Although androgens are known to exert anabolic effects in skeletal muscle, overexpression of androgen receptor (AR) selectively in this tissue causes androgen dependent motor deficits and muscular atrophy. The cellular and subcellular changes underlying this phenotype are unknown. Therefore, this study aimed to elucidate the ultrastructural and histologic changes accompanying myopathy and to determine the importance of androgens and overexpression level for myopathic features. Transmission electron microscopy revealed augmented mitochondrial content and reduced myofibril width in androgen exposed transgenics. Additionally, male transgenics demonstrated increased glycogen content. Histochemical analyses confirmed sex-specific changes in glycogen content and revealed a surprising loss in the proportion of oxidative fibers in symptomatic animals. However, increased mitochondrial content was confirmed by the presence of ragged red fibers. Overexpression of AR in muscle fiber results in mitochondrial pathology and dysregulation of glycogen metabolism, possibly reflecting normal but exaggerated function of androgens in skeletal muscle fibers.

Although androgens are known to exert anabolic effects in skeletal muscle, overexpression of androgen receptor (AR) selectively in this tissue causes androgen dependent motor deficits and muscular atrophy. The cellular and subcellular changes underlying this phenotype are unknown. Therefore, this study aimed to elucidate the ultrastructural and histologic changes accompanying myopathy and to determine the importance of androgens and overexpression level for myopathic features. Transmission electron microscopy revealed augmented mitochondrial content and reduced myofibril width in androgen exposed transgenics. Additionally, male transgenics demonstrated increased glycogen content. Histochemical analyses confirmed sex-specific changes in glycogen content and revealed a surprising loss in the proportion of oxidative fibers in symptomatic animals. However, increased mitochondrial content was confirmed by the presence of ragged red fibers. Overexpression of AR in muscle fiber results in mitochondrial pathology and dysregulation of glycogen metabolism, possibly reflecting normal but exaggerated function of androgens in skeletal muscle fibers.

Thesis (Ph.D.)--University of Central Florida, 2009. / Adviser: Pamela McCauley Bush. Includes bibliographical references (p. 149-159).

Despite the apparent hegemony of vision in racial categorization, historically vocality has borne the brunt of as much racial presumption as physical appearance. This project explores ideas about Blackness, and how the voice in performance engenders conversations on racial authenticity within the United States. Broadly, the work examines how “sounding Black” functions within dramatic performance, and how wider concerns of racial identity adhere to a performer’s vocal choices. The contextualization of racialized sound presented in this project begins with an historical overview of how a “Blackness of tongue” has been framed in U.S. theatrical performance from the early 1800s through the 1960s. It then addresses the dynamics of voice and racial authenticity through two performance case studies: August Wilson’s The Piano Lesson and Adrienne Kennedy’s Funnyhouse of a Negro. These cases will be used to explore how issues of racial authenticity thrive in the space between vocal sound production and perception. As case studies based on specific productions of these two plays, text, directorial choices, and the vocal characteristics of the actors themselves occupy equal space at the center of each analysis. At a deeper level, this research seeks an understanding of the cultural assumptions that support the idea of a uniquely Black vocal sound, and what that sound purchases within American societies. In addressing both the phonological and the interpretive qualities of these performances, the central research concerns of this project attempt to pinpoint with more accuracy how voice, fore-grounded in performance, triggers different sets of assumptions that have been commonly identified as a significant component of Blackness / text

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This article examines the role of epideictic rhetoric as a tool for promoting civic virtue in the public realm through the application of Kenneth Burke's theory of identification and John Dewey's explanation of an aesthetic experience. Long the jurisdiction of Aristotle's logical arguments, civic discussion usually works within the realm of forensic or deliberative persuasion. However, scholarship in the last fifty years suggests there is an unexplored dimension of Aristotle's discussion of epideictic and emotion that needs to be examined in an attempt to identify its usefulness as a tool for examining human experience and practical behavior in the political realm. I attempt to add to the discussion by exploring the presidential funerals of Abraham Lincoln, John F. Kennedy, and Ronald Reagan as opportunities for a nation to display a hero's virtues as extensions of society's virtues. Virtues often define what a nation considers good which, in turn, influences the nature of the discussion and often determines political action.

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The subject of this bachelor thesis in political science has been to study how populistic rhetoric has evolved as a political phenomenon. The study has more specifically researched how presidential candidates have used populism in presidential debates. The bachelor thesis also studied if populistic rhetoric has changed over a time period between 1960 to 2016. To be able to study this, the essay has used critical discourse analysis to develop and understand how populism works. Ernesto Laclau’s On Populist Reason has also been used to create three models of understanding populism to develop the essays framework.  Through this the study has found that populistic rhetoric has come to be used more frequently in presidential debates. The study has also found that populistic rhetoric has changed form into a more aggressive style of rhetoric targeting the opponent’s character instead of the individual’s style of politics.