifoamers and the issue of digestate foaming itself, it was observed how three selected antifoamers (i.e. rapeseed oil, silicone antifoamer Erbslöh Schaum-ex and oleic acid), together with the decrease in the pH factor of the evaporating digestate, influence the final foam production. For the purposes of the research, an apparatus simulating the vacuum evaporating process was set up in which the heated sample was brought to boil by gradual pressure decrease. The process of foaming was observed in a transparent cylinder of a testing culumn. The essential part of the experimental activity is represented by a planned experiment which by means of a DoE (Design of experiments) method proved rapeseed oil to be very efficient. In contrast, other antifoamers, as well as the influence of the pH factor decrease, manifested themselves as insignificant factors, while the oleic acid even supported the foaming. The supplementary measurements led to a more detailed research of the effects of rapeseed oil and to the construction of a mathematical model describing how the concentration of rapeseed oil undermines the amount of generated foam. The main contribution of the thesis is firstly the evidence that rapeseed oil plays an important part in the reduction process of digestate foaming and secondly the determination of minimum substance concentration leading to the foaming reduction of a particular sample which is considered efficient enough to enable functioning of a vacuum evaporator. The thesis has also experimentally demonstrated the influence of some polymer organic flocculants which have been proved to support the foaming.

The content of study is related to reducing the production times of milling of aluminum component of vacuum pump. The primary aim of the thesis is to experimentally verify the proposed cutting conditions when milling the rotor blades and then evaluate them according to predetermined parameters. The output is reducing machining time with respect to cost, tools and machine.

The main aim of this thesis is to provide and explore main factors that affect a drying process. The first part contains brief description of the drying process and focuses on a convectional industrial drying process. The following section discusses the theory of an experiment planning followed by an experiment design of the compact tumble industrial dryer. The thesis also includes an exact description of the executed experiment, then outputs of the measurements and model characterizing the drying process of the tested dryer. The last part deals with the methodology and recommendations for the measurements in operating conditions.

The dissertation is focused on streamlining production on wire electric discharge machine during cutting metal alloys, specifically low-alloy steel quality by CSN 41 4220. The first part contains a study of the current and modern technologies EDM wire cutting. The second part is focused on identifying key parameters to influence the WEDM process, a detailed analysis of the machined surfaces of samples and wire electrodes used for cutting. The result of this work was to explore the possibility, whether by performing planned experiment and subsequent evaluation in the future to determine exactly setting the key parameters influencing the process of WEDM.

Companies within the manufacturing industry are often aiming to increase productivity and simultaneously maintain the quality of their products. To achieve higher productivity and quality it is imperative to have tools with a high speed and accuracy. Atlas Copco BLM's STbench is a measurement system which enables manufacturers to validate their tools during different situations. The purpose of this case study was to improve the robustness of the STbench so it would operate well during situations with both low and high tool speed. To define and investigate how to improve the STbench, a modified DMAIC-approach was used. During the investigation it was found that the area with the largest improvement possibilities was the STbench's PID-controllers. Design of Experiments was used as the method to optimize the P- and I-element of the PID-controllers; hence, increase the robustness. The optimal settings could improve the robustness of the STbench with approximately 50%, but the result has not been verified. This case study presents results that can increase the robustness of the STbench; thus answering the purpose. Furthermore, this master thesis presents several revelations regarding using experimental plans while optimizing control systems, an area that has not been extensively investigated in previous literature.

Parmi les différents procédés d’élaboration de minigranules, le procédé d’extrusion-sphéronisation présente de nombreux avantages, puisqu’il permet notamment d’élaborer des minigranules fortement chargées en principe actif et d’éviter l’emploi de solvants organiques. Ce travail a pour objectif de comparer les performances de plusieurs systèmes d’extrusion à vis, de l’échelle du laboratoire jusqu’à la transposition à l’échelle industrielle. Pour cela, des plans d’expériences ont été construits afin d’identifier les variables critiques et de sélectionner l’extrudeur le plus favorable selon différentes approches spécifiques à cette étude. En effet, le système d’extrusion idéal est défini dans ce travail comme celui donnant les meilleurs résultats en termes de productivité et de caractéristiques des minigranules (« qualité »), entraînant le moins d’impact sur le produit après transposition d’échelle (« transposabilité »), montrant le moins d’influence sur le produit lorsque la formule utilisée change (« robustesse »), et permettant d’ajuster ou d’améliorer la qualité des minigranules lorsque les conditions opératoires varient (« flexibilité »). Quelle que soit l’approche étudiée, les résultats ont permis de mettre en évidence l’influence de paramètres critiques et de leurs interactions sur les différentes réponses et ont montré des différences entre les différents systèmes d’extrusion. L’étude à l’échelle du laboratoire a permis de comparer les extrudeurs radial, dôme et frontal et a mis en évidence l’intérêt des systèmes frontal et dôme en termes de qualité des minigranules, et du système radial en termes de robustesse et de flexibilité du procédé. L’étude à l’échelle industrielle a permis de comparer les extrudeurs radial et frontal, et a permis d’identifier l’extrudeur frontal comme étant le plus favorable en termes de qualité des minigranules, de robustesse, de flexibilité et de transposabilité. Les conclusions observées à l’échelle industrielle sont donc différentes de celles considérées à l’échelle du laboratoire, pour l’étude comparative des différents systèmes. Cela confirme l’importance de tester les systèmes à échelle industrielle avant l’acquisition d’un équipement. / Among the various methods of developing minigranules, extrusion-spheronization has many advantages, particularly since it allows to develop minigranules highly charged with active pharmaceutical ingredient and to avoid the use of organic solvents. This work aims to compare the performance of several extrusion screws systems, from the lab to the scale-up at industrial scale. Designs of experiments were built to identify critical variables and compare the extruder in terms of different approaches specific to this study. As a matter of fact, the ideal extrusion system is defined in this work as the one which gives the best results in terms of productivity and pellets characteristics (“quality”), the one which shows less impact on the product after scaling-up (“scalability”), the one which shows the less influence on these same properties when the formula used changes (“robustness”), and the one which allows the possibility to adjust or improve pellets properties with operating variables (“flexibility”). Whatever the approach studied, the results allowed to highlight the influence of critical parameters and their interactions on the different responses and showed differences between the different extrusion systems. The study at lab scale compared radial, dome and axial extruders and underlined the interest of axial and dome systems in terms of pellets quality, and radial system in terms of process robustness and flexibility. The study at industrial scale compared radial and axial systems, and identified the axial system as the most favorable in terms of pellets quality , robustness, flexibility and scalability. The conclusions observed at industrial scale are different from those observed at lab scale for the different systems comparative study. This confirms the importance to test systems at industrial scale before investing in one equipment.

A torque transducer or a torque sensor is a device for measuring and recording the torque on a rotating system. Torque transducers usually employ strain gauges to measure the torsional moment applied to a rotating shaft.It is to be noted that for an ideal torque transducer, it should measure only the strain that is caused by a torque. Strain due to bending load should be compensated as per the Wheatstone bridge arrangement. However, because of geometrical tolerances and assembly errors, the compensation doesn’t occur and the measured strain is a resultant of bending loads and axial loads which are undesired to measure the torque associated with the system. An analytical formulation has been developed using Matlab and this thesis gives the generalized indication of the strain due to all the associated loads. The user shall also entire the region where the strain needs to be computed and this knowledge can be useful for placing the strain gauges in the shaft accordingly. Initially, the formulation is based on a standard Torque Transducer used at Atlas Copco and then, a generalized result has been developed. The theoretical formulation is verified using the ProEngineer Mechanica software. The end user shall enter the different loads (if any) along with the geometrical tolerance values and the output will be an indication of the strain at point, strain at a region and sensitivity. The main intention of the thesis is to create a better understanding of the strain associated with the twisting, bending and axial loads and also the geometrical imperfections. The user can also make a decision on the location of strain gauges on a shaft for maximum accuracy. Finally, the differences in error from different possible configurations are compared and a conclusion has been made based on factorial design pertaining to design of experiments. / Momentgivare är små sensorer som används för att mäta och registrera vridmomentet på en roterande axel. Momentgivare baseras vanligtvis på trådtöjningsmätare för att mäta vridmomentetet kring axeln de är fixerade på. Det skall noteras att en ideal momentgivare endast bör mäta den yttöjning som uppkommer på grund av ett vridmoment. Den belastning som uppkommer på grund av axelns böjning kompenseras bort med hjälp av en Wheatstonebrygga. Men på grund av geometriska toleranser och monteringsfel kan kompensationen bli felaktig och då påverkas det uppmätta momentet även av böj och axialbelastningar vilket är oönskat. En analytisk modell har utvecklats med hjälp av Matlab och denna rapport undersöker de olika lastfallens bidrag till momentfelet. Användaren kan ange området där yttöjningen skall beräknas och utifrån de beräkningarna bestämma var trådtöjningsgivarna bör placeras. Inledningsvis är beräkningarna baserade på en av Atlas Copcos momentgivare och sedan har generaliserade resultat utvecklats. De teoretiska beräkningarna verifieras med hjälp av programmet ProEngineer Mechanica. Användaren kan ange vilka belastningar som axeln känner samt de geometriska toleransvärdena och modellen beräknar då ytspänningen för den valda regionen. Det huvudsakliga syftet med denna avhandling är att skapa en bättre förståelse av ytspänningen som uppkommer på grund av vridning, böjning och axiella belastningar och även geometriska imperfektioner. Modellen kan också användas för att göra beräkningar som visar var töjningsgivare bör placeras på axeln för maximal precision. Slutligen har de introducerade felet från de olika möjliga konfigurationerna jämförts och en slutsats har dragits baserat på faktorförsök.