Visame pasaulyje skrandžio vėžys yra didelė problema, kasmet diagnozuojama apie 875000 naujų atvejų ir 645000 miršta nuo šios ligos. Lietuvos vėžio registro duomenimis, 2005 m. Lietuvoje sergamumas skrandžio vėžiu buvo 35,0 vyrų ir 22,1 moterų tarpe 100000 gyventojų. Šis susirgimas vis dar dažniausiai diagnozuojamas vėlyvose stadijose, kuomet radikali operacija jau nėra galima. Skrandžio vėžio vystymasis yra kompleksinis ir šiuo metu dar pilnai neišaiškintas procesas. Nauji tyrimai patvirtino, kad epigenetinė pažaida – TPEF/HPP1 geno metilinimas yra dažnas reiškinys tulžies ir šlapimo pūsles, kolorektalinio vėžio atvejais. Vis dėlto, nebuvo pakankamai duomenų apie TPEF/HPP1 geno metilinimo reikšmę skrandžio kancerogenezėje. Atliktame tyrime nustatyta, kad TPEF/HPP1 geno metilinimas gali būti ankstyvas šio pažeidimo požymis. Taip pat galima daryti prielaidą, kad TPEF/HPP1 genas yra skrandžio naviką slopinantis genas. Kitas svarbus skrandžio vėžio rizikos faktorius yra H. pylori sąlygotas atrofinis gastritas. Tyrimo metu nustatytas didelis vyresnių nei 55 m. dispepsija sergančių pacientų infekuotumas H. pylori. Statistiškai patikimo skirtumo tarp atrofijos ir žarninės metaplazijos dažnumo dispepsija sergantiems pacientams Taivanyje, Lietuvoje, Latvijoje negauta. Buvo nustatyta stipri koreliacija tarp skrandžio atrofijos ir žarninės metaplazijos. Klinikinėje praktikoje atrofinis gastritas patvirtinamas histologiškai (pagal 1994 m. Hiūstone modifikuotą Sidnėjaus klasifikaciją)... [toliau žr. visą tekstą] / INTRODUCTION Gastric cancer is rampant in many countries around the world and it accounts for approximately 875000 new cases and 645000 deaths annually [Jemal A et al, 2004]. While overall incidence of gastric cancer is falling, in many countries of the world it remains one the most frequent causes of cancer related deaths. According to GLOBOCAN age-standardized cancer incidence data, in Germany 15.1 males and 8.8 females per 100.000 persons developed gastric cancer in 2002, in Lithuania – 25.3 males and 13.0 females, in Latvia – 24.6 males and 11.1 females, respectively. According to the data of Lithuanian Cancer Registry, gastric cancer incidence was 35.0 in male, 22.1 in female per 100.000 persons in 2005, 30.4 in male, 17.8 in female in 2004, respectively [Kurtinaitis J, 2004]. At present, primary or secondary prevention is likely to be the most effective means of reducing the incidence and mortality from this disease. However, to be successful, this strategy depends upon knowledge of the etiological factors and pathogenetic mechanisms involved in gastric carcinogenesis. Helicobacter pylori (H. pylori) has been categorized as a group I carcinogen by the International Agency for Research on Cancer and World Health Organization (WHO) in 1994. Development of gastric cancer is a complex and poorly understood process. It is clear that besides chronic gastritis caused by H. pylori, dietary factors, high salt and nitrate intake, smoking and, possibly, alcohol consumption are... [to full text]

Daktaro disertacijos „Nėštumo laukimo laiką prognozuojančių veiksnių tyrimas“ tikslas - įvertinti nėštumo laukimo laiko sąsajas su demografiniais, socialiniais, gyvensenos, darbo, aplinkos ir genetiniais veiksniais ir sudaryti prognostinius jų įtakos modelius. Tyrimo uždaviniai: 1.Įvertinti demografinių, socialinių, gyvensenos, darbo ir gyvena–mosios aplinkos veiksnių sąsajas su nėštumo laukimo laiku. 2.Sudaryti svarbiausių demografinių, socialinių, gyvensenos, darbo ir gyvenamosios aplinkos veiksnių, kurie nulemia 12 mėnesių ir ilgesnį nėštumo laukimo laiką, prognostinį įvertinimo modelį. 3.Įvertinti FSH receptoriaus geno polimorfizmo variantų įtaką nėš–tumo laukimo laikui. 4.Sudaryti FSH receptoriaus geno polimorfizmo įtakos svarbiausiems demografiniams, socialiniams, gyvensenos, darbo ir gyvenamosios aplinkos veiksniams, kurie nulemia 12 mėnesių ir ilgesnį nėštumo laukimo laiką, prognostinį modelį. Nustatėme, kad svarbiausi nepriklausomi 12 mėnesių ir ilgesnį nėštumo laukimo laiką nulemiantys prognostiniai veiksniai yra 30 metų ir vyresnis amžius, anksčiau gydyti vaisingumo sutrikimai, ginekologinės ligos, kontracepcijos priemonių naudojimas iki nėštumo planavimo pradžios ir FSH receptoriaus geno SER/SER variantas, kurie pastojimo po 12 ir daugiau mėnesių tikimybę didino, atitinkamai, 1,95, 1,57, 2,21, 1,87 ir 1,68 kartus. / “Study of time to pregnancy prognostic factors”. The aim of the study was to investigate the relation between various factors and female fecundity, which was expressed as time to pregnancy (TTP) and to create prognostic models. Tasks of the study were: 1.Estimate the relation between socioeconomic, demographic, life-style, environmental and job-related factors and time to pregnancy; 2.Create prognostic valuation model for the most important social, demographic, life-style, environmental and job-related factors what are associated with 12 month or longer time to pregnancy; 3.Estimate the impact of FSH receptor gene polymorphism variant on time to pregnancy; 4.Create prognostic model for the most important factors what are associated with 12 month or longer time to pregnancy under the influence of FSH receptor gene polymorphism. We established, that the most important independent risk factors prognoses time to pregnancy of 12 or more months in women analyzed for FSH receptor gene polymorphism group were older age, having gynecological diseases or fertility problems in the past, the use of contraception prior to conception and SER/SER polymorphism variant, what increased the probability of conceiving after 12 or more months 1.95, 1.57, 2.21, 1.87 and 1.68 times respectively.

?rea de concentra??o: Pol?tica, cultura e sociedade. / Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-09-13T19:26:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) rochelle_foltram.pdf: 2142931 bytes, checksum: 548ed360ff0a9e0a81fd8dfa2aad23e9 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-09-18T16:49:21Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) rochelle_foltram.pdf: 2142931 bytes, checksum: 548ed360ff0a9e0a81fd8dfa2aad23e9 (MD5) / Made available in DSpace on 2017-09-18T16:49:21Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) rochelle_foltram.pdf: 2142931 bytes, checksum: 548ed360ff0a9e0a81fd8dfa2aad23e9 (MD5) Previous issue date: 2017 / A presente disserta??o pretendeu analisar as pol?ticas do Estado Brasileiro para as popula??es ind?genas durante a Ditadura Militar brasileira (1964-1985). Num primeiro momento, foram analisadas as pol?ticas de Estado para os ?ndios, desde o per?odo colonial at? as primeiras d?cadas do regime republicano, momento da cria??o do Servi?o de Prote??o ao ?ndio, primeiro ?rg?o estatal voltado para tratar das quest?es ind?genas. Posteriormente, procurou-se investigar o sistema de ideias e projetos que cercava as popula??es ind?genas durante o regime militar, refletindo sobre as raz?es que levaram a cria??o da Funda??o Nacional do ?ndio (1967) e dos reformat?rios agr?colas em v?rias partes do Brasil. Atrav?s da investiga??o de uma gama variada de documentos ? imprensa, relat?rios, legisla??es, depoimentos, fotografias ? foi poss?vel elucidar como o Estado pensava e agia em rela??o ?s popula??es ind?genas, tratadas, de modo gen?rico e preconceituoso, como brutas, selvagens, ignorantes, ociosas e despreparadas para o conv?vio social. A sa?da encontrada pelo Estado para solucionar o ?problema? da quest?o ind?gena, quase sempre, foi ? persegui??o, reclus?o, marginaliza??o e genoc?dio dessas popula??es. / Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Ci?ncias Humanas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017. / The present dissertation aimed to analyze the policies of the Brazilian State for indigenous populations during the Brazilian Military Dictatorship (1964-1985). At first, we analyze the State policies for the indians, from the colonial period to the first decades of the republican regime, when the Servi?o de Prote??o ao ?ndio was created, the first state body to deal with indigenous issues. Subsequently, it was investigated the system of ideas and projects that surrounded the indigenous populations during the Military Regime, reflecting on the reasons that led to the creation of the Funda??o Nacional do ?ndio (1967) and the agricultural reformatories in various parts of Brazil. Through the investigation of a wide range of documents ? press, reports, legislation, testimonies, photographs ? it was possible to elucidate how the state thought and acted towards indigenous populations, treated in a generic and prejudiced way, as crude, savage, ignorant, Idle and unprepared for social interaction. The exit found by the State to solve the ?problem? of the indigenous question, almost always, was to the persecution, reclusion, marginalization and genocide of these populations.

Made available in DSpace on 2014-12-17T15:25:23Z (GMT). No. of bitstreams: 1 HelderAMM.pdf: 3008647 bytes, checksum: 088776a576ac21c9ecf600ec16509854 (MD5) Previous issue date: 2007-06-21 / The objective of this work is to understand some of the modifications caused for the phenomenon of the westernization in the hinterland of the Capitania do Rio Grande e in the life of the indians populations that inhabited there during the Colonial Period. We break of the quarrel of Serge Gruzinski concerning the westernization, understood while immersed phenomenon in the context of the expansion of the commercial capitalism and that, for the imposition of the culture occidental person to the alteridades of the New World, emprende the conquest of its territories, bodies and souls. The space clipping has covered the hinterland of the Capitania do Rio Grande, specifically the colonial territory of the Freguesia da Gloriosa Senhora Santa Ana do Serid?. The chosen chronological limit for the research corresponds to the Colonial Period and part of the Imperial one. However, the emphasis falls again on the period that it initiates in 1670, year of the oldest concession of would sesmaria known until the moment in the hinterland of the Rio Grande, extending itself until the decade of 1840. Sources of written by hand nature, cartographic printed and compose the used document roll: official correspondence and legislation, petitions of would sesmaria, inventories post-mortem, justifications of debt, registers of parish, maps, action civil court jurisdiction, notes of notary's office, land landmarks. We take the method, analyzed for Carlo Ginzburg, to cross these sources between itself and to detect its implied particularitities and ideas in the space between lineses, but, attributing it status to they of a colonial speech, fruit of the bureaucracy of where it was originated and of the social place of who produced it. We look for to demonstrate, throughout the work, that the phenomenon of the westernization desestruturou the aboriginal societies and its habitat, constructing, over its rubbles, a colonial territory that found in the cartography of the Freguesia de Santa Ana an efficient instrument of control of the space and the population. On the other hand, if the imposition of the culture occidental person exterminou great part of the native population that inhabited the hinterland of the Rio Grande, the remainders of these indians and the mestizos of descending them had survived in diverse ways in the freguesia: in the condition of captives of war or in regimen of servile work, as living or assistants in the farms, populations and village; rambling without route in the fields and the population spots; as mediating agents between the world occidental person and the native, exerting military or civil positions and still appealing to Justice in search of its rights of inheritance. Experiences of slavery, servitude, err?ncia and mediation, but, also of resistance, adaptation, mestization in the Freguesia de Santa Ana / O objetivo deste trabalho ? o de compreender algumas das modifica??es causadas pelo fen?meno da ocidentaliza??o no sert?o da Capitania do Rio Grande e na vida das popula??es ind?genas que a? habitavam durante o Per?odo Colonial. Partimos da discuss?o de Serge Gruzinski acerca da ocidentaliza??o, entendida enquanto fen?meno imerso no contexto da expans?o do capitalismo comercial e que, pela imposi??o da cultura ocidental ?s alteridades do Novo Mundo, emprende a conquista dos seus territ?rios, corpos e almas. O recorte espacial cobre o sert?o da Capitania do Rio Grande, especificamente o territ?rio colonial da Freguesia da Gloriosa Senhora Santa Ana do Serid?. O limite cronol?gico escolhido para a pesquisa corresponde ao Per?odo Colonial e parte do Imperial. Entretanto, a ?nfase recai sobre o per?odo que inicia em 1670, ano da mais antiga concess?o de sesmaria conhecida at? o momento no sert?o do Rio Grande, estendendo-se at? a d?cada de 1840. Fontes de natureza manuscrita, impressa e cartogr?fica comp?em o rol de documentos utilizados: correspond?ncia e legisla??o oficiais, requerimentos de sesmaria, invent?rios post-mortem, justifica??es de d?vida, registros de par?quia, mapas, a??es c?veis, notas de cart?rio, demarca??es de terra. Tomamos o m?todo indici?rio, problematizado por Carlo Ginzburg, para cruzar essas fontes entre si e detectar as suas particularidades e id?ias subentendidas nas entrelinhas, mas, atribuindo a elas o status de um discurso colonial, fruto da burocracia de onde foi originado e do lugar social de quem o produziu. Procuramos demonstrar, ao longo do trabalho, que o fen?meno da ocidentaliza??o desestruturou as sociedades ind?genas e seu habitat, construindo, por cima dos seus escombros, um territ?rio colonial que encontrou na cartografia da Freguesia de Santa Ana um eficiente instrumento de controle do espa?o e da popula??o. Por outro lado, se a imposi??o da cultura ocidental exterminou grande parte da popula??o nativa que habitava o sert?o do Rio Grande, os remanescentes desses ?ndios e os mesti?os deles descendentes sobreviveram de diversas maneiras na Freguesia de Santa Ana: na condi??o de cativos de guerra ou em regime de trabalho servil, como moradores ou assistentes nas fazendas, povoa??es e vila; perambulando sem rumo nos campos e nas manchas populacionais; como agentes mediadores entre o mundo ocidental e o nativo, exercendo cargos militares ou civis