La línia temàtica que ocupa el contingut fonamental d'aquesta tesi és la presentació de les visions més significatives en materia de identitat moral, i que podem discernir en el fil de la història de las idees. En la retrospectiva històrica que he desenvolupat he volgut mostrar l'evolució del concepte d'humanitat. La reconstrucció d'aquesta idea ha estat possible a través de la recuperació de tres paradigmes conceptuals: la visió del món grec, que s'expressa a través del moment aristotèlic; la visió cristiana, a través del pensament de sant Agustí; i el periode il·lustrat des de la filosofia de Kant. La clau interpretativa utilizada para abordar el pensament dels autors esmentats constitueix un enfoc analític adreçat als conceptes rellevants que composen els seus respectius discursos; tant pel què fa a l'antropologia filosòfica, com al pensament moral i social. A partir d'aquest tipus d'anàlisi ha estat possible el reestabliment del nexe, siempre subjacent, entre la teoria antropològica, i la filosofia moral i social. Per la qual cosa, els diferents conceptes de natura humana, que se'ns descobreixen a través del viatge per les fases claus de la història de la filosofia, mantenen un vincle molt estret amb els valors que prescriuen el marc de la legitimitat moral. Aquest retrat antropològic és, a la vegada, concordant amb els elements que defineixen el fonament d'allò que anomenem social en cada periode històric. La reflexió sobre l'estructura de l'esser humà, entesa com a indissociable del pensament sobre l'acción mora i també del pensament sobre la natura de les relaciones sociales, és el que m'ha permès dilucidar la gènesi i l'evolució en el contingut conceptual de la idea d'humanitat. Aristòtil va comprendre constitutivament a l'ésser humà des de l'ontologia de l'ésser natural, des d'aquesta premisa, l'ésser humà és essencialment natura. Quan des de el paradigme aristòtelic la humanitat s'ha pensat com a natura, el seu contingut s'ha explicat en termes de gènere. El gènere es defineix per una qualitat essencial que és l'intel·lecte. Així, per Aristòtil som humans en la mesura que ens reconeixem en el gènere. Aquest reconeixement significa justament retrobar-se en la vida de l'intel·lecte. La vida humana entesa des de l'exercici de l'intel·lecte posseix uns valors concordants: l'amistat, la justícia i la prudència. Aquests valors, als quals Aristòtil anomena virtuts, fan possible que el vincle social es fonamenti en una mateixa forma de vida i en un projecte comú d'existència. La fórmula de reconeixement pels humans que planteja el paradigme aristotèlic condueix a una comunitat de natura. Sant Agustí va comprendre constitutivament a l'ésser humà des de l'ontologia de l'ésser personal. Quan des del paradigme agustinià l'humanitat s'ha pensat com a persona el contingut d'aquesta humanitat s'ha explicat en termes de condició. En aquest cas el reconeixement del caràcter de l'ésser humà es produeix pel retrobament en una situació paral·lela respecte a un principi creador. Tal situació consisteix a tenir el mateix grau de proximitat en l'estatus per part dels ésssers creats i respecte el principi creador. A diferència del gènere aristotèlic la condició agustiniana remet a la singularitat de l'existència. En aquest cas la voluntat és l'atribut dels humans com a éssers creats. La vida humana entesa des de l'exercici de la voluntat posseix també un valor concordant que es la gratuïtat. Aquest valor, que sant Agustí li atribueix a la vegada un sentit ontològic i moral és el fonament de la concepció agàpica de l'amor. El fonament de la teoría social agustiniana és justament el contingut de l'amor quan es defineix com a inclinació indiscriminada i il·limitada. Finalment, en l'últim paradigme que correspon al moment de la filosofia kantiana es compren a l'ésser humà des de l'ontologia de l'ésser subjecte. La humanitat del subjecte s'ha explicat en termes d'autonomia. La vida del individu autònom es desenvolupa des de l'anomenada raó pràctica. La vida humana entesa com a individualitat té com a atribut fonamental aquesta raó pràctica. El exercici de la raó pràctica es correspon a la autonomia individual de la misma forma que l'exercici de la voluntat es corresponia a la condició en el pensament de sant Agustí, i l'intel·lecte es corresponia al gènere en la filosofia Aristòtelica. He mostrat en aquesta tesi que el pensament de cadascun dels autors esmentats constitueix respectivament, un paradigme conceptual. Es tracta, tant en el model aristotèlic, com en l'agustinià, com en el mateix model kantià de discursos sobre la realitat de l'ésser humà en el quals conflueixen els pressupòsits antropològics, ètics i socials. El repàs per la coherència en els resultats en aquestes tres formes de pensament constitueix la única fórmula que ens permet, avui, reelaborar una definició dels continguts que conformen el caràcter moral de la nostra humanitat. / The thematic line comprising the basic content of this thesis is the exposition of the principal views in respect of moral identity to be found running through the history of thought. The historical retrospection that I have set out here shows the development of a concept of humanity whose reconstruction has been possible through the recovery of three conceptual paradigms: the view of the Greek world, as expressed through the moment of Aristotle, the Christian view, through the thought of Saint Augustine, and the Enlightenment, as seen in the philosophy of Kant.The interpretive key used to examine the thought of these authors constitutes an analytical approach focusing on the pertinent concepts comprising their respective discourses, both in respect of philosophical anthropology and of moral and social thought. On the basis of this type of approach, it has been possible to re-establish the consistently underlying nexus between anthropological theory and moral and social philosophy. Thus, the different concepts of human nature, revealed in the key periods of the history of philosophy, are seen to be linked closely to the values that prescribe the framework of moral legitimacy. This anthropological view is, in turn, in agreement with the defining elements of social issues in each historical period. Reflection on the structure of human beings, seen as being inseparable from thought on moral action and thought on the nature of social relationships, makes it possible to clarify the origin and evolution of the conceptual content of the idea of humanity.Aristotle understood human beings constitutively on the basis of the ontology of the natural being, taking human beings as essentially nature. Where the Aristotelian paradigm has been applied and humanity thought of as nature, its content has been explained in terms of genus. The genus is defined by an essential quality, namely the intellect. Thus, in Aristotle's view, we are humans insofar as we recognise ourselves in the genus. This recognition signifies a re-encounter in the life of the intellect. On the basis of exercise of the intellect, human life has concordant values: fellowship, justice and prudence. These values, recognised by Aristotle as virtues, permit the existence of a social bond based on a common form of life and a common aspiration to existence. The formula of recognition for human beings set out by the Aristotelian paradigm leads to a commonality of nature.Saint Augustine understood human beings constitutively on the basis of the ontology of the personal being. Where the Augustinian paradigm has been applied and humanity thought of as personal, its content has been explained in terms of condition. In this case recognition of the character of human beings is produced by the re-encounter in a parallel situation in respect of a creator principle. This situation consists of proximity in the status of created being. Unlike the Aristotelian genus, the Augustinian condition refers back to the singularity of existence. In this case, will is the attribute of humans as created beings. Human life understood on the basis of the exercise of will also has a concordant value in gratuitousness. This value, to which Augustine in turn attributes an ontological and moral sense, is the basis of the concept of love as agape. The foundation of Augustine's social theory is precisely the content of love when defined as an indiscriminate and unlimited inclination.Lastly, in the final paradigm, corresponding to the moment of Kantian philosophy, human beings are understood on the basis of the ontology of the subject being. The humanity of the subject has had to be explained in terms of autonomy. The life of the autonomous individual is developed on the basis of what is known as practical reason. Human life understood as individuality has practical reason as its fundamental attribute. The exercise of practical reason corresponds to individual autonomy, just as the exercise of will corresponds to condition in Saint Augustine and intellect corresponds to genus in Aristotle.I have shown in this thesis that the thought of each of these authors constitutes, respectively, a conceptual paradigm. What is found, in the Aristotelian model, the Augustinian model and the Kantian model as well, is a discourse on the reality of human beings in which anthropological, ethical and social suppositions are combined. The review of the coherence of these three forms of thought constitutes the only formula available to us today that will allow a redefinition of the contents making up the moral character of our humanity.

No description available.

Brahms is an important German romantic composer.In additional to his outstanding output in orchestral composition, he also finished thirty-four female choral pieces. Most of them were written during 1857-62, when he was still in Hamburg and dirdcting the Hamburg Women's Chorus. Opus17 belongs to this category. It is for three-part female choir, with harp and horns as the accompaniment. It includes four short pieces, text in German, with the feeling of lament. The form is simple and clear. The texture is mostly choral. The melodies in each vocal part are not difficult; however, it is the harmonic color that gives this work its special taste. This thesis consists of five chapters. The first chapter is the introduction. The second chapter inclides three parts. Part one introduces the life of Brahms. Part two is the chronological discussion of Brahms choral composing. Part three focuses on the female choral works. The third chapter analyzes the four pieces of Brahms Opus 17. The fourth chapter presents suggestions for teaching Opus 17, including vocalization, interpretation, diction, and conducting technique. The fifth chapter draws conclusion from the study.

Thèse de doctorat : Sciences de la vie et de la santé : Tours : 2008. / Titre provenant de l'écran-titre.

Nitrate is a common groundwater contaminant. Due to adverse health effects, waters above the Maximum Contaminant Level (MCL) of 10 mg NO3-N/L or 0.71 mmols/L, are banned from domestic consumption by the EPA. Studies have measured elevated nitrate concentrations in arid land soils and groundwater around the world. These elevated concentrations could be detrimental to the environment and to human health. Thus, it is important to consider the different sources and processes affecting nitrate concentrations Here, a novel triple isotope system approach was employed, coupling δ17O with δ18O and δ15N of nitrate to determine the sources (atmospheric, terrestrial, fertilizer, wastewater) and removal processes influencing nitrate concentrations in the Tucson basin groundwater system. Results show low groundwater nitrate concentrations (0.2 mmols/L) where wastewater was not a predominant source of water, versus high concentrations (1 mmols/L) above the MCL in groundwaters where wastewater was the dominant water source. Furthermore, groundwater up to 1.6 Km away from the wastewater stream was contaminated with effluent recharge waters. In addition, denitrification was inferred from δ18O and δ15N data with this inference reinforced by δ17O data and δ15N enrichments up to 26. Finally, low atmospheric nitrate was measured in groundwater, representing up to 6% of total nitrate. The triple isotope approach studied here is ideal for determining the proportion of atmospheric nitrate versus other terrestrial nitrate sources and the significance of nitrate removal processes.

Akt (also called PKB) is a 63 kDa serine/threonine kinase involved in promotion of cell survival, proliferation a nd metabolic responses downstream the phosphoinositide-3-kinase (PI 3-kinase) signaling pathway. In resting cells, Akt is a predominantly cytosolic enzyme; however generation of PI 3-kinase lipid products recruits Akt to the plasma membrane, resulting in a conformational change which confers full enzymatic activity through the phosphorylation of the membrane-bound protein at two residues, Thr308, and Ser473. Activated Akt redistributes to cytoplasm and nucleus, where phosphorylation of specific substrates occurs. Both the presence and the activity of Akt in the nucleus have been described. An interesting mechanism that mediates nuclear translocation of Akt has been described in human mature T-cell leukemia: the product of TCL1 gene, Tcl1, interacts with the PH domain of phosphorylated Akt, thus driving Akt to the nucleus. In this context, Tcl1 may act as a direct transporter of Akt or may contribute to the formation of a complex that promotes the transport of active Akt to the nucleus, where it can phosphorylate nuclear substrates. A well described nuclear substrate if Foxo. IGF-1 triggers phosphorylation of Foxo by Akt inside the nucleus, where phospho-Foxo associates to 14.3.3 proteins that, in turn, promote its export to the cytoplasm where it is sequestered. Remarkably, Foxo phosphorylation by Akt has been shown to be a crucial event in Akt-dependent myogenesis. However, most Akt nuclear substrates have so far remained elusive, as well as nuclear Akt functions. This lack of information prompted us to undertake a search of substrates of Akt in the nucleus, by the combined use of 2D-separation/mass spectrometry and anti-Akt-phosphosubstrate antibody. This study presents evidence of A-type lamins as novel nuclear substrates of Akt. Lamins are type V intermediate filaments proteins found in the nucleus of higher eukaryotes where, together with lamin-binding proteins, they form the lamina at the nuclear envelope, providing mechanical stability for the nuclear membrane. By coimmunoprecipitation, it is demonstrated here that endogenous lamin A and Akt interact, and that A-type lamins are phosphorylated by Akt both in vitro and in vivo. Moreover, by phosphoaminoacid analysis and mutagenesis, it is further demonstrated that Akt phosphorylates lamin A at Ser404, and, more importantly, that while lamin A/C phosphorylation is stable throughout the cell cycle, phosphorylation of the precursor prelamin A becomes detectable as cells enter the G2 phase, picking at G2/M. This study also shows that lamin phosphorylation by Akt creates a binding site for 14.3.3 adaptors which, in turn, promote prelamin A degradation. While this mechanism is in agreement with a general role of Akt in the regulation of a subset of its substrates, opposite to what has been described, degradation is not mediated through a ubiquitination and proteasomal mechanism but through a lysosomal pathway, as indicated by the reverting action of the lysosomal inhibitor cloroquine. Phosphorylation is a key event in the mitotic breakdown of the nuclear lamina. However, the kinases and the precise sites of phosphorylation are scarcely known. Therefore, these results represent an important breakthrough in this very significant but understudied area. The phosphorylation of the precursor protein prelamin A and its subsequent degradation at G2/M, when both the nuclear envelop and the nuclear lamina disassemble, can be view as part of a mechanism to dispose off the precursor that is not needed in this precise context. The recently reported finding that patients affected by Emery-Dreifuss muscular dystrophy carry a mutation at Arg 401, in the Akt phosphorylation motif, open new perspective that warrant further investigation in this very important field.

Pig meat quality is determined by several parameters, such as lipid content, tenderness, water-holding capacity, pH, color and flavor, that affect consumers’ acceptance and technological properties of meat. Carcass quality parameters are important for the production of fresh and dry-cure high-quality products, in particular the fat deposition and the lean cut yield. The identification of genes and markers associated with meat and carcass quality traits is of prime interest, for the possibility of improving the traits by marker-assisted selection (MAS) schemes. Therefore, the aim of this thesis was to investigate seven candidate genes for meat and carcass quality traits in pigs. In particular, we focused on genes belonging to the family of the lipid droplet coat proteins perilipins (PLIN1 and PLIN2) and to the calpain/calpastatin system (CAST, CAPN1, CAPN3, CAPNS1) and on the gene encoding for PPARg-coactivator 1A (PPARGC1A). In general, the candidate genes investigation included the protein localization, the detection of polymorphisms, the association analysis with meat and carcass traits and the analysis of the expression level, in order to assess the involvement of the gene in pork quality. Some of the analyzed genes showed effects on various pork traits that are subject to selection in genetic improvement programs, suggesting a possible involvement of the genes in controlling the traits variability. In particular, significant association results have been obtained for PLIN2, CAST and PPARGC1A genes, that are worthwhile of further validation. The obtained results contribute to a better understanding of biological mechanisms important for pig production as well as for a possible use of pig as animal model for studies regarding obesity in humans.

In un quadro internazionale di forte interesse verso uno sviluppo sostenibile e sfide energetiche per il futuro, il DIEM, in collaborazione con altri istituti di ricerca ed imprese private, sta progettando l’integrazione di componentistica avanzata su di una caldaia alimentata a biomasse. Lo scopo finale è quello di realizzare una caldaia a biomasse che produca energia in maniera più efficiente e con un impatto ambientale ridotto. L’applicazione è indirizzata inizialmente verso caldaie di piccola-media taglia (fino a 350 kW termici) vista la larga diffusione di questa tipologia di impianto. La componentistica in oggetto è: - filtro sperimentale ad alta efficienza per la rimozione del particolato; - celle a effetto Seebeck per la produzione di energia elettrica direttamente da energia termica senza parti meccaniche in movimento; - pompa Ogden per la produzione di energia meccanica direttamente da energia termica; La finalità dell’attività di ricerca è la progettazione dell’integrazione dei suddetti dispositivi con una caldaia a biomassa da 290 kW termici per la realizzazione di un prototipo di caldaia stand-alone ad impatto ambientale ridotto: in particolare, la caldaia è in grado, una volta raggiunte le condizioni di regime, di autoalimentare le proprie utenze elettriche, garantendo il funzionamento in sicurezza in caso di black-out o consentendo l’installazione della caldaia medesima in zone remote e prive di allaccio alla rete elettrica. Inoltre, la caldaia può fornire, tramite l'utilizzo di una pompa a vapore o pompa Ogden, energia meccanica per il pompaggio di fluidi: tale opportunità si ritiene particolarmente interessante per l'integrazione della caldaia nel caso di installazione in ambito agricolo. Infine, l'abbinamento di un filtro ad alta efficienza e basso costo consente l'abbattimento delle emissioni inquinanti, favorendo una maggiore diffusione della tecnologia senza ulteriori impatti sull'ambiente. / In a context of international interest in sustainable development and energy challenges for the future, DIEM, in collaboration with other research institutes and private companies, is planning the integration of advanced components of a biomass-fired boiler. The final aim is to provide a biomass boiler which produces energy more efficiently and with a reduced environmental impact. The application is initially targeted towards small to medium size boilers (up to 350 kW thermal) view of the prevalence of this type of system. The component is: - Experimental high efficiency filter for particulate removal; - Seebeck effect cells for the production of electrical energy directly from thermal energy without moving mechanical parts; - Ogden pump for the production of mechanical energy directly from thermal energy; The purpose of research is the design of the integration of these devices with a biomass boiler from 290 kW thermal for the realization of a prototype of a stand-alone boiler to reduced environmental impact: in particular, the boiler is able, upon reaching the steady state, toe feed its own electric utilities, to ensure safe operation in case of power failure or to allow the installation of the boiler in remote areas with no connection to the grid. In addition, the boiler can be provided through the use of a steam pump or pump Ogden mechanical energy for pumping fluids: this opportunity is considered particularly interesting for the integration of the boiler in the case of installation in the agricultural field. Finally, the combination of a high efficiency and low cost filter allows the reduction of particulate emissions, by increasing the dissemination of technology without additional impacts on the environment.

El trabajo presenta un estado de la cuestión, destacándose los aportes y los investigadores más representativos de las Comunidades Discursivas de Historia de la Educación, entre ellos: Argentina, Brasil, Colombia, México, Chile, y Venezuela. Se abunda en el surgimiento y desarrollo de la bibliografía relativa a los temas específicos de este trabajo, esto es, la formación de grupos académicos y tomando en cuenta algunos de los indicadores bibliométricos. El Corpus Teórico se inicia con el curriculum como historia social, y la construcción del campo intelectual en Venezuela. En paralelo se analiza las políticas educativas del Estado venezolano en materia de ciencia y tecnología (1998-2008). Luego se tocan otros temas como la importancia del debate postmoderno, las apreciaciones deontológicas de la universidad a debate. Lo propio sucede con el balance sobre la historia de la universidad en Venezuela, y la evolución de la historia de la educación. / This work represents a state of the question, standing out the contributions and the most representative investigators of the Discursive's Community of The History of Education, among them: Argentina, Brazil, Colombia, Mexico, Chile, and Venezuela. We focus in the sprouting and development of relative bibliography about specific subjects on this work, this is, the conformation of academic groups and looking some of the bibliométric indicators. The Theoretical Corpus begins with the curriculum social history, and the construction of the intellectual field in Venezuela. In parallel on it, analyze the educative policies of the Venezuelan State in the matter of science and technology (1998-2008). Then it strokes other subjects as the importance of the postmodern debate, the deontological appreciations from the university to debate. The own thing happens to the balance on the history of the university in Venezuela, and the evolution of the history of the education.

Este trabajo tiene como objetivo principal ofrecer un modelo filosófico de la ciencia que asuma la complejidad de la dinámica de sus diferentes procesos y actividades. Para ello, se partirá de un enfoque naturalizado de la filosofía de la ciencia, en el que se utilizará la investigación en ciencias cognitivas y sus hallazgos empíricos y conceptuales sobre el funcionamiento de la mente humana y la naturaleza de los procesos cognitivos para sentar las bases de cómo llevan a cabo los científicos las actividades de experimentación y teorización, así como la relación entre ellas. Los modelos filosóficos de la ciencia que han predominado desde los inicios de esta disciplina hasta la actualidad nos han permitido comprender esta actividad humana con mayor profundidad, y nos han dejado un legado inestimable de herramientas de análisis lógicas y conceptuales. Sin embargo, hay aún algunos obstáculos por superar. Por un lado, los modelos en filosofía de la ciencia que han ocupado la hegemonía de la disciplina hasta la actualidad han enfatizado algunos aspectos de la actividad científica, dejando otros como algo secundario, lo que ha llevado a analizar la ciencia de un modo parcial. Por otro lado, estos modelos han partido de unos presupuestos acerca de cómo funciona la mente humana (que no han sido explicitados). Posteriormente, cuando en el campo de las ciencias cognitivas se han estudiado en mayor profundidad estos presupuestos por modelos cognitivos inspirados parcialmente en los modelos de la filosofía de la ciencia, han aparecido problemas conceptuales y empíricos que han llevado a las ciencias cognitivas a descartar estos modelos explicativos y buscar otras bases conceptuales desde las que estudiar la cognición humana. Para superar estos obstáculos, antes de centrarnos en el desarrollo de un modelo filosófico de la ciencia, dedicaremos una parte de esta tesis a proponer una teoría unificada e integrada de la cognición, que denominaremos ‘experiencialismo’. Esta teoría partirá de los últimos hallazgos en ciencias cognitivas para partir de una base sólida. De este modo evitaremos partir de supuestos de la mente que posteriormente presenten problemas para explicar cómo funciona la cognición humana. En nuestro caso, partiremos de la base de que todos los procesos cognitivos (desde la percepción hasta el razonamiento abstracto) parten y se anclan en las bases corporales e interactivas de nuestra especie. En este sentido, decimos que nuestra teoría es una teoría unificada, ya que basa todos los procesos cognitivos en una misma propiedad fundamental de nuestra experiencia. Por otro lado, el modelo experiencialista de la cognición asumirá el reto de explicar de un modo coherente e integrado todas las propiedades de la cognición humana que han sido estudiadas por los modelos anteriores, ofreciendo así una imagen compleja de la cognición, en la que los diferentes procesos cognitivos parten de una misma base corporal e interactiva pero luego se relacionan entre sí de un modo dinámico y bidireccional, llegando a transformar nuestra propia experiencia, así como las estructuras materiales del mundo. Sentadas las bases del modelo ‘experiencialista’ estaremos preparados para ofrecer un modelo filosófico de la ciencia capaz de explicar los diferentes elementos de la misma, así como las relaciones entre ellos. En nuestro trabajo nos limitaremos al análisis de la teoría y la experimentación científica, dejando de lado otros aspectos como los modelos conceptuales no teóricos, o métodos observacionales y cuasiexperimentales. En primer lugar, analizaremos separadamente la experimentación y la teoría. Veremos qué propiedades de la cognición estudiadas en el modelo experiencialista se utilizan en cada una de estas actividades de la ciencia, y cómo cada una de ellas conduce a diferentes resultados desde el punto de vista epistémico. También analizaremos el modo en que teoría y experimentación se anclan de un modo diferente en las bases corporales e interactivas de la experiencia y la cognición. Finalmente, y lo que nos parece más importante, analizaremos de qué manera teoría y experimentación generan una dinámica interactiva y bidireccional, que da como resultado la objetivación de diferentes dominios de la experiencia humana. La idea principal de esta tesis es que la actividad experimental y la teoría tienen una autonomía relativa la una con respecto a la otra (a pesar de tener una base corporal e interactiva común), pero que es en su dinámica donde la ciencia produce sus mayores logros epistémicos, y una transformación efectiva del mundo y de nuestra experiencia mediante el desarrollo tecnológico. La teoría se convertirá de este modo en un aspecto esencial de la ciencia para llevar a la experimentación en nuevos dominios más allá de sí misma, partiendo de dominios de la experiencia que han alcanzado previamente un mayor nivel de objetivación. / This work has as a main goal to offer a philosophical model of science. This model has to be able to account for the complexity of the dynamics of scientific practices. In order to do that, we assume a naturalized approach to philosophy of science, in which we use the research in cognitive science, at an empirical as well as at a conceptual level, considering what they conclude about the working of human mind and the nature of our cognitive processes. We will take in account this information to make a model of science and explain the way scientists carry out their theoretical and experimental research. Philosophical models of science existing since its beginnings until today have allowed us to understand science in a deeper way, and they have given us an invaluable legacy of logical and conceptual tools of analysis. However, there are some obstacles to overcome. On one side, philosophical models of science that have been dominant have emphasized some aspects of science, taking others as someone secondary. This has allowed to analyze very deep some aspects of science, but in a partial way. On the other side, these models start of assumptions about how the human mind works (without being stated explicitly). Subsequently, these assumptions have been studied in cognitive science (being this discipline partly inspired in philosophical models of science), and they have had some conceptual and empirical problems. Consequently, cognitive scientists have ruled out these assumptions, looking for other conceptual basis to understand human cognition. In order to overcome these problems, we will dedicate a central part of this thesis to propose an unified and integrated theory of human cognition, that we call ‘experientialism’. This theory start from the last findings in cognitive science to establish a solid basis of our next analysis. Likewise, we avoid to start from assumptions of mind and cognition that can carry unexpected problems to explain how human cognition (and, therefore, scientific activity), works. In our case, we take the assumption that every cognitive process (from perception to abstract reasoning) comes out and is anchored or embedded in the corporal and interactive properties of human race. In that sense, we state that our theory is unified, since it acnhors every cognitive process in a unique and fundamental propoerty of our experience. On the other side, experiential theory of human cognition has the challenge of explaining in a coherent and integrated way every cognitive property of human cognition analyzed before for previous models of cognition, giving an integrated view of complexity of human cognition, in which different cognitive processes start from the same bodily and interactive basis, but go beyond, and lastly they relate to each other in a dynamical and bidirectional way, transforming our own experience, as well as the material structures of the world we live in. Given these basis of experientialist model of cognition, we will be ready to develop a philosophical model of science able to account for its different aspects, as well as the relationship between them. We will resctrict our analysis of theory and experimentation in science, leaving other aspects as pretheoretical (or atheoretical) conceptual models, and observational and quasi-experimental methods. Firstly, we analyze experimentation and theory separately. We will study what properties of cognition mentioned in the experientialist model of cognition are related to each one of these aspects of science, and the way how they lead to different outcomes from an epistemical point of view. We will also analyze the way theory and experimentation are both of them anchored, in a different way, in the bodily and interactive basis of experience and human cognition. Finally, the main proposal of this thesis is to highlight the way how theory and experimentation generate as interactive and bidirectional dynamics, that has as a result the objetivation of new domains of human experience. The main idea of this thesis is that experimental and theoretical activities have a relative autonomy to each other (although they have the same bodily and interactive basis), but it is in their dynamical relations where science produces its most important epistemological achievements, and an effective transformation of our experience and the material structures of the world we live in, by technological development. Theory in science is, in this way, an essential part of science, as long as it allows carry the experimentation in new domains of experience beyond itself, starting from phenomena that have got before a greater level of objetivation.