Fundamentação: O tromboembolismo pulmonar (TEP) é uma doença freqüente no ambiente hospitalar e com significativa mortalidade. A investigação diagnóstica envolve uma série de etapas e o desfecho dos pacientes investigados para TEP, mas cuja investigação não confirmou nem excluiu TEP, não está bem documentado. Objetivo: Comparar a mortalidade intra-hospitalar nos casos com suspeita de TEP agudo entre aqueles com diagnóstico confirmado, diagnóstico excluído e investigação inconclusiva. Métodos: Estudo observacional, comparado, retrospectivo (coorte histórica), de pacientes adultos ( 18 anos) com suspeita de TEP internados no HCPA de 1996 a 2000 que realizaram testes diagnósticos para TEP (cintilografia pulmonar perfusional, angio-TC ou arteriografia pulmonar convencional) ou com CID-9 413/CID10 I26 (embolia pulmonar) na ficha de admissão ou na nota de alta/óbito. Resultados: Dos 741 pacientes selecionados, 687 constituíram a amostra final (54 excluídos). A média de idade foi 61,53 ± 16,75 anos, sendo 292 homens (42,5%). Ocorreu início dos sintomas de TEP no domicílio em 330 casos (48%) e no hospital em 357 (52%). Em 120 pacientes (17,5%) TEP foi objetivamente confirmado, em 193 (28,1%) foi objetivamente excluído e em 374 (54,4%) a investigação foi não conclusiva. A mortalidade intra-hospitalar da amostra foi de 19,1% (n=134). Na análise univariada, sexo masculino, hipotensão, TEP nosocomial, neoplasia maligna, investigação não conclusiva, ausência de tratamento para TEP, investigação em 1996-1997 foram associados à maior mortalidade. Na análise multivariada, hipotensão (beta 2,49, IC95% 1,35-4,63), TEP objetivamente confirmado (beta 2,199, IC95% 1,15-4,21), investigação não conclusiva (beta 1,70, IC95% 1,00 – 2,87), neoplasia maligna (beta 2,868, IC95% 1,80-4,45), TEP nosocomial (beta 1,57, IC95% 1,02-2,41), ano de inclusão 1996- 1997 (beta 1,71, IC95% 1,15-2,67) e infecção torácica ou abdominal (beta 1,71, IC95% 1,08-2,71) foram independentemente associados à maior mortalidade intrahospitalar (p<0,05). Conclusões: Pacientes com TEP agudo objetivamente confirmado tiveram mortalidade intra-hospitalar significativa-mente maior que pacientes nos quais TEP foi excluído. A investigação não conclusiva para TEP foi um fator independente para mortalidade intra-hospitalar em pacientes com suspeita desta doença. / Background: Pulmonary thromboembolism (PE) is frequent in hospital setting and has significant mortality. Diagnostic approach of PE has many steps and follow-up of patients with non-confirmed PE is unknown. Purpose: To compare the inhospital mortality in cases with suspected acute PE among those with confirmed diagnosis, excluding diagnosis and inconclusive diagnostic workup. Methods: Historical cohort including adult patients ( 18 years) with clinically suspected PE that performed perfusion lung scan, CT-angiography, pulmonary arteriography or had PE ICD-9 413/ICD-10 I26 at admission or in discharge charts, from 1996 to 2000. We excluded patients with incomplete or lost medical records. Medical records were reviewed using a standardized form. Statistical analysis was done by chi-square-test, Student’s t test and logistic regression, with statistical significance of 5% (bilateral). Results: Of 741 patients, 687 were included (54 were excluded). Mean age was 61.53 ± 16.75 years, 292 patients were men (42.5%). Primary PE was identified in 330 cases (48%) and secondary PE in 357 (52%). In 120 patients (17.5%), PE was objectively confirmed, in 193 (28.1%) was objectively excluded, and in 374 cases (54.4%) the diagnostic approach was non-conclusive. In-hospital mortality was 19.1% (n=134). In univariate analysis, male gender, hypotension, secondary PE, cancer, non-conclusive approach, untreated PE, inclusion in 1996- 1997 were associated to the highest mortality. In multivariate analysis, hypotension (beta 2.49, 95% confidence interval [CI] 1.35-4.63), PE objectively confirmed (beta 2.199, 95%CI 1.15-4.21), non-conclusive approach (beta 1.70, 95%CI 1.00-2.87), cancer (beta 2.87, 95%CI 1.80-4.45), secondary PE (beta 1.57, 95%CI 1.02-2.41), inclusion in 1996-1997 (beta 1.71, 95%CI 1.15-2.67) and thoracic or abdominal infection (beta 1.71, 95%CI 1.08-2.71) were associated with the highest in-hospital mortality (p<0.05). Conclusions: Patients with acute PE objectively confirmed had significantly higher in-hospital mortality than patients in whom PE was excluded. Non-conclusive approach of PE was an independent factor for in-hospital mortality in patients with suspected disease.

Fundamentação: O tromboembolismo pulmonar (TEP) é uma doença freqüente no ambiente hospitalar e com significativa mortalidade. A investigação diagnóstica envolve uma série de etapas e o desfecho dos pacientes investigados para TEP, mas cuja investigação não confirmou nem excluiu TEP, não está bem documentado. Objetivo: Comparar a mortalidade intra-hospitalar nos casos com suspeita de TEP agudo entre aqueles com diagnóstico confirmado, diagnóstico excluído e investigação inconclusiva. Métodos: Estudo observacional, comparado, retrospectivo (coorte histórica), de pacientes adultos ( 18 anos) com suspeita de TEP internados no HCPA de 1996 a 2000 que realizaram testes diagnósticos para TEP (cintilografia pulmonar perfusional, angio-TC ou arteriografia pulmonar convencional) ou com CID-9 413/CID10 I26 (embolia pulmonar) na ficha de admissão ou na nota de alta/óbito. Resultados: Dos 741 pacientes selecionados, 687 constituíram a amostra final (54 excluídos). A média de idade foi 61,53 ± 16,75 anos, sendo 292 homens (42,5%). Ocorreu início dos sintomas de TEP no domicílio em 330 casos (48%) e no hospital em 357 (52%). Em 120 pacientes (17,5%) TEP foi objetivamente confirmado, em 193 (28,1%) foi objetivamente excluído e em 374 (54,4%) a investigação foi não conclusiva. A mortalidade intra-hospitalar da amostra foi de 19,1% (n=134). Na análise univariada, sexo masculino, hipotensão, TEP nosocomial, neoplasia maligna, investigação não conclusiva, ausência de tratamento para TEP, investigação em 1996-1997 foram associados à maior mortalidade. Na análise multivariada, hipotensão (beta 2,49, IC95% 1,35-4,63), TEP objetivamente confirmado (beta 2,199, IC95% 1,15-4,21), investigação não conclusiva (beta 1,70, IC95% 1,00 – 2,87), neoplasia maligna (beta 2,868, IC95% 1,80-4,45), TEP nosocomial (beta 1,57, IC95% 1,02-2,41), ano de inclusão 1996- 1997 (beta 1,71, IC95% 1,15-2,67) e infecção torácica ou abdominal (beta 1,71, IC95% 1,08-2,71) foram independentemente associados à maior mortalidade intrahospitalar (p<0,05). Conclusões: Pacientes com TEP agudo objetivamente confirmado tiveram mortalidade intra-hospitalar significativa-mente maior que pacientes nos quais TEP foi excluído. A investigação não conclusiva para TEP foi um fator independente para mortalidade intra-hospitalar em pacientes com suspeita desta doença. / Background: Pulmonary thromboembolism (PE) is frequent in hospital setting and has significant mortality. Diagnostic approach of PE has many steps and follow-up of patients with non-confirmed PE is unknown. Purpose: To compare the inhospital mortality in cases with suspected acute PE among those with confirmed diagnosis, excluding diagnosis and inconclusive diagnostic workup. Methods: Historical cohort including adult patients ( 18 years) with clinically suspected PE that performed perfusion lung scan, CT-angiography, pulmonary arteriography or had PE ICD-9 413/ICD-10 I26 at admission or in discharge charts, from 1996 to 2000. We excluded patients with incomplete or lost medical records. Medical records were reviewed using a standardized form. Statistical analysis was done by chi-square-test, Student’s t test and logistic regression, with statistical significance of 5% (bilateral). Results: Of 741 patients, 687 were included (54 were excluded). Mean age was 61.53 ± 16.75 years, 292 patients were men (42.5%). Primary PE was identified in 330 cases (48%) and secondary PE in 357 (52%). In 120 patients (17.5%), PE was objectively confirmed, in 193 (28.1%) was objectively excluded, and in 374 cases (54.4%) the diagnostic approach was non-conclusive. In-hospital mortality was 19.1% (n=134). In univariate analysis, male gender, hypotension, secondary PE, cancer, non-conclusive approach, untreated PE, inclusion in 1996- 1997 were associated to the highest mortality. In multivariate analysis, hypotension (beta 2.49, 95% confidence interval [CI] 1.35-4.63), PE objectively confirmed (beta 2.199, 95%CI 1.15-4.21), non-conclusive approach (beta 1.70, 95%CI 1.00-2.87), cancer (beta 2.87, 95%CI 1.80-4.45), secondary PE (beta 1.57, 95%CI 1.02-2.41), inclusion in 1996-1997 (beta 1.71, 95%CI 1.15-2.67) and thoracic or abdominal infection (beta 1.71, 95%CI 1.08-2.71) were associated with the highest in-hospital mortality (p<0.05). Conclusions: Patients with acute PE objectively confirmed had significantly higher in-hospital mortality than patients in whom PE was excluded. Non-conclusive approach of PE was an independent factor for in-hospital mortality in patients with suspected disease.

Fundamentação: O tromboembolismo pulmonar (TEP) é uma doença freqüente no ambiente hospitalar e com significativa mortalidade. A investigação diagnóstica envolve uma série de etapas e o desfecho dos pacientes investigados para TEP, mas cuja investigação não confirmou nem excluiu TEP, não está bem documentado. Objetivo: Comparar a mortalidade intra-hospitalar nos casos com suspeita de TEP agudo entre aqueles com diagnóstico confirmado, diagnóstico excluído e investigação inconclusiva. Métodos: Estudo observacional, comparado, retrospectivo (coorte histórica), de pacientes adultos ( 18 anos) com suspeita de TEP internados no HCPA de 1996 a 2000 que realizaram testes diagnósticos para TEP (cintilografia pulmonar perfusional, angio-TC ou arteriografia pulmonar convencional) ou com CID-9 413/CID10 I26 (embolia pulmonar) na ficha de admissão ou na nota de alta/óbito. Resultados: Dos 741 pacientes selecionados, 687 constituíram a amostra final (54 excluídos). A média de idade foi 61,53 ± 16,75 anos, sendo 292 homens (42,5%). Ocorreu início dos sintomas de TEP no domicílio em 330 casos (48%) e no hospital em 357 (52%). Em 120 pacientes (17,5%) TEP foi objetivamente confirmado, em 193 (28,1%) foi objetivamente excluído e em 374 (54,4%) a investigação foi não conclusiva. A mortalidade intra-hospitalar da amostra foi de 19,1% (n=134). Na análise univariada, sexo masculino, hipotensão, TEP nosocomial, neoplasia maligna, investigação não conclusiva, ausência de tratamento para TEP, investigação em 1996-1997 foram associados à maior mortalidade. Na análise multivariada, hipotensão (beta 2,49, IC95% 1,35-4,63), TEP objetivamente confirmado (beta 2,199, IC95% 1,15-4,21), investigação não conclusiva (beta 1,70, IC95% 1,00 – 2,87), neoplasia maligna (beta 2,868, IC95% 1,80-4,45), TEP nosocomial (beta 1,57, IC95% 1,02-2,41), ano de inclusão 1996- 1997 (beta 1,71, IC95% 1,15-2,67) e infecção torácica ou abdominal (beta 1,71, IC95% 1,08-2,71) foram independentemente associados à maior mortalidade intrahospitalar (p<0,05). Conclusões: Pacientes com TEP agudo objetivamente confirmado tiveram mortalidade intra-hospitalar significativa-mente maior que pacientes nos quais TEP foi excluído. A investigação não conclusiva para TEP foi um fator independente para mortalidade intra-hospitalar em pacientes com suspeita desta doença. / Background: Pulmonary thromboembolism (PE) is frequent in hospital setting and has significant mortality. Diagnostic approach of PE has many steps and follow-up of patients with non-confirmed PE is unknown. Purpose: To compare the inhospital mortality in cases with suspected acute PE among those with confirmed diagnosis, excluding diagnosis and inconclusive diagnostic workup. Methods: Historical cohort including adult patients ( 18 years) with clinically suspected PE that performed perfusion lung scan, CT-angiography, pulmonary arteriography or had PE ICD-9 413/ICD-10 I26 at admission or in discharge charts, from 1996 to 2000. We excluded patients with incomplete or lost medical records. Medical records were reviewed using a standardized form. Statistical analysis was done by chi-square-test, Student’s t test and logistic regression, with statistical significance of 5% (bilateral). Results: Of 741 patients, 687 were included (54 were excluded). Mean age was 61.53 ± 16.75 years, 292 patients were men (42.5%). Primary PE was identified in 330 cases (48%) and secondary PE in 357 (52%). In 120 patients (17.5%), PE was objectively confirmed, in 193 (28.1%) was objectively excluded, and in 374 cases (54.4%) the diagnostic approach was non-conclusive. In-hospital mortality was 19.1% (n=134). In univariate analysis, male gender, hypotension, secondary PE, cancer, non-conclusive approach, untreated PE, inclusion in 1996- 1997 were associated to the highest mortality. In multivariate analysis, hypotension (beta 2.49, 95% confidence interval [CI] 1.35-4.63), PE objectively confirmed (beta 2.199, 95%CI 1.15-4.21), non-conclusive approach (beta 1.70, 95%CI 1.00-2.87), cancer (beta 2.87, 95%CI 1.80-4.45), secondary PE (beta 1.57, 95%CI 1.02-2.41), inclusion in 1996-1997 (beta 1.71, 95%CI 1.15-2.67) and thoracic or abdominal infection (beta 1.71, 95%CI 1.08-2.71) were associated with the highest in-hospital mortality (p<0.05). Conclusions: Patients with acute PE objectively confirmed had significantly higher in-hospital mortality than patients in whom PE was excluded. Non-conclusive approach of PE was an independent factor for in-hospital mortality in patients with suspected disease.

Introdução: A internação psiquiátrica pode ser: voluntária; involuntária; compulsória. Esta última é determinada pela autoridade judicial não podendo ser questionada em seu aspecto legal, entretanto cabem questionamentos quanto aos aspectos técnicos e éticos. Objetivo: Discutir como a Equipe Multiprofissional de uma enfermaria psiquiátrica que vivencia o cuidado ao paciente em internação compulsória. Método: estudo de caso descritivo, compreensivo, por meio de pesquisa quantiqualitativa, no Serviço de Internação Psiquiátrica do Hospital de Clínicas Dr. Alberto Lima, no município de Macapá- AP. Participaram os servidores maiores de 18 anos, de ambos os sexos, de locais e níveis socioeconômicos variados e que assinaram o Termo de Consentimento Livre e Esclarecido. Coleta de dados: utilizou-se o questionário sociodemográfico e econômico e foram feitas entrevistas semiestruturadas. Foi realizado Grupo Focal (GF), em que se apresentaram os discursos elaborados, a fim de que, diante dos diferentes entendimentos, os discursos espontâneos analisados fossem apresentados aos entrevistados da equipe multiprofissional e, para isso, foi estabelecida uma conversa sobre a realidade vivenciada. Para o tratamento dos dados qualitativos, aplicou-se a técnica do Discurso do Sujeito Coletivo (DSC); os dados quantitativos foram expressos pelo pacote Excel e analisados por meio do software Bioestat 5.3. Resultados: Destacaram-se características da Enfermaria Psiquiátrica e a caracterização sociodemográfica e clínica das internações. A equipe é predominantemente do sexo feminino, a maior parte trabalha em outros serviços e possui nível de escolaridade superior completo. A partir das entrevistas, emergiram os DSCs, apresentados por categoria, as ancoragens, vistas como desafios éticos identificados sob a ótica da vivência do cuidado. O estudo mostrou que há empatia dos profissionais com o sofrimento das mães e familiares das pessoas com transtornos mentais e que precisam internação compulsória e consideram que a internação compulsória é uma forma de tratamento, desde que bem indicada. Os participantes destacaram que a ordem médica deveria valer mais que a ordem judicial na determinação da internação compulsória. O Grupo Focal fez emergir as categorias: A difícil experiência do cuidar em internação involuntária/ compulsória; Incipiência da RAPS; Obstáculos para o cuidar de qualidade na internação compulsória e involuntária. Os desafios éticos de cuidar dos pacientes psiquiátricos internados contra a vontade foram revelados pelas ancoragens isoladas nos DSCs: os apenados são pessoas com comportamento inadequado; autoritarismo e paternalismo no tratamento da pessoa com transtorno mental; empatia com o sofrimento familiar; internação psiquiátrica compulsória amparada em sólida avaliação e indicação técnicas; judicialização da saúde e as questões éticas e técnicas desta prática; internação psiquiátrica é necessária, mas somente por avaliação da equipe técnica; justiça não tem poder para avaliar a pessoa se tem ou não indicação para a internação psiquiátrica. Considerações Finais: os profissionais, diante de fatos impositivos pela justiça nas internações psiquiátricas involuntárias/ compulsórias, elegem como prioridade o diálogo entre o Judiciário e os profissionais de saúde como caminho para um possível consenso entre esses segmentos, sem minimizar a responsabilidade de cada um, com o intuito único de prestar atenção adequada e com qualidade à pessoa envolvida no processo de internação compulsória. / Introduction: Psychiatric hospital admission can be: voluntary; involuntary; compulsory. The last one is legally enforced, it cannot be questioned in its legal aspect, however there can be questioning on technical and ethical issues. Objective: To discuss how the Multiprofessional Team of a Psychiatric Ward to experience a patients health care in compulsory hospitalization. Method: descriptive, comprehensive case study by means of quanti-qualitative research at the Psychiatric Admission Service of Hospital de Clínicas Dr. Alberto Lima in the municipality of Macapá Amapá State, Brazil. Male and female healthcare professionals over 18 years of age from varied places and socioeconomic status participated in the study, who signed the Free Informed Consent Form. Data collection: the questionnaire on economic and sociodemographic status was used, as well as semi-structured interviews were carried out. The Focus Group (FG) was held and the elaborated discourses were presented so that the analyzed spontaneous accounts, due to their different understandings, were presented to the participants of the multiprofessional team. Thus, a conversation on the experienced reality was established. The technique of the Discourse of the Collective Subject (DCS) was applied to analyze the qualitative data; quantitative data were expressed by the Excel package and analyzed by means of the Bioestat 5.3 software. Results: Psychiatric Nursing characteristics as well as the sociodemographic and clinical profile of the hospital admissions stood out. Females prevail in the team, most of them work in other services and have complete Higher Education level. From the interviews, the DCSs emerged, presented by category, the anchorages viewed as ethical challenges and identified in the light of lived caring. The study showed the empathy between the professionals and the suffering of mothers and family members of the mentally-ill who need compulsory hospital admission, and they consider it a way of treatment as long as it is well referred. The participants pointed out that a medical order should outstand a legal order in order to determine compulsory admission. The following categories emerged from the Focus Group: The hard experience of caring for the involuntary/compulsory admitted ones; The incipience of the Psychosocial Care Network; Obstacles for the quality care of those undergoing involuntary and compulsory hospital admission. The ethical challenges to care for psychiatric patients hospitalized against their will were unfolded by the isolated anchorages in the DCSs: the convicts are improperly behaved people; authoritarianism and patronizing in the treatment of people with mental disorders; empathy towards family suffering; compulsory psychiatric admission grounded in sound assessment and technical referral; healthcare judicialization and ethical and technical issues in this practice; psychiatric admission is necessary, but only if assessed by a technical team; justice has no power to assess whether a person can be referred to a psychiatric hospital admission or not. Final considerations: due to court orders for involuntary/compulsory hospital admissions, professionals find dialogue as the priority between judicial officers and healthcare professionals as a way for them to come to an agreement, without minimizing the responsibility of any parties, aiming at delivering proper and quality care to the person involved in the process of compulsory hospital admission.

Por existirem poucos estudos sobre o momento da internação hospitalar para a realização da cirurgia por câncer de mama, decidiu-se melhor compreender este momento a partir do referencial da teoria das representações sociais e da teoria do enfrentamento, buscando-se em um grupo de mulheres a identificação do significado da admissão hospitalar necessária para a realização da cirurgia, bem como as estratégias de enfrentamento por elas utilizadas nesse momento. A coleta de dados foi realizada numa amostra composta por 10 mulheres e pelos principais profissionais envolvidos em suas admissões. Com as mulheres foram realizadas observações participantes com a utilização do diário de campo e entrevistas semi-estruturadas, analisadas qualitativamente; e os profissionais foram observados com a utilização de um instrumento aberto-fechado, analisado qualitativa e quantitativamente. Em relação às mulheres, foram identificadas as seguintes categorias: perda da mama, medo da morte, cura, cuidado enquanto estratégia de retorno à saúde e dia normal. As estratégias de enfrentamento identificadas foram: médicos, Deus, ela própria, crenças próprias, família, namorado, outros que passaram pela mesma experiência, coragem, confiança, força de vontade, oração, não pensar e convivência com pessoas brincalhonas capazes de passar energia boa. A análise conjunta das representações sociais com as estratégias de enfrentamento evidenciou que em 70% das participantes houve relação entre o significado atribuído à admissão hospitalar e as estratégias de enfrentamento utilizadas. A relação entre as representações sociais e as estratégias de enfrentamento mostrou que as categorias: cura, cuidado enquanto estratégia de retorno à saúde e dia normal foram as mais eficazes no enfrentamento da admissão hospitalar. O instrumento utilizado com os principais profissionais que realizaram as admissões hospitalares mostrou que 100% dos principais responsáveis pelas admissões hospitalares foram enfermeiras; 100% delas tentaram estabelecer um vínculo positivo com as mulheres no momento do chamamento; 80% não se apresentaram às mulheres que receberam; 90% utilizaram preferencialmente o termo senhora no período em que permaneceram com as mulheres; 100% demonstraram preocupação com o ambiente físico relacionado à admissão hospitalar; 70% mostraram-se dispostas a ouvir as mulheres recebidas; 80% receberam as mulheres na posição ereta e, 60% das admissões hospitalares ocorreram com a presença de uma enfermeira e uma auxiliar de enfermagem. Alguns desses dados permitiram verificar que esses profissionais forneceram suporte às mulheres, mas ao mesmo tempo outros dados mostraram que estes mesmos profissionais se distanciaram de um cuidado capaz de contemplar os aspectos físicos, mentais e espirituais dessas mulheres. Pontua-se, a partir desta análise, a necessidade do estabelecimento da subjetividade no momento da internação como forma de identificação das necessidades das mulheres com câncer de mama. Para tanto, sugere-se a construção de um complemento para o protocolo de admissão hospitalar atualmente utilizado na enfermaria, onde os dados deste estudo foram coletados. / For existing few studies on the moment of the hospital internment for the accomplishment of the surgery for breast cancer, it was more good decided to understand this moment from the referencial of the theory of the social representations and the theory of coping, searching in a group of women the identification of the meaning of the necessary hospital admission for the accomplishment of the surgery. The collect of data was carried through in a composed sample for 10 women and the main involved professionals in its admissions. With the women were done participant observations with utilization of field notes and semi-structured interviews that were qualitative analyzed, and the professionals were observed with utilization of open-closed instrument, that was analyzed in a qualitative and quantitative way. In relation to the women, were identified these categories: loss of the breast, fear of the death, cure, care while return strategy the health and normal day. The strategies of coping identified were: physicians, God, herself, own believes, family, boyfriend, others that had passed for the same experience, courage, confidence, will-power, prayer, don’t think and stay together of joking people that are capable to pass good energy. The analyze of social representations and strategies of coping together showed that in 70% of participants were relation between the meaning attributed to he hospital admission and the strategies of coping used. The relation between social representations and strategies of coping showed that the categories: cure, holistic care and normal day were the most effective in the coping of hospital admission. The instrument used with the main professionals who had carried through the hospital admissions showed that 100% of these professionals were nurse; 90% had used the term preferential lady in the period where they had remained with the women; 100% had demonstrated concern with the related physical environment to the hospital admission; 70% had revealed made use to hear the received women; 80% had received the women in erect position e, 60% of the hospital admissions had occurred with the presence of a nurse and one nurse aid. Some of these data had allowed to verify that these professionals had supplied support to the women, but at the same time other data had shown that these same professionals were distant of a care capable to contemplate the physical aspects, mental and spirituals of these women. From this analyze the necessity of the establishment of subjectivity in the moment of admission is emphasized as form of identification of the necessities of the women with breast cancer. For this, it is suggested construction of a complement for the protocol of hospital admission currently used in the infirmary, where the data of this study had been collected.

Chronic obstructive lung disease is among the leading causes of adult hospital admissions and readmissions in the United States. Preventing acute exacerbations is the primary approach in therapy. Combinations of smoking cessation, pulmonary rehabilitation, vaccinations and inhaled and oral medications may all reduce the overall risk of acute exacerbations. When prevention is unsuccessful, treatment of exacerbations often does not require hospitalization but can be safely executed in the outpatient setting. In the patient who does not require mechanical ventilation or who manifests respiratory acidosis, oxygen supplementation, frequent short-acting inhaled bronchodilators, oral corticosteroids and often antibiotics can abort the decompensation and sometimes return the patient to his or her pre-attack baseline lung function. Several models exist for delivering this care in the ambulatory setting. Follow-up care after an exacerbation has resolved is important, though there are few hard data suggesting which approach is best in this setting.

京都大学 / 0048 / 新制・課程博士 / 博士(社会健康医学) / 甲第20623号 / 社医博第81号 / 社新制||医||9(附属図書館) / 京都大学大学院医学研究科社会健康医学系専攻 / (主査)教授 木原 正博, 教授 中川 一路, 教授 平家 俊男 / 学位規則第4条第1項該当 / Doctor of Public Health / Kyoto University / DFAM

Yes / Ninety-five percent of the population are estimated to carry at least one genetic variant that is discordant with at least one medication. Pharmacogenomic (PGx) testing has the potential to identify patients with genetic variants that puts them at risk of adverse drug reactions and sub-optimal therapy. Predicting a patient's response to medications could support the safe management of medications and reduce hospitalization. These benefits can only be realized if prescribing clinicians make the medication changes prompted by PGx test results. This review examines the current evidence on the impact PGx testing has on hospital admissions and whether it prompts medication changes. A systematic search was performed in three databases (Medline, CINAHL and EMBASE) to search all the relevant studies published up to the year 2020, comparing hospitalization rates and medication changes amongst PGx tested patients with patients receiving treatment-as-usual (TAU). Data extracted from full texts were narratively synthesized using a process model developed from the included studies, to derive themes associated to a suggested workflow for PGx-guided care and its expected benefit for medications optimization and hospitalization. A meta-analysis was undertaken on all the studies that report the number of PGx tested patients that had medication change(s) and the number of PGx tested patients that were hospitalized, compared to participants that received TAU. The search strategy identified 5 hospitalization themed studies and 5 medication change themed studies for analysis. The meta-analysis showed that medication changes occurred significantly more frequently in the PGx tested arm across 4 of 5 studies. Meta-analysis showed that all-cause hospitalization occurred significantly less frequently in the PGx tested arm than the TAU. The results show proof of concept for the use of PGx in prescribing that produces patient benefit. However, the review also highlights the opportunities and evidence gaps that are important when considering the introduction of PGx into health systems; namely patient involvement in PGx prescribing decisions, thus a better understanding of the perspective of patients and prescribers. We highlight the opportunities and evidence gaps that are important when considering the introduction of PGx into health systems. / This research was supported by the National Institute for Health Research (NIHR) Yorkshire and Humber Patient Safety Translational Research Centre (NIHR Yorkshire and Humber PSTRC). GS was supported by the National Institute for Health Research Leeds In vitro Diagnostics Co-operative. This manuscript presents independent research funded by Leeds Teaching Hospitals NHS Trust and the University of Bradford.

Esta tese analisou o efeito da poluição atmosférica nas doenças respiratórias em crianças de 0 (zero) a 6 (seis) anos de idade incompletos residentes em Campinas, Cubatão, Santos, São José dos Campos, São José do Rio Preto e Santo André, caracterizados por seus diferentes perfis de emissão de poluentes do ar, no período de janeiro de 2011 a dezembro de 2014. As concentrações dos poluentes (PM10, NO2, SO2 e O3) foram extraídas de relatórios da CETESB. Foram usados modelos de defasagem com distribuição polinomial, além de uma metarregressão para o PM10, identificando um padrão de efeito deste poluente, independentemente de sua composição. O NO2 e o SO2 não apresentaram concentrações fora dos padrões de qualidade do ar em nenhum dos municípios. O O3 se apresentou em concentrações acima dos padrões de qualidade do ar em diversos dias no período estudado, em todos os municípios, trazendo grande preocupação com relação aos agravos à saúde oriundos deste poluente. O efeito do interquartil (13,81?g/m3) na concentração de PM10 na saúde respiratória das crianças em Campinas foi um aumento de 10,45% (IC95%: 6,39-14,51) dos casos de internação, com efeito já no dia 0; em Cubatão o aumento das internações foi de 14,49% (IC95%: 5,56-23,42); em São José dos Campos o aumento foi de 8,64% (IC95%: 2,41-14,86) nos casos de internações, com uma elevação nestes dados a partir do dia 1; em São José do Rio Preto, no dia da exposição à elevação de concentração de PM10 o aumento de internações nas crianças já foi de 5,75% (IC95%: 1,26-10,25), maior que a somatória dos eventos em uma semana; Santo André, teve um incremento nas internações a partir do dia 1, com uma somatória de 7,30% (IC95%: 1,34-13,25) após seis dias de exposição. Santos não possui significância no efeito adverso em nenhum dos dias após o dia de exposição, nem na somatória dos eventos, mesmo com uma elevação apresentada na ordem de 4,81%. Confirma-se o padrão de efeito, independente do perfil de emissão do PM10 com efeito adverso estatisticamente significante nos dias 0 e 1, respectivamente com 1,84% (IC95%: 1,78-1,89) e 1,03% (IC95%: 1,00-1,07) de aumento nos casos de internações nas crianças expostas / This thesis analyzed the effect of atmospheric pollution on respiratory diseases in children from 0 (zero) to 6 (six) years of age incomplete residing in Campinas, Cubatão, Santos, São José dos Campos, São José do Rio Preto and Santo André, characterized by their different emission profiles of air pollutants in the period from January 2011 to December 2014. The concentrations of pollutants (PM10, NO2, SO2 and O3) were extracted from CETESB reports. Lag models with polynomial distribution were used, in addition to a metarregression for PM10, identifying a pattern of effect of this pollutant, regardless of its composition. NO2 and SO2 did not present concentrations outside the air quality standards in any of the municipalities. O3 was present in concentrations above air quality standards in several days during the study period, in all municipalities, bringing great concern regarding health problems arising from this pollutant. The effect of interquartile (13,81?g/m3) on the concentration of PM10 in the respiratory health of children in Campinas was an increase of 10.45% (95%CI: 6,39-14,51) of the cases of hospitalization, with effect already on day 0; in Cubatão, the increase in hospitalizations was 14.49% (95%CI: 5.56-23,42); in São José dos Campos the increase was 8.64% (95%CI: 2,41-14,86) in cases of hospitalizations, with an elevation in these data from day 1; in São José do Rio Preto, on the day of exposure to the elevation of PM10 concentration, the increase in hospitalizations in children was 5.75% (95%CI: 1.26-10,25), higher than the sum of the events in one week; Santo André, had an increase in hospitalizations from day 1, with a summation of 7.30% (95%CI: 1.34-13,25) after six days of exposure. Santos does not have any significance in the adverse effect in any of the days after the day of exposure, nor in the summation of the events, even with an elevation presented in the order of 4.81%. The effect pattern is confirmed regardless of the PM10 emission profile with a statistically significant adverse effect on days 0 and 1, respectively with 1.84% (95%CI: 1.78-1,89) and 1.03% (95%CI: 1.00-1.07) of increase in cases of hospitalizations in children exposed

Medication safety and improving communication at care transitions are an international priority. There is vast evidence on the scale of error associated with medicines reconciliation and some evidence of successful interventions to improve reconciliation. However, there is insufficient evidence on the factors that contribute towards medication error at transitions, or the roles of those involved. This thesis examined current UK medicines reconciliation practice within primary and secondary care, and the role of HCPs and patients. Using a mixed-method, multi-centre design, the type and severity of discrepancies at admission to hospital were established and staff undertaking medicines reconciliation across secondary and primary care were observed, using evidence-informed framework, based on a narrative literature review. The overall processes used to reconcile medicines were similar; however, there was considerable inter and intra-organisational variation within primary and secondary care practice. Patients were not routinely involved in discussions about their medication, despite their capacity to do so. Various human factors in reconciliation-related errors were apparent; predominantly inadequate communication, individual factors e.g. variation in approach by HCP, and patient factors e.g. lack of capacity. Areas of good practice which could reduce medicines reconciliation-related errors/discrepancies were identified. There is a need for increased consistency and standardisation of medicines reconciliationrelated policy, procedures and documentation, alongside communication optimisation. This could be achieved through a standardised definition and taxonomy of error, the development of a medicines reconciliation quality assessment framework, increased undergraduate and post-graduate education, improved patient engagement, better utilisation of information technology and improved safety culture.