Buffalo Boys 100 years of wearing his heart on his sleeve is the sum of my experience at the University of Saskatchewan. It is an exploration of or coming to know my worldview. I have come to know that history is a construction, fragments of memory told through the bias of time, place and privilege. <p>Bison in the Bowl: This is Indian Land is a site of resistance. A layering of energy over matter through image projection over a colonizing space, the college building. I will place my family tipi in the bowl to honour the bison; the projected images will be of bison, buffalo boy and other contemporary aboriginal experiences. Through projection, I enlighten matter, a union of disparate histories that can be healed through the presence of an aboriginal healing device, the tipi. Happenings dependent on weather will occur September 21, 22 and 23. <p>Crow Chief Plenty Coups refused to speak of the years after the last wild bison herds were gone, saying, when the buffalo went away the hearts of my people fell to the ground, and they could not lift them again. After this nothing happened. <p>Nothing Happened: Old Sun represents the reconstruction of cultural icons through bison fragments, manufactured steel and a light from the Old Sun Residential School on the Blackfoot Reserve. Shadows of the past interrogate traditional and contemporary ideas. I believe that objects hold energy; this light that once shone above the heads of many children within the school is a witness to cultural genocide. Illumination of our histories can bring us out of the shadows and enlighten our being. Time is the Western paradox; it is to be played with. It is a container, a crypt that fragments real time image. It is a space of introspection and the cosmic dance. Bison Heart connects me to the heart of my art practice. In the context of my aboriginal experience, this painting can be romantic, iconic and political. I invite the viewer to move between the values to uncover their own meaning and relationship with the subject and self. <p>Gambling the Prairie Winnings is the construction of time through narrative, image and artifact. It is a serious and humorous view of how the west was dumb, it parodies the Western Development Museums centennial theme Winning the Prairie Gamble. The reinforcement of the colonial project occurs primarily through media, my intent is to subvert this medium. <p>Mission Impossible: Buffalo Boys Wild West Peep Show is an altar and a stage based on the first Blackfoot Mission church. It is a video projection where Buffalo Boy can dream of missions past, play in the present and vision the future. <p>This exhibition includes but is not limited to ideas within indigenous knowledge, meta/ quantum physics role in creating unity, the re-immergence of two-spirit peoples history, colonial or post -colonial critique, ecology, spirituality and healing modalities within the creative process. Through my art making I transcend the constructions of history, I heal myself for others to see, it is a new place from which to view the world.

Abstract Networks are a general feature of Taiwan¡¦s industry. Alongside rapid developments in technology, the island¡¦s industrial structure is being transformed; at the same time, new approaches to administration and management are developing. Hi tech industries are playing a vital role in Taiwan¡¦s economic growth, and this thesis aims to uncover the network characteristics of these industries. The thesis uses the extensive literature available today as the source material for analyzing and comparing the industrial and network characteristics of both traditional and hi tech industries. Three important underlying factors are presented in this thesis; together, these factors help to understand the differences between network characteristics in traditional and hi tech industries. Our research into the characteristics of networks in hi tech industries revealed some interesting results. Firstly, we found that these networks are more elastic, and better able to react to changes in the business environment than traditional networks. Secondly, we discovered that job status in hi tech industries is generally less obvious, more equal and more fluid. Thirdly, existing personal connections still play an important role in hi tech industries, but are less important than in traditional businesses. Networks in hi tech industries have inherited many characteristics of the traditional network; however, as the industrial environment has changed, so networks within hi tech industries have developed many interesting characteristics which differ from traditional industrial networks in important ways.

No description available.

Chemical warfare agents including organophosphorus nerve agents (NA) continue to be a significant threat to both military and civilian populations. The current Canadian Armed Forces (CAF) treatment of NA poisoning includes administration of the oxime HI-6 (used to reactivate inhibited acetylcholinesterase) in combination with atropine contained in an autoinjector, with a benzodiazepine also being administered. Two salts of HI-6 are currently available: HI-6 2Cl (1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyiminio)methyl] pyridinium dichloride (MW 376.22 g/mol) and HI-6 DMS (1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyiminio)methyl] pyridinium dimethanesulfonate (MW 477.49 g/mol). Currently HI-6 is available to the Canadian Armed Forces under a special access program. In order to attain licensure of HI-6 numerous studies must be carried out in animal models to ensure its safety (tolerability and toxicity), efficacy and pharmacokinetics prior to human clinical trials. The present experiment aimed to determine and compare the pharmacokinetic parameters of HI-6 in two animal models under various conditions including: direct comparison of salts (HI-6 2Cl compared to HI-6 DMS), comparison of routes of administration (intramuscular compared to intravenous), comparison of effect of anaesthetic, comparison of different concentrations of HI-6, determination of the effect of atropine sulphate co-administration and evaluation of calculated pharmacokinetic parameters when infusing HI-6. Serial plasma samples were collected and HI-6 levels were quantified using a HPLC method. In all studies a significant difference was reported for absorption/distribution parameters when comparing salts. Additionally the absorption/distribution parameters when comparing routes of administration were significantly different however all other parameters were similar. Significant differences in calculated parameters were reported when examining the effect of anaesthetic on the pharmacokinetics of HI-6. Similar to previous ascending dose studies, differences were reported for the absorption/distribution kinetics. Co-administration of HI-6 with atropine sulphate did not have significant effect on the pharmacokinetics of HI-6. The determined pharmacokinetic values for both salts were accurate for the determination of an infusion rate to reach and maintain a target plasma concentration. Finally the calculated animal model pharmacokinetic data was compared to previously published human clinical trial data and the calculated pharmacokinetic values were found to be similar.

No description available.

Made available in DSpace on 2018-08-24T22:53:37Z (GMT). No. of bitstreams: 1 tese_8872_Dissertação de Mestrado - Fillipe Tesch.pdf: 5590750 bytes, checksum: 9880e0664f2f87463c559fd9d087c3ee (MD5) Previous issue date: 2015-03-02 / A resolução de problemas relacionados aos recursos hídricos tem sido baseada em modelos matemáticos, na maioria das vezes, utilizados como ferramentas de planejamento integrado de recursos naturais. Neste contexto, o modelo Soil and Water Assessment Tool SWAT tem sido aplicado a diversas bacias hidrográficas que necessitam da resoluçao de problemas que integram qualidade e quantidade de água com o manejo do uso e ocupação do solo. No Brasil e no Estado do Espírito Santo um dos maiores problemas relacionados à poluição difusa em bacias hidrográficas rurais são as estradas não pavimentadas. O modelo SWAT têm sido amplamente difundido e pesquisado no Brasil, sendo amplamente utilizado pelas universidades brasileiras, para a modelagem da quantidade e da qualidade da água, bem como para planejar o uso, ocupação e manejo do solo. Considerando, que o manejo de estradas não pavimentas deve ser inserido na pauta do manejo do uso e ocupação do solo, o presente projeto dedicou-se a avaliar a calibração do modelo SWAT para a simulação de estradas não pavimentadas em bacias hidrográficas. Foi escolhida como área de estudo a subbacia hidrográfica do Rio Perdido, afluente direto do Rio Santa Maria do Doce. O modelo SWAT foi aplicado em dois cenários: o primeiro cenário desconsiderou a existência de estradas não pavimentadas na bacia; o segundo cenário, por sua vez, considerou a existência das estradas não pavimentadas como parte do uso e ocupação do solo da bacia hidrográfica. Os cenários modelados foram calibrados a partir do software de calibração SWAT- CUP. Os resultados da calibração indicaram que o Cenário 1 apresentou desempenho muito superior ao Cenário 2, principalmente tratando-se da sedimentologia. Verificou-se que, de modo geral, tanto o Cenário 1 como o Cenário 2 apresentaram desempenho ruim para a simulação de vazões de pequena magnitude. O modelo apresentou melhor desempenho de calibração para vazões com maior frequência ao longo do período monitorado. Por fim, a simulação de estradas não pavimentadas em bacias hidrográficas pelo modelo SWAT exige um maior empenho no monitoramento e realização de ensaios para a cacterização física das condições hidrológicas das estradas, facilitando a definição dos parâmetros requeridos pelo modelo.

Development and application of genomic approaches based on 3C methods combined with increasingly powerful imaging approaches have enabled high-resolution genome-wide analysis of the spatial organization of chromosomes in genome function. In this thesis, I first describe an updated protocol for Hi-C (Hi-C 2.0), integrating recent improvements that significantly contribute to the efficient and high-resolution capture of chromatin interactions. Secondly, I present an assessment of the epigenetic landscape and chromosome conformation around the MYC gene in acute myeloid leukemia (AML) cells before and after small molecule, AI-10-49, treatment. MYC is up-regulated upon inhibition of the RUNX1 repressor by the fusion oncoprotein CBFβ-SMMHC. Treatment of AML cells with AI-10-49 blocks the RUNX1-CBFβ-SMMHC interaction, restoring RUNX1 at MYC regulatory elements. We demonstrate that the established loop is maintained and exchange between activating and repressive chromatin complexes at the regulatory elements, rather than altered chromatin topology, mediates disruption of target gene expression. Finally, Hi-C interaction maps represent the population-averaged steady-states. To understand the forces that promote and maintain the association of loci with specific sub-nuclear structures genome-wide, we developed liquid chromatin Hi-C. Detection of intrinsic locus-locus interaction stabilities and chromatin mobility are enabled by fragmenting chromosomes prior to fixation and Hi-C, thus removing strong polymeric constraints. Nuclear compartmentalization was found to be stable for average fragment lengths are 10-25 kb while fragmentation below 6kb led to a gradual loss of spatial genome organization. Dissolution kinetics of chromatin interactions vary widely for different domains and are analyzed in detail in the final chapter of this thesis., with lamin-associated domains being most stable, and speckle-associated loci most dynamic.

The aim of this work was to create a communication interface of standard ARINC Aerospace Industry Bus 429. The work has slightly outlined existing solutions, from which it can draw inspiration. Further analysis was performed, analysis of ARINC 429 bus, analysis of Raspberry Pi platform on which the solution will be built, and analysis of selected bus controller HI-3593. After that concept was created, based on concept was created the scheme contains circuitry HI-3593. On the basis of the scheme was created DPS. Next was created software for DPS. In the end of this work was tested abilities to receive and send messages on the bus ARINC 429.

Le projet international de synthèse des chromosomes de S. cerevisiae (projet Sc2.0) a débuté il y a une dizaine d'années en suivant des principes établis par le Pr. Jef Boeke. Les chromosomes synthétiques ont été conçus pour augmenter la stabilité du génome en supprimant toutes les séquences répétées (ARNt, éléments transposables...), tout en y ajoutant un système d'évolution inductible dépendant du système Cré/LoxP (système SCRaMbLE), permettant de générer rapidement des réarrangements chromosomiques. Bien que le design du projet Sc2.0 soit très conservateur en ce qui concerne le contenu des gènes, la suppression de plusieurs classes de séquences répétées peut affecter l'organisation du génome et potentiellement altérer les fonctions cellulaires. En utilisant la méthode de capture de conformation de chromosome couplée au séquençage de seconde génération (Hi-C), mon objectif a été de caractériser l'organisation 3D des génomes des souches synthétiques et évoluées. À ce jour, huit chromosomes (syn I, II, III, V, VI, IX-R, X et XII) ont été entièrement assemblés séparément. En utilisant les souches contenant un ou plusieurs de ces chromosomes, nous avons pu montrer que leur organisation génomique n'est globalement pas affectée par leur présence. Quelques exceptions subsistent, avec synIII dont les cassettes HML et HMR ont été retirées, et synXII d'où l'ADNr a été déplacé sur un autre chromosome. À ce stade, nous concluons que l'ADN répétitif dispersé ne conduit pas la conformation moyenne globale du génome de S. cerevisiae. Nous avons aussi exploité les cartes de contacts pour identifier les réarrangements dans les souches SCRaMbLE. / The international project Sc2.0 started 10 years ago by the Pr. Jef Boeke aims to build a fully synthetic genome of S. cerevisiae which increases the genome stability by removing all repeated sequences (tRNA, transposable elements, etc.), and implements SCRaMbLE (for Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution), an inducible, high-throughput chromosome rearrangement system. This design is highly conservative with respect to gene content, the deletion of several classes of repeated sequences and the introduction of thousands of designer changes. However, it may affect genome organization and potentially alter cellular functions. To determine wether those modifications affected the three-dimensional conformation of synthetic chromosmes, we investigated it using chromosomes conformation capture coupled to second generation sequencing method (Hi-C). Currently, eight synthetic chromosomes (synI, synII, synIII, synV, synVI, synIX-R, synX et synXII) have been fully assembled. Using these strains we observed that the large-scale genomic organization is globally unaffected by the presence of synthetic chromosome(s). Two exceptions are synIII, which lacks the silent mating-type cassettes, and synXII, specifically when the ribosomal DNA is moved to another chromosome. We also exploited the contact maps to detect rearrangements induced in these SCRaMbLE strains.

The topic of this thesis deals with the spiral structure in disk galaxies with a specific aim of probing the influence of the dark matter halo and the interstellar gas on the origin and longevity of the spiral arms in late-type galaxies through theoretical modeling and numerical calculations. The basic theoretical model of the galactic disk used involves gravitationally-coupled two-component system (stars and gas) embedded in a rigid and non-responsive dark matter halo, i.e., the static potential of the dark matter is used in the calculations. However, at places, depending on the nature of the problem addressed, the disk is treated as consisting of only stellar component or only gas component followed by proper justifications for the assumptions. The disk is rotationally-supported in the plane and pressure-supported perpendicular to the plane of the disk. The first part of the thesis involves searching for the dynamical effect of dark matter halo on small-scale spiral structure in dwarf low surface brightness (LSB) galaxies and also some dwarf ir-regular galaxies which host an extended H I disk. In both cases, the rotation curves are found to be dominated by the contribution of the dark matter halo over a large radial distance, starting from the inner regions of the galaxies. The next part of the thesis deals with the investigation of the possible effect of the interstellar gas on the persistence is-sue and the pattern speeds of the spiral structure in the disk galaxies. The last part of the thesis involves in studying the dynamical effect of dark matter halo on large-scale spiral structure. Following is the layout of the thesis. Chapter 1 gives a general introduction to the topic of spiral structure of late-type disk galaxies, followed by a broad overview of the theoretical development of the topic and the present status of the topic. Then the thesis starts with studying the small-scale spiral features and evolves to studying the large-scale spiral features seen in disk galaxies in the following way: Chapters 2 & 3 deal with the effect of dark matter halo on small- scale spiral structure. Chapters 4 & 5 focus on the dynamical effect of the interstellar gas on the spiral structure using the local dispersion relation. Chapters 6 & 7 discuss the possible effect of dark matter halo on large-scale spiral structure in disk galaxies. Chapter 8 contains the summary of results and future plans. Effect of dark matter halo on small-scale spiral structure The spiral arms in the disks of galaxies are often broken into several smaller parts or patches that create a messy visual impression when viewed from a ‘face-on’ configura-tion. They are generally termed as ‘small-scale’ or flocculent spiral arms. Several stud-ies showed that the small-scale spiral arms are basically material arm, i.e., they can be thought of as ‘tubes’ filled with stars and gas. Spiral arms are known to participate in the secular evolution of the disk galaxies. Since disk galaxies are believed to reside within a halo of dark matter, therefore a detailed understanding of possible effects of dark matter halo on the spiral arms is necessary. In Chapter 2, we investigate the effect of dark matter halo on small-scale spiral fea-tures in the disks of LSB galaxies. Modeling the mass distribution within a galaxy from the rotation curve of a typical small LSB galaxy reveals the generic fact that for most of the radii, dark matter halo dominates over the stellar disk. This trend is found to be true from the very inner regions of an LSB disk which in turn makes the LSBs a suitable laboratory for probing the effect of dark matter halo on the dynamics of disk galaxies. Following a semi-analytic approach, and using the observationally measured input pa-rameters for a typical superthin LSB galaxy, UGC 7321, we showed that the dominant dark matter halo suppresses the small-scale spiral structure in the disk of UGC 7321. Since UGC 7321 possesses features typical of a LSB galaxy, we argued that this finding will also hold true for other typical LSBs. The result is at par with the observational evi-dences for the lack of prominent, strong small-scale spiral structure in LSB galaxies. In Chapter 3, we employed the similar techniques for probing the effect of dark matter halo on small-scale spiral structure, except this time we took five dwarf irregular galaxies with an extended H I disk as the sample for our investigation. The main im-portant difference between these dwarf irregular galaxies with the earlier LSB galaxies is that for these dwarf irregular galaxies with extended H I disk, the largest baryonic con-tribution comes from the interstellar gas (mainly H I ), and not from the stars (as seen in LSBs). The extended H I disks of these galaxies allow one measure the rotation curve, and hence modeling the dark matter halo parameters for a large radial range from the galactic center. Here also the rotation curves are found to be dominated by dark matter halo over most of the disk, thus providing yet another ‘laboratory’ for testing the dynam-ical effect of dark matter halo on the dynamics of the disks. Using the observed input parameters for five such dwarf irregular galaxies, we showed that the dense and com-pact dark matter halo is responsible for preventing strong small-scale spiral structure in these galaxies, which is in fair agreement with the observations. Dynamical effect of interstellar gas on longevity of spiral arms Any late-type disk galaxy contains a finite amount of interstellar gas along with the stel-lar component. The atomic hydrogen (H I ) constitutes the bulk of the interstellar gas along with the molecular hydrogen (H2), ionized hydrogen (H I I ), and a trace amount of heavy elements like helium. The mass fraction present in the interstellar gas in disk galaxies is found to vary with the Hubble sequence, with the amount of interstellar gas increasing from Sa type to Scd type of galaxies. Due to the lower value of velocity disper-sion as compared to that of stars, gas is known to have a larger destabilizing effect in the disk. Therefore, the natural question arises about what possible role the interstellar gas could play in the origin and the persistence issue of spiral arms. In Chapter 4, we explored how the interstellar gas could influence the longevity of the spiral arms in late-type disk galaxies by treating the spiral structure as density waves in the disk. The disk is modeled as a gravitationally coupled stars plus gas (two-component) system, where the stars are modeled as a collisionless system and the gas treated as a fluid system. Using the appropriate local dispersion relation for the above mentioned model for the disk of galaxy, we calculated the group velocity of a wavepacket of density wave and then studied the variation of the group velocity with increasing amount of interstellar gas in the system. We showed that the group velocity of a wavepacket in a Milky Way-like disk galaxy decreases steadily with the inclusion of gas, implying that the spiral pattern will survive for a longer time-scale in a more gas-rich galaxy by a factor of few. In Chapter 5, we investigated the role of interstellar gas in obtaining a stable den-sity wave corresponding to the observed pattern speed for the spiral arms. The under-lying local dispersion relation remains same as that is in Chapter 4. Using the observa-tionally measured pattern speed and the rotation curves for three late-type disk galaxies we showed that the presence of interstellar gas in necessary in order to maintain a stable density wave corresponding to the observed values for pattern speeds. Also we proposed a method to determine a range of pattern speed values at any particular radius, corre- sponding to which the density wave can be stable. We applied this method to the same three late-type galaxies which we used in the earlier part of this chapter. We found that, for these three galaxies, the observed pattern speed values indeed fall in the predicted range. Imprint of dark matter halo on large-scale spiral structure Along with the small-scale spiral arms, there also exists another type of spiral arms – the large-scale spiral structure, like what we see M 51 or in NGC 2997, which occupy almost the entire outer optical disk in the galaxy. These spiral arms are termed as ‘grand-design’ spiral structure. One of the competing theories, namely, Density wave theory proposes that the large-scale structure is basically a density wave in the disk and the pattern ex-hibits a rigid-body rotation with a definite constant pattern speed. In the earlier part this thesis (Chapters 2 & 3), it was shown that the small-scale spiral structure gets damped by the dominant dark matter halo. Therefore, a natural question arises whether dominant dark matter plays any role on these large-scale spiral structure; and if yes, to what extent it affects the large-scale spiral structure. In Chapters 6 & 7, we investigated how the large-scale structure in disk galaxies gets affected when the disk galaxy hosts a dark matter halo that dominates over most of the disk regions. We again chose the LSB galaxies as laboratory for this study. In Chapter 6, we modeled the stellar component as a fluid system and in Chapter 7, we treated the stellar system as more realistic collisionless system. In both cases, global spiral modes are identified from the appropriate dispersion relations via a novel quantization rule, and they are used as a ‘proxy’ for the large-scale spiral structure. Using the input pa-rameters for UGC 7321, in Chapter 6 we showed that the fluid representation of stellar system failed to make an impression in suppression of the global spiral modes. However, when stellar component is treated as a more realistic collisionless system, we found that the dark matter halo suppresses the large-scale spiral features as well in the disks of LSB galaxies, in fair agreement with the observations. Finally, in Chapter 8, the thesis concludes with a summary of main results and a brief discussion of the scope for future work.