Preclinical single-photon emission computed tomography (SPECT) is an essential tool for studying progression, response to treatment, and physiological changes in small animal models of human disease. The wide range of imaging applications is often limited by the static design of many preclinical SPECT systems. We have developed a prototype imaging system that replaces the standard static pinhole aperture with two sets of movable, keel-edged copper-tungsten blades configured as crossed (skewed) slits. These apertures can be positioned independently between the object and detector, producing an anamorphic image in which the axial and transaxial magnications are not constrained to be equal. We incorporated a 60 mm x 60 mm, millimeter-thick megapixel silicon double-sided strip detector that permits ultrahigh-resolution imaging. While the stopping power of silicon is low for many common clinical radioisotopes, its performance is sufficient in the range of 20-60 keV to allow practical imaging experiments. The low-energy emissions of ¹²⁵I fall within this energy window, and the 60-day half life provides an advantage for longitudinal studies. The flexible nature of this system allows the future application of adaptive imaging techniques. We have demonstrated ~225-μm axial and ~175-μm transaxial resolution across a 2.65 cm³ cylindrical field of view, as well as the capability for simultaneous multi-isotope acquisitions. We describe the key advancements that have made this system operational, including bringing up a new detector readout ASIC, development of detector control software and data-processing algorithms, and characterization of operating characteristics. We describe design and fabrication of the adjustable slit aperture platform, as well as the development of an accurate imaging forward model and its application in a novel geometric calibration technique and a GPU-based ultrahigh-resolution reconstruction code.

The need and desire to create robust and accurate joining of materials has been one of up most importance throughout the course of history. Many forms have often been employed, but none exhibit the strength or durability as the weld. This study endeavors to explore some of the aspects of welding, more specifically relating to the Double Sided Arc Welding process and how best to model the dynamic non-linear response of such a system. Concepts of the Volterra series, NARMAX approximation and neural networks are explored. Fundamental methods of the neural network, including radial basis functions, and Back-propagation are investigated.

How can a textile designer work in an exploratory way to find methods and taking advantage as much of a fabrics surfaces as possible?   This work explores a combination of techniques as laser cutting and transfer printing, how they can be developed and combined to influence each other. The aim of this project is to explore the combined techniques of laser cutting and transfer printing, with a focus on designing adjustable printed textiles.   Through a method in practical working, exploration was carried out in techniques like laser cutting and transfer print, as well as the combined visual expression of several patterns with cut-outs and modularity.   The result of this project is three pieces each representing adjustment in different combinations; One adjustable repeat, modularity, and modularity with cutouts. All three except one consist of two repeated patterns on each side of the fabric. They present examples of how a textile can be changed, the relation between construction and surface print. They all show that a printed textile could be more than just a static surface.   By taking the method of printing two patterns and use laser cutting gives a value for both sides of the fabric and shows how to produce printed textiles with modularity. Additional material or more prints and colors could be investigated further.

Made available in DSpace on 2017-07-10T17:48:01Z (GMT). No. of bitstreams: 1 Camila_Andrine_Hunoff.pdf: 2006508 bytes, checksum: a3e8f500b1cd79a42581254e91a7ba6d (MD5) Previous issue date: 2015-03-31 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Two experiments were conducted in order to evaluate the storage conditions of the Bermuda grass for hay production. In the first experiment was evaluated the storage period on the nutritional composition in the internal and external portions of Bermuda grass bales for 64 days. The experimental design was a randomized complete block in a split-plot arrangement so that in the main plots were allocated the four storage environments on field under clear plastic canvas, double-sided canvas and without canvas and covered shed with side walls and in the split-plots the four periods 20, 30, 34 and 64 days with 5 replications. There was a significant difference, in the storage conditions in the inner portion of the Bermuda grass bale, for CP, NDIP, NDF, hemicellulose and soluble carbohydrates content presenting higher values for closed shed and double-sided canvas. On the external portion of the bale, there was a significant difference, only to soluble carbohydrates content in closed shed conditions and double-sided canvas, with concentrations of 33.31 dag/Kg of DM to 27.05 dag/Kg of DM respectively. Regarding the storage time, there was a linear and quadratic effect on DM, MM, CP, ADIP, NDIP, NDF, cellulose, and soluble carbohydrates, decreasing after 34 days of storage and extending throughout the experimental period. In turn there was a linear increase to the levels of lignin and hemicellulose, rising throughout the experimental period. In a second experiment was evaluated the occurrence of mold in Bermuda grass hay in the inner and outer portion of the bales in four storage conditions: on field under clear plastic canvas, double-sided canvas and without canvas and covered shed with side walls, using a randomized block design with split-plots, in the main plots the four storage environments were assigned and in the split-plots the four periods: before baling, 20, 34 and 64 days with five replications. It was observed mold growth in Bermuda grass in all environment studied, with marked population of Aspergillus and Penicillium throughout the experimental period. In all storage conditions assessed the bale temperature was always greater than or equal to the room temperature. However the hay stored on field without canvas, showed higher moisture 22% with high temperatures above 45°C, causing heating of the stored hay and thus showing not be the best choice to producers when storing hay / Realizou-se dois experimentos com o objetivo de avaliar as condições de armazenamento do capim-vaquero, destinado à produção de feno. No primeiro experimento, avaliou-se o período de armazenamento sobre a composição bromatológica nas porções interna e externa de fardos de capim vaquero por 64 dias. O delineamento, utilizado, foi em blocos casualizados em esquema de parcelas subdivididas no tempo, de forma que nas parcelas foram alocados os quatro ambientes de armazenamento a campo sob lona plástica transparente, lona dupla face e sem lona a galpão fechado, coberto com paredes laterais e nas sub parcelas os quatro períodos 20, 30, 34 e 64 dias com 5 repetições. Verificou-se diferença significativa nas condições de armazenamento na porção interna do fardo de capim-vaquero, para os teores de PB, PIDN, FDN, hemicelulose e carboidratos solúveis, apresentando valores superiores para galpão fechado e lona dupla face. Na porção externa do fardo, houve diferença significativa, apenas para teor de carboidratos solúveis, nas condições de galpão fechado e lona dupla face, com concentrações de 33,31 dag/Kg de MS a 27,05 dag/kg de MS respectivamente. Em relação ao tempo de armazenamento, houve efeito linear descrescente e efeito quadrático com ponto de máxima e mínima redução sobre os teores de MS, MM, PB, PIDA, PIDN, FDN, celulose, e CHOʼS, apresentando decréscimo após 34 dias de armazenamento e estendo-se ao longo do período experimental. Por sua vez, houve efeito linear crescente para os teores de lignina e hemicelulose, elevando-se ao longo do período experimental. Num segundo experimento, avaliou-se a ocorrência de fungos em feno de capim-vaquero na porção interna e externa dos fardos sob quatro condições de armazenamento a campo, sob lona plástica transparente, lona dupla face e sem lona, a galpão fechado coberto com paredes laterais, utilizando o delineamento experimental em blocos casualizados com parcelas subdivididas no tempo de forma que nas parcelas foram alocados os quatro ambientes de armazenamento e nas sub-parcelas os quatro períodos: antes de enfardar, 20, 34 e 64 dias com cinco repetições. Observou se desenvolvimento de fungos no feno de capim-vaquero em todos os ambientes estudados, com acentuada população dos gêneros Aspergillus e Penicillium ao longo de todo o período experimental. Em todas as condições de armazenamento, avaliadas, a temperatura do fardo sempre foi maior ou igual a temperatura ambiente. Porém, o feno armazenado a campo sem lona, apresentou maior umidade 22% com elevadas temperaturas superiores a 45°C, acarretando aquecimento do feno, armazenado e, assim, mostrando não ser a melhor escolha para o produtor quando for armazenar feno

Forms of abuse of dominance in the area of the Internet platforms The thesis is dedicated to the topic of abuse of dominant position in the area of the Internet platforms. Its aim is, firstly, to outline the challenges arising from the specific nature of the area, which might, from the competition-authorities' point of view, complicate the enforcement of competition law in the case of abuse of dominance. Secondly, the thesis tries to find the answer on the question to what extent these problems have been reflected in the existing decision-making practice. The structure of the thesis is divided into four main parts. The first part is an introduction. The second part provides an essential introduction to the area in question. It defines the term "Internet platform", provides an overview of the most important types of the Internet platforms and describes the specifics of the area in question, whose description is essential for the following parts. The third part analyses the problems that competition law may face in the context of possible abuse of dominance within the meaning of Art. 102 TFEU in the area of the Internet platforms. This section is divided according to three basic steps of a competition analysis of abuse of dominance, i.e. definition of the relevant market, the determination of market...

Submitted thesis called "Integration of foreigners as a double-sided process" studies a complicated process of integration of foreigners into majority society of the Czech republic. The goal of the thesis is the research of the young people's opinions and attitudes to the so-called third-country foreigners and integration of foreigners into the Czech society. Farther in the thesis is presented the positive example of the integration of foreigners in practice. On the basis of that, in the thesis also will be shown the own draft of the multicultural education project that targets to improve an integration in education system.

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Double-sided module exhibits electrical and thermal characteristics that are superior to wire-bonded counterpart. Such structure, however, induces more than twice the thermo-mechanical stress in a single-layer structure. Compressive posts have been developed and integrated into the double-sided module to reduce the stress to a level acceptable by silicon dice. For a 14 mm x 21 mm module carrying 6.6 mm x 6.6 mm die, finite-element simulation suggested an optimal design having four posts located 1 mm from the die; the z-direction stress at the chip was reduced from 17 MPa to 0.6 MPa. / Ph. D.

Made available in DSpace on 2016-04-26T20:21:54Z (GMT). No. of bitstreams: 1 Antonio Sergio Cordeiro Piedade.pdf: 864222 bytes, checksum: d3582818ffd5715d01a1141977d6da40 (MD5) Previous issue date: 2013-06-19 / This paper aims to make a critical analysis of the punitive system, with a focus on criminal organizations. Nowadays we break free from the paradigm of rude crimes which makes us draw a new perspective to the Criminal Law, in the conception of a democratic state, where the criminal response must be considered for the organized crime, faceless, transnational, which often presents tentacles within the apparatus of the state itself and is an affront to democracy. Within this context, we will analyze the evolution of different forms of state and the dimensions of fundamental guarantees, with discussions about the importance of the constitutional principles of criminal law not only related to limiting, but also in the basis and in the legitimating of a current criminal justice system, in which threats do not come only from the state, like in the past, but from a diffuse criminality. The State must act within this perspective to ensure the fundamental guarantees not only of the agent who violated the criminal standard, but also of society. The double sided proportionality principle, especially in the aspect of the prohibition of poor protection emerges as an instrument of materialization of human dignity , so that it is not allowed for them to violate the fundamental rights in their collective bias, with a failure protection of the highest values of a society in order to ensure a harmonious coexistence in society, through an efficient crime policy that preserves the democratic healthiness and credibility of republican institutions / O presente trabalho tem por objetivo fazer uma análise crítica do sistema punitivo, com foco nas organizações criminosas. Hodiernamente rompemos com o paradigma do crime artesanal o que impõe traçarmos uma nova perspectiva para o Direito Penal, dentro da concepção de um Estado Democrático de Direito, onde a resposta penal precisa ser pensada para uma criminalidade organizada, sem rosto, transnacional, que, muitas vezes, encontra-se com tentáculos dentro do aparato do próprio Estado e representa uma afronta à democracia. Dentro desse contexto, será analisada a evolução das diferentes formas de Estado e as dimensões das garantias fundamentais, com a discussão acerca da importância dos princípios constitucionais do Direito Penal não somente na limitação, mas também na fundamentação e na legitimação de um sistema penal atual, no qual as ameaças não partem, como no passado, exclusivamente do Estado, mas de uma criminalidade difusa. O Estado, dentro desta perspectiva, deve agir para assegurar as garantias fundamentais do agente que violou a norma penal, mas também da sociedade. A dupla face do princípio da proporcionalidade, notadamente na vertente da proibição da proteção deficiente, surge como um instrumento de materialização da dignidade da pessoa humana de índole social, de modo a não permitir que se vulnerem os direitos fundamentais em seu viés coletivo, com uma insuficiência de proteção aos valores mais caros de uma sociedade, visando assegurar uma convivência harmônica em sociedade, mediante uma política criminal eficiente que preserve a higidez democrática e a credibilidade das instituições republicanas