Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-02-01T17:23:24Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) luiz_egidio_silva_tibaes.pdf: 1586755 bytes, checksum: 3ea3d6b3efb50bfdd237c565921a33bb (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2018-02-03T12:09:15Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) luiz_egidio_silva_tibaes.pdf: 1586755 bytes, checksum: 3ea3d6b3efb50bfdd237c565921a33bb (MD5) / Made available in DSpace on 2018-02-03T12:09:15Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) luiz_egidio_silva_tibaes.pdf: 1586755 bytes, checksum: 3ea3d6b3efb50bfdd237c565921a33bb (MD5) Previous issue date: 2017 / O presente trabalho constitui-se como um estudo de caso e tem como objeto de estudo a regulamenta??o da pol?tica institucional de propriedade intelectual e inova??o tecnol?gica da Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM). Com o advento do marco regulat?rio de ci?ncia, tecnologia e inova??o (Lei n? 13.243/2016), o qual alterou a lei de inova??o em vigor (Lei n? 10.973/2004), as chamadas Institui??es Cient?ficas, Tecnol?gicas e de Inova??o (ICTs), caso da UFVJM, foram desafiadas no sentido de instituir a sua pol?tica de inova??o, consoante ?s diretrizes e objetivos legalmente estabelecidos. Nessa perspectiva, este estudo tem como objetivo geral propor considera??es que possam contribuir para o debate junto ? comunidade universit?ria visando o aperfei?oamento do marco regulat?rio das pol?ticas de propriedade intelectual e inova??o tecnol?gica da UFVJM. Visando alcan?ar esse prop?sito, foram estabelecidos como objetivos espec?ficos aferir a conformidade da regulamenta??o das pol?ticas de propriedade intelectual e inova??o tecnol?gica da UFVJM com a Lei n? 10.973/2004 e discutir sua rela??o com as principais quest?es tratadas no escopo metajur?dico deste trabalho; e avaliar a compatibilidade entre a regulamenta??o das pol?ticas de propriedade intelectual e inova??o tecnol?gica da UFVJM com as necessidades dessa universidade, tendo como base o Plano de Desenvolvimento Institucional- PDI da institui??o. Nesse sentido, metodologicamente esta pesquisa ? descritiva, com vi?s bibliogr?fico e documental, efetivada em livros, revistas, artigos e p?ginas da internet. A pesquisa bibliogr?fica, que fundamenta este estudo, foi desenvolvida com a contribui??o de diversos autores, precipuamente no referencial te?rico denominado Escopos Jur?dicos e Metajur?dicos. Por sua vez, a pesquisa documental foi realizada tendo como alicerce a Constitui??o da Rep?blica Federativa do Brasil de 1988, Lei n? 9.279/1996, Lei n? 9.394/1996, Lei n? 10.973/2004, Lei n? 17.348, de 17 de janeiro de 2008 (lei mineira de inova??o), Delibera??o da Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (Fapemig) n? 72, de 13 de agosto de 2013, Lei n? 13.243/2016 e resolu??es da UFVJM. Concluiu-se pela necessidade de a UFVJM regulamentar a sua pol?tica de propriedade intelectual e inova??o tecnol?gica, de forma integral em um ?nico documento. Ponderou-se ainda que a constru??o e regulamenta??o de tais pol?ticas levem em considera??o as principais necessidades da UFVJM dispostas em seu Plano de Desenvolvimento Institucional (PDI). Por fim, recomenda-se que a regulamenta??o de tais pol?ticas busque fomentar e consolidar o desenvolvimento socioecon?mico da regi?o de abrang?ncia da UFVJM. Dessa forma, espera-se que este trabalho possa contribuir para o desenvolvimento cient?fico, tecnol?gico e intelectual desta institui??o federal de ensino superior. / Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Educa??o, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017. / The present work constitutes a case study and has as object of study the regulation of the institutional policy of intellectual property and technological innovation of the Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM). With the advent of the regulatory framework for science, technology and innovation (Law n? 13.243 / 2016), which amended the current innovation law (Law 10.973 / 2004), the so-called Scientific, Technological and Innovation Institutions (ICTs) in the case of the UFVJM, were challenged in order to establish their innovation policy, according to legally established goals and guidelines. In this perspective, this study has as general objective to propose considerations that can contribute to the debate with the university community aiming at perfecting the regulatory framework of the intellectual property policies and technological innovation of the UFVJM. In order to achieve this purpose, it was established as specific objectives to verify the compliance of the regulation of intellectual property policies and technological innovation of UFVJM with Law 10,973 / 2004 and discuss its relationship with the main issues addressed in the metajuridic scope of this work; and to evaluate the compatibility between the regulation of intellectual property policies and technological innovation of UFVJM with the needs of that university, based on the Institutional Development Plan - PDI of the institution. In this sense, methodologically, this research is descriptive, with a bibliographic and documentary bias, carried out in books, magazines, articles and internet pages. The bibliographical research, which bases this study, was developed with the contribution of several authors, mainly in the theoretical framework called Juridical and Metajuridic Scopes. On the other hand, documentary research was carried out with the foundation of the Constitution of the Federative Republic of Brazil of 1988, Law 9,279 / 1996, Law 9,394 / 1996, Law 10,973 / 2004, Law 17,348, of January 17, 2008 (Mining Law for Innovation), Determination of the Foundation for Support of Research of the State of Minas Gerais (Fapemig) n? 72, of August 13, 2013, Law n? 13.243 / 2016 and resolutions of the UFVJM. It was concluded by the need for the UFVJM to regulate its policy of intellectual property and technological innovation, in an integral form in a single document. It was also pointed out that the construction and regulation of such policies take into account the main needs of the UFVJM set forth in its Institutional Development Plan (IDP). Finally, it is recommended that the regulation of such policies seek to foster and consolidate the socioeconomic development of the UFVJM's region. Thus, it is expected that this work can contribute to the scientific, technological and intellectual development of this federal institution of higher education.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-10-26T23:26:57Z No. of bitstreams: 1 EltonCortesRochaSiqueiraFilho_DISSERT.pdf: 3184427 bytes, checksum: b388da19aaa7b9e266615fa005cc0c92 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-12-26T19:24:57Z (GMT) No. of bitstreams: 1 EltonCortesRochaSiqueiraFilho_DISSERT.pdf: 3184427 bytes, checksum: b388da19aaa7b9e266615fa005cc0c92 (MD5) / Made available in DSpace on 2016-12-26T19:24:57Z (GMT). No. of bitstreams: 1 EltonCortesRochaSiqueiraFilho_DISSERT.pdf: 3184427 bytes, checksum: b388da19aaa7b9e266615fa005cc0c92 (MD5) Previous issue date: 2016-06-03 / Na atualidade as inova??es tecnol?gicas devem ser vistas como uma estrat?gia competitiva das organiza??es no setor da constru??o civil. A difus?o de novas tecnologias neste setor ? muito similar ao aplicado em aos demais setores industriais, por?m, no caso da constru??o civil, ainda se verifica certo grau de resist?ncia das partes envolvidas. Desde os projetistas, passando pelos administradores e chegando at? os trabalhadores, persiste uma relativa resist?ncia ? inova??o tanto no que diz respeito ?s t?cnicas construtivas quanto na introdu??o de novos materiais, pois as incertezas do sucesso os tornam receosos. Discutiremos alguns aspectos associados ? ado??o de inova??es tecnol?gicas no setor da constru??o civil como estrat?gia do Mercado imobili?rio. A problem?tica desta pesquisa concentra-se em ampliar a compreens?o do uso das inova??es tecnol?gicas na produ??o imobili?ria como um reflexo das mudan?as nos sistemas construtivos e materiais. Partindo do caso emp?rico e utilizando a base estabelecida pretende-se testar a hip?tese de que o processo de introdu??o de inova??es tecnol?gicas no mercado da constru??o segue a l?gica de valoriza??o dos empreendimentos imobili?rios privilegiando os empreendimentos de alto padr?o e localizados nos bairros mais valorizados, com a ado??o de materiais e processos construtivos mais atuais e eficientes. Pretende-se estudar ent?o a evolu??o no uso de inova??es tecnol?gicas relacionadas com os processos construtivos enquanto diferencial nas estrat?gias utilizadas pelos promotores imobili?rios no munic?pio de Natal entre 1990 e 2010. / In the present the technological innovations must be seen as a competitive strategy of the organizations in the sector of the civil construction. The diffusion of new technologies in this sector is very similar to the applied one in to too many industrial sectors, however, in case of the civil construction, still there happens certain degree of resistance of the wrapped parts. We will discuss some aspects associated to the adoption of technological innovations in the sector of the civil construction like strategy of the offer of the property Market. The problematics of this inquiry is concentrated in enlarging the understanding of the use of the technological innovations in the property production like a reflex of the changes in the constructive and material systems. Leaving from the empirical case and using the established base there is claimed to test the hypothesis of which the process of introduction of technological innovations in the market of the construction follows the logic of increase in value of the property undertakings privileging the undertakings of high standard and located in the most valued districts, with the adoption of materials and the most current and efficient constructive processes. It intends to study then the evolution in the use of technological innovations connected with the constructive processes while differential in the strategies used by the property promoters in the local authority of Natal / RN between 1990 and 2010. For so much there was taken like base the database lifted by QUEIROZ (2012), selecting a representative sample through the stratification of the elements inside the outlined universe, which turned in 83 vertical residential property undertakings investigated, distributed in four administrative regions of the local authority. Finally there is ended which property market of Natal / RN, did not use the moment of strong development in the city to grow and to develop his constructive processes to (innovate), relative of attracting consumers and even obtaining bigger profits in the property undertakings, in other words, they did not use the technological innovation as strategy in the offer of his property products

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-10-11T22:51:16Z No. of bitstreams: 1 LilianGraceDaSilvaSolon_TESE.pdf: 7051337 bytes, checksum: 79a5b10c1ce003624bdd49bff3af8afd (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-10-18T00:03:19Z (GMT) No. of bitstreams: 1 LilianGraceDaSilvaSolon_TESE.pdf: 7051337 bytes, checksum: 79a5b10c1ce003624bdd49bff3af8afd (MD5) / Made available in DSpace on 2016-10-18T00:03:19Z (GMT). No. of bitstreams: 1 LilianGraceDaSilvaSolon_TESE.pdf: 7051337 bytes, checksum: 79a5b10c1ce003624bdd49bff3af8afd (MD5) Previous issue date: 2016-02-04 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / A ind?stria farmac?utica e laborat?rios anal?ticos de todo o mundo tem focado na qualidade, seguran?a e efic?cia de seus produtos. Processos utilizados para minimizar os riscos, como o Quality by Design (QbD), recentemente tem sido atribu?do ao desenvolvimento de m?todos anal?ticos, principalmente os m?todos cromatogr?ficos. O Analytical Quality by Design ou Qualidade Anal?tica Baseada no Projeto (aQbD), utiliza ferramentas de planejamento de experimentos, an?lise de risco e monitoramento cont?nuo. Para isso, faz-se uso de softwares simuladores, ferramentas estat?sticas e quimiom?tricas. Sabe-se que os m?todos cromatogr?ficos de an?lise s?o bastante consolidados e exigidos pelas ag?ncias regulat?rias, aplicando-se em diversas determina??es dentro do campo farmac?utico, como identifica??o e quantifica??o de f?rmacos, metab?litos, impurezas e produtos de degrada??o. O presente estudo teve como objetivo, utilizar ferramentas aQbD para o desenvolvimento de m?todos em cromatografia l?quida de ultra efici?ncia. Foram desenvolvidos quatro m?todos, a saber: quantifica??o simult?nea de dexametasona acetato e clotrimazol em formas farmac?uticas semiss?lidas, atrav?s de transfer?ncia de m?todo de CLAE para CLUE (cap?tulo 1); determina??o simult?nea de corticosteroides e conservantes em coluna de n?cleo s?lido com tamanho de part?cula 1.3 ?m utilizando software simulador (cap?tulo 2); quantifica??o de betametasona valerato em amostras de creme, gel, lo??o e pomada ap?s desenvolvimento de m?todo por planejamento fatorial completo 33 (cap?tulo 3); e determina??o simult?nea de corticosteroides ap?s desenvolvimento de modelo de previs?o de fator de reten??o por QSRR (cap?tulo 4). Os resultados mostraram que apesar da necessidade de otimiza??o pelo analista, o uso de ferramentas aQbD, como o planejamento estat?stico ou uso de softwares, s?o promissoras no desenvolvimento de m?todos cromatogr?ficos de ultra efici?ncia, uma vez que foram capazes de promover economia de tempo, diminuir os gastos e riscos. Os ensaios apresentaram resultados satisfat?rios em termos de velocidade anal?tica e diminui??o no consumo de solventes. / The pharmaceutical industry and analytical laboratories around the world have focused on quality, safety and efficacy of their products. Processes used to minimize risks, such as Quality by Design (QbD), which recently has been attributed to the development of analytical methods, especially chromatographic methods. The Analytical Quality by Design (aQbD) uses planning tools experiments, risk analysis and continuous monitoring. For this, it makes use of simulation software, statistical tools and chemometrics. It is known that chromatographic methods are well consolidated and required by the regulatory agencies. It has been applied in various determinations in the pharmaceutical field, such as identification and quantification of drugs, metabolites, degradation products and impurities. The aim of this study was to use aQbD tools for the development of methods for ultra high performance liquid chromatography (UHPLC). Four methods were developed, namely: simultaneous quantification of dexamethasone acetate and clotrimazole in semisolid dosage forms, via HPLC to UHPLC method transfer (Chapter 1); simultaneous determination of corticosteroids and preservatives in solid core column with particle size of 1.3 ?m by using simulation software (Chapter 2); betamethasone valerate quantification in samples of cream, gel, lotion and ointment after method development by full factorial design 33 (Chapter 3); and simultaneous determination of corticosteroids after retention factor prediction model by QSRR (Chapter 4). The results showed that despite the need for optimization by the analyst, the use of aQbD tools such as statistical design or use of software, the aQbD is promising in the development of chromatographic methods of ultra efficiency, since they were able to promote time savings, lower costs and risks. The tests showed satisfactory results in terms of analysis speed and decrease of solvent consumption.

Submitted by Gustavo Gomes (gustavolascasas@gmail.com) on 2013-09-06T13:56:05Z No. of bitstreams: 2 Incuba????o de empresas de base tecnol??gica.pdf: 1177225 bytes, checksum: 039998b84d8cc15e0be04246d4ef0da5 (MD5) license_rdf: 23599 bytes, checksum: 9e2b7f6edbd693264102b96ece20428a (MD5) / Approved for entry into archive by Roger Guedes (roger.guedes@fjp.mg.gov.br) on 2013-09-06T16:31:53Z (GMT) No. of bitstreams: 2 Incuba????o de empresas de base tecnol??gica.pdf: 1177225 bytes, checksum: 039998b84d8cc15e0be04246d4ef0da5 (MD5) license_rdf: 23599 bytes, checksum: 9e2b7f6edbd693264102b96ece20428a (MD5) / Made available in DSpace on 2013-09-06T16:31:53Z (GMT). No. of bitstreams: 2 Incuba????o de empresas de base tecnol??gica.pdf: 1177225 bytes, checksum: 039998b84d8cc15e0be04246d4ef0da5 (MD5) license_rdf: 23599 bytes, checksum: 9e2b7f6edbd693264102b96ece20428a (MD5) Previous issue date: 2008 / Funda????o Jo??o Pinheiro / Este estudo trata de um aspecto relevante do desenvolvimento cient??fico e tecnol??gico: o processo de incuba????o de empresas de base tecnol??gica no Brasil. Ele prop??e e aplica um ??ndice sint??tico que procura retratar dimens??es importantes do processo de incuba????o de empresas de base tecnol??gica. O trabalho, de natureza explorat??ria e descritiva, utiliza como instrumentos de pesquisa, o levantamento bibliogr??fico e documental, a explora????o de dados e informa????es estat??sticas, e a aplica????o do m??todo distancial para padroniza????o de vari??veis. O ??ndice proposto, ??ndice de dimensionamento do processo de incuba????o de empresas de base tecnol??gica ??? IEBT ?? composto por quatro dimens??es: Prioridade governamental ?? pol??tica p??blica de C,T&I, Amplitude e difus??o do processo de incuba????o, N??vel de inova????o tecnol??gica nas empresas, e N??vel de educa????o formal da popula????o, e a cada dimens??o corresponde um conjunto de indicadores. O IEBT possibilita ordenar a posi????o relativa dos estados quanto ao est??gio de desenvolvimento do processo de incuba????o de empresas de base tecnol??gica, sob as dimens??es que o comp??em. Os resultados do IEBT para os estados das regi??es sudeste e sul do pa??s, sugerem que o est??gio de desenvolvimento do processo de incuba????o de empresas de base tecnol??gica apresenta-se avan??ado nos estados de S??o Paulo e Rio Grande do Sul, enquanto o Rio de Janeiro, Paran?? e Santa Catarina corresponderiam a um est??gio intermedi??rio. Minas Gerais corresponderia a um est??gio pouco avan??ado, superando apenas o Esp??rito Santo (que apresentou o mais baixo IEBT dentre os estados das regi??es sudeste e sul do Brasil). No que diz respeito especificamente a Minas Gerais, os resultados sugerem que as principais fragilidades do processo de incuba????o de empresas de base tecnol??gica est??o associadas ??s dimens??es N??vel de educa????o formal da popula????o e ?? Prioridade governamental ?? pol??tica p??blica de C,T&I. J?? a dimens??o Amplitude e difus??o do processo de incuba????o e a dimens??o N??vel de inova????o tecnol??gica nas empresas apresentaram potencialidades para o desenvolvimento e consolida????o do processo de incuba????o de empresas de base tecnol??gica no estado. / This study treats of a relevant aspect of the scientific and technological development: the process of incubation of companies of technological base in Brazil. He proposes and it applies a synthetic index that it tries to portray important dimensions of the process of incubation of companies of technological base. The work, of exploratory and descriptive nature, uses as research instruments, the bibliographical and documental rising, the exploration of data and statistical information, and the application of the method distancial for standardization of variables. The proposed index, Index of measurement of the process of incubation of companies of technological base - IEBT is composed by four dimensions: Government priority to the public politics of C,T&I, Width and diffusion of the incubation process, Level of technological innovation in the companies, and Level of formal education of the population, and to each dimension it corresponds a group of indicators. IEBT makes possible to order the relative position of the states as for the apprenticeship of development of the process of incubation of companies of technological base, under the dimensions that compose it. The results of IEBT for the states of the areas southeast and south of the country, they suggest that the apprenticeship of development of the process of incubation of companies of technological base comes advanced in the states of S??o Paulo and Rio Grande do Sul, while Rio de Janeiro, Paran?? and Santa Catarina would correspond to an intermediate apprenticeship. Minas Gerais would correspond to a little advanced apprenticeship, just overcoming the Esp??rito Santo (that presented lowest IEBT among the states of the areas southeast and south of Brazil). In what it says respect specifically to Minas Gerais, the results suggest that the main fragilities of the process of incubation of companies of technological base are associated at the dimensions Level of formal education of the population and the Government priority to the public politics of C,T&I. Already the dimension Width and diffusion of the incubation process and the dimension Level of technological innovation in the companies presented potentialities for the development and consolidation of the process of incubation of companies of technological base in the state. / Ci??ncia, Informa????o e Comunica????o

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-03-22T19:40:44Z No. of bitstreams: 1 MarianaAngelicaOliveiraBitencourt_TESE.pdf: 3370621 bytes, checksum: 9ed06db62a38c6ae8f8b6f074ccf7b06 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-03-28T20:16:41Z (GMT) No. of bitstreams: 1 MarianaAngelicaOliveiraBitencourt_TESE.pdf: 3370621 bytes, checksum: 9ed06db62a38c6ae8f8b6f074ccf7b06 (MD5) / Made available in DSpace on 2016-03-28T20:16:41Z (GMT). No. of bitstreams: 1 MarianaAngelicaOliveiraBitencourt_TESE.pdf: 3370621 bytes, checksum: 9ed06db62a38c6ae8f8b6f074ccf7b06 (MD5) Previous issue date: 2015-03-20 / Os acidentes ocasionados por animais pe?onhentos, pela frequ?ncia com que ocorrem e pela mortalidade que ocasionam, representam um s?rio problema de sa?de p?blica em diversas regi?es do Brasil, bem como em outros pa?ses do mundo. O uso de extratos de plantas medicinais como ant?doto para casos de envenenamento ? uma antiga pr?tica utilizada, ainda hoje, em muitas comunidades que n?o t?m acesso ? soroterapia. As plantas medicinais representam uma importante fonte de obten??o de compostos bioativos capazes de auxiliar diretamente no tratamento do envenenamento ou indiretamente, suplementando a soroterapia utilizada atualmente. O objetivo deste trabalho ? avaliar o efeito dos extratos aquosos, fra??es e compostos isolados das esp?cies Mimosa. Tenuiflora (jurema preta) e Harconia speciosa (mangaba) no processo inflamat?rio induzido por carragenina e as pe?onhas de Bothrops jararaca e Tityus. serrulatus. Os resultados demonstraram que tanto os extratos de M. tenuiflora quanto de H. speciosa foram capazes de inibir a migra??o celular e a produ??o de citocinas no modelo de peritonite induzido por carragenina e pe?onha de T. serrulatus. No modelo de envenenamento por B. jararaca, os camundongos tratados com os extratos das plantas em estudo reduziram o influxo leucocit?rio para a cavidade peritoneal. Por ?ltimo, os extratos das plantas M. tenuiflora e H. speciosa apresentaram atividade antiflog?stica, reduzindo a forma??o do edema exercendo tamb?m uma a??o inibit?ria da migra??o de leuc?citos e dano tecidual na inflama??o local induzida pela pe?onha de B. jararaca. Al?m disso, foi desenvolvida a an?lise fitoqu?mica de ambos os extratos aquosos obtidos. Nessa abordagem,foi poss?vel identificar, por meio de Cromatografia em Camada Delgada (CCD), a presen?a de flavon?ides e saponinas ou terpenos no extrato aquoso da esp?cie vegetal M. tenuiflora. Paralelamente, por meio da an?lise por Cromatografia L?quida de Alta Efici?ncia (CLAE), foi poss?vel identificar a presen?a de rutina e ?cido clorog?nico no extrato aquoso da planta H. speciosa. A partir dos resultados apresentados, pode-se concluir ent?o, que a administra??o dos extratos, fra??es e compostos isolados de M. tenuiflora e H. speciosa resultou na inibi??o do processo inflamat?rio em diversos modelos experimentais. Este estudo demonstra, pela primeira vez, o efeito das plantas M. tenuiflora e H. speciosa na inibi??o da inflama??o causada pelas pe?onhas de B. jararaca e T. serrulatus. / Accidents caused by venomous animals represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world by the frequency with which they occur and the mortality they cause. The use of plant extracts as an antidote for poisoning cases is an ancient practice used in many communities that have no access to antivenom. Medicinal plants represent an important source of obtaining bioactive compounds able to assist directly in the treatment of poisoning or indirectly supplementing serum therapy currently used. The aim of this study was to evaluate the effect of extracts, fractions and isolated compounds from M. tenuiflora and H. speciosa in the inflammatory process induced by carrageenan and the venom of B. jararaca and T. serrulatus. The results showed that both M. tenuiflora and H. speciosa were capable of inhibiting cell migration and cytokines levels in peritonitis induced by carrageenin and venom of T. serrulatus. In poisoning by B. jararaca model, mice treated with the plants in studies decreased the leukocyte influx into the peritoneal cavity. Finally the M. tenuiflora and H. speciosa had antiphlogistic activity, reducing edema formation and exerted inhibitory action of leukocyte migration in local inflammation induced by the venom of B. jararaca. Through of Thin Layer Chromatography (TLC) analysis was possible identified the presence of flavonoids ,saponins and/or terpenes in aqueous extract of M. tenuiflora. By High Performance Liquid Chromatography analysis, it was possible to identify the presence of rutin and chlorogenic acid in aqueous extract of H. speciosa. We conclude that the administration of extracts, fractions and isolated compounds of H. speciosa and M. tenuiflora resulted in inhibition of the inflammatory process in different experimental models. This study demonstrates for the first time the effect of M. tenuiflora and H. speciosa in inhibition of the inflammation caused by B. jararaca and T. serrulatus venom.

Made available in DSpace on 2014-12-17T14:53:19Z (GMT). No. of bitstreams: 1 BrunaCS_DISSEERT.pdf: 3394084 bytes, checksum: 6654b39078699171ed0900232cadff42 (MD5) Previous issue date: 2013-05-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / No Brasil, com a promulga??o da Lei de Inova??o Tecnol?gica, tem-se intensificado as medidas de incentivo ? inova??o e ? pesquisa cient?fica no ambiente empresarial, visando ao alcance da autonomia tecnol?gica e ao desenvolvimento industrial do pa?s. Avalia??o dos investimentos p?blicos pode ser um instrumento importante para garantir o adequado direcionamento na aloca??o de recursos limitados. Com base nisso, o presente trabalho tem como objetivo geral analisar a efici?ncia e os ganhos de produtividade de micro e pequenas empresas beneficiadas com investimentos da Funda??o de Apoio ? Pesquisa do Estado do Rio Grande do Norte, pelo Programa PAPPE Integra??o INOVA, para a realiza??o de pesquisas em inova??o tecnol?gica. A pesquisa foi desenvolvida no Estado do Rio Grande do Norte, nas empresas financiadas pela FAPERN, sendo conduzida por meio de um survey explorat?ria-descritiva, com o prop?sito de coletar dados prim?rios necess?rios para a execu??o das t?cnicas An?lise Envolt?ria de Dados e ?ndice de Produtividade Malmquist. O plano populacional contemplou uma amostra de 26 projetos vinculados a 25 empresas. Para conduzir essa avalia??o, utilizaram-se os modelos: (1) DEA-BCC, para determinar a efici?ncia t?cnica e esclarecer os retornos vari?veis ? escala, empregando dois inputs (capital FAPERN e capital empresa) e tr?s outputs (faturamento para o projeto INOVA-RN, crescimento das vendas e n?mero de novos empregos); e, (2) DEA-Malmquist, para avaliar a evolu??o da produtividade, utilizando dois input (capital FAPERN e capital empresa) e dois outputs (faturamento para o projeto INOVA-RN e crescimento das vendas). Admitiu-se, em ambos os casos, a orienta??o ? maximiza??o dos outputs. Os resultados foram apresentados em tr?s etapas: etapa I caracteriza??o qualitativa do perfil dos projetos baseados nos aspectos da inova??o tecnol?gica; etapa II an?lise da efici?ncia das empresas; e, etapa III evolu??o da produtividade das empresas. Por fim, esses resultados possibilitaram identificar, para o ?rg?o fomentador, quais empresas aplicaram melhor os recursos p?blicos em inova??o tecnol?gica, colaborando na orienta??o futura de empresas a maximiza??o dos efeitos de investimentos em inova??o, com base nos diagn?sticos das empresas que obtiveram efici?ncia m?xima e, ainda, promovendo subs?dios te?ricos e anal?ticos que possam vir auxiliar ? tomada de decis?o de organiza??es p?blicas no direcionamento a efetividade de pr?ticas mais promissoras como no planejamento de pol?ticas p?blicas

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-13T19:28:10Z No. of bitstreams: 1 MilenaCristinaDuarteDeAlmeida_DISSERT.pdf: 2444655 bytes, checksum: d92fbe1d894733c5406dc080921af13b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-14T18:21:04Z (GMT) No. of bitstreams: 1 MilenaCristinaDuarteDeAlmeida_DISSERT.pdf: 2444655 bytes, checksum: d92fbe1d894733c5406dc080921af13b (MD5) / Made available in DSpace on 2017-02-14T18:21:04Z (GMT). No. of bitstreams: 1 MilenaCristinaDuarteDeAlmeida_DISSERT.pdf: 2444655 bytes, checksum: d92fbe1d894733c5406dc080921af13b (MD5) Previous issue date: 2016-08-25 / As organiza??es em geral t?m se preocupado com o alcance das estrat?gias e dos objetivos tra?ados, e partindo dessa premissa, a Gest?o da Qualidade adentra para otimizar ainda mais os resultados bem como a satisfa??o e a expectativa dos clientes. Em meio a isso, a NBR ISO 9001:2015, uma das ferramentas de certifica??o da qualidade de car?ter gen?rico, possibilita que qualquer empresa possa adotar padr?es e sistemas de gest?o da qualidade de acordo com as condi??es da norma, a fim de padronizar os seus processos aos requisitos requeridos pelos clientes. Aliado ao interesse de certifica??o e da inser??o de pr?ticas que gerem por meio da pesquisa, do ensino e da extens?o, a melhoria nos servi?os prestados, o Laborat?rio de Inova??o Tecnol?gica em Sa?de (LAIS), refer?ncia em pesquisa e tecnologia no Rio Grande do Norte, almejou que tais procedimentos fossem adotados. Dessa forma, o objeto de estudo ? o LAIS, que trabalha com o trip? da educa??o e com vistas a entrega de solu??es tecnol?gicas para o Sistema ?nico de Sa?de (SUS). O estudo ? conduzido por meio de uma pesquisa-a??o, norteado pelos princ?pios da NBR ISO 9001:2015 e sua an?lise ? de car?ter qualitativo. Desse modo, tem como finalidade o mapeamento do macroprocesso da unidade de neg?cio de Sistemas de Informa??o em Sa?de e posteriormente a sua modelagem, utilizando o m?todo BPMN com o direcionamento ? adequa??o dos princ?pios da NBR ISO 9001:2015. Quanto ao planejamento, optou-se pela revis?o bibliogr?fica e pelo estudo de caso. A condu??o da pesquisa ? de suma import?ncia, uma vez que verificou e preconizou a melhoria dos processos de inova??o, al?m de servir como base para outras organiza??es e pesquisas na ?rea. Os resultados do trabalho podem ser considerados para maiores contribui??es e relev?ncia sobre o tema estudado. / The organizations in general have been concerned about the scope of the strategies and goals set and, based on this premise, the Quality Management enters to further optimize the results, satisfaction and expectations of the customers. Among that, the NBR ISO 9001:2015, one of the quality tools of generic character, enables any company to adopt standards and quality management systems according to the requirements of the standard, in order to standardize its processes to the requirements of customers. Coupled with the interest in the certification and the inclusion of practices that generate an improvement in the services offered, through research, education and extension, the Innovation Lab in Health (LAIS), a reference in research and technology in Rio Grande do Norte, aims for such procedures to be adopted. Thus, the object of the study is the LAIS, working with the tripod of education and with a goal to deliver technology solutions for the Brazil's Unified Health System (SUS). The study is conducted by means of an action research, guided by the requirements of the NBR ISO 9001:2015, and its analysis is qualitative and quantitative. Furthermore, it has the purpose of mapping the process of the business unit of the LAIS, the Systems of Health Information (SIS), and later modeling the process using the BPMN method guided by the principles of the NBR:ISO 9001:2015. As for the planning, the literature review and the case study were chosen. The conduct of this research is very important, as it promotes the improvement of the innovation processes and the credibility of the institution and serves as the basis for other organizations and researches in the area. The results of the work may be considered for major contributions and relevance of the studied subject.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-04-17T23:38:51Z No. of bitstreams: 1 LeticiaStreck_TESE.pdf: 2733282 bytes, checksum: a29543b300520c0b87fa69110b9016dc (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-04-21T00:04:14Z (GMT) No. of bitstreams: 1 LeticiaStreck_TESE.pdf: 2733282 bytes, checksum: a29543b300520c0b87fa69110b9016dc (MD5) / Made available in DSpace on 2017-04-21T00:04:14Z (GMT). No. of bitstreams: 1 LeticiaStreck_TESE.pdf: 2733282 bytes, checksum: a29543b300520c0b87fa69110b9016dc (MD5) Previous issue date: 2017-02-02 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Doen?as negligenciadas, incluindo a doen?a de Chagas, representam um problema de sa?de mundial devido ao desinteresse da ind?stria na pesquisa por novos f?rmacos. Benznidazol (BNZ), f?rmaco dispon?vel no Brasil para o tratamento da doen?a de Chagas, e distribu?do pelo Minist?rio da Sa?de, apresenta algumas limita??es quanto ao seu uso, em especial na fase cr?nica da doen?a. A tecnologia farmac?utica proporciona o desenvolvimento de sistemas que aumentam a solubilidade do f?rmaco ou aumento de sua concentra??o nas c?lulas/tecidos infectados o que reflete diretamente no aumento da biodisponibilidade e efici?ncia terap?utica do BNZ. Assim, sistemas l?quidos tais como os sistemas coloidais lip?dicos (SCL), como emuls?es, microemuls?es, nanoemuls?es s?o uma alternativa interessante para o aumento da biodisponilidade oral e parenteral do BNZ. Este trabalho tem como objetivo o desenvolvimento de nanoemuls?es biocompat?veis contendo triglicer?deo de cadeia m?dia (Miglyol?812) estabilizados por uma mistura adequada de tensoativos (fosfatidilcolina de soja e oleato de s?dio), al?m de avaliar o efeito tripanocida. As condi??es ideais para obten??o dos sistemas de interesse foi avaliada pelo estudo da temperatura de invers?o de fases (TIF) e da adi??o de um novo componente. Nanoemuls?es foram formadas com adi??o de 2-metilpirrolidona (NMP) com tamanho de got?cula uniforme e menor que 162,66 nm. Os sistemas permaneceram est?veis at? 60 dias quando armazenados a temperatura de 25 ?C. As propriedades reol?gicas mostraram comportamento dependente com a quantidade de co-solvente adicionada ao sistema. As imagens de microscopia de luz polarizada e espalhamento de raios-X a baixo ?ngulo confirmaram a forma??o de sistemas isotr?picos quando o co-solvente est? em concentra??o superior a 5%. A libera??o de BNZ nos sistemas contendo ?cido si?lico em diferentes concentra??es, foi at? 3 (tr?s) vezes mais r?pida que os sistemas sem a subst?ncia. Os sistemas apresentaram biocompatibilidade em diferentes linhagens celulares (Vero, SiHa e LLC-MK2). Nanoemuls?es apresentaram capacidade de veicular o BNZ em sistemas biocompat?veis e com excelente atividade tripanocida, representando assim um futuro promissor no tratamento da doen?a de Chagas, considerando que at? o presente n?o existem formas farmac?uticas l?quidas de administra??o, o que impossibilita o ajuste da dose e a redu??o de efeitos colaterais. / Neglected diseases, including Chagas disease, represent a global health problem due to the industry's lack of interest in research for new drugs. Benznidazole (BNZ), a drug available in Brazil for the treatment of Chagas disease, and distributed by the Health Ministery, presents some limitations regarding its use, especially in the chronic phase of the disease. Pharmaceutical technology provides the development of systems that increase drug solubility or increase its concentration in infected cells / tissues which directly reflects the increased bioavailability and therapeutic efficacy of BNZ. Thus, liquid systems such as lipid colloidal systems (LCS), such as emulsions, microemulsions, nanoemulsions are an interesting alternative for increasing oral and parenteral bioavailability of BNZ. This work aims to develop biocompatible nanoemulsions containing medium chain triglycerides (Miglyol?812) stabilized by a suitable mixture of surfactants (soybean phosphatidylcholine and sodium oleate), and to evaluate the trypanocidal effect. The ideal conditions for obtaining the systems of interest were evaluated by the study of phase inversion temperature (PIT) and the addition of a new component. Nanoemulsions were formed with addition of 2-methylpyrrolidone (NMP) with uniform droplet size and less than 162.66 nm. The systems remained stable for up to 60 days when stored at 25 ? C. The rheological properties showed a behavior dependent on the amount of co-solvent added to the system. The polarized light microscopy and low angle X-ray scattering images confirmed the formation of isotropic systems when the cosolvent is in a concentration greater than 5%. The release of BNZ in systems containing sialic acid at different concentrations was up to 3 (three) times faster than systems without the substance. The systems showed biocompatibility in different cell lines (Vero, SiHa and LLCMK2). Nanoemulsions were able to transport BNZ in biocompatible systems with excellent trypanocidal activity, thus representing a promising future in the treatment of Chagas' disease, considering that to date there are no liquid dosage forms of administration, which makes it impossible to adjust the dose and decrease of side effects.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-06-13T20:29:52Z No. of bitstreams: 1 AndreLuizSilvaDavim_TESE.pdf: 2927049 bytes, checksum: c70bf3fe6cd0580d21ea07690845a8e8 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-06-19T14:43:48Z (GMT) No. of bitstreams: 1 AndreLuizSilvaDavim_TESE.pdf: 2927049 bytes, checksum: c70bf3fe6cd0580d21ea07690845a8e8 (MD5) / Made available in DSpace on 2017-06-19T14:43:48Z (GMT). No. of bitstreams: 1 AndreLuizSilvaDavim_TESE.pdf: 2927049 bytes, checksum: c70bf3fe6cd0580d21ea07690845a8e8 (MD5) Previous issue date: 2017-02-23 / Atualmente os custos no tratamento de pacientes com doen?as inflamat?rias que progridem de forma sist?mica, com destaque para a sepse, s?o muito elevados e representa a maior causa de morte em unidades de terapia intensiva, n?o cardiol?gica, em todo o mundo. No Brasil, a incid?ncia de pacientes com sepse ? cada vez mais frequente. Apesar dos avan?os farmacol?gicos, tecnol?gicos e cir?rgicos, a mortalidade por sepse e/ou doen?as associadas continua alta em todo o mundo, e por isso se busca alternativas terap?uticas de f?cil acesso e baixo custo para conter o avan?o dessa doen?a. Os produtos naturais v?m desempenhando importante papel na ind?stria farmac?utica, pois algumas dessas subst?ncias agem de forma ben?fica sobre o sistema imunol?gico humano. Nos ?ltimos tempos, h? uma crescente investiga??o das poss?veis propriedades biol?gicas e terap?uticas atribu?das ao ?leo de r?-touro, pois esse ?leo vem sendo utilizado de forma indiscriminada pela popula??o no tratamento de diversas doen?as como bronquite, asma, l?quem escleroso, furunculose, cisto seb?ceo e para cicatriza??o de pele e mucosas. Por?m as poss?veis consequ?ncias no consumo excessivo desse ?leo s?o, o aumento da produ??o de eicosanoides derivados do ?cido araquid?nico proinflamat?rio e a defici?ncia na regula??o hep?tica, predispondo ? esteatose podendo progredir para inflama??o hep?tica e fibrose. Muitas hip?teses se baseiam na atua??o dos compostos presentes no ?leo de r?-touro na modula??o da resposta inflamat?ria, impedindo assim a instala??o de inj?rias teciduais. Dessa forma, a microemuls?o apresenta-se como uma poss?vel alternativa para um novo sistema de libera??o de f?rmacos, com o intuito de diminuir a incid?ncia de hepatoxicidade e protegendo o organismo contra instala??o de les?es teciduais em fun??o do quadro s?ptico. Assim, o presente estudo teve como objetivo avaliar o potencial anti-inflamat?rio do ?leo de r?-touro puro e em um sistema microemulsionado em modelo experimental. Neste estudo, foi preparado e caracterizado um sistema microemulsionado (WIV) e, aplicado em ensaios biol?gicos a fim de avaliar o potencial antiinflamat?rio do ?leo puro e em microemuls?o. Foram utilizados o modelo de sepse, induzida pela t?cnica da CLP (cecal ligant puncture), e a les?o muscular induzida pela formalina. Os ensaios foram realizados em modelos murinos, onde os animais foram separados aleatoriamente em grupos e tratados com o ?leo de r?-touro puro e em microemuls?o, atrav?s da t?cnica de gavage para posterior avalia??o do potencial hepatot?xico e anti-inflamat?rio. Para a an?lise do potencial antiinflamat?rio em modelo de sepse, foram realizadas lavagens bronco alveolares com posterior contagem de c?lulas inflamat?rias e an?lises histopatol?gicas do tecido pulmonar. Para a an?lise no modelo de les?o muscular, foi avaliado extens?o horizontal da pata dos animais, bem como feita a an?lise histopatol?gica do tecido muscular. Para a an?lise do potencial hepatot?xico das subst?ncias, foram avaliados a taxa de sobrevida dos animais p?s-sepse e as an?lises histopatol?gicas dos tecidos hep?ticos dos animais. Quando avaliado a toxicidade do ?leo de r?-touro puro e em sistema microemulsionado, foi observado que no grupo em que foi administrado a microemuls?o (ME), o f?gado teve a arquitetura preservada, mas com sinais cl?nicos de esteatose hep?tica, diferentemente do grupo ?leo de r?-touro puro (OR), que apresentou m?ltiplos focos de necrose hepatoc?tica acompanhado de infiltrado de polimorfonucleares. Esses achados evidenciam um quadro de esteatohepatite, ou seja, um est?gio mais avan?ado e um precursor do carcinoma hep?tico. Quando avaliada a sobrevida dos animais, foi observado que no grupo ME a taxa foi significativamente maior quando comparado ao grupo OR. Quando avaliado o potencial antiinflamat?rio da ME e OR em modelo de sepse, foi observado em ambos os grupos potencial de modula??o da resposta inflamat?ria, visto a capacidade de reduzir de forma significativa (P?0.01) a migra??o de leuc?citos para os pulm?es ap?s a indu??o da sepse. Quando analisado a histologia dos tecidos pulmonares dos animais dos dois grupos, foi verificado intenso desgaste nos animais do grupo OR quando comparados com o grupo ME, onde evidenciou-se pouco comprometimento tecidual. No ensaio de les?o muscular, foi observado que o grupo ME e OR apresentaram bom potencial antiedematog?nico at? a segunda hora da indu??o da les?o, quando comparados ao grupo controle (P?0.01), mas n?o sendo observado diferen?as significativas entre os dois grupos at? a vig?sima quarta hora p?s-les?o. Nas an?lises histol?gicas foram observadas maior desgaste no tecido muscular do grupo OR, com intensa presen?a de infiltrado celular (edema) e comprometimento de fibras musculares, n?o sendo observado a mesma intensidade de inj?ria no grupo ME. Assim, conclui-se que o ?leo de r?-touro puro e em sistema microemulsionado apresentam bom potencial anti-inflamat?rio nos modelos avaliados, embora o ?leo puro tenha apresentado alto potencial hepatot?xico, caracterizando que este em um sistema microemulsionado, se mostra com um poss?vel novo sistema de libera??o de f?rmacos (NSLF). / Current costs of treating patients with systemically progressing inflammatory diseases, especially sepsis, are the leading cause of death in non-cardiological intensive care units worldwide. In Brazil, the incidence of sepsis in patients is becoming more frequent. Despite pharmacological, technological and surgical advances, mortality due to sepsis and/or associated diseases remains high worldwide, hence the search for easily accessible and inexpensive therapeutic alternatives to contain the progression of this disease. Natural products have played an important role in the pharmaceutical industry because some of these substances act in a beneficial way on the human immune system. In recent times, there is a growing investigation of the possible biological and therapeutic properties attributed to bullfrog oil, since this oil has been used indiscriminately by the population in the treatment of various diseases, such as bronchitis, asthma, lichen sclerosus, furunculosis, sebaceous cyst, and for healing of skin and mucous membranes. However, the possible consequences of excessive consumption of this oil are increased production of eicosanoids derived from proinflammatory arachidonic acid and deficiency in hepatic regulation, predisposing to steatosis, which may progress to hepatic inflammation and fibrosis. Many hypotheses are based on the performance of the compounds present in bullfrog oil in the modulation of the inflammatory response, thus preventing the onset of tissue injuries. The microemulsion is presented as a possible alternative to a new drug delivery system, in order to reduce the incidence of hepatotoxicity and protect the organism against the installation of tissue lesions as a function of the septic condition. The present study is aimed to evaluate the anti-inflammatory potential of pure bullfrog oil and a microemulsion system in an experimental model. In this study, a microemulsified system (WIV) was determined and characterized, and applied in biological tests to evaluate the anti-inflammatory potential of pure oil and microemulsion. We used the sepsis model, induced by cecal ligant puncture (CLP) technique, and the formalin-induced muscle injury. The tests were performed in murine models, where the animals were randomly separated into groups and treated with pure bullfrog oil and microemulsion, using the gavage technique for further evaluation of the hepatotoxic and anti-inflammatory potential. For the analysis of the anti-inflammatory potential in a sepsis model, bronchoalveolar lavage was performed with subsequent inflammatory cell counts and histopathological analyzes of lung tissue. For the analysis in the muscle injury model, the horizontal extension of the limbs of the animals was evaluated, as well as the histopathological analysis of the muscle tissue. For the analysis of the hepatotoxic potential of the substances, the post-sepsis survival rate and the histopathological analyzes of the hepatic tissues of the animals were evaluated. When evaluating the toxicity of pure bullfrog oil and in a microemulsion system, it was observed that in the group that received the microemulsion (ME), the liver had the architecture preserved, but with clinical signs of hepatic steatosis, unlike the pure bullfrog oil group, which presented multiple outbreaks of hepatocytic necrosis accompanied by polymorphonuclear infiltrates. These findings indicate a picture of steatohepatitis, that is, a more advanced stage and a precursor of hepatic carcinoma. When evaluating the survival of the animals, it was observed that the ME group survival rate was significantly higher when compared to the oil group. When evaluating the anti-inflammatory potential of the ME and the oil group in a sepsis model, the potential for modulation of the inflammatory response was observed in both groups, since the leukocyte migration to the lungs was significantly reduced (P<0.01) after the induction of sepsis. When analyzing the histology of the lung tissues of the animals of both groups, intense wear was observed in the animals of the oil group, when compared with the ME group, where there was little tissue compromise. In the muscle injury test, it was observed that the ME and oil group had good anti-nematode potential until the second hour of injury induction, when compared to the control group (P<0.01), but no significant differences were observed between the two groups until twenty-fourth hour post-injury. In the histological analyzes, greater wear was observed in the oil group muscle tissue, with an intense presence of cellular infiltrate (edema) and muscle fibers involvement, and the same intensity of injury was not observed in the ME group. Thus, it is concluded that pure bullfrog oil and microemulsion system present good anti-inflammatory potential in the evaluated models, although the pure oil showed high hepatotoxic potential, characterizing that in a microemulsified system, it is shown with a possible new drug delivery system (NSLF).

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-12-12T19:38:30Z No. of bitstreams: 1 ReginaCarmenEsposito_TESE.pdf: 1609404 bytes, checksum: bbff08f10f8b71c6162cfba459bc5243 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-12-14T19:40:52Z (GMT) No. of bitstreams: 1 ReginaCarmenEsposito_TESE.pdf: 1609404 bytes, checksum: bbff08f10f8b71c6162cfba459bc5243 (MD5) / Made available in DSpace on 2017-12-14T19:40:52Z (GMT). No. of bitstreams: 1 ReginaCarmenEsposito_TESE.pdf: 1609404 bytes, checksum: bbff08f10f8b71c6162cfba459bc5243 (MD5) Previous issue date: 2017-09-29 / O aumento benigno da pr?stata, mais conhecido como hiperplasia benigna da pr?stata (HBP), leva a sintomas do trato urin?rio inferior (STUI), que contribuem para diminuir a qualidade de vida dos homens acima da quarta d?cada. O mesmo vem sendo tratado, na sua maioria, por medicamentos alop?ticos do grupo dos inibidores da 5-alfa-redutase e/ou alfa-bloqueadores e/ou fitoter?picos. A literatura cient?fica apresenta uma escassez de ensaios cl?nicos randomizados, controlados com cegamento sobre a efic?cia de medicamentos homeop?ticos que j? tenham mat?ria m?dica para esta doen?a, bem como de novos rem?dios homeop?ticos. O presente estudo visou a avaliar a efic?cia do produto homeop?tico, contendo Momordica charantia 12CH, no controle dos STUI, devido ? HBP em ensaio cl?nico, randomizado, duplo cego e placebo controlado. Foram aleatorizados 81 pacientes em grupo A - Placebo e grupo B - Momordica charantia 12CH e avaliados a cada consulta pela anamnese, com o Escore Internacional de Sintomas Prost?ticos (IPSS), pelos exames de imagem com mensura??o do Volume Prost?tico (PV) e do Volume de Urina Residual P?s-esvaziamento (PVR) e laboratoriais pelo Ant?geno Prost?tico Espec?fico (PSA), Prote?na C Reativa quantitativa (PCR) e Interleucina-6 (IL-6). Em 72 amostras, foram realizados imunofenotipagem de linf?citos e subpopula??es por citometria de fluxo. Tanto a vari?vel principal (IPSS) quanto as vari?veis secund?rias (PSA, PV, PVR e PCR) e acess?rias (IL-6, linf?citos totais, linf?citos B, linf?citos T, linf?citos T helper, linf?citos T citot?xico e rela??o CD4/CD8 e c?lulas Natural Killer) n?o apresentaram signific?ncia estat?stica nas m?dias entre os grupos tratado e Placebo. Quanto ?s vari?veis de seguran?a, o uso da medica??o homeop?tica, pelos pacientes, n?o trouxe interfer?ncia durante os seis meses do experimento, seja na taxa de glicemia de jejum, seja nas dosagens de alanina aminotransferase, aspartato aminotransferase, fosfatase alcalina, bilirrubinas totais e fra??es e creatinina, usadas para avalia??o hep?tica e da fun??o renal respectivamente. A aus?ncia de infec??o urin?ria, confirmada pelo sum?rio de urina dos pacientes, predominou em ambos os grupos A e B durante todo o per?odo do ensaio cl?nico. Pode-se concluir que o tratamento com a Momordica charantia 12CH n?o apresentou diferen?a significativa para o placebo, quanto ? efic?cia no controle dos STUI, por HBP, por?m mostrou-se seguro. Pesquisas de alta qualidade, que permitam a prescri??o, a partir da individualiza??o dos sintomas e com diferentes dinamiza??es, devem ser realizadas, para possibilitar uma interpreta??o mais decisiva. / The benign enlargement of the prostate, better known as benign prostatic hyperplasia (BPH) results in symptoms of the lower urinary tract (LUTS) that contributes to lower quality of life of men over the fourth decade, and is mostly treated by allopathic drugs of the group of 5-alpha-reductase inhibitors and / or alpha-blockers, and / or phytotherapics. The scientific literature shows lack research from randomised and doubleblind clinical trials on the efficacy of homeopathic medicinal products that already have homeopathic medical materia and new homeopathic medicinal for BPH.The present study aimed to evaluate the effectiveness of the homeopathic product containing Momordica charantia 12CH in the LUTS control caused by BPH in a clinical, randomized, double-blind and placebo-controlled trial.A total of 81 patients were randomized to group A - Placebo and group B - Momordica charantia 12CH and evaluated at each visit by anamnesis with the International Prostate Symptom Score (IPSS), by imaging tests measured prostate volume (PV) and post-void residual (PVR) and laboratory tests for prostate specific antigen (PSA), quantitative C-reactive protein (CRP) and interleukin-6 (IL-6), and in 72 samples, lymphocyte and subpopulation immunophenotyping were performed by flow cytometry.Both the main variable (IPSS) and the secondary variables (PSA, PV, PVR and CRP) and accessory variables (IL-6, total lymphocytes, B lymphocytes, T lymphocytes, T helper cells, cytotoxic T lymphocytes and CD4 / CD8 ratio and Natural Killer cells) did not present statistical significance in the means between the groups treated and Placebo.About the safety variables, the use of homeopathic medication by the patients did not interfere during the six months of research, either in the fasting glucose level, as well as in the dosages of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubins and fractions and creatinine levels used for hepatic evaluation and renal function respectively.The absence of urinary infection confirmed by urinalysis of patients predominated in both groups A and B throughout the clinical trial period. It can be concluded that treatment with Momordica charantia 12CH did not show a significant difference for placebo in the efficacy in the control of STUI by BPH, but it demostrated to be safe. High quality researchs, which allows prescription, from the individualization of symptoms and with different dynamizations, must be performed, to enable more decisiveinterpretation of its effectiveness.