Global ETD Search

281	Development of a Closed-Loop, Implantable Electroceutical Device for Glaucoma Jay V Shah (11197311) 28 July 2021 (has links) <p>Glaucoma is the leading cause of irreversible blindness worldwide. While current therapies aim to lower elevated intraocular pressure (IOP) to prevent blindness, they often do not provide the desired long-term efficacy, can fail over time, and have systemic side effects. Electroceutical stimulation can be a solution to many of these current issues with glaucoma treatment, as it is believed to have fewer systemic side effects and quicker response times. The goal of this work is to develop and demonstrate a novel system using electrical stimulation to lower intraocular pressure. I present data from a human clinical study and an ongoing clinical trial of the IOPTx™ system, a wearable electroceutical for treating glaucoma, that provides preliminary evidence of efficacy and safety. <a>Furthermore, no current glaucoma treatments allow for closed-loop, continuous monitoring of IOP, requiring more frequent doctor visits or forcing patients and clinicians to operate in the dark. Using an electroceutical therapeutic device with closed-loop feedback and continuous IOP recording can improve glaucoma management. I combined a pressure sensor with this electroceutical therapy, implanted the sensor and stimulation coils in rabbits, and stimulated the eyes. However, to better understand the optimal stimulation parameters, long-term effects, and mechanisms of action, an integrated circuit is designed as part of a fully implantable, closed-loop device. The chip was fabricated in 0.18 </a>µm CMOS process and validated on the benchtop and <i>in vivo</i>. In the future, this electroceutical device has the potential to be a novel treatment for patients suffering from glaucoma.</p> Biomedical Instrumentation Medical Devices ASIC Integrated Circuit Electrical Stimulation Circuit Design Pressure Sensing Glaucoma Implantable Wearable Contact Lens Ophthalmology
282	INFRARED NEURAL STIMULATION AND FUNCTIONALRECRUITMENT OF THE PERIPHERAL NERVE Peterson, Erik J. 19 August 2013 (has links) No description available. Biomedical Engineering Biomedical Research Optics Infrared neural stimulation motor recruitment selectivity electrical stimulation peripheral nerve sciatic extraneural membrane capacitance computational model
283	The Feasibility of an Upper Extremity Poststroke Neuroprosthesis Makowski, Nathaniel Steven 23 August 2013 (has links) No description available. Biomedical Engineering Biomedical Research Rehabilitation Functional Electrical Stimulation (FES) stroke reach neuroprosthesis motor control motor unit overlap upper extremity recruitment robotic assistance force
284	REANIMATION OF A DENERVATED MUSCLE USING UPPER MOTONEURON INJURED LOWER MOTONEURONS IN SPINAL CORD INJURY PATIENTS: A RAT MODEL Narayan, Sreenath January 2006 (has links) No description available. reanimation denervation reinnervation nerve transfer spinal cord injury rat peripheral nerve FES functional electrical stimulation lower motoneurons motor neurons direct spinal cord stimulation
285	Computationally Efficient Method in Predicting Axonal Excitation Izad, Olivier 27 March 2009 (has links) No description available. Anatomy and Physiology Bioinformatics Biomedical Research Mathematics activating function Deep Brain Stimuatlion, DBS Functional Electrical Stimulation, FES NEURON real time axon behavior algorithm recruitment order linear algorithm axon behavior
286	Optimized Design of Neural Interfaces for Femoral Nerve Clinical Neuroprostheses: Anatomically-Based Modeling and Intraoperative Evaluation Schiefer, Matthew Anthony 25 March 2009 (has links) No description available. Biomedical Research Engineering Flat Interface Nerve Electrode (FINE) nerve-electrode interface Functional Electrical Stimulation (FES) femoral nerve finite element method (FEM) anatomically-based modeling
287	Development of an Electromyogram-Based Controller for Functional Electrical Stimulation-Assisted Walking After Partial Paralysis Dutta, Anirban 03 April 2009 (has links) No description available. Biomedical Research Computer Science Engineering Health Care Neurology Rehabilitation gait event detector electromyogram functional electrical stimulation gait, spinal cord injury biomechanics neuroprosthesis controller
288	A Reinforcement Learning Controller for Functional Electrical Stimulation of a Human Arm Thomas, Philip S. January 2009 (has links) No description available. Computer Science reinforcement learning locally wieghted regression incremental locally weighted regression LWR ILWR ANN actor-critic continuous actor-critic functional electrical stimulation FES adaptive control
289	Command of a Virtual Neuroprosthesis-Arm with Noninvasive Field Potentials Foldes, Stephen Thomas January 2010 (has links) No description available. Biomedical Engineering Neurosciences Rehabilitation Brain Machine Interfacing Brain Computer Interfacing Electroencephalography Functional Electrical Stimulation Neuroprosthesis Spatial Filtering Rehabilitation Engineering Neural Engineering Biomedical Engineering Signal Processing
290	Optimization of High Density Nerve Cuff Stimulation in Upper Extremity Nerves Brill, Natalie Amber 06 February 2015 (has links) No description available. Biomedical Engineering Peripheral nerves neuromodulation fascicles neural engineering computational nerve model neuroprostheses nerve stimulation nerve cuff intraneural morphology functional electrical stimulation neural interface neural devices

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