Global ETD Search

1	Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study Buch, Stephan, Innes, Hamish, Lutz, Philipp Ludwig, Nischalke, Hans Dieter, Marquardt, Jens U., Fischer, Janett, Weiss, Karl Heinz, Rosendahl, Jonas, Marot, Astrid, Krawczyk, Marcin, Casper, Markus, Lammert, Frank, Eyer, Florian, Vogel, Arndt, Marhenke, Silke, von Felden, Johann, Sharma, Rohini, Atkinson, Stephen Rahul, McQuillin, Andrew, Nattermann, Jacob, Schafmayer, Clemens, Franke, Andre, Strassburg, Christian, Rietschel, Marcella, Altmann, Heidi, Sulk, Stefan, Thangapandi, Veera Raghavan, Brosch, Mario, Lackner, Carolin, Stauber, Rudolf E, Canbay, Ali, Link, Alexander, Reiberger, Thomas, Mandorfer, Matthias, Semmler, Georg, Scheiner, Bernhard, Datz, Christian, Romeo, Stefano, Corradini, Stefano Ginanni, Irving, William Lucien, Morling, Joanne R, Guha, Indra Neil, Barnes, Eleanor, Ansari, M Azim, Quistrebert, Jocelyn, Valenti, Luca, Müller, Sascha A, Morgan, Marsha Yvonne, Dufour, Jean-François, Trebicka, Jonel, Berg, Thomas, Deltenre, Pierre, Mueller, Sebastian, Hampe, Jochen, Stickel, Felix 22 February 2024 (has links) Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis. - Design: Patients with alcohol-related cirrhosis and HCC (cases: n=1214) and controls without HCC (n=1866), recruited from Germany, Austria, Switzerland, Italy and the UK, were included in a two-stage genome-wide association study using a case–control design. A validation cohort of 1520 people misusing alcohol but with no evidence of liver disease was included to control for possible association effects with alcohol misuse. Genotyping was performed using the InfiniumGlobal Screening Array (V.24v2, Illumina) and the OmniExpress Array (V.24v1-0a, Illumina). - Results: Associations with variants rs738409 in PNPLA3 and rs58542926 in TM6SF2 previously associated with an increased risk of HCC in patients with alcohol-related cirrhosis were confirmed at genome-wide significance. A novel locus rs2242652(A) in TERT (telomerase reverse transcriptase) was also associated with a decreased risk of HCC, in the combined meta-analysis, at genome-wide significance (p=6.41×10⁻⁹, OR=0.61 (95% CI 0.52 to 0.70). This protective association remained significant after correction for sex, age, body mass index and type 2 diabetes (p=7.94×10⁻⁵, OR=0.63 (95% CI 0.50 to 0.79). Carriage of rs2242652(A) in TERT was associated with an increased leucocyte telomere length (p=2.12×10⁻⁴⁴). - Conclusion: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis. info:eu-repo/classification/ddc/610 ddc:610
2	Development of microsatellites in sycamore maple (Acer pseudoplatanus L.) and their application in population genetics / Die Entwicklung von Mikrosatelliten bei Bergahorn (Acer pseudoplatanus L.) und deren Anwendung in der Populationsgenetik Pandey, Madhav 01 August 2005 (has links) No description available. 500 Naturwissenschaften Forest Sciences and Forest Ecology Acer pseudoplatanus Bergahorn Mikrosatelliten autotetraploid genetische Variation räumliche genetische Strukturen Selbstbefruchtungsanteil Acer pseudoplatanus sycamore maple microsatellites autotetraploid genetic variation spatial genetic structure rate of self-fertilization 48 Land- und Forstwirtschaft
3	Genetic Variation for Nitrogen Efficiency in Oilseed rape (Brassica napus L.) / Genetische Variation der Stickstoff-Effizienz bei Winterraps (Brassica napus L.) Nyikako, John 17 July 2003 (has links) No description available. 630 Landwirtschaft Veterinärmedizin Agricultural Sciences Brassica napus N Effizienz Genetische Variation Korrelationen Divergenten Bulks Protein Gehalt DH Linien Brassica napus N efficiency Genetic variation Correlations Divergent bulks Protein content DH lines 48.58 48.52
4	Development of microsatellites in Prosopis spp. and their application to study the reproduction system / Entwicklung von Mikrosatelliten für Prosopis spp. und ihre Anwendung zur Untersuchung des Reproduktionssystems Mottura, Martin Carlos 12 October 2006 (has links) No description available. 500 Naturwissenschaften Forest Sciences and Forest Ecology Mikrosatelliten SSRs Entwicklung von Mikrosatelliten Prosopis chilensis Prosopis flexuosa Reproduktionssystems genetische Variation Hybrid-Schwarm Hybridisierung Vaterschaftsanalysen Fremdbefruchtungsrate Loci genetischen Diversität microsatellites SSRs microsatellite development Prosopis chilensis Prosopis flexuosa genetic variation hybrid swarm reproduction system hybridization paternity analysis outcrossing rate loci gene diversity 48.00 YQH 000: Genetik Fortpflanzung Züchtung {Forstbotanik}
5	Genetic variation of the genus <i>Shorea</i> (Dipterocarpaceae) in Indonesia / Genetische Variation bei <i>Shorea</i> (Dipterocarpaceen) Indonesiens Cao, Cui-Ping 20 February 2006 (has links) No description available. 500 Naturwissenschaften Forest Sciences and Forest Ecology AFLP Erhaltung genetischer Ressourcen Dipterocarpaceen genetische Variation Phylogenie <i>Shorea</i> Tropenwälder AFLP conservation of genetic resources Dipterocarpaceae genetic variation phylogeny <i>Shorea</i> tropical rainforests 48 Land- und Forstwirtschaft

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