The final master‘s work analyzes problems which occur or may occur due to taking the land for public needs when implementing the program of asphalt works on gravel roads in the area of activity of state enterprise „Telšių regiono keliai“. A research of sections of gravel roads intended for reconstruction and included into the program of maintenance and expansion of public highways for 2002–2015 was carried out, in the course of which a road plan was projected following norms of road engineering and the extent of taking the land for public needs was evaluated. Recommendations regarding the expedience of taking the land for road lane when implementing the program of asphalt works on gravel roads in the area of activity of state enterprise „Telšių regiono keliai“ were rendered.

Le virus de l'immunodéficience humaine (VIH) est à l’origine d’une infection chronique, elle-même responsable du développement du syndrome d'immunodéficience acquise (SIDA), un état de grande vulnérabilité où le corps humain est à la merci d’infections opportunistes pouvant s’avérer fatales. Aujourd’hui, 30 ans après la découverte du virus, même si aucun vaccin n’a réussi à contrôler la pandémie, la situation s’est grandement améliorée. Conséquemment à l’arrivée de traitements antirétroviraux hautement actifs (HAART) à la fin des années 1990, la mortalité associée au VIH/SIDA a diminué et un plus grand nombre de personnes vivent maintenant avec l'infection. La présente thèse avait pour objectif d’aborder trois situations problématiques, en dépit de l’efficacité reconnue des HAART, plus particulièrement la faible charge virale persistante (LLV) et sa relation avec l’échec virologique, ainsi que les effets de certains antirétroviraux (ARV) sur les fonctions rénale et hépatique. Les objectifs précis étaient donc les suivants : 1) étudier le risque d’échec virologique à long terme chez les patients sous HAART dont la charge virale est indétectable comparativement aux patients affichant une LLV persistante; 2) évaluer sur le long terme la perte de fonction rénale associée à la prise de ténofovir (TDF) 3) étudier sur le long terme l'hyperbilirubinémie associée à la prise d’atazanavir (ATV) et ses autres déterminants possibles. Afin d’atteindre les trois objectifs susmentionnés, une cohorte de 2 416 patients atteints du VIH/SIDA, suivis depuis juillet 1977 et résidant à Montréal, a été utilisée. Pour le premier objectif, les résultats obtenus ont montré un risque accru d’échec virologique établi à >1000 copies/ml d’ARN VIH chez tous les patients qui présentaient une LLV persistante de différentes catégories durant aussi peu que 6 mois. En effet, on a observé qu’une LLV de 50-199 copies/ml persistant pendant six mois doublait le risque d’échec virologique (Hazard ratio (HR)=2,22, Intervalle de confiance (CI) 95 %:1,60–3,09). Ces résultats pourraient modifier la façon dont on aborde actuellement la gestion des patients affichant une LLV, et plus particulièrement une LLV de 50-199 copies/ml, pour laquelle aucune recommandation clinique n’a encore été formulée en raison du manque de données. Pour le deuxième objectif, on a observé une augmentation du risque de perte de fonction rénale de l’ordre de 63 % (HR=1,63; 95% CI:1,26–2,10) chez les patients sous TDF comparativement aux patients traités avec d’autres ARV. La perte de fonction rénale directement attribuable à la prise de TDF, indique que cette perte est survenue au cours des premières années de l’exposition du patient au médicament. D’une perspective à long terme, cette perte est considérée comme modérée. Enfin, pour ce qui est du troisième objectif, on a constaté que l’incidence cumulative d’hyperbilirubinémie était très élevée chez les patients sous ATV, mais que cette dernière pouvait régresser lorsque l’on mettait fin au traitement. L’hyperbilirubinémie à long terme observée avec la prise d’ATV n’a été associée à aucun effet néfaste pour la santé. Dans l’ensemble, la présente thèse a permis de mieux comprendre les trois situations problématiques susmentionnées, qui font actuellement l’objet de débats au sein de la communauté scientifique, et d’éclairer sous un jour nouveau la gestion des patients séropositifs sous traitement médicamenteux. / Human immonudeficiency virus (HIV) is a virus causing a chronic infection responsible for Acquired Immunodeficiency Syndrome (AIDS), a state of vulnerability of the body where different opportunistic infections will ultimately be fatal. About 30 years after the discovery of the virus, even if no vaccine is available to control the pandemia, situation has changed for the best. With the arrival of highly active anti-retroviral therapy (HAART) in the late 90's, a reduction in HIV/AIDS mortality rate and growing number of persons living with the infection were observed. The overall objective of this thesis was to address three problematic situations, despite recognised HAART efficacy, especially low-level viremia (LLV) and its relationship with virologic failure, and the impacts of certain antiretrovirals (ARV) on kidney and hepatic functions. The specific objectives were: 1) to study the risk of virologic failure in long-term perspective in undetectable patients under HAART in comparison to patients with persistent LLV; 2) to evaluate the long-term loss of kidney function related to tenofovir (TDF) exposure 3) to evaluate long-term hyperbilirubinemia related to atazanavir (ATV) exposure and other possible determinants. In order to address the three specific objectives, a cohort of patients 2416 living with HIV/AIDS followed in Montreal since July 1977 was used. For the first objective, analyses and results shown an increased risk of virological failure defined as >1000 copies/mL of HIV RNA, for all categories of persistent LLV as soon as 6 months of persistent duration. Persistent LLV of 50-199 copies/mL for 6 months doubled the risk of virologic failure (Hazard ratio (HR)=2,22, Confidence interval (CI) 95%: 1,60-3,09). The results shed new light for the management of patients with LLV, especially for LLV of 50-199 copies/mL, for which no clinical recommendation is currently available due to a lack of data. For the second objective, an increased risk of loss of kidney function of 63% (HR=1.63; 95% CI:1.26–2.10) associated to TDF exposure in comparison to patients taking other ARV was observed. The cumulative eGFR loss directly attribuable to TDF also shown that this loss occured during the first years of exposure. This loss was mild in a long-term perspective. For the third objective, it has been shown that the cumulative incidence of hyperbilirubinemia in ATV users was very high and that regression was possible if ATV exposure was ended. Long-term hyperbilirubinemia related to ATV use was not associated with adverse health outcome. Overall, this thesis allowed a better understanding of these three problematics currently debated in scientific literature and shed new lights on management of HIV positive patients under therapy.

Aim of this thesis is to introdukce the issues related to price calculations building. The theoretical part focuses on the different type sof calculations formula and related procedures. The practical part is focused on creating practical calculations using software. Problems is illustrated in Example.Everything is comleted by evaluating, comparing the individual type sof calculation methods and a description os possibleproblems witch the recommended tutorials on thein solution.

In this diploma thesis it is solved issue of determining the estimated value by public authority of works contract and determining price in the pre-investment phase of build-up. The work is based on a questionnaire survey, which is supplemented by practical examples of finished works contract.

博士(スポーツ健康科学) / Doctor of Philosophy in Health and Sports Science / 同志社大学 / Doshisha University

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One of the major applications of wireless sensor networks is to sense accurate and reliable data from the physical environment with or without a priori knowledge of data statistics. To extract accurate data from the physical environment, we investigate spatial data correlation among sensor nodes to develop data accuracy models. We propose three data accuracy models namely Estimated Data Accuracy (EDA) model, Cluster based Data Accuracy (CDA) model and Distributed Cluster based Data Accuracy (DCDA) model with a priori knowledge of data statistics. Due to the deployment of high density of sensor nodes, observed data are highly correlated among sensor nodes which form distributed clusters in space. We describe two clustering algorithms called Deterministic Distributed Clustering (DDC) algorithm and Spatial Data Correlation based Distributed Clustering (SDCDC) algorithm implemented under CDA model and DCDA model respectively. Moreover, due to data correlation in the network, it has redundancy in data collected by sensor nodes. Hence, it is not necessary for all sensor nodes to transmit their highly correlated data to the central node (sink node or cluster head node). Even an optimal set of sensor nodes are capable of measuring accurate data and transmitting the accurate, precise data to the central node. This reduces data redundancy, energy consumption and data transmission cost to increase the lifetime of sensor networks. Finally, we propose a fourth accuracy model called Adaptive Data Accuracy (ADA) model that doesn't require any a priori knowledge of data statistics. ADA model can sense continuous data stream at regular time intervals to estimate accurate data from the environment and select an optimal set of sensor nodes for data transmission to the network. Data transmission can be further reduced for these optimal sensor nodes by transmitting a subset of sensor data using a methodology called Spatio-Temporal Data Prediction (STDP) model under data reduction strategies. Furthermore, we implement data accuracy model when the network is under a threat of malicious attack.

This thesis deals with a comparison of classification methods. At first, these classification methods based on machine learning are described, then a classifier comparison system is designed and implemented. This thesis also describes some classification tasks and datasets on which the designed system will be tested. The evaluation of classification tasks is done according to standard metrics. In this thesis is presented design and implementation of a classifier that is based on the principle of evolutionary algorithms.

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No description available.