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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
151

Charakterisierung Subtyp-spezifischer Autophagieproteine / Characterisation of subtype specific autophagic proteins

Tolstrup, Jörn 23 April 2009 (has links)
No description available.
152

Control of E-cadherin Function in Cell Intercalation by ER Glucosylation Enzymes / Regulation der Funktion von E-cadherin in Zellinterkalation durch ER Glukosylierungsenzyme

Zhang, Yujun 11 September 2012 (has links)
No description available.
153

Heteronormativa ideologier : i det motsägelsefulla gränslandet En studie om femininitet(er) och maskulinitet(er)

Sandra, Karlsson January 2017 (has links)
The aim of the study has been to examine women's participation in the reproduction of the system of heteronormative expectations of femininity and masculinity through narrative method, analyze books within the erotic women’s literature, as well as interviews with females. The study's focus was on the presentation and representations of the femininity(s) and masculinity(s). Through the questions , How represents heteronormative femininity(s) and masculinity(s) in the erotic women´s litterateur? How portray women, their views on femininity(s) and masculinity(s)? The study were linked with the radical feminist theory regarding the male patriarchate's role as a hegemony in society, as well as one of queer theory's definitions of the gender and heteronormativity. The study also included elements of feminist research on popular culture. On the basis of my purpose and the research question I have come to the conclusion that women are involved in the reproduction of the system of heteronormative expectations of femininity and masculinity. But the study also shows a shifting duality of " ideal woman" and "ideal man". / Studiens syfte har varit att undersöka kvinnors delaktighet i reproduktion av heteronormativa förväntningar på kvinnlighet och manlighet genom narrativmetod, analysera böcker inom erotisk kvinnolitteratur samt intervjuer med kvinnor. Studiens fokus handlade om samtidens framställande samt representationer av femininitet(er) och maskulinitet(er). Genom frågeställningarna, Hur framställs heteronormativ femininitet(er) och maskulinitet(er) i erotisk kvinnolitteratur? Hur framställer kvinnor sin syn på femininitet(er) och maskulinitet(er)? Studien kopplades samman med radikal feministisk teori rörande det manliga patriarkatets roll som hegemoni i samhället samt queerteorins definitioner av genus och heteronormativitet. Studien innefattade också inslag av feministisk forskning rörande populärkulturen. Utifrån mitt syfte samt frågeställning har jag kommit fram till att kvinnor är delaktiga i reproduktionen av heteronormativa förväntningar på kvinnlighet och manlighet. Men studien visar också på en skiftande dubbelhet rörande "idealkvinnan" och "idealmannen".
154

An empirical study for the application of the evidential reasoning rule to decision making in financial investment

Gao, Quanjian January 2016 (has links)
The aim of this thesis is to explore the adaptability of the Evidential Reasoning (ER) Rule as a method to provide a useful supporting tool for helping investors make decisions on financial investments. Decision making in financial investment often involves conflicting information and subjective judgment of the investors. Accordingly, the ER Rule, extended from the original popular Evidential Reasoning algorithm and developed for MCDM (Multiple Criteria Decision Making), is particularly suited for handling conflicts in information and to allow for judgmental weighting on the sources of evidence. In order to do so, a specific EIA (Efficient Information Assessment) process modeled by the mass function of Dempster-Shafer Theory has been constructed such that the underlying architecture of the model satisfies the requirement of the ER rule. The fundamental concern is to define and assess “efficient information”. For this purpose, a process denoted the Efficient Information Assessment (EIA) is defined which applies the mass function of Dempster-Shafer theory. Any relevant information selected from an expert’s knowledge database is “efficient” if the data is fully in compliance with the requirement of the ER rule. The logical process of the EIA model proceeds with a set of portfolio strategies from the information recommended by top financial analysts. Then, as a result, the model enables the ER rule to make an evaluation of all strategies for helping investors make decisions. Experiments were carried out to back-test the investment strategy using data from the China Stock Market & Accounting Research (CSMAR) Database for the four-year period between 2009 and 2012. The data contained more than 270,000 reports from more than 4,600 financial analysts. The risk-adjusted average annual return of the strategy outperformed that of the CSI300 index by as much as 10.69% for an investment horizon of six months, with the p value from Student’s t-test as low as 0.02%. The EIA model serves as the first successful application adapting the ER Rule for a new and effective decision-making process in financial investment, and this work is the only empirical study applying the ER Rule to the opinions of financial analysts, to the best of my knowledge.
155

Implantação de um sexto eixo no robô Scorbot-Er V em um sistema didático / Implementation of a sixth axis at the robot Scorbot-Er V in didactic system

Francisco Osmar de Jesus 07 May 2009 (has links)
Esse trabalho tem como objetivo o estudo e análise da implantação de um elo prismático (sexto eixo no robô Scorbot-Er V), para translação do robô em atividades didáticas visando diminuir o tempo de troca do robô e das estações de trabalho em sala de aula, melhorando a visão do aluno em relação à aprendizagem na área de automação industrial e robótica tornando-a sistêmica, dando-lhe assim capacidade de integrar vários sistemas e estudar o sistema de frenagem. Feita uma análise dos ambientes onde os alunos são treinados na programação de robôs, observou-se que no desenvolvimento desta tarefa, havia duas restrições básicas: A dificuldade na programação e movimentação física do robô na troca das estações de trabalho, que levavam em torno de três horas e que não era possível a integração de CLP, IHM, inversores de freqüência, motores AC, sensor de posicionamento e fuso de esferas no ambiente de laboratório. Desenvolveu-se uma análise da precisão do sistema mecânico do sexto eixo implantado, permitindo uma visão do funcionamento do posicionamento, através do sensor acoplado no eixo de fuso esférico, o qual é acionado por um motor AC, transmitindo e convertendo o movimento circular para linear através de uma relação de polias. O resultado obtido foi à diminuição do tempo de três horas para cinco minutos na troca das estações de trabalho e uma precisão de décimos de milímetros para o posicionamento do robô e com a integração dos sistemas foi possível melhorar a aprendizagem do aluno obtendo um ganho pedagógico. / This work aims to study and analyze the implementation of a prismatic link (sixth axis in robot Scorbot-Er V) for translation of the robot in didactic activities to reduce the time to change the robot and workstations in the classroom, improving students vision for learning in the area of industrial automation and robotics becoming systemic, thus giving you ability to integrate various systems and studying the braking system. Made an analysis of the environments where students are trained in the programming of robots and it was observed that the development of this task, there were two basic restrictions: The difficulty in planning and handling of the robot in the physical exchange of workstations, which took around three hours and it was not possible the integration of PLC, HMI, frequency inverters, AC motor, sensor of positioning and axis ball screew in a laboratory environment. It was developed an analysis of the accuracy of the mechanical of sixth axis implanted, allowing a view of the positioning operation by the sensor coupled to the axis ball screew, which is powered by an AC motor transmitting and converting the linear motion to move through a relationship of pulleys. The result was a reduction of time in three hours to five minutes in the exchange of workstations and a precision of tenths of millimeters for positioning the robot and the integration of the systems have improved the learning of students achieving pedagogical gain.
156

Avaliação dos efeitos do laser de Er,Cr:YSGG sobre superfícies radiculares expostas no tratamento da hipersensibilidade dentinária cervical. Estudo in vitro e in vivo / Desensitizing effects of Er:YAG and Er,Cr:YSGG lasers on dentin hypersensitivity. An in vitro and in vivo study

Ana Cecilia Corrêa Aranha 03 August 2005 (has links)
O objetivo deste estudo foi o de avaliar os efeitos da irradiação laser de Er,Cr:YSGG em superfícies dentinárias no tratamento da hipersensibilidade dentinária cervical, em busca de um protocolo para ser aplicado clinicamente. Para o teste de permeabilidade, foram preparados 144 pré-molares, as coroas seccionadas e as raízes impermeabilizadas. Duas áreas de irradiação antagônicas foram delimitadas e livres da impermeabilização (controle e experimental). A seguir, os dentes foram subdivididos em dois sub-grupos, diferindo o condicionamento da superfície irradiada (EDTA 24% e ácido fosfórico 35%) e em grupos diferindo o protocolo:G1)Er:YAG, 60mJ/2Hz; G2)0,25W; G3)0,5W; G4)0,75W; G5)1W, G6)1,25W; G7)1,50W; G8)1,75W G9)2W. Após as irradiações, os espécimes foram imersos em azul de metileno 2% por 4 horas, e incluídos em resina epóxica para a realização dos cortes longitudinais. Estes tiveram suas imagens trabalhadas em computador para mensuração do nível de infiltração. Os dados foram submetidos à análise estatística. O Sub-grupo 1, condicionado com EDTA, apresentou diferenças entre os grupos sendo que as amostras irradiadas com Er:YAG demonstraram menor infiltração, diferindo estatisticamente dos grupos 3, 6 e 9. Os resultados do sub-grupo 2 mostraram que as médias das amostras irradiadas com Er:YAG tenderam a zero entretanto, não houve diferença entre os grupos. Na Fase B, fragmentos de dentina foram obtidos da região cervical de dentes humanos, preparados para análise em microscopia eletrônica de varredura. Morfologicamente, observou-se oclusão parcial dos túbulos dentinários após irradiação com Er:YAG e Er,Cr:YSGG nas condições de 0,25W e 0,50W. A partir de 0.75W, foi observado abertura dos túbulos e à medida que as energias aumentaram, foram observadas carbonização e fendas. De posse dos resultados dos trabalhos in vitro, foram selecionados os parâmetros para a aplicação e o acompanhamento clínico de 1 mês: G1)controle (placebo); G2)Er:YAG; G3)Er,Cr:YSGG 0,25W e G4)Er,Cr:YSGG 0,75W. Após a triagem, foram selecionados voluntários de acordo com critérios de exclusão e inclusão. O nível de sensibilidade de cada voluntário foi avaliado através da escala visual analógica de dor (VAS) com auxílio do ar da seringa tríplice 1 semana antes (Pré-1), 5 minutos anterior ao tratamento (Pré-2), após 5 minutos (Pós-1), 1 semana (Pós-2) e 1 mês após o tratamento (Pós-3). Os dados foram coletados e submetidos à análise estatística separadamente para os dois estímulos realizados: spray de ar e sonda exploradora. Tanto para o estímulo ar quanto para o estímulo sonda, não foram observadas diferenças estatisticamente significantes nas escalas Pré-1 e Pré-2, concluindo que os pacientes estavam padronizados e não houve efeito da profilaxia nos níveis de dor. Ao estímulo do spray de ar, nota-se uma redução nos níveis de dor na escala Pós-1, porém há uma estabilidade dos valores das escalas seguintes. O grupo 2 (Er:YAG) apresentou o menor nível de dor quando comparado aos outros grupos. Ao estímulo mecânico foi observado que o grupo 4 (Er,Cr:YSGG 0,50W) demonstrou o decréscimo de dor mais acentuado imediatamente após o tratamento, porém ao final do estudo, apresentou os maiores níveis de dor. Os grupos 1, 2 e 3 apresentam redução de dor, porém estatisticamente diferentes do grupo 4. Com base nos resultados apresentados e dentro dos limites e parâmetros estudados, pode-se concluir que nenhuma condição foi capaz de eliminar completamente a microinfiltração e diminuir a permeabilidade dentinária; porém o laser de Er:YAG e o laser de Er,Cr:YSGG 0,25W apresentaram resultados satisfatórios nos três estudos realizados. / The aim of the present study was to determine the correct parameters of the Er,Cr:YSGG laser in the treatment of cervical dentin hypersensitivity. This work was presented in 3 different stages. In the first one, it was evaluated the decrease in dentin permeability of dentinal tubules after Er,Cr:YSGG laser irradiation in radicular surfaces. Ninety premolars were prepared with its crows sectioned, and the roots completely impermeabilized. Two antagonist areas of irradiation were determined as control and experimental. Each surface was conditioned with EDTA 24% (sub-group1) and phosphoric acid 35% (sub-group2) and the selected parameters were: 1)Er:YAG, 60mJ, 2Hz, 4 irradiations of 20sec each, defocused mode; and groups 2 to 9 received irradiation with Er,Cr:YSGG laser, 20Hz, Z6 tip, 600µm diameter, defocus mode, 0% of air and water: 2)Er,Cr:YSGG 0,25W; 3) 0,5W; 4) 0,75W; 5) 1,0W; 6) 1,25W, 7) 1,50W, 8) 2W; 9) 2 W. After irradiation, samples were immersed in a solution of methylene blue for 4 hours, washed for 5 min and included in epoxy resin to allow longitudinal cuts. The images were digitalized and computed worked. Data was statistically analyzed. Although the samples irradiated with Er:YAG showed less microleakage, the sub-group 1 showed differences between the groups, statistically different from groups 3, 6 e 9. The results of the sub-group 2 showed that the mean values of the Er:YAG samples had a tendency to be negative, however, no differences were detected between the groups. In the second stage, cuts from the cervical area were obtained and prepared for scanning electron microscopy to evaluate the superficial morphology. It was observed the partial closure of dentinal tubules after the irradiation with Er:YAG and Er,Cr:YSGG laser in the 0.25 and 0.50W protocols. From the 0.75W until 2W, it was observed the dentinal tubules opened as the energy densities raised. With the results of the in vitro studies, the parameters were selected: G1)control; G2)Er:YAG; G3)Er,Cr:YSGG 0,25W e G4)Er,Cr:YSGG 0,75W. Thirty subjects, who met the entry criteria, were admitted into the study. The assessment method used to quantify sensitivity was the cold air syringe, recorded by the visual analogue scale (VAS), prior to treatment as baseline (Pre-1), immediately before (Pre-2) and immediately after (Post-1) the topical treatment, after 1 week (Post-2) and after 1 month (Post-3). Teeth were assigned to the 4 groups. After the follow-up, data was collected and submitted to statistical analysis for both kinds of stimulus: evaporative (air) and mechanical (probe). For both air and probe it was not observed differences among the Pre-1 and Pre-2 moments, for what it can be concluded that patients were standardized. Analyzing the evaporative stimulus, it can be observed the reduction in the pain level immediately after the treatment; however there was stability in the next values. Group 2 (Er:YAG) showed the least level of pain. Throughout the mechanical stimulus, it was observed that group 4 (Er,Cr:YSGG 0,50W) showed the most pronounced decrease of pain immediately after treatment, however, at the end of the study, the levels of pain increased. Groups 1, 2 e 3 showed reduction of pain, statistically different from the group 4. Based on the results and within the limits of this study, it can be concluded that none of the parameters and lasers studied were capable of eliminate the microleakage and decrease the dentin permeability, however, the Er:YAG and Er,Cr:YSGG 0,25W lasers showed satisfactory results in the three studies performed.
157

Avaliação in vitro da morfologia e da resistência de união de adesivos à dentina humana hígida ou submetida à ciclagem erosiva e irradiada com os lasers de Er:YAG e Er,Cr:YSGG / In vitro evaluation of the morphology and the bond strength of adhesives to sound and artificially eroded human dentin irradiated with Er:YAG and Er,Cr:YSGG laser

Thaysa Monteiro Ramos 04 July 2012 (has links)
A erosão dental provoca alterações histológicas complexas na dentina e, apesar do aumento da ocorrência desta patologia na última década, a literatura apresenta poucos estudos sobre a adesão na dentina erodida. Com o aprimoramento da tecnologia e o conhecimento de que os lasers de érbio apresentam grande afinidade pela água e hidroxiapatita, sua utilização tem sido considerada um método alternativo para tratamento da superfície dentinária antes dos procedimentos adesivos. Assim, o objetivo deste trabalho in vitro foi avaliar o efeito de diferentes tratamentos de superfície (ponta diamantada, laser de Er:YAG 2,94 m, 60 mJ, 2 Hz, 0,2 W, 19,3 J/cm2 - e laser de Er,Cr:YSGG 2,78 m, 50 mJ, 30 Hz, 1,5 W, 4,5 J/cm2), prévios ao tratamento restaurador, tanto na dentina humana hígida quanto na dentina artificialmente erodida. Metade das amostras foi submetida à ciclagem erosiva, a qual foi realizada durante 5 dias por meio da imersão em solução de ácido cítrico 0,05 M (pH 2,3, 10 minutos, 6x/dia) e solução supersaturada (pH 7,0, 60 minutos entre os ataques ácidos). Na fase experimental 1, 32 fragmentos de dentina foram divididos aleatoriamente em 8 grupos (n = 4) e com o auxílio da Microscopia Eletrônica de Varredura (MEV), realizou-se a análise da morfologia da superfície da dentina hígida e da submetida à ciclagem erosiva, após os diferentes tratamentos de superfície. Na fase experimental 2, 192 terceiros molares humanos foram divididos aleatoriamente em 2 grupos (dentina hígida e dentina submetida à ciclagem erosiva) e 8 subgrupos (n = 12) para avaliação da resistência de união entre as superfícies tratadas e 2 sistemas adesivos (01 autocondicionante e 01 com condicionamento ácido prévio), por meio do ensaio de microtração e da análise do padrão de fratura. Para o ensaio de microtração, blocos de resina composta microhíbrida foram confeccionados na superfície de dentina e, após armazenados em água destilada-deionizada por 24h (37oC), palitos foram obtidos para serem tracionados na máquina de ensaio universal (0,5mm/min). A análise do padrão de fratura realizada em microscópio ótico (40x) e as avaliações das eletromicrografias foram feitas de forma descritiva. Os valores obtidos de resistência de união(MPa) foram submetidos aos testes de ANOVA (dois fatores) e de comparações múltiplas de Tukey (p<0,05). A análise morfológica de superfície mostrou alterações significativas da dentina hígida e da dentina artificialmente erodida, submetidas aos diferentes tratamentos de superfície. Quanto à resistência de união, na dentina hígida, o grupo controle, tanto do sistema autocondicionante (54,69 ± 7,80 MPa) quanto do condicionamento ácido total (47,36 ± 9,35 MPa), apresentou valores significativamente maiores que os outros grupos, sendo, porém, diferentes entre si. Na dentina erodida, a maior resistência de união foi alcançada com o grupo tratado com o laser de Er,Cr:YSGG associado ao adesivo autocondicionante (28,26 ± 9,22 MPa), o qual foi significativamente diferente de todos demais grupos. Com base nos parâmetros de irradiação utilizados neste estudo, pode-se concluir que em dentina hígida, os tratamentos de superfície com os lasers de Er:YAG e Er,Cr:YSGG apresentaram resultados de adesão inferiores, mas satisfatórios, em relação ao grupo controle. Já em substrato dentinário erodido, a irradiação com laser de Er,Cr:YSGG, associada ao uso de sistema adesivo autocondicionante, promoveu efeito positivo para a adesão à resina composta. / Dental erosion can cause complex histological changes in dentin and, despite the increase in its incidence during the last decade, limited information is available regarding adhesion to eroded dentin. With improvements in technology and due to the fact that the erbium lasers have high affinity to water and hydroxyapatite, the use of laser can consist on an alternative for the treatment of dentin surface before adhesive procedures. The aim of this in vitro study was to evaluate the effect of different surface treatments (diamond bur, Er:YAG laser 2.94 m, 60 mJ, 2 Hz, 0.2 W, 19.3 J/cm2 - and Er,Cr:YSGG laser 2.78 m, 50 mJ, 30 Hz, 1.5 W, 4.5 J/cm2) prior to restorative treatment, in sound and artificially eroded human dentin. Half of the samples was submitted to the erosive cycling, which was performed by immersion in 0.05 M citric acid (pH 2.3, 10 min, 6x/day) and in supersaturated solution (pH 7.0, 1h, between acid attacks), during 5 days. In phase 1, 32 dentin fragments were randomly divided into 8 groups (n = 4). The analysis of surface morphology of both sound and eroded dentin was performed by Scanning Electron Microscopy (SEM), after the different surface treatments. In phase 2, 192 human third molars were randomly divided into 2 groups (sound and eroded dentin) and 8 subgroups (n=12) to evaluate the bond strength between the treated surfaces and composite resin, with two adhesive systems (self-etching and total-etching) by means of the microtensile bond strength (TBS) test and fracture pattern analysis. For the microtensile bond strength test, blocks of composite resin were bonded to the samples and, after 24 h-storage in distilled/deionized water (37°C), stick-shapped samples were obtained and submitted to TBS test in a universal testing machine (0.5 mm/min). The fracture pattern was performed with an optical microscopy (40x) and the evaluations of the electromicrographs were made under a descriptive mode. The bond strength values (MPa) were analyzed by two-way ANOVA and Tukey tests ( = 0.05). In sound dentin, for the control group, both self-etching (54.69 ± 7.8 MPa) and total-etching adhesive system (47.36 ± 9.3 MPa) showed significantly higher values than all other groups (p<0.05), even though they differ from each other. However, in eroded dentin groups, the self-etching on the samples treated with the Er,Cr:YSGG laser presented the highest mean (28.3 ± 9.2 MPa), which was statistically significant higher than all the other treatments (p<0.05). Based on the irradiation parameters considered for this study, it can be concluded that in healthy dentin, the surface treatment with Er:YAG and Er,Cr:YSGG irradiation showed bonding values lower than the control group, but they presented satisfactory results. However, in eroded dentin, the use of Er,Cr:YSGG laser, associated with the self-etching adhesive system, promoted positive effect on adhesion to composite resin.
158

Antagonisiert ein ER β-Agonist die Wirkung von ER α im Fett- und Muskelgewebe der ovarektomierten Ratte? / Does an ER β-Agonist antagonize the effect of ER α in the fat and muscle tissue of ovarectomized rats?

Wellendorf, Jens 28 February 2018 (has links)
No description available.
159

Návrh informačního systému / Design of an Information System

Horák, Martin January 2015 (has links)
The aim of the master thesis is design of an information system for concert management of music ensembles. The information system is developed in cooperation with LimetaApps s.r.o.
160

Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response

Sommerweiß, Dietlind 25 March 2015 (has links)
In this project I sought to analyse the effects of different free fatty acids (FFAs) on INS-1E β-cells. The saturated fatty acid palmitate is considered toxic whereas the monounsaturated fatty acid oleate is harmless. In my working hypothesis I assumed an additional protective effect of oleate when used in combination with palmitate. Furthermore I aimed to explore in detail the possible causes and signalling pathways responsible for apoptosis or sustained cell survival. I examined the Endoplasmic Reticulum (ER) stress response, called unfolded protein response (UPR), as one essential criterion deciding about cell death or life. Analysis of viability and apoptosis confirmed the deleterious effect of palmitate on INS-1E β-cells after 24h of incubation. Oleate proved not to be harmful and even reversed the toxicity of palmitate. When the main components of the UPR were assessed using Western blot analyses and quantitative PCR was performed I found positive proof that palmitate activated the UPR and ultimately led to apoptosis. By contrast, oleate completely prevented UPR signalling. I conclude that oleate rescues INS-1E β-cells by inhibiting ER stress and its signalling.

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