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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Inova??o tecnol?gica: do funcionamento da palavra ao funcionamento do termo

Lenzi, L?via Aparecida Ferreira 20 February 2006 (has links)
Made available in DSpace on 2016-04-04T18:36:25Z (GMT). No. of bitstreams: 1 Livia Lenzi.pdf: 642882 bytes, checksum: f32ecef8127269ba98b58daff4d268d1 (MD5) Previous issue date: 2006-02-20 / It studies the language of specialty of the domain of the Technological Innovation, under the optics of the terminology in the enrolled one. The research intends to answer to following investigations/problem: Exists terminological statute in the vocabulary used in the domain of the technological innovation? How the theories of the terminology can assist in the establishment of mediating languages of the technological innovation? Objective with this work auxiliary in the transference of scientific knowledge for the productive sector, controlling it semantic-conceptual dispersion of the units vocabularies of the domain of the innovation. Using fiches of collection of terms, terms used in the domain of the Technological Innovation will be collected. With the accomplishment of the collection, it will be proceeded analysis from the terms, which will result in a proposal of establishment of the structure of the terminology of the domain Technological Innovation. / Estudo da linguagem de especialidade do dom?nio da Inova??o Tecnol?gica, sob a ?tica da terminologia nela inscrita. A pesquisa pretende responder ?s seguintes indaga??es/problema: Existe estatuto terminol?gico no vocabul?rio utilizado no dom?nio da inova??o tecnol?gica? Como as teorias da terminologia podem auxiliar no estabelecimento de linguagens mediadoras da inova??o tecnol?gica? Objetiva-se com este trabalho auxiliar na transfer?ncia de conhecimento cient?fico para o setor produtivo, controlando-se a dispers?o sem?ntico-conceitual das unidades vocabulares do dom?nio da inova??o. Empregando-se fichas de coleta de termos, foram coletados termos utilizados no dom?nio da Inova??o Tecnol?gica. Com a realiza??o da coleta, procedeu-se a an?lise dos termos, a qual resultou numa proposta de estabelecimento da estrutura da terminologia do dom?nio Inova??o Tecnol?gica, para, assim, sugerir a articula??o, a partir do escopo proposto, entre termo e descritor. A proposta de escopo do campo da Inova??o Tecnol?gica apresentada ao final permitir? subsidiar a estrutura??o terminologia do campo, conferindo maior rigor ? circula??o da informa??o, sua recupera??o e uso para a produ??o do conhecimento.
22

Perspectiva e potencialidades para cria??o de um curso de Mestrado em Plantas Medicinais e Fitoter?picos na Universidade Federal Rural do Rio de Janeiro - UFRRJ / Perspective and potentials for the creation of a Masters Course in Medicinal and Phytotherapeutic Plants at the Federal Rural University of Rio de Janeiro - UFRRJ

LEITE, Maria Rita de C?ssia 13 December 2016 (has links)
Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-11-09T18:52:39Z No. of bitstreams: 1 2016 - Maria Rita de C?ssia Leite.pdf: 1099983 bytes, checksum: da7271c85d41e6b55aba8269523b7988 (MD5) / Made available in DSpace on 2017-11-09T18:52:39Z (GMT). No. of bitstreams: 1 2016 - Maria Rita de C?ssia Leite.pdf: 1099983 bytes, checksum: da7271c85d41e6b55aba8269523b7988 (MD5) Previous issue date: 2016-12-13 / In all eras and culture, human being has learned to take advantage from local natural resources, including the use of medicinal plants. Therefore, phytotherapy has presented great potential for economic and social development, considering not only Brazilian plant diversity, as well as medicinal plants has closely been associated to popular culture. In the last 25 years, 77.8% of the anti-cancer agents tested becoming unquestionable their contribution to new drugs development (Nogueira et al, 2010). On the other hand, the University has been responsible for following reality and time, as well as generating knowledge and critical mass for transforming verities for the benefit of the society, training ethical and competent professionals and citizens committed to the well-being of present and future society. Need for Stricto Sensu Post Graduation course for professional generation in the quality processing, production and control from plant raw material to herbal products has been fundamental to understand the differences between the concept of phytotherapic as medicine and the use of medicinal plants in Integrative and Complementary Therapies, always observing the rational relevance of its use. Thus, this study aimed considering the UFRRJ potential by interdisciplinary and multiprofessional manner proposing the establishment of a Stricto Sensu Post Graduation course in phytotherapics and medicinal plants prioritizing the formation of human resources acting in whole productive chain from plant raw material harvested in the field and its processing to phytotherapic medicine industrial manufacture, as well as establishing criteria for the rational use of medicinal plants within the context of the Practices of Integrative and Complementary Actions of Health Ministry for health professionals besides complying with the National Policy Guidelines for Medicinal Plants and Phytotherapics. This qualitative, descriptive and exploratory research was carried out at Universidade Federal Rural do Rio de Janeiro (UFRRJ) in Serop?dica municipality-RJ. Data from January to July, 2016 were collected. Open unstructured interviews of participant observations by telephone and e-mail with professionals working in related areas were the instruments used. As a result, the UFRRJ, for its tradition in Agricultural Sciences teaching and research has presented in its Institutes, Departments, Disciplines, Laboratories and Research Groups all the potential and infrastructure for organizing and complying with the implementation of Phytotherapics and Medicinal Plants Stricto sensu Post Graduation course . / Em todas as ?pocas e culturas o homem aprendeu a tirar proveito dos recursos naturais locais, incluindo-se o uso de plantas medicinais. A fitoterapia apresenta grande potencial de desenvolvimento econ?mico e social, considerando-se n?o somente a diversidade vegetal que o Brasil possui, mas tamb?m porque o uso das plantas medicinais est? intimamente ligado ? cultura popular. Nos ?ltimos 25 anos, 77,8% dos agentes anticancer?genos testados e aprovados foram derivados de produtos naturais sendo inquestion?vel a contribui??o dos mesmos no desenvolvimento de novos f?rmacos (NOGUEIRA et al., 2010). Por outro lado, a Universidade tem por responsabilidade acompanhar a realidade de seu tempo e gerar conhecimento e massa cr?tica para transformar realidades, em benef?cio da sociedade, formando profissionais competentes, ?ticos e cidad?os comprometidos com o bem-estar da sociedade de hoje e do futuro. Nesse sentido, a cria??o de um curso de p?s-gradua??o stricto sensu nos moldes de Mestrado em Plantas Medicinais e Fitoter?picos para forma??o de profissionais capacitados para o processamento, a produ??o e controle de qualidade desde a mat?ria prima vegetal at? o produ??o de fitoter?picos torna-se fundamental para que os profissionais prescritores possam entender as diferen?as entre o conceito de fitoter?pico como medicamento e o uso de plantas medicinais segundo as pol?ticas do governo de Terapias Integrativas e Complementares, observando sempre a import?ncia racional do seu uso. Assim, este trabalho tem como objetivo geral levantar as potencialidades da UFRRJ para de forma interdisciplinar e multiprofissional, avaliar as condi??es para propor a cria??o de um curso de p?s-gradua??o stricto sensu em plantas medicinais e fitoter?picos priorizando a forma??o de recursos humanos para atuar em toda a cadeia produtiva que vai desde a mat?ria prima vegetal cultivada no campo, seu processamento, at? a produ??o industrial do medicamento fitoter?pico, bem como estabelecer crit?rios para o uso racional de plantas medicinais dentro do contexto das Pr?ticas de A??es Integrativas e Complementares do Minist?rio da Sa?de para os profissionais da sa?de al?m de atender as Diretrizes da Pol?tica Nacional de Plantas Medicinais e Fitoter?picos. A pesquisa foi qualitativa, descritiva e explorat?ria, realizada na Universidade Federal Rural Rio de Janeiro no munic?pio do Serop?dica ? RJ. A coleta dos dados ocorreu de janeiro a julho de 2016. Os instrumentos utilizados foram: entrevistas abertas, n?o estruturadas, observa??o participante, por meio telef?nico, eletr?nico (e-mail) com profissionais que atuam em ?reas afins dentro das IES. Como resultado, constatou-se que a Universidade Federal Rural do Rio de Janeiro, pela sua tradi??o em pesquisa e ensino em Ci?ncias Agr?rias, apresenta em suas ?reas de conhecimento, Institutos, Departamentos, Disciplinas, Laborat?rios e Grupos de Pesquisa, potencialidades e infraestrutura capaz de se organizar para atender a cria??o de um curso de p?s-gradua??o stricto sensu em Plantas Medicinais e Fitoter?picos.
23

Avalia??o de duas variedades de Passiflora edulis sobre as respostas comportamentais de camundongos e um poss?vel mecanismo de a??o

Ayres, Adriana Soeiro de Farias Silva Junqueira 11 December 2015 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-08-09T23:58:08Z No. of bitstreams: 1 AdrianaSoeiroDeFariasSilvaJunqueiraAyres_TESE.pdf: 4492005 bytes, checksum: 363e585cddc1b3b004eb5170356b575b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-08-15T23:16:31Z (GMT) No. of bitstreams: 1 AdrianaSoeiroDeFariasSilvaJunqueiraAyres_TESE.pdf: 4492005 bytes, checksum: 363e585cddc1b3b004eb5170356b575b (MD5) / Made available in DSpace on 2016-08-15T23:16:31Z (GMT). No. of bitstreams: 1 AdrianaSoeiroDeFariasSilvaJunqueiraAyres_TESE.pdf: 4492005 bytes, checksum: 363e585cddc1b3b004eb5170356b575b (MD5) Previous issue date: 2015-12-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / As plantas medicinais constituem uma rica fonte de compostos biologicamente ativos com seu potencial terap?utico para o tratamento de diversos transtornos psiqui?tricos, como os transtornos de ansiedade e depress?o. O transtorno de ansiedade generalizada tem aumentado de forma significativa, sendo o segundo transtorno mais prevalente em locais de assist?ncia ? sa?de p?blica. A depress?o ? considerada um transtorno psiqui?trico cr?nico e comum que afeta 350 milh?es de indiv?duos de todas as idades ao redor do mundo. Neste contexto as condutas de interven??o farmacol?gica que v?m sendo empregadas, embora eficazes, deixam a desejar, quando observados seus efeitos adversos. A Passiflora ? uma variedade comumente conhecida comercialmente, mas tamb?m ? usada na medicina tradicional brasileira. A Passiflora edulis exibe consider?vel variabilidade morfol?gica. Esta planta produz dois tipos de fruto: o roxo (P. edulis var. edulis) e o amarelo (P. edulis var. flavicarpa). O presente estudo investigou os efeitos centrais do extrato aquoso das folhas de duas variedades da esp?cie Passiflora edulis em testes comportamentais utilizados para avaliar comportamentos relacionados ? ansiedade e depress?o, bem como investigou o potencial efeito do tipo antidepressivo das subfra??es da Passiflora edulis var. edulis e os mecanismos neurofarmacol?gicos respons?veis por essa a??o. Para a realiza??o desse estudo foram utilizados camundongos Swiss machos (2 meses de idade, pesando 30-35 g). Os animais receberam o extrato aquoso das folhas das duas esp?cies de Passiflora: Passiflora edulis Sims var. edulis (PEE - 100, 300, 1000 mg/Kg) e subfra??es AcOet, BuOH e residual (25, 50, 75, 100 mg/Kg), e a P. edulis var. flavicarpa (PEF - 30, 100, 300, 1000 mg/Kg) ou solu??o salina, por gavagem, 60 minutos antes dos testes do labirinto em cruz elevado (LCE), teste de campo aberto (TCA), teste de nata??o for?ada (TNF) e teste de seda??o induzido por tiopental. Para investigar o mecanismo de a??o da atividade do tipo antidepressiva das subfra??es foram utilizadas as seguintes drogas: PCPA (inibidor da s?ntese de 5-HT), AMPT (inibidor da s?ntese de catecolaminas), DSP-4 (neurotoxina noradren?rgica) e Sulpiride (antagonista seletivo de receptor dopamin?rgico D2). Foram utilizados como controle positivo padr?o, a fluoxetina e a nortriptilina. Os resultados do perfil fitoqu?mico demonstram caracter?sticas bem distintas para o extrato aquoso das variedades de P. edulis ?flavicarpa? e ?edulis?. Os extratos aquosos de ambas as variedades de P. edulis compartilham atividade do tipo ansiol?tica (PEE 300 mg/Kg; PEF 300 e 1000 mg/Kg) e antidepressiva (PEE 300 mg/Kg; PEF 1000 mg/Kg), enquanto o efeito hipolocomotor/sedativo s? foi visto para a PEE (1000 mg/Kg). Ambas subfra??es AcOet e BuOH do extrato aquoso da PEE apresentaram atividade do tipo antidepressiva na dose de 50 mg/Kg no TNF. Os dados sugerem que o efeito do tipo antidepressivo das subfra??es da P. edulis envolve a neurotransmiss?o serotonin?rgica e catecolamin?rgica, principalmente dopamin?rgica, haja visto que o pr?-tratamento com DSP-4 n?o afetou a a??o antidepressiva das subfra??es, enquanto que mostrou ser dependente da ativa??o de receptores dopamin?rgicos D2. / The medicinal plants constitute a rich source of biologically active compounds used for the treatment of many psychiatric disorders, such as anxiety disorders and depression. Generalized anxiety disorder has increased significantly, being the second most prevalent disorder in care facilities to public health. Depression is considered a chronic and common psychiatric disorder that affects 350 million people of all ages around the world. In this context, the pharmacological intervention conduits have been employed, effective, although leave to be desired when observed adverse effects. The genus Passiflora is commonly commercially known by its fruit, but is also widely used in traditional Brazilian medicine. Passiflora edulis displays considerable morphological variability. This plant produces two types of fruit: Purple (Passiflora edulis Sims fo. edulis) and yellow (Passiflora edulis fo. flavicarpa Degener). This study investigated the central effects of aqueous extract of the leaves of the two varieties of the species Passiflora edulis in tests used to assess behavior related to anxiety and depression, as well as investigating the potential effect of the antidepressant-like fractions of edulis fo. edulis and neuropharmacological mechanisms responsible for this action. To conduct this study used male Swiss mice (2 months old, weighing 30-35 g). The animals received the aqueous extract of the leaves of the two species of Passiflora: edulis fo. edulis (100, 300, 1000 mg / kg) and fractions ethyl acetate, butanol and aqueous waste (25, 50, 75, 100 mg / kg) and edulis fo. flavicarpa (30, 100, 300, 1000 mg / kg) or saline by gavage 60 minutes prior to the maze tests at high cross the open field test, test forced swim test and sedation induced by thiopental. To investigate the mechanism of action of the activity of antidepressant type of fractions the following drugs were used: PCPA (inhibitor of 5-HT synthesis) AMPT (inhibitor of catecholamine synthesis), DSP-4 (noradrenergic neurotoxin) and Sulpiride (antagonist selective dopamine D2 receptor). They were used as a standard positive control, fluoxetine and nortriptyline. The results of the phytochemical profile show very different characteristics to the aqueous extract of the varieties of Passiflora edulis "flavicarpa" and "edulis". The aqueous extracts of both varieties of Passiflora edulis share anxiolytic activity type (edulis fo. edulis 300 mg/kg; edulis fo. flavicarpa 300 and 1000 mg/kg) and antidepressant (edulis fo. edulis 300 mg/kg; edulis fo flavicarpa 1000 mg/kg), while the effect hipolocomotor/sedative was only seen for edulis fo. edulis (1000 mg/kg). Both fractions ethyl acetate, butanol aqueous extract edulis fo. edulis showed activity type antidepressant at a dose of 50 mg/kg in the forced swim test. The data suggest that the effect of antidepressant-like fractions edulis fo. edulis involves catecholaminergic and serotonergic neurotransmission, particularly dopaminergic, there is seen that pre-treatment DSP-4 is not affected antidepressant action of fractions as was dependent activation of dopamine D2 receptors.
24

A gest?o do conhecimento e a inova??o tecnol?gica como fatores de sobreviv?ncia e de competitividade na sociedade do conhecimento: uma an?lise explorat?ria das MPEs do Rio Grande do Norte

R?gis, Josiana Flor?ncio Vieira 22 December 2009 (has links)
Made available in DSpace on 2014-12-17T14:52:50Z (GMT). No. of bitstreams: 1 JosianaFVR_DISSERT.pdf: 4062433 bytes, checksum: 07efe5a289d33a87d6e4d3ebf39cb0e2 (MD5) Previous issue date: 2009-12-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The study examines the process of Knowledge Management and Technological Innovation in Small and Micro Enterprises (SME) in Rio Grande do Norte, Brazil, and proposes actions that can contribute to regional development and competitiveness of SME. Presents as technological innovation can help to make the SME entrepreneurial activities with innovative and competitive. Defines the phases and activities of the construction of knowledge in small organizations. Examines the process of Innovation, Research and Development (R & D) in SME. Identifies the use of knowledge management and technological innovation in management practices and social interaction to influence the competitiveness of SME. Covers the communities of practice as a diffuser of knowledge and learning. To obtain the data were used questionnaires with closed questions with multiple choice, direct observations and interviews with companies. The questionnaires and interviews covered the topics of Innovation, Knowledge Management and Competitive Intelligence on SME. The sample consisted of a total of 13 Small and Micro Enterprises Award winning MPE Brazil Competitiveness, sponsored by SEBRAE in the State of Rio Grande do Norte. The assessment questionnaires dealing with the Knowledge Management (KM Diagnostics - Model Bukowitz and Williams, 2002) and the process of Technological Innovation (Adaptation of ANPEI - National Association for Research, Development and Engineering of Innovative Companies). With the analysis, we concluded that the SME perceive knowledge management, but not formalized management practices so as to facilitate the dissemination of information. Soon, these companies need additional supports to direct them to the innovative activities that generate added value and competitiveness in the market / O estudo analisa o processo de Gest?o do Conhecimento e Inova??o Tecnol?gica nas Micro e Pequenas empresas no Rio Grande do Norte e prop?e a??es que possam contribuir para o desenvolvimento regional e a competitividade das MPEs. Apresenta como a Inova??o Tecnol?gica pode contribuir para tornar as MPEs empreendedoras com atividades inovadoras e competitivas. Define as fases e atividades do processo de constru??o do conhecimento nas organiza??es de pequeno porte. Examina o processo de Inova??o, Pesquisa e Desenvolvimento (P&D) nas MPEs. Identifica o uso da Gest?o do Conhecimento e inova??o tecnol?gica nas pr?ticas administrativas e de intera??o social ao influenciar a competitividade das MPEs. Aborda as comunidades de pr?tica como difusoras do conhecimento e da aprendizagem. Para a obten??o dos dados foram utilizados question?rios com perguntas fechadas de m?ltipla escolha, entrevistas e observa??es diretas com as empresas. Os question?rios e as entrevistas abordaram os temas de Inova??o, Gest?o do Conhecimento e Intelig?ncia competitiva nas MPEs. A amostra constituiu-se por um total de 13 Micro e Pequenas empresas vencedoras do Pr?mio MPE Brasil de Competitividade, promovido pelo SEBRAE no Estado do Rio Grande do Norte. Os question?rios de avalia??o versam sobre a Gest?o do Conhecimento (Diagn?stico de GC - Modelo de Bukowitz e Williams, 2002) e o processo de Inova??o Tecnol?gica (Adapta??o da ANPEI Associa??o Nacional de Pesquisa, Desenvolvimento e Engenharia das empresas Inovadoras). Com a an?lise dos resultados, conclui-se que as MPEs percebem a gest?o do conhecimento, por?m n?o formalizam as pr?ticas gerenciais de forma que facilitem a dissemina??o das informa??es. Logo, estas empresas precisam de suportes adicionais que as direcionem para as atividades inovativas que gerem um valor agregado e competitividade no mercado
25

An?lise energ?tica in silico das intera??es: ER?-Tamoxifeno, ER?- Raloxifeno e Integrina ?V?3-Cilengitide

Mota, Kyvia Bezerra 07 October 2016 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-03-09T22:56:49Z No. of bitstreams: 1 KyviaBezerraMota_TESE.pdf: 5202658 bytes, checksum: 44dd9aeba607843c325d09b4d48f945d (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-13T23:39:17Z (GMT) No. of bitstreams: 1 KyviaBezerraMota_TESE.pdf: 5202658 bytes, checksum: 44dd9aeba607843c325d09b4d48f945d (MD5) / Made available in DSpace on 2017-03-13T23:39:17Z (GMT). No. of bitstreams: 1 KyviaBezerraMota_TESE.pdf: 5202658 bytes, checksum: 44dd9aeba607843c325d09b4d48f945d (MD5) Previous issue date: 2016-10-07 / Essa tese trata de duas pesquisas com diferentes naturezas conceituais no campo da modelagem molecular, por?m baseadas em semelhantes princ?pios te?ricos da f?sica qu?ntica e da qu?mica computacional. No primeiro estudo, as estabilidades dos sistemas ER?-OHT (Receptor ? de Estr?geno-Hidroxitamoxifeno), ER?-RAL (Receptor ? de Estr?geno-Raloxifeno) e Integrina ?v?3-Cilengitide foram determinadas em termos energ?ticos a partir da t?cnica de fracionamento molecular com capuzes conjugados (MFCC) e no escopo da teoria do funcional da densidade (DFT) seguindo o esquema GGA-PBE-Grimme para calcular a intera??o energias dos sistemas estudados. No primeiro estudo, foi poss?vel predizer a relev?ncia individual dos amino?cidos Glu, Asp, Arg, Lys no sistema com o Tamoxifeno e Glu, Asp e Lys com o Raloxifeno. Para isso ser poss?vel, as for?as de atra??o e repuls?o dos res?duos que comp?em os sistemas foram calculadas. Cada um desses res?duos apresentou uma energia de intera??o que variou dependendo da natureza qu?mica da sua cadeia lateral, do ambiente de microsolvata??o que o envolve e dos contatos intermoleculares que estabelece. O estudo pioneiro da estabilidade conformacional em termos energ?ticos de uma regi?o livre de amino?cidos incitar? pesquisas centradas no desenvolvimento e s?ntese de novos antagonistas utilizados no tratamento de diversas patologias comuns na popula??o geral. No segundo estudo, foram determinadas as propriedades energ?ticas do sistema Integrina ?V?3-Cilengitide, cuja estrutura cristalogr?fica apresenta c?tions Mn+2. Observou-se a import?ncias dos amino?cidos Ser, Asp, Leu, Arg, Lys, Ala e Pro na intera?ao da integrina com o fragmento RGD (R: arginina; G: glicina; D: ?cido asp?rtico) do cilengitide. A import?ncia da integrina com o fragmento RGD no mecanismo de ades?o de diversas c?lulas envolvidas nas doen?as cancer?genas e tamb?m na implanta??o embrion?ria permitir? o desenvolvimento de novas terapias impactantes na sobrevida de pacientes portadores de diversas neoplasias e na reprodu??o humana. / This thesis deals with two researches with different conceptual nature in the field of molecular modeling based on similar theoretical principles of quantum physics and computational chemistry. In the first study the stabilities of ER?-OHT (Receptor ? Estrogen co-crystalyzed with Hydroxytamoxifen), ER?-RAL (?-Estrogen Receptor co-crystalyzed with Raloxifene) and integrin ?v?3 co-crystalyzed with cilengitide systems were determined in terms of energy from the Molecular Fractionation Technique Caps Conjugates (MFCC), and the scope of the Density Functional Theory (DFT) following GGA-PBE-Grimme scheme for calculating the interaction energy of the systems studied. In the first study, it was possible to predict the relevance of individual amino acids Glu, Asp, Arg, Lys in the system with Tamoxifen and Glu, Asp and Lys in Raloxifene system. For this to be possible, the attraction and repulsion forces of the residues that comprise the systems were calculated. Each of these residues had an energy of interaction that varied depending on the chemical nature of the side chain, the microsolvation environment that surrounds and intermolecular contacts establishing. The pioneer study of conformational stability in terms of energy of free amino acid region will encourage research focusing on the development and synthesis of new antagonists used in the treatment of several common diseases in the general population. In the second study, we determined the energetic properties of Integrin ?V?3-cilengitide system, whose crystallographic structure has Mn+2 cations. It was noted the importance of amino acids Ser, Asp, Leu, Arg, Lys, Ala and Pro in integrin interaction with the RGD fragment (R: arginine; G: glycine; D: aspartic acid) of cilengitide. The importance of integrin with the RGD fragment in the adhesion mechanism of various cells involved in cancers and in embryo implantation allows the development of new therapies impacting on survival of patients with various forms of neoplasms and in human reproduction.
26

Aplica??o do m?todo MACBETH para subsidiar migra??o de plataforma tecnol?gica de redes de Telecomunica??es / Application of MACBETH method to support telecommunication network migration to MPLS

Assolari, Ana Cristina Pereira de Pedrosa 11 February 2011 (has links)
Made available in DSpace on 2016-04-04T18:31:31Z (GMT). No. of bitstreams: 1 Ana Cristina Pereira de P Assolari.pdf: 1062992 bytes, checksum: 86b8f894fb835cd2496911a4689155b6 (MD5) Previous issue date: 2011-02-11 / IT and Telecommunication Managers need to be on top of rnarket trends so they rnay proceed to necessary changes and improvement on their network in order to keep up with business challenges and ensure the future of the cornpany, The decision making related to network migration should not be rnade without a consistent and reliable method that would support the decision taken, protecting the managers and companies from risks and losses. This paper has the objective to propose the usage of multicriteria decision making methodology, with focus on the MACBETH method in arder to support the network migration, based on information extracted from the financiai reports published on the public internet. This paper will show the study of two companies that have m igrated to MPLS in the last five years, buildlng the MACBETH Model from information present on the Financiai Report at the time of contract was signed and validating the information extracted with executives from the commercial and technical departments who lived through that period in the company. Within this scenario it can be verified that MACBETH Method once provided with the correct information that reflects the period the cornpany is living rnay help executives to decide if they should migrate ar not migrate their network / Gestores de telecomunica??es e TI precisam estar sempre atentos aos rumos da organiza??o e com isso procederem a mudan?as necess?rias nas estruturas e redes de comunica??o que subsidiam os neg?cios da empresa. A tomada de decis?o a respeito da migra??o de tecnologias n?o dever ser efetuada sem um m?todo consistente que as subsidie, livrando o gestor de riscos e preju?zos empresariais que podem ser minjmizados quando uma abordagem estruturada elencando os principais crit?rios a serem considerados ? utilizada. Este trabalho tem como objetivo propor o uso de metodologia para tomada de decis?o multicrit?rio, com foco no m?todo MACBETH, para subsidiar a migra??o de plataformas de redes de telecomunica??es. Com base em informa??es oriundas de boletins financeiros disponibilizados publicamente na Internet. O trabalho analisa duas empresas que migraram para plataforma MPLS, construindo a estrutura do m?todo MACBETH a partir das informa??es obtidas nos boletins financeiros dessas organiza??es e validando a an?lise com dados obtidos de gerentes das ?reas comerciais e de tecnologias que vivenciaram esse per?odo. Dentro desse quadro, considerou-se que o m?todo MACBETH, uma vez alimentado com informa??es corretas que reflitam o momento da empresa, pode orientar gestores a decidirem se devem ou n?o proceder ? migra??o de suas bases tecnol?gicas

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