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A thrust anemometer was designed to measure the three components of wind velocity fluctuations in the atmospheric boundary layer over the surface of the sea, and hence to evaluate directly the Reynolds stress of the wind on the sea. The anemometer was shown to be suitable for its intended purpose first by wind tunnel tests and then by comparisons with spectra from measurements in the field by cup and hot-wire anemometers. Spectra and cospectra of wind velocity fluctuations were calculated by analog analysis for thirty-two runs of 32 minutes' duration each at the Spanish Banks experimental site and for one run at another site. The spectra of downwind and of vertical velocity fluctuations were each found to be grouped closely when plotted in normalized form, and an empirical formula was given for the low-frequency end of the vertical velocity spectrum. The correlation of the downwind and vertical velocity fluctuations was found to be -0.5 at low frequencies and to approach zero at higher frequencies. The average value of the drag coefficient of the surface of the sea for the thirty-three runs was .0010 and no significant variation with wind speed was observed over the range 3 to 13 m/sec. / Science, Faculty of / Physics and Astronomy, Department of / Graduate

A study of laminar free convection about horizontal plates of finite width with one side heated isothermally and the other insulated is presented in this thesis. This investigation forms part of a continuing program, and its technological origin and significance are discussed in the introduction. The governing partial differential equations comprising the continuity, momentum and energy equations are solved numerically through a finite difference method using a successive-over relaxation technique for a Rayleigh number range from 0.22 to 500, at three values of Prandtl number (0.72, 5.0 and 10.0). The variation of the flow, vorticity and temperature fields with the change of both Grashof and Prandtl numbers is discussed on the basis of the streamline, iso-vorticity and isothermal plots obtained . The effect of Prandtl number alone on the momentum field, energy distribution and heat transfer rate is discussed, by a comparison of the isotherms, streamlines and correlation curves obtained for the three different Prandtl numbers. The theoretical analysis places emphasis on the singular nature of the boundary conditions specified and on the influence of the finite size of the domain of the finite difference scheme. Some results for an upward facing horizontal isothermally heated plate of finite width were also obtained, and were compared to data for the downward facing case. A semi-focussing Schlieren colour system was used order to investigate experimentally the flow behaviour on a horizontal plate with the heated surface facing-downward The experimental results sought were evidence of the non-boundary layer nature of the flow. The evidence of non-boundary layer flow was obtained conclusively. / Applied Science, Faculty of / Mechanical Engineering, Department of / Graduate

Flat plate turbulent boundary layers disturbed by periodic moving wakes have been observed in an experimental rig mounted in a low speed wind tunnel. The wakes are produced periodically by cylinders traversing in front of the leading edge of a flat plate on which the boundary layers are measured. This is to simulate the unsteady flow pattern generated by upstream blades on the downstream blade boundary layer in an axial flow turbomachine. Both the time-averaged and ensemble-averaged data are taken from the free stream and boundary layer at different flow conditions. Free stream steady and unsteady wakes are compared and found to be similar to each other. The wake disturbance in the free stream is a function of time and distance from the cylinder. The periodic disturbance in the inner half of the boundary layer lags behind that in the free stream. This phase lag is due to the lower convection velocity near the solid surface. Similar to a steady wake, the velocity defect of an unsteady wake is higher in boundary layer than in free stream. This results in the maximum velocity defect amplitude in the inner half of the boundary layer. Phase lag and amplitude ratio profiles of the boundary layers are plotted and found to be similar to data obtained from axial flow turbomachines. Phase-averaged velocity and turbulence intensity profiles at different phase angles between two successive wakes are shown in a series of transparencies. / Applied Science, Faculty of / Mechanical Engineering, Department of / Graduate

The velocity profile shape and boundary layer thickness of an equilibrium boundary layer grown over a long fetch of roughness are closely matched with those of a boundary layer artificially thickened using spires (by adjusting the shape and height of the spires). Other turbulent characteristics of these two wind tunnel simula tions of the atmospheric wind are then compared. At the same time, more information on rough wall boundary layers is obtained to allow for a rational choice of the shape and spacing of roughness elements required to produce a particular simulation of the full scale boundary layer. A technique for calculating the shape of boundary layers in exact equilibrium with the roughness beneath, using a data correlation for the wall stress associated with very rough boundaries and a semi-empirical calculation method, is examined experimentally. Wall shear stress, measured directly from a drag plate, i combined with boundary layer integral properties to show that the shear stress formula is reasonably accurate and that the boundary layer grown over a long fetch of roughness is close to equilibrium after passing over a streamwise distance equal to about 350 times the roughness element height. The boundary layer quickly generated using spires proved to be a fair approximation to that grown over a long fetch of roughness, but did not accurately represent the longitudinal turbulence intensity of the full scale atmospheric wind or the naturally grown boundary layer. The boundary layer produced here by spires showed little change in gross characteristics after travelling about eight spire heights downstream of the spires. A distance of six or seven such heights has been advised by other workers in the past. / Applied Science, Faculty of / Mechanical Engineering, Department of / Graduate

The growth of single and multilayer BN films on several substrates was investigated. A typical atomic layer deposition (ALD) process was demonstrated on Si(111) substrate with a growth rate of 1.1 Å/cycle which showed good agreement with the literature value and a near stoichiometric B/N ratio. Boron nitride films were also deposited by ALD on Cu poly crystal and Cu(111) single crystal substrates for the first time, and a growth rate of ~1ML/ALD cycle was obtained with a B/N ratio of ~2. The realization of a h-BN/Cu heterojunction was the first step towards a graphene/h-BN/Cu structure which has potential application in gateable interconnects.

Water scarcity is a serious global issue, due to the increasing population and developing economy, and membrane technology is an essential way to address this problem. Forward osmosis (FO) is an emerging membrane process, due to its low energy consumption (not considering the draw solute regeneration). A bottleneck to advance this technology is the design of the support layer for FO membranes to minimize the internal concentration polarization. In this dissertation, we focus on the structural study and modification of the support layer for FO membranes. Firstly, we digitally reconstruct different membrane morphologies in 3D and propose a method for predicting performance in ultrafiltration operations. Membranes with analogous morphologies are later used as substrate for FO membranes. Secondly, we experimentally apply substrates with different potentially suitable morphologies as an FO support layer. We investigate their FO performance after generating a selective polyamide layer on the top, by interfacial polymerization. Among the different substrates we include standard asymmetric porous membranes prepared from homopolymers, such as polysulfone. Additionally block copolymer membrane and Anodisc alumina membrane are chosen based on their exceptional structures, with cylindrical pores at least in part. 3D digitally reconstructed porous substrates, analogous to those investigated for ultrafiltration, are then used to model the performance in FO operation. Finally, we analyze the effect of intermediate layers between the porous substrate and the interfacial polymerized layer. We investigate two materials including chitosan and hydrogel. The main results are the following. Pore-scale modeling for digital membrane generation effectively predicts the velocity profile in different layers of the membrane and the performance in UF experiments. Flow simulations confirm the advantage of finger-like substrates over sponge-like ones, when high water permeance is sought. Cylindrical pores are advantageous for mass transfer. Block copolymer substrates have cylindrical pores in the top layer and very regular pore pattern at the surface. The Anodisc alumina membrane has cylindrical pores from top to bottom. Both substrates were experimentally tested for FO application successfully. A Darcy permeability higher than 1E-20 m2 for the intermediate layer would be necessary in order to facilitate the water flow.

The main objective of root canal therapy is cleaning, shaping and obturating the root canal system in three dimensions, as well as preventing reinfection. The objective of this in vitro study was: <ul> <li>to establish the antimicrobial efficacy of nine different root canal irrigation solutions, </li> <li>to determine the smear layer dissolving capabilities of these irrigating solutions, at various levels in straight root canals, and </li> <li>to examine the degree of erosion caused by the irrigation solutions on the root canal walls. </li></ul> Antimicrobial Effects: In this test the antimicrobial activity of nine irrigation solutions against E. faecalis was measured using a disc diffusion test. The antibacterial activity of materials was apparent from circular clear inhibition zones forming around the filtration paper. Effect on Smear Layer: Root canals were prepared by using Pro Taper nickel titanium rotary files. During preparation, the canals were irrigated with copious amounts of 3.5% sodium hypochlorite for 15 minutes. Thereafter, the teeth were randomly divided into nine groups. One group was kept as control. The other eight groups received a final rinse with one of the following irrigation solutions: 18% EDTA, Sterilox, Top Clear 17% EDTA, 2% Chlorhexidine, 10% Citric acid, Biopure MTAD, Ozonated water and Smear Clear. A total of 25ml of each solution was utilized to irrigate each root canal system, and left undisturbed in the root canal for 2 minutes. Biopure MTAD was left in the root canals for 5 minutes. Finally, the irrigation solutions were removed from the root canals with 10ml sterile distilled water. Each root was sectioned horizontally with a diamond disc in sections corresponding with the coronal, middle and apical levels of the root canal system. Each fragment was fractured laterally and prepared according to standard methods for biological SEM evaluation. The absence or presence of the smear layer as well as the amount of erosion of the peritubular dentine was assessed. The One-way ANOVA test was used to determine whether there were any statistical significant differences between the different test groups. No significant inhibition of E. faecalis was observed with sterile water (control) and the undiluted solutions of Sterilox, 10% Citric acid and Ozonated water. However, 3.5% NaOCl, 18% EDTA, Top Clear 17% EDTA, 2% Chlorhexidine, Biopure MTAD and Smear Clear showed significant inhibition of E. faecalis. For the 1/10 diluted solutions no inhibition of E. faecalis was observed with sterile water (control), 3.5% NaOCl, Sterilox, 10% Citric acid and Ozonated water. Biopure MTAD and Smear Clear demonstrated significant inhibition of E. faecalis compared to 18% EDTA, Top Clear 17% EDTA and 2% Chlorhexidine. Biopure MTAD was the only solution that showed significant inhibition of E. faecalis using a 1/100 diluted solution. No inhibition was observed with the 1/1000 diluted test solutions.Scanning electron microscope examination revealed that 3.5% NaOCl and Ozonated water had no visible effect on the smear layer. The 10% Citric acid solution slightly modified the smear layer at the coronal and middle levels of the root canals. There was no visible effect on the smear layer at the apical levels. Sterilox and 2% Chlorhexidine removed the smear layer at the coronal levels, modified it slightly in the middle levels and left the smear layer undisturbed in the apical levels of the root canals. 18% EDTA, Top Clear 17% EDTA, Biopure MTAD and Smear Clear removed the smear layer completely at the coronal levels. At the middle and apical levels of the root canals most of the smear layer was removed. However, there were less open dentinal tubules visible at the apical levels compared to the samples examined at the middle levels of the root canals. It was also noted that Top Clear 17% EDTA caused a significantly high percentage of erosion of the peritubular dentine at the coronal levels of the root canals compared to all the other irrigation solutions. Considering all the results of the present study Biopure MTAD demonstrated the best antimicrobial activity against E. faecalis, and removed most of the smear layer at all three levels of the root canal systems without significant erosion of the peritubular dentine. / Dissertation (MSc(Odont))--University of Pretoria, 2008. / Community Dentistry / unrestricted

Systemisch applizierte Therapeutika können erhebliche Nebenwirkungen auslösen, welche auf Grund eines unspezifischen Transports oder einer hohen Dosis von appliziertem Wirkstoff auftreten. Daher bedarf es der Entwicklung neuartiger Wirkstoff-Transportsysteme (Drug Delivery Systems) welche in der Lage sind, Wirkstoffe in genau definierbaren Dosen gezielt in die adressierte Zelle zu transportieren. Ein vielversprechender Ansatz, welcher diesen Anforderungen nachkommt, findet sich in der Layer-by-Layer-Technik (LbL), d.h. der wechselseitigen Assemblierung von Polymeren/Wirkstoffen auf soliden sphärischen Templaten, eines funktionellen Supported Lipid Bilayers sowie der Oberflächenfunktionalisierung mit spezifischen Antikörpern. Dabei ist die Homogenität und Regularität des Supported Lipid Bilayers von großer Bedeutung, um in biomedizinischen Anwendungen eine ungewollte Interaktion mit Serumkomponenten sowie eine Opsonierung zu verhindern. Insbesondere die funktionelle Lipidkomponente besitzt allerdings maßgebliche Auswirkungen auf diese Parameter. In dieser Arbeit wurde die Idee der Oberflächenfunktionalisierung von LbL-beschichteten Silica-Mikropartikeln (SiO2) mit einem funktionellen Supported Lipid Bilayer aufgegriffen und weiterentwickelt, wobei insbesondere die Homogenität des Supported Lipid Bilayers auch auf sehr kleinen Längenskalen (wenige Nanometer) bestimmt wurde. In einem letzten Schritt konnte anhand zweier verschiedener Zelllinien (3T3 und Vero) die Adaptivität und Effektivität des entwickelten Drug Delivery Systems nachgewiesen werden.

The subject of the thesis is to compare layered model and tomographic model. These models are used for description of low velocity layer in seismic survey. The goal of the work was to find out the conditions whether to prefer tomographic model instead of layered model. Program Geostar was used for modelling of low velocity layer. This program is a part of software package produced by CGG Veritas company. Geostar is available at department of Applied Geophysics for study purposes. Four synthetic models were created for comparison of tomographic and layered models. Models of low velocity layer were computed for layered an tomographic model in Geostar environment. Original models were compared to created models. Accuracy was estimated on root mean square error and static correction which was exactly known. In all cases, layered model showed better results then tomographic model. 1