Background: In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anatomic MRI or proton density weighted zero-time imaging may solve this problem in the future. However, there is an ongoing debate if the current error is acceptable for clinical use and/or research. Methods: We examined this feature for [18F] fluorodeoxyglucose (FDG) brain PET in 13 patients with clinical signs of dementia or movement disorders who subsequently underwent PET/CT and PET/MRI on the same day. Multiple MR-AC approaches including a CT-derived AC were applied. Results: The resulting PET data was compared to the CT-derived standard regarding the quantification error and its clinical impact. On a quantitative level, −11.9 to +2 % deviations from the CT-AC standard were found. These deviations, however, did not translate into a systematic diagnostic error. This, as overall patterns of hypometabolism (which are decisive for clinical diagnostics), remained largely unchanged. Conclusions: Despite a quantitative error by the omission of bone in MR-AC, clinical quality of brain [18F]FDG is not relevantly affected. Thus, brain [18F]FDG PET can already, even now with suboptimal MR-AC, be utilized for clinical routine purposes, even though the MR-AC warrants improvement.

Stringent pollutant regulations on diesel-powered vehicles have resulted in the development of new technologies to reduce emission of nitrogen oxides (NOx). The urea Selective Catalyst Reduction (SCR) system and Lean NOx Trap (LNT) have become the two promising solutions to this problem. Whilst the LNT results in a fuel penalty due to periodic regeneration, the SCR system with aqueous urea solution or ammonia gas reductants could provide a better solution with higher NOx reduction efficiency. This thesis describes an experimental investigation which has been designed for comparing the effect NOx abatement of a SCR system with AdBlue urea spray and ammonia gas at 5% and 4% concentration. For this study, a SCR exhaust system comprising of a diesel particulate filter (DPF), a diesel oxidation catalyst (DOC) and SCR catalysts was tested on a steady state, direct injection 1998 cc diesel engine. It featured an expansion can, nozzle and diffuser arrangement for a controlled flow profile for CFD model validation. Four different lengths of SCR catalyst were tested for a space velocity study. Chemiluminescence (CLD) based ammonia analysers have been used to provide high resolution NO, NO2 and NH3 measurements across the SCR exhaust system. By measuring at the exit of the SCR bricks, the NO and NO2 profiles within the bricks were found. Comparison of the measurements between spray and gas lead to insights of the behaviour of the droplets upstream and within the SCR bricks. From the analysis, it was deduced that around half to three quarters of the droplets from the urea spray remain unconverted at the entry of the first SCR brick. Approximately 200 ppm of potential ammonia was released from the urea spray in the first SCR brick to react with NOx. The analysis also shows between 10 to 100 ppm of potential ammonia survived through the first brick in droplet form for cases from NOx-matched spray input to excess spray. Measurements show NOx reduction was complete after the second SCR bricks. Experimental and CFD prediction showed breakthrough of all species for the short brick with gas injection due to the high space velocity. The long brick gas cases predictions gave reasonable agreement with experimental results. NO2 conversion efficiency was found higher than NO which contradicts with the fast SCR reaction kinetics. Transient response was observed in both cases during the NOx reduction, ammonia absorption and desorption process. From the transient analysis an estimate of the ammonia storage capacity of the bricks was derived. The amount of ammonia slippage was obtained through numerical integration of the ammonia slippage curve using an excel spreadsheet. Comparing the time constant for the spray and gas cases, showed a slightly faster time response from the gas for both NOx reduction and ammonia slippage.

Purpose: The five point Deauville (D) scale is widely used to assess interim PET metabolic response to chemotherapy in Hodgkin lymphoma (HL) patients. An International Validation Study reported good concordance among reviewers in ABVD treated advanced stage HL patients for the binary discrimination between score D1,2,3 and score D4,5. Inter-reader reliability of the whole scale is not well characterised. Methods: Five international expert readers scored 100 interim PET/CT scans from paediatric HL patients. Scans were acquired in 51 European hospitals after two courses of OEPA chemotherapy (according to the EuroNet-PHL-C1 study). Images were interpreted in direct comparison with staging PET/CTs. Results: The probability that two random readers concord on the five point D score of a random case is only 42% (global kappa = 0.24). Aggregating to a three point scale D1,2 vs. D3 vs. D4,5 improves concordance to 60% (kappa = 0.34). Concordance if one of two readers assigns a given score is 70% for score D1,2 only 36% for score D3 and 64% for D4,5. Concordance for the binary decisions D1,2 vs. D3,4,5 is 67% and 86% for D1,2,3 vs D4,5 (kappa = 0.36 resp. 0.56). If one reader assigns D1,2,3 concordance probability is 92%, but only 64% if D4,5 is called. Discrepancies occur mainly in mediastinum, neck and skeleton. Conclusion: Inter-reader reliability of the five point D-scale is poor in this interobserver analysis of paediatric patients who underwent OEPA. Inter-reader variability is maximal in cases assigned to D2 or D3. The binary distinction D1,2,3 versus D4,5 is the most reliable criterion for clinical decision making.

Fossil fuels continue to deplete with use as they are irreplaceable. In addition, the environmental impact with the continuous use of these conventional fuels has generated global concern due to the production of harmful emission gases. An alternative source of energy has become inevitable. Technological advancements in the area of biomass use for both aviation and power generation are at different levels of development. There is however the need for an integrated approach to assess gas turbine engine behaviour in terms of performance, emission and economics when they are running on biofuels. The current research work is concerned with finding alternative fuel resources for use on stationary gas turbine engines for power generation with the necessary identification of suitable biofuels using a multidisciplinary approach. A techno-economic, environmental and risk assessment (TERA) model comprising the performance, emissions, economics and risk modules has been developed. There had been several simulations of two gas turbine engines (GTEs) to ascertain the effects of both ambient and operating conditions and the effect of fuel types on the engines. These simulations were done with the use of an in-house code-the Turbomatch and a code developed for the steam cycle which is employed for the combined cycle simulation. Cont/d.

The intensified greenhouse effect is the biggest cause for a negative climate change. Global warming is a result of enhanced greenhouse effect and poses a potential threat for humans and its surrounding environment that can result in disastrous consequences. The rise in temperature is driven by increased human activity whereas the leading cause for emissions of greenhouse gases is the combustion of fossil fuels. The prominent source of emissions is from the following sectors: transport, industrial and energy. The task of reducing the emissions of greenhouse gases is both globally and internationally prioritized. Progress has been made although every potential source for emissions has to be investigated in order to reduce the total climate impact. Based on scientific research, wastewater treatment plants are also a contributing factor to the greenhouse effect by emissions of gases. This bachelor’s thesis is investigating two wastewater treatment plants and identifying which processes contribute to the climate impact. The climate impact is calculated with an Excel-based analyzing tool and the results show the Carbon Footprints for the treatment plants. The purpose of this paper is to present result acquired from the treatment plants and identify the processes that have the biggest impact on our climate. Afterwards, solutions derived from the analysis of results will be suggested to improve and bring additional help to the treatment plants with their climate work. In conclusion, it is determined that the treatment plants both have net emissions of greenhouse gases. The biggest contributor is the wastewater treatment and the use of biogas. Results from analysis show that some of the assumptions on emissions made in the tool make the initial results doubtful. Therefore, further research is needed on this subject in order to produce more reliable facts.

Abu Dhabi, the Capital City of United Arab Emirates, evolved through various stages since its formation. However, unlike other Golf cities, policy makers, planners, and designers sought to guide its growth and development towards a sustainable responsive city. Sustainability has become a central theme of policy and practice, and the design of the built environment is playing a major role towards this. Abu Dhabi developed the World renowned City of Masdar, as a model of sustainable development and design, and established the Estidama Rating System to enforce specific sustainable applications. This aim of this study is to examine the cost-effectiveness of shifting the development of Abu Dhabi from a conventional approach to a sustainable one. In particular, it sought to determine whether vernacular design and architecture could help to address the quest for a sustainable city. The methodology adopted for this research was based on quantitative and qualitative approaches. Three buildings were selected to determine the cost-effectiveness of the proposed sustainable solutions. 1. Masdar building was studied to represent what is classified as a sustainable prototype. 2. Educational Building of Abu Dhabi Police Academy, which has an open courtyard at the centre of the building, represents a vernacular design. 3. Administrative Building of Abu Dhabi Police Academy, which has a closed atrium in the centre without any skylight, represents a conventional building design. The research involved an environmental investigation of power consumption, carbon dioxide emissions, indoor and outdoor temperature, indoor and outdoor relative humidity, and levels of indoor carbon dioxide. Monitors were installed in the three prototype buildings for a period of time, and the results of the readings were compared and analysed. In addition, a questionnaire survey was used to determine the impact of the three buildings on sustainable lifestyles and attitudes. Ninety users of the three buildings responded to the questionnaire. Their responses were also compared and analysed. The results of the monitoring of the thermal performance, power consumption and carbon dioxide levels indoors confirmed that most indoor temperature readings were similar due to the use of air-conditioning in the three buildings. However, cooler temperatures were recorded in similar rates in the alleyways of Masdar and in the courtyard of the Police Academy Educational building. In some cases, courtyard spaces in the Educational Building in the Police Academy recorded even lower temperatures than those of Masdar. These readings were much higher than those of the outdoor exposed temperature, whether in Masdar or in the Police Academy outdoor spaces. Considering that the cost per square meter of the Masdar prototype was almost the double of the other prototypes, these findings challenged the cost-effectiveness of the prevailing Masdar City approach. The results also highlighted the importance of the architectural heritage of Abu Dhabi to address the sustainability agenda, including its implications on planning and building regulations. The findings of the questionnaire survey revealed that there were no significant differences between user responses of Masdar and the Police Academy buildings. These also questioned the cost effectiveness of the Masdar prototype. However, the results also confirmed that the lack of awareness of the sustainability agenda for the users of the three buildings, thus highlighting the wider implications on the sustainability agenda.

Traffic population in the UK has grown by 27% in 2002 and predicted to continue to an estimated 38% in 2016 and up to 60% by 2031. This means vehicular emissions from road transport may account for higher proportion of total emissions of pollutants resulting in air pollution with its attendant consequences. Although poor air quality concerns has often been linked to urban areas, many rural areas apparently have locations where air quality objectives may be threatened especially in the wake of increasing vehicular population. Thus, this elicits the necessity to investigate the relationship between vehicular emissions and air quality. This study investigated the influence of vehicular traffic on a major trunk road on rural air quality through continuous measurements of nitrogen dioxide, sulphur dioxide and hydrocarbon between June 2008 and April 2010 along a major trunk road in a catalogued rural environment in the UK. Collection and analysis of pollutants was by Dräger short-term tubes and Dräger passive diffusion tube techniques. Throughout the sampling period, concentrations of sulphur dioxide were not detected using the short-term tube technique but were detected by the passive diffusion tubes. The study found that variations in mean concentrations of the pollutants were synonymous with traffic frequency and were influenced by meteorological conditions especially wind speed, temperature and relative humidity. Results observed concentration decline trend with increasing distance and showed maximum concentrations during winter, mainly in areas of close proximity to anthropogenic source, and minimum in summer. Values between winter year 1 and winter year 2 monitoring campaigns showed significant difference (P<0.05 and R=0.91) as was in summer year 1 and year 2 (P<0.05 and R=0.94), spring year 1 and year 2 (P<0.05 and R=0.84) and autumn year 1 and year 2 (P<0.05 and R=0.79). When compared with the guidance limits, NO2 Page ii showed exceededance at roadside and 50 m, and at some sample sites, up to 100 m from the road. Conversely, SO2 did not show any exceedance but statistical analyses was mostly significant between concentrations and distance at p≤0.05, suggesting the variability of pollutants, as well as the influence of distance on their temporal and spatial distribution. Results also show that pollutants correlated very well with daily traffic population with strong positive r2 and R-values. Similarly, the study considered the application of hazel leave (Corylus avellana) and ryegrass (Lolium perenne) vegetation samples in monitoring rural air quality. Both samples were collected in different seasons and distances (5m, 50m, and 100m) from the A49 trunk road at four rural sites characterised with diverse traffic densities and anthropogenic activities. The aim was to determine the elemental content and trends within the samples and to investigate the influence of distance from the road, height from ground level, and sampling season on the elemental levels. The levels of Al, As, Ba, Ca, Si, Mg, S, Cd, Cr, Na, Ni, Sb, Se, Sn, Mo, Mn, C, K, P, Cl, Ti, Fe, Zn, and Pb were determined using X-ray fluorescence (XRF), inductively coupled plasma-mass spectrometer (ICP-MS), and Scanning Electron Microscopy-Energy Dispersive X-ray spectrometer (SEM-EDX). Results show that despite the traffic differentials between the sampling sites, the pollution level of heavy metals were generally low in all sampling site and concentrations of Cr, Cu, Ni, Pb, and Ti exhibited inverse relationship with distance, decreasing in levels with increasing distance from the trunk road. Although root uptake from the soil is a potential source of heavy metals, geochemistry research of the study area did not show any evidence that proves any major heavy metals deposit concerns in the soil. It is therefore possible that heavy metal emissions were deposited in a form that was not readily available for root uptake, thereby narrowing the presence of heavy metal pollutants to other potential Page iii sources. However, this study found high level of heavy metals at the roadside measurements in the order of Zn (0.703 ppm) > Ti (0.346 ppm) > Cr (0.111 ppm) > Cu (0.106 ppm) > Pb (0.026 ppm) > Ni (0.025 ppm). They were found in different magnitudes higher than their respective levels at 50 and 100 m from the trunk road and therefore tend to support traffic origin. Findings from this study show that heavy metals exhibited different degree of correlation between individual elements, ranging from very strong positive to weak, as well as negative correlations. Statistical analyses show that the elements predominantly exhibited statistically significant differences between elements and between distances from the road. Overall, findings from this study demonstrate that both vegetation species prove to be successfully useful in determining the pollution status and trends of traffic-related heavy metals.

published_or_final_version / Speech and Hearing Sciences / Master / Master of Science in Audiology

published_or_final_version / Speech and Hearing Sciences / Doctoral / Doctor of Philosophy

Social, political, and economic trends suggest that the United States may soon join other United Nations Framework Convention on Climate Change (UNFCCC) countries in drafting substantive, national climate change policy. After providing a brief overview of past and present climate action taken both nationally and internationally, this paper explores different economic solutions to address the externalities of fossil fuel emissions. Alternatives include command-and-control regulation, a carbon tax, and a cap-and-trade program. Several factors, including domestic political anti-tax sentiment, suggest that a cap-and-trade framework is the most promising market-based alternative to reduce carbon emissions within the United States’s electricity sector. Case studies focus on the power generation components of four Texas utilities: Austin Energy, CPS Energy of San Antonio, NRG Energy, and Luminant and assess cap-and-trade’s ramifications on electricity prices. Utilities would seek to pass through to customers in the form of higher electricity prices up to 100 percent of expenses incurred from mitigating greenhouse gas (GHG) emissions. Three primary factors will determine how a given carbon dioxide cap-and-trade allowance price will affect the electricity price charged by utilities: the carbon intensity of the generation fuel mix, whether the wholesale electricity market is regulated or competitive, and whether greenhouse gas allowances are auctioned or grandfathered to covered entities. Consumer elasticity would determine resulting demand for the higher priced energy. Relatively inelastic electricity consumption could cause electricity sector customers to incur financial losses approximately eight times larger than producers by the year 2020 under a mature cap-and-trade framework. Furthermore, evidence suggests market-based GHG reduction tools such as a cap-and-trade schema alone are not sufficient to decarbonize the electricity generation sector. Without complementary regulatory policies that mandate transition to clean energy sources, cap-and-trade will only succeed in redistributing the opportunity cost associated with the carbon externality. / text