Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-24T19:48:00Z No. of bitstreams: 1 Bruna Maria De Lima.pdf: 719703 bytes, checksum: 34e42e0d0dacbd0d1980eefea4fe2232 (MD5) / Made available in DSpace on 2016-05-24T19:48:00Z (GMT). No. of bitstreams: 1 Bruna Maria De Lima.pdf: 719703 bytes, checksum: 34e42e0d0dacbd0d1980eefea4fe2232 (MD5) Previous issue date: 2014-12-11 / Frequent pain complaints in the anterior knee, difficulties in activities of daily living, such as up and down stairs, ramps and walking are common symptoms in women with patellofemoral pain syndrome (PFPS). The syndrome is related to weakness of the lateral rotator muscles and the hip abductors, consequent changes in joint angles. The poor coaptation of the femur and patella, the various angles of the joints of the lower limb can influence the manifestation of pain. However, although we found studies on the lower limb kinematics, there is little description of the importance and influence of the foot in the syndrome. Therefore, this study aimed to evaluate the influence of two treatment programs on pain, function and three-dimensional kinematics of the legs in women with PFPS. The effects of the interventions were calculated by paired t test for parametric measurements and Friedman test with Post Hoc analysis for intra-group with non-parametric values. P values <0.05 were considered significant. Our results showed that both protocols promote significant improvement of the power levels of the abductor muscles and lateral rotators of the hip and knee extensors. Strength training was effective for both patients FG as for SMG. There was a statistically significant increase in torque of the abductor muscles (P = 0, 011; P = 0.039 respectively) and lateral rotator (P = 0.025; P = 0.005 respectively) of the hip and knee extension (P = 0.002; P = 0.005 respectively) . There were no differences in range of motion (ROM) intra Group Force (GF) and intra sensorimotor group (GSM), so both treatments did not influence the kinematics of the feet. / Queixas álgicas frequentes na região anterior do joelho, dificuldades nas atividades de vida diária, como subir e descer escadas, rampas e caminhar são sintomas frequentes em mulheres com a síndrome da dor femoropatelar (SDFP). A síndrome está relacionada com fraqueza dos músculos rotadores laterais e abdutores do quadril, conseqüente alteração nas angulações articulares. A má coaptação do fêmur e patela, as várias angulações das articulações do membro inferior podem influenciar a manifestação da dor. Entretanto, apesar de encontrarmos estudos referentes à cinemática de membro inferior, ainda há pouca descrição sobre a importância e influência do pé na síndrome. Portanto, este estudo teve como objetivo avaliar a influência de dois programas de tratamento sobre a dor, a função e a cinemática tridimensional dos pés em mulheres com a SDFP. Os efeitos das intervenções foram calculados através de Teste t pareado para medidas paramétricas e teste de Friedman com post hoc para análise intragrupo com valores não paramétricos. Os valores de p < 0,05 foram considerados significantes. Nossos resultados demonstraram que ambos os protocolos promovem melhora significante dos níveis de força dos músculos abdutores e rotadores laterais do quadril e extensores do joelho. O treinamento de força mostrou-se eficaz tanto para as pacientes do GF quanto para as do GSM. Houve aumento estatisticamente significante do torque da musculatura abdutora (P = 0, 011; P = 0,039 respectivamente) e rotadora lateral (P = 0,025; P = 0,005 respectivamente) do quadril e extensora do joelho (P = 0,002; P = 0,005 respectivamente). Não foram encontradas diferenças nas amplitudes de movimento (ADM) intra Grupo de Força (GF) e intra grupo Sensóriomotor (GSM), sendo assim, ambos os tratamentos não influenciaram a cinemática dos pés.

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Class of 2010 Abstract / OBJECTIVES:The main purpose of this study was to review recent and good quality studies of the antimicrobial therapy of for moderate to severe (“limb threatening”) DFI. The analysis of these studies was to conclude with one or two “standard” approach to the routine management of this clinical entity. METHODS: This literature review study consisted of an evaluation of clinical trials that compare two or more active systemic antimicrobial regimens for the treatment of moderate to severe (i.e., “limb-threatening”) diabetic foot infections in human patients. Literature sources were identified primarily from OVID MEDLINE, but also included additional tertiary sources. The primary criteria for the clinical studies were: prospective, controlled, randomized and investigator blinded. Studies had to be published after the year 2003, and be available in full-text in English. RESULTS: Ultimately, only four studies were found that met the criteria for consideration. Trials differed in numerous features. All four studies were sponsored by the manufacturer of one of the comparator drugs. Three of the four were non-inferiority design. Evidence is lacking that any of the suggested regimens are superior. CONCLUSIONS: Instead of meeting our original goal of concluding that one or two regimens could be the “standard” management of DFI, we were limited to commentary on the quality and applicability of the current literature on this clinical entity. Numerous suggestions for improvement in the clinical information provided by DFI studies were offered. We eagerly anticipate the publication of the updated IDSA guideline document on DFI.

Diabetic foot ulcers (DFUs) are a common and severe adverse event associated with diabetes, as 25% of diabetic patients will experience DFUs. The lack of effective DFU therapies results in 20% of diabetic patients requiring amputation. We first developed an algorithm to account for polydispersity when calculating nanoparticle concentration, which will reduce variability between batches and treatments. We also developed a novel 2-layer biomaterial, which combines anti-microbial properties of CLKRS peptide coated silver nanoparticles (CLKRS- AgNPs) with a pro-regenerative collagen matrix embedded with microscopic skin tissue columns (MSTC), to promote DFU wound healing. The collagen hydrogel formulation was optimized, and the physical properties, biocompatibility, and wound healing properties were assessed. Our results indicate that the CLKRS-AgNPs prevent bacterial growth and the collagen matrix provides a regenerative environment. Last, we developed and tested antimicrobial fabrics which can also be applied to chronic wounds, such as DFUs, to prevent and treat infections.