Submitted by SERGIO SOUZA PARMEZZANI null (sergiopaulasouza@hotmail.com) on 2018-02-19T17:42:35Z No. of bitstreams: 1 Doc Sergio S Parmezzani.pdf: 1315195 bytes, checksum: 5bd1fd0c3b822876284a4cd004a1d9a8 (MD5) / Rejected by ALESSANDRA KUBA OSHIRO ASSUNÇÃO (alessandra@fct.unesp.br), reason: Solicitamos que realize correções na submissão seguindo as orientações abaixo: - Colocar folha de aprovação contendo as assinaturas dos membros da banca - Alterar ordem do resumo e do abstract. Segundo a norma da ABNT NBR 14724, eles devem vir após os agradecimentos e antes das listas de figuras, tabelas, etc. Agradecemos a compreensão. on 2018-02-19T18:37:47Z (GMT) / Submitted by SERGIO SOUZA PARMEZZANI null (sergiopaulasouza@hotmail.com) on 2018-02-19T19:52:26Z No. of bitstreams: 1 Doc Sergio S Parmezzani.pdf: 1525296 bytes, checksum: 720bdb75c678cc48c3a69150984743ff (MD5) / Approved for entry into archive by ALESSANDRA KUBA OSHIRO ASSUNÇÃO (alessandra@fct.unesp.br) on 2018-02-19T20:14:45Z (GMT) No. of bitstreams: 1 parmezzani_ss_me_prud.pdf: 1525296 bytes, checksum: 720bdb75c678cc48c3a69150984743ff (MD5) / Made available in DSpace on 2018-02-19T20:14:46Z (GMT). No. of bitstreams: 1 parmezzani_ss_me_prud.pdf: 1525296 bytes, checksum: 720bdb75c678cc48c3a69150984743ff (MD5) Previous issue date: 2017-12-18 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O treinamento concorrente (TC) é uma estratégia eficaz para desenvolver a aptidão aeróbia e força. Contudo, parece que o TC pode apresentar interferência nos ganhos de força, sendo assim, a análise aguda e crônica do salto vertical (SV) podem ser consideradas como uma ferramenta importante para o monitoramento da força. Dessa forma, a presente dissertação tem como objetivo avaliar a resposta aguda e crônica do TC e treinamento de força (TF) no SV. Para tanto, a amostra consistiu de 21 homens fisicamente ativos, randomizados em dois grupos: concorrente (n= 11; 28,45 ± 3,8 anos; 75,18 ± 7,73 Kg; 178,1 ± 6 cm) (GC) e força (GF) (n= 10; 25,5 ± 2,9 anos; 78 ± 11,8 Kg; 178,2 ± 7 cm). O TF consistiu em quatro exercício para membro inferior e quatro para membro superior, intercalados entre si (três séries de oito a 12 repetições máximas). O TC foi realizado de forma intermitente de alta intensidade (TIAI) (1:1) a 100% da Vmax, até que os sujeitos completassem cinco km, associado ao TF na mesma sessão de treinamento. O SV foi realizado pré e pós sessão de treinamento em uma plataforma de salto da marca Cefise® (Nova Odessa, Brasil) na modalidade Squat Jump, na 1a, 2a, 4a, 8a e 10a semana de treinamento. Para o tratamento estatístico foi realizado o teste de normalidade Kolmogorov-Smirnov, seguido pelo teste T-independentevisando comparar as variáveis (idade, massa corporal, massa gorda, massa magra de membro inferior, estatura, IMC, Vmax, V̇O2max, SV, tonelagem total, tonelagem de membro inferior e RM) no momento pré intervenção entre o GF e GC. Em ambas as etapas, um (aguda) e dois (crônica), foi realizada a analise de medidas repetidas e ANOVA e Post-Hoc de Bonferroni. Para primeira etapa não foi encontrado efeito para altura, delta absoluto (Δ abs) e percentual (Δ %) do salto. Na etapa dois, nenhum efeito foi observado na V̇O2max, já para Vmax, houve efeito entre grupos. Não houve efeito para massa magra de membro inferior. Para a tonelagem total e de membro inferior, houve efeito para momento. Desta forma, é possivel concluir que o TC e TF são capazes de melhorar a força muscular, mas não o SV, provavelmente devido a fatores neuromusculares, que geraram economia de movimento. / Concurrent training (TC) is an effective strategy for developing aerobic fitness and strength. However, it seems that TC may interfere with force gains, thus, acute and chronic vertical jump (SV) analysis can be considered as an important tool for force monitoring. Thus, the present dissertation aims to evaluate the acute and chronic response of the TC and strength training (TF) in the SV. The sample consisted of 21 physically active men, who were randomized into two groups: concurrent (n = 11, 28.45 ± 3.8 years, 75.18 ± 7.73 kg, 178.1 ± 6 cm) (GC) and strength (GF) (n = 10, 25.5 ± 2.9 years, 78 ± 11.8 kg, 178.2 ± 7 cm). The TF consisted of four exercises for the lower limb and four for the upper limb, interspersed with each other (three sets of eight to 12 maximal repetitions). TC was performed intermittently high intensity (HIIT) (1: 1) at 100% of the Vmax, until subjects completed 5 km, associated with TF in the same training session. The SV was performed pre and post training session on a jump platform of the brand Cefise® (Nova Odessa, Brazil) in the modality Squat Jump, in the 1st, 2nd, 4th, 8th and 10th week of training. For the statistical treatment, the Kolmogorov-Smirnov normality test was performed, followed by the independent T-test, comparing the variables (age, body mass, fat mass, lean body mass, stature, BMI, Vmax, V̇O2max, SV, total tonnage, lower limb tonnage and MRI) at the pre-intervention time between GF and GC. In both steps, one (acute) and two (chronic), was performed the analysis of repeated measures and ANOVA and Post-Hoc of Bonferroni. For the first step no effect was found for height, absolute delta (Δ abs) and percentage (Δ%) of the jump. In step two, no effect was observed on the V̇O2max, already for Vmax, there was effect between groups. There was no effect on lean lower limb mass. For total tonnage and lower limb, there was effect for moment. Thus, it is possible to conclude that TC and TF are capable of improving muscle strength, but not SV, probably due to neuromuscular factors, which generated movement savings. / 1587674

Resumo: Apesar dos avanços nas pesquisas na área de atividade física e medicina, ainda existem diversas contradições a respeito do real risco e benefício da utilização do exercício físico resistido, principalmente o de força de alta intensidade, para hipertensos no que tange suas variáveis metabólicas. Desta forma, o objetivo desta dissertação foi analisar a influência de um programa de treinamento físico de alta intensidade sobre o metabolismo glicídico, protéico, lipídico e hormonal de ratos espontaneamente hipertensos. Para isso utilizamos ratos machos da linhagem de animais espontaneamente hipertensos (SHR) e ratos Wistar Kyoto (WKY), com 20 semanas de vida. Os animais foram divididos em quatro grupos: SHR Sedentário (SHRS); SHR Treinado (SHRT); WKY Sedentário (WKYS); WKY Treinado (WKYT). O treinamento físico de alta intensidade constituía de natação em tanques individuais, na qual os animais realizavam saltos através de uma mochila com velcro acoplada ao tórax do animal, na qual continha uma resistência equivalente a 50% da massa corporal do mesmo, na forma de chumbinhos. Eram realizadas quatro séries de 10 saltos, tendo um intervalo de 1 minuto entre cada série, em cinco dias na semana, durante um período de oito semanas consecutivas. Após o final do treinamento físico os animais passaram pelos testes de tolerância oral a glicose e tolerância a insulina, e após este período os animais forma eutanasiados e coletado soro, através do sangue coletado diretamente do coração, apara as dosagens de glicose, triglicerídeos, colesterol total, HLD e LDL colesterol, proteínas totais, albumina e creatina quinase (CK) e CK-MB, insulina e IGF-1, GH e ácidos graxos livres (A.G.L). Amostras do músculo gastrocnêmio, porções brancas e vermelhas, sóleo, fígado e coração foram coletados e utilizados para avaliação do conteúdo de glicogênio, proteína e DNA... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: In spite of progress in researches in exercise and medicine area, still several contradictions exist regarding the real risk and benefit of use resistance exercise, mainly the high-intensity, for hypertension in what plays their metabolic variables. This way, objective of this dissertation was to analyze the influence of a high-intensity training program on the glucose, protein, lipids and hormonal metabolism of spontaneously hypertensive rats. For that we used male of lineage of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), with 20 weeks of life. The animals were divided in four groups: Sedentary SHR (SHRS); Trained SHR (SHRT); Sedentary WKY (WKYS); Trained WKY (WKYT). The high intensity training constituted of jumps in the water, in individual tanks, wearing a jacket coupled to the thorax containing a lead overload equivalent to 50% of the body mass. Four series of 10 jumps were accomplished, with an interval of 1 minute among each series, five days a week, during eight consecutive weeks. After the end of exercise training the animals went by the glucose tolerance tests and insulin tolerance test, and after this period all animals were killed and serum collected, through the blood collected directly of heart, it trims the glucose, triglycerides, total cholesterol, HLD and LDL cholesterol, total proteins, albumin and creatine kinase (CK) and CK-MB, insulin and IGF-1, GH and free fat acids (FFA). Samples of muscle gastrocnemius, white and red portions, soleus, liver and heart were collected and used for glycogen content, protein and DNA. In the hepatic and heart samples were still collected for analysis of IGF-1 and triglycerides. The supra-renal glands were removed for evaluation levels of total cholesterol through method enzymatic colorimeter. In the soleus muscle they were removed sliced for analyses synthesis and degradation for muscle... (Complete abstract click electronic access below) / Orientador: Eliete Luciano / Coorientador: Maria Alice Rostom de Mello / Banca: Cláudio Alexandre Gobatto / Banca: Ricardo José Gomes / Mestre

abstract: Cardiovascular disease (CVD) is the number one cause of death in the United States and type 2 diabetes (T2D) and obesity lead to cardiovascular disease. Obese adults are more susceptible to CVD compared to their non-obese counterparts. Exercise training leads to large reductions in the risk of CVD and T2D. Recent evidence suggests high-intensity interval training (HIT) may yield similar or superior benefits in a shorter amount of time compared to traditional continuous exercise training. The purpose of this study was to compare the effects of HIT to continuous (CONT) exercise training for the improvement of endothelial function, glucose control, and visceral adipose tissue. Seventeen obese men (N=9) and women (N=8) were randomized to eight weeks of either HIT (N=9, age=34 years, BMI=37.6 kg/m2) or CONT (N=8, age=34 years, BMI=34.6 kg/m2) exercise 3 days/week for 8 weeks. Endothelial function was assessed via flow-mediated dilation (FMD), glucose control was assessed via continuous glucose monitoring (CGM), and visceral adipose tissue and body composition was measured with an iDXA. Incremental exercise testing was performed at baseline, 4 weeks, and 8 weeks. There were no changes in weight, fat mass, or visceral adipose tissue measured by the iDXA, but there was a significant reduction in body fat that did not differ by group (46±6.3 to 45.4±6.6%, P=0.025). HIT led to a significantly greater improvement in FMD compared to CONT exercise (HIT: 5.1 to 9.0%; CONT: 5.0 to 2.6%, P=0.006). Average 24-hour glucose was not improved over the whole group and there were no group x time interactions for CGM data (HIT: 103.9 to 98.2 mg/dl; CONT: 99.9 to 100.2 mg/dl, P>0.05). When statistical analysis included only the subjects who started with an average glucose at baseline > 100 mg/dl, there was a significant improvement in glucose control overall, but no group x time interaction (107.8 to 94.2 mg/dl, P=0.027). Eight weeks of HIT led to superior improvements in endothelial function and similar improvements in glucose control in obese subjects at risk for T2D and CVD. HIT was shown to have comparable or superior health benefits in this obese sample with a 36% lower total exercise time commitment. / Dissertation/Thesis / Ph.D. Exercise and Wellness 2013

abstract: The Western Pattern diet has been characterized by having greater than 50 percent consumption coming from fat and sugar. This macronutrient allocation has been shown to have deleterious effects on endothelial function and metabolic markers of cardiovascular disease. Exercise has been shown to improve vascular reactivity and metabolic markers related to cardiovascular health. The objective of the study was to determine if exercise training can prevent the anticipated deleterious effects of a fat-sugar supplemented diet on endothelial function and blood markers of cardiovascular risk in young men. Twenty-one, healthy college-aged males were randomly assigned to either the doughnut + exercise or doughnut only groups. Both groups were fed 2 doughnuts per day, 6 days per week, for three weeks, while maintain their current diet. The exercise group completed 4 exercise training sessions per week consisting of 2 high intensity interval training bouts (up to 95% VO2peak) on a cycle ergometer and two moderate intensity, steady-state bouts (at 75% VO2peak) on a treadmill. Changes in body weight and composition, markers of endothelial function, oxidative stress, serum lipids, and blood glucose were measured in each group. As expected, cardiovascular fitness increased significantly in the doughnut-supplemented + exercise group as compared to the doughnut-supplemented (p=0.005). Significant increases in body weight (p=0.036), fat mass (p=0.013), and body fat percentage (p=0.014) were seen in the doughnut only group as compared to the doughnut + exercise group. The doughnut + exercise group showed significant improvements in fasting serum triglycerides (p=0.036), plasma insulin (p=0.039) and insulin sensitivity (HOMA; p=0.05) as compared to the doughnut only group. The doughnut + exercise group saw a significant improvement in nitric oxide availability whereas the doughnut only group experienced a significant decline (p=0.014). There were no significant changes in other markers. Despite the addition of a fat/sugar supplement of ~11,600 kcal over three weeks, 4 exercise sessions per week were sufficient to prevent a gain in body weight and fat mass, and also improve some measures of cardiometabolic risk. These results suggest that exercise may be necessary to prevent some adverse health outcomes associated with transient periods of excessive energy consumption. / Dissertation/Thesis / Ph.D. Physical Activity, Nutrition and Wellness 2013

O objetivo do presente estudo foi verificar os efeitos do treinamento intervalado de alta intensidade (TIAI), específico e não específico, sobre respostas fisiológicas e desempenho em testes aeróbios e anaeróbios, bem como sobre ações técnicas e táticas durante a luta de judô. 35 atletas de judô realizaram uma série de testes antes e após quatro semanas de treinamento, sendo aleatoriamente divididos em quatro grupos: TIAI para membros inferiores, TIAI para membros superiores, TIAI específico [por meio de entrada de golpes (uchi-komi)] e grupo controle. Os grupos experimentais treinaram o exercício intervalado de alta intensidade (EIAI) adicionalmente ao treino de judô e o grupo controle realizou apenas judô. Foi utilizado o mesmo tipo de estímulo em regiões corporais distintas: realização de duas sessões semanais de EIAI constituídas por dois blocos de 10 estímulos de 20s por 10s de intervalo entre os estímulos e 5 min entre os blocos, i.e., grupo de membros superiores e inferiores utilizaram cicloergômetros específicos para cada região corporal, enquanto o grupo específico desempenhou uchi-komi em intensidade all-out com atleta de massa corporal similar. Os grupos e momentos foram comparados via análise de variância (ANOVA) a dois fatores (grupo e momento do treinamento) ou a três fatores (grupo, momento do treinamento e momento da medida), seguida pelo teste de Bonferroni. Quando encontrada diferença entre os grupos durante as semanas de treinamento, foi efetuada uma ANOVA a um fator com medidas repetidas, bem como o teste-t pareado para os valores pré e pós-treinamento. Os principais resultados apontam que: para o grupo de membros inferiores houve aumento da potência equivalente ao onset blood lactate accumulation (OBLA) no teste progressivo para membros superiores, aumento da potência média no teste de Wingate adaptado para membros inferiores, redução da frequência cardíaca após o Special Judo Fitness Test (SJFT), redução do número de sequências em pé durante a simulação de luta e aumento da razão testosterona/cortisol (T/C) pós-simulação de luta no momento pós-treinamento; para o grupo de membros superiores, houve elevação da potência aeróbia máxima no teste progressivo máximo para membros superiores, aumento do número total de projeções no SJFT, redução das concentrações de CK e elevação da razão T/C pós-simulação de luta no pós-treinamento, bem como elevação das concentrações de LDH nas mensurações conduzidas em repouso; para o grupo uchi-komi, houve aumento da potência pico no teste de Wingate para membros superiores e inferiores, redução do índice no SJFT e aumento da razão T/C pós-simulação de luta no momento pós-treinamento. Não foram detectadas alterações no desempenho para o grupo controle pós-treinamento. Além disso, não foram detectadas quaisquer alterações para as respostas psicométricas, hormonais, assim como para o sistema nervoso autônomo após as quatro semanas de intervenção. Os resultados indicam que a adição do TIAI à rotina de treinamento usual de judô eleva a potência aeróbia máxima para membros superiores e desempenho intermitente de alta intensidade para membros superiores e inferiores em testes genéricos. Adicionalmente, o TIAI melhora aspectos relevantes para o desempenho em tarefas específicas do judô. Por fim, o TIAI de baixo volume não promoveu alterações nas respostas do sistema nervoso autônomo, questionários psicométricos e respostas hormonais ao longo das quatro semanas de treinamento / The aim of the present study was to verify the effects, specific and non-specific, of high intensity interval training (HIIT) on physiological and performance responses to aerobic and anaerobic tests, as well as on technical and tactical actions during judo combat. In order to achieve this purpose, 35 judo athletes were randomly selected into four groups: HIIT for lower-body, upper-body, specific group (by means of technique-entrance, uchi-komi) and a control group. These groups completed a series of tests, before and after a 4-week training period. The experimental groups did high intensity interval exercise (HIIE) in addition to judo training while the control group did judo training only. The same type of stimulus was used on distinct body regions: two weekly sessions of HIIE consisting of two blocks of 10 x 20s stimuli with a 10s interval between stimuli and a 5-min interval between blocks, i.e., the lower and upper-body group used cycle-ergometer for each body region, while the specific group carried out uchi-komi at all-out intensity with another athlete of similar body mass and stature. The groups and moments were compared via variance analysis (ANOVA) to two factors (group and training) or to three factors (group, training and time of measurement), followed by the Bonferroni test. When a difference was detected between groups during the training weeks, a one-way (ANOVA) was carried out with repeated measures, as well as the paired t-test, for pre and post-training values. The main results indicate that: The lower-body group showed increase in the equivalent power to onset blood lactate accumulation (OBLA), in aerobic fitness test for upper- limbs, increase in the mean power in the Wingate test (4 sets of 30s interspersed with 3-min recovery period) for lower limbs, heart rate reduction after the Special Judo Fitness Test (SJFT), reducing the number of standing sequences during the match simulation and increasing the testosterone/cortisol ratio (T/C) after the match simulation in the post-training period; For the upper-body group, showed an increase of the maximum aerobic power in aerobic fitness test for upper limbs, increase in the total number of projections in SJFT, reduced CK concentrations (post-training period), increase in T/C ratio post-match in the post-training period and increase in LDH concentrations in measurements conducted at rest. Uchi-komi group, showed an increased in the peak power in the Wingate test for upper and lower limbs, reduction of the SJFT index and increasing the T/C ratio after the match-simulations in the post-training period. As expected, were not found any performance changes after 4-weeks of intervention for the control group Furthermore, were not detected any changes to the psychometric, hormonal responses, as well as the autonomic nervous system after four weeks of intervention for all experimental groups. Therefore, these findings suggest that addition of the HIIT to usual judo training increases the maximum aerobic power for upper limbs and high-intensity intermittent performance for upper and lower limbs, in generic tests. Moreover, HIIT improves relevant aspects to performance in specific judo tasks. Finally, low volume HIIE did not bring about any alterations to the autonomous nervous system responses, psychometric responses or hormonal responses throughout the four weeks of training

Sabe-se que o aumento na temperatura do tecido tumoral pode aumentar a eficiência de técnicas convencionais de combate ao câncer (radioterapia e quimioterapia). Além disso, a variação de temperatura em tumores pode ser uma forma de tratamento alternativo à cirurgia, feito por meio do fornecimento de calor direcionado às células cancerosas e preservando o tecido sadio. Para maior eficácia e segurança no emprego de técnicas que utilizam fornecimento de calor ao tecido biológico, é necessário o monitoramento da temperatura tecidual para garantir que a morte celular por ablação térmica seja limitada ao tecido alvo, minimizando os danos aos tecidos adjacentes. A imagem fotoacústica é uma técnica baseada no efeito fotoacústico, o qual consiste na absorção de radiação eletromagnética pelo tecido e, devido à expansão termoelástica, na geração de ondas acústicas. A amplitude da onda de pressão gerada pelo efeito fotoacústico possui dependência com a temperatura do meio pelo parâmetro de Grueneisen, que depende das propriedades mecânicas do material. Portanto, mudanças na amplitude do sinal fotoacústico carregam informações a respeito da variação na temperatura do material. Neste trabalho, a dependência da amplitude do sinal fotoacústico com a temperatura foi estudada em um material simulador de tecido biológico (phantom) em condições similares a de tratamentos por hipertermia Nesse caso, imagens fotoacústicas foram adquiridas para cada grau de temperatura em uma faixa de 36 até 41 ºC durante o procedimento de aquecimento por banho térmico. Mudanças na amplitude e fase do sinal fotoacústico foram avaliadas através da aplicação de algoritmos de speckle tracking. Para estimar a variação na amplitude do sinal também foram utilizados e avaliados diferentes métodos de comparação. Os resultados são apresentados por imagens fotoacústicas termais produzidas pela aplicação de um fator de calibração aos mapas de variação relativa da amplitude do sinal em função da temperatura do meio. Finalmente, avaliamos um experimento de hipertemia por ultrassom focalizado de alta intensidade (High Intensity Therapeutic Ultrasound - HITU) em uma amostra de músculo suíno. Nesse caso foram geradas imagens termais fotoacústicas e imagens termais produzidas pela mudança de fase do sinal pulso-eco de ultrassom. Os resultados sugerem uma maneira não invasiva de calcular a distribuição da variação de temperatura do meio que pode ser aplicada para monitoramento durante tratamentos que utilizam o fornecimento de calor ao tecido biológico. / Several studies have shown that elevating the temperature of tumoral tissue improves standard cancer treatments success rate (radiotherapy and chemotherapy). This procedure can also be a therapy to cancer by delivering heat and killing cancer cells while healthy tissues are preserved. For improved efficiency and security in heat applications, it is important to monitor tissue temperature during treatments. Photoacoustic (PA) pressure wave amplitude has a temperature dependence given by the sample mechanical properties (Gruenesein parameter). These changes in photoacoustic signal amplitude carry information about temperature variation in tissue. Therefore, PA has been proposed as an imaging technique to monitor temperature during hyperthermia. In this study, PA images were acquired for temperatures ranging from 36ºC to 41ºC using a tissue-mimicking phantom immersed in a temperature controlled thermal bath. Relative amplitude variation was calculated using speckle tracking algorithms using four different methods to estimate these variations in PA signal amplitude. The results are presented as PA-based thermal images, generated using a calibration factor to the percentage variations in the amplitude maps. Finally, PA-based and ultrasound-based thermal images were acquired during heating by high intensity focused ultrasound (High Intensity Therapeutic Ultrasound - HITU) in a porcine muscle. The results suggest a non-invasive way to monitor temperature during hyperthermia procedures.

Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(工学) / 甲第17563号 / 工博第3722号 / 新制||工||1567(附属図書館) / 30329 / 京都大学大学院工学研究科原子核工学専攻 / (主査)教授 森 義治, 教授 伊藤 秋男, 教授 中島 健 / 学位規則第4条第1項該当

京都大学 / 新制・課程博士 / 博士(医学) / 甲第23467号 / 医博第4774号 / 新制||医||1053(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 森信 暁雄, 教授 上野 英樹, 教授 小柳 義夫 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Orientador: Daniele Cristina Cataneo / Resumo: Introdução: Há evidências que o exercício físico é benéfico em pacientes com câncer pois fornece independência funcional ao indivíduo. Entretanto pouco se sabe sobre os efeitos do treinamento intervalado de alta intensidade (HIIT) nesses indivíduos, fazendo-se necessário uma revisão sistemática para reunir estudos que utilizaram esta modalidade de exercício, possibilitando o conhecimento de seus reais efeitos no paciente com câncer. Objetivos: Avaliar a efetividade, viabilidade e segurança do treinamento intervalado de alta intensidade nos pacientes com câncer. Método: Foi conduzida uma revisão sistemática (RS) de ensaios clínicos randomizados (ECR), quase randomizados ou controlados que avaliaram o HIIT em pacientes com câncer. Foram avaliados os desfechos: Efetividade (condicionamento físico e qualidade de vida), Viabilidade (fadiga, composição corporal e aderência ao tratamento) e Segurança (efeitos adversos e sobrevida). Todas as buscas foram conduzidas sem restrição de idiomas ou datas nas seguintes bases de dados: Lilacs, Pubmed, Cochrane, Web of Science, Embase e Scopus. Resultados: A pesquisa identificou 333 estudos, dos quais 20 artigos foram incluídos. A duração média da intervenção foi de 9,5 ± 4,7 semanas, com 2,9 ± 0,2 sessões por semana. A meta- análise do consumo de oxigênio (VO2) para o condicionamento físico mostrou superioridade do HIIT em comparação aos Cuidados Usuais (UC) (MD 3,29, IC95% 1,94, 4,64; p<0,00001), mas não quando comparado ao exercício modera... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: There is evidence that physical exercise is beneficial in cancer patients as it provides functional independence to the individual. However, little is known about the effects of high-intensity interval training (HIIT) on these individuals, making a systematic review necessary to gather studies that used this exercise modality, enabling the knowledge of its real effects on cancer patients. Objectives: To evaluate the effectiveness, feasibility and safety of high-intensity interval training in cancer patients. Method: A systematic review of randomized, quasi-randomized or controlled clinical trials that evaluated HIIT in cancer patients was conducted. The outcomes evaluated were: Effectiveness (physical conditioning and quality of life), Viability (fatigue, body composition and adherence to treatment) and Safety (adverse effects and survival). All searches were conducted without restriction of languages or dates in the following databases: Lilacs, Pubmed, Cochrane, Web of Science, Embase and Scopus. Results: The research identified 333 studies, of which 20 articles were included. The average duration of the intervention was 9.5 ± 4.7 weeks, with 2.9 ± 0.2 sessions per week. The meta-analysis of oxygen consumption (VO2) for physical conditioning determined superiority of HIIT compared to Usual Care (UC) (MD 3.29, 95% CI 1.94, 4.64; p <0.00001), but not when compared to moderate continuous intensity exercise (MIC) (MD 1.83, 95% CI -0.40, 4.06; p = 0.11). Likewise, d... (Complete abstract click electronic access below) / Mestre

This study investigated the effects of ungraded running and graded walking as modalities of HIIT on enjoyment, perceived exertion, and affect. 29 healthy males and females (aged 23.3 ± 5.1) volunteered to participate in the study. Participants completed six visits to the laboratory: the first was a medical screening to ensure safety of the participants. For the second and third visits, participants completed two maximal treadmill exercise tests, one running and one walking. On the fourth visit, the speed needed for the run HIIT (running speed: 6.9 ± 1.2mph) and the grade needed for the walk HIIT (walking speed: 3.3 ± 0.3mph, walking grade: 17.2 ± 3.1%) experimental trials were confirmed. During the last two visits, participants completed both of the two (run HIIT and walk HIIT) randomized and counterbalanced experimental trials. Affective valence was measured at baseline and post-exercise. The single-item Feeling Scale (FS) and the Borg 6-20 RPE scale (both overall exertion and legs-only exertion) were used to measure in-task ratings of affect and exertion. The Physical Activity Enjoyment Scale (PACES) and FS were used to measure post-exercise ratings of enjoyment and affect. Results revealed a main effect for condition for post-exercise enjoyment (p < 0.001), with the run HIIT being more enjoyable. A main effect was also found for time for both overall exertion and legs-only exertion (p < 0.001 for both interactions), with the walk HIIT producing higher exertion ratings. There was a main effect for condition of legs-only exertion (p = 0.004), again walk HIIT produced higher exertion ratings. Lastly, there was a main effect when comparing 20% and 100% of total time in the run HIIT and the walk HIIT conditions, for both overall exertion and legs-only exertion (p < 0.001 for all interactions). This shows that exertion increased over time for both conditions. Exertion ratings, both overall and legs-only tended to be highest during the run HIIT condition when compared to the walk HIIT. The opposite was true for affective valence, the ratings were higher in the run HIIT condition than the walk HIIT. In conclusion, the perceptual responses in this study, which represent enjoyment, exertion and affective valence, were generally more favorable during the run HIIT condition. These results support previous findings to suggest that doing a running protocol is a well-tolerated and favorable modality for HIIT exercise.