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Coherent vortices are generated in flow fields due to flow interaction with sharp solid surfaces. Such vortices generate significant disturbances in the flow and affect its further development. In this dissertation attention is focused on the interaction of vortices with solid or free liquid/air surfaces. We examine vortices with their axis parallel or normal to the surface. Three main cases were examined: the interaction of a vortex pair propagating towards a solid boundary, the interaction of spanwise vortices in a turbulent boundary layer, and finally the interaction of spanwise vortices with a flat-plate wake and a free liquid surface. These problems hold significance in several engineering applications, including investigations into trailing wing tip vortices and their interaction with the ground, vortical effects on the development of turbulent boundary layers and free surface signatures and their detection in ship/submarine wakes. Data are acquired with a laser Doppler velocimetry system (LDV) and with Particle-Image Velocimetry (PIV), using a high-speed digital video camera. The LDV system measures two components of velocity along appropriately chosen planes. Grids of data were acquired for different pitch rates of a disturbing flap that generates vortices. Phase-averaged vorticity and turbulence level contours are estimated and presented. It is found that vortices with diameter the order of the boundary layer quickly diffuse and disappear while their turbulent kinetic energy spreads uniformly across the entire boundary layer. Larger vortices have a considerably longer life span and in turn feed more vorticity into the boundary layer. Trailing edge vortices are generated in a water tunnel by sharp hinged motions of a flap. These vortices are allowed to reconnect with the free surface and mix with a turbulent free shear layer. The flow is conditionally sampled via frame grabbing of free surface shadowgraphs. It is found that the vortex core bends away from the plane of the shear layer. Moreover, contrary to earlier findings, organized velocity fluctuations decrease as the free surface is approached. / Ph. D.

We present an analysis of the effects of heating, suction, and compressibility on the stability characteristics of boundary-layer flows within the framework of a complete nonparallel, linear, spatial stability theory. Included in the theory are disturbances due to velocity, Pressure, temperature, density, and transport properties as well as 'variations of the fluid properties with temperature. The method of multiple scales is used to account for the nonparallelism of the mean flow and equations are derived for the evolution of the disturbance amplitude and wave number vector. / Ph. D.

The subharmonic instability in two-dimensional boundary layer on a flat plate is analyzed using the parametric instability model and the resonant triad model. The problems arising from both models are solved numerically using the shooting technique and results are presented. It is found that in the presence of a strong interaction (e.g., large amplitude of the two-dimensional wave), results from the resonant triad model are inaccurate as compared with the experimental data and the t results from the parametric instability model. This is mainly because the resonant triad model is a weakly nonlinear model, and it does not account for the modification of the eigenfunctions of the interacting waves which really takes place as we find out from the experiments. The parametric instability model is a powerful model, despite all the assumptions included. The model, however, does not introduce a clear understanding of how the subharmonic mode originates from the three-dimensional Tollmien-Schlichting modes. For a weak interaction results from the resonant triad model and the parametric instability model get close to each other. / Master of Science

The Reynolds stresses in a three-dimensional turbulent boundary layer were examined using octant analysis. The representative flow was a pressure driven, three-dimensional turbulent boundary layer on the leeside (x/L=0.76-0.78, φ=105°-130°) of a 6:1 prolate spheroid at 10° angle of attack. The Reynolds number for the flow was Re_L=4.2x10⁺⁶. The LDV data of Chesnakas, Simpson, and Madden (1994) were the basis of examination. This data set employed a post-processing technique for refining the radial location of the measurements. A least-squares fit of the Spalding wall law was used to both correct the measurement locations and estimate the wall shear stress. This paper presents a previously unpublished assessment of the technique. Octant analysis was performed on the corrected data under free-stream and wall-collateral coordinates. (The wall-collateral coordinate system is aligned with the mean tangential velocity in the buffer-layer.) The octant analysis led to the development of a structural model that extends the sweep/ejection process to three dimensions. Ejections and sweeps produce w' through the same mechanism that produces u'; they transport fluid across a spanwise velocity gradient. The model's results remain consistent with coordinate rotation. The model also describes the asymmetries that evolve between ejections and sweeps with spanwise fluctuations (w') of opposite sign. These asymmetries cause non-zero u'w' and v'w' in the buffer layer. Comparison of the two coordinate systems reveals that wall-collateral coordinates provides a simpler foundation for octant analysis. The sweep and ejection octants maintain a nearly equal distribution of velocity events throughout the buffer and lower log layers. Also, the spanwise velocity profile monotonically decreases to a constant value at the boundary layer edge, simplifying application of the sweep/ejection model to spanwise fluctuations. Comparison with other 3DTBL experiments suggests that the wall-collateral coordinates are more closely aligned with the quasi-streamwise vortex structures than free-stream coordinates. The octant analysis also reveals structural behavior consistent with the four mechanisms revealed by the direct numerical simulation of Sendstad and Moin (1992). / Master of Science

For steady free-stream, zero and favorable pressure gradient turbulent boundary layers, the unsteadiness in the form of turbulent fluctuations was investigated. Phase ensemble-averaged flow characteristics of a large amplitude periodic unsteady turbulent boundary layer was also investigated at a reduced frequency k = 0.61 based on the length of the converging and diverging test section with amplitude to mean velocity ratio of 0.8. In steady flow cases, both zero and favorable pressure gradient flows show good two-dimensional flow characteristics and mean flow characteristics are compared with other researchers’ data. Measured power spectral data show good agreement with those of Klebanoff, Ueda and Hinze, Perry, Lim and Henbest for the zero pressure gradient flows and Jones and Launder for the favorable pressure gradient flow. The power spectral data measured in the turbulent wall region of the zero pressure gradient flow closely follow the model equation proposed by Perry, Lim and Henbest. Convective wave speed also show good agreement with those of Favre, Gaviglio and Dumas and Sternberg within the experimental uncertainties. In the inner region of the boundary layer where y+ < 40, convective wave speed is higher than local mean velocity at all eddy scales as observed by Kline, Reynolds, Schraub and Runstadler. In the unsteady flow case, in the absence of flow reversal, the flow behaves in a quasi-steady manner and can be described by the steady flow structure as in the case of moderate amplitude flows. The Ludwieg·Tillmann skin friction equation and the Perry-Schofield universal velocity defect law hold at these phases. Except the laminariscent velocity profile observed during the acceleration phases, the large amplitude unsteady flow shows basically the same flow characteristics as the moderate amplitude flows. / Master of Science

<p> This thesis is an experimental study of the effects of injecting dilute polymer solutions into a turbulent boundary layer developed on a flat plate submerged in water.</p> <p> A flat plate having a plexiglass surface together with a separate leading edge piece were specially designed for observing the boundary layer phenomena. Aqueous polymer solutions were introduced into the boundary layer through a slit situated in the leading edge piece. Hot-film anemometer technique was employed in the measurements of velocity profiles, turbulence intensities and lateral correlation coefficients at several locations on the plate. The investigation was carried out for two Reynolds Numbers, based on the length of the plate, of 2.4 x 10^5 and 6.4 x 10^5. The variation in the drag force with respect to the polymer concentrations and the injection rates was assessed based on the velocity profile data. It was found that the momentum diffusivity was smaller than for pure water, and that the presence of the polymer molecules seemed to promote a more uniform distribution of the sizes of the turbulence eddies.</p> / Thesis / Master of Engineering (MEngr)

<p dir="ltr">As silicon (Si) technology advances to 3 nm node and beyond, vertically stacking in 3D is considered as the primary choice to increase the density of transistors per unit area for better chip performance. Therefore, looking for new materials capable of replacing Si in back-end-of-line (BEOL) compatible monolithic 3D (M3D) integration has become one of the most important topics in the current field of electronic devices. Recent developed atomic layer deposition (ALD) deposited indium oxide (In₂O₃) field-effect transistors (FETs) have realized excellent electrical performance including field effect mobility over 100 cm²/V·s, on/off ratio up to 10¹⁷ and on-state current (I_ON) over 2.5 mA/μm in nanometer thin In₂O₃ FETs, providing promising prospect for next generation electronics. In this thesis, four main In₂O₃ related topics are discussed to examine the practicality of ALD In₂O₃ as channel material in BEOL compatible applications. First, the bias stability of planar In₂O₃ transistors and the effect of tin doping are studied. Second, gate-all-around (GAA) In₂O₃ FETs are implemented to improve I_ON up to record high 20 mA/μm, and its reliability is systematically measured and analyzed. Third, multilayer In₂O₃ FETs are constructed to investigate the possibility of vertical stacking. Last, vertical full oxide transistors with In₂O₃ gate are demonstrated to prove the feasibility of potential 3D integration.</p>

Das hygroskopische Verhalten von Holz wird im Kontext zahlreicher Anwendungen des Materials zumeist negativ interpretiert. Durch einen grundlegenden Perspektivwechsel werden Potenziale und Lösungsansätze sichtbar, die interessante Zukunftsperspektiven für das reaktive Phänomen des Werkstoffes eröffnen. Im Rahmen einer Masterthesis im Studiengang Architektur wurde ein Konzept entwickelt, welches das Quell- und Schwindverhalten zur Realisierung klimasensitiver Verschattungselemente aus Bi-Layer-Holzfurnieren nutzen möchte. Die feuchte- und temperaturbedingten Formänderungen von Holz sind vom Maß der Feuchtezufuhr, vom Schnittbereich des Holzes und von dessen Struktur abhängig. Vor dem Hintergrund des natürlichen Ursprungs des Materials resultiert daraus ein kaum vorhersagbares Verformungsverhalten. Das Projekt folgt der Idee, die Formänderung durch die Kombination von zwei Furnierarten maßgeblich zu beeinflussen. Durch eine schubsteife Verklebung der Furniere eröffnet sich ein weites Feld an Kombinationsmöglichkeiten von Parametern (Furnierdicke, Faserausrichtung, Dimension), um zunächst deutlich weniger streuende Ergebnisse zu erzielen. Um das Krümmungsverhalten der Bi-Layer zu untersuchen, wurde eine Versuchsserie von sechs Kombinationsvarianten mit jeweils zwei Proben pro Variante konzipiert und in einem Klimaschrank mit drei Versuchsarten durchgeführt. Im Ergebnis der Versuche konnte die Eingangsthese plausibilisiert werden. Die gewonnenen Erkenntnisse zeigen erhebliche Potenziale das Materialverhalten kalkulierbar und skalierbar zu machen. Auf der Basis der Messwerte und der per 3D-Scan aufgenommenen Biegeverhalten wurde ein parametrisches Simulationsmodell erzeugt und genutzt, um den Anwendungsansatz als Verschattungspaneele in der Architektur an einer Musterfassade zu veranschaulichen.

Abstract  Lack of clinical relevance is assumed to be the main reason behind the high failure rate of medical drugs in the very initial phases of clinical trials. Clinical relevance is difficult to achieve with current tools as they lack the biological and physiological cues found in vivo. Microfluidics, the knowledge of fluid manipulation in small channels, has proven to be a promising science to bridge the gap between the current in vitro and the real in vivo features. In this thesis, a scaffold for the growth of spheroids inside a microfluidic device for potential drug screening was developed. Firstly, the surface of a microfluidic device was coated with the polymers cellulose nanofibrils, polyallylamine hydrochloride, and polyethyleneimine using the Layer-by-Layer technique to achieve an even surface coverage. Here, different chip designs, polymer concentrations, and pressure directions were tested. It was decided that using a negative pressure direction with a polymer concentration of 50 mg/L in a chip design with micropillars was optimal and these conditions were then used for testing the spheroid formation. Secondly, spheroids were grown inside the microfluidic channels using different coatings: the previously mentioned polymer buildup, one non-coated channel, and one coated with attachment factor proteins. These three surface conditions were compared and it was shown that the polymer-based surface cover was indeed superior as a scaffold as it encouraged and promoted cell growth in the spheroid formation of liver cancer cells from the HepG2 cell line. Further development of this cellulose nanofibrils-coated microfluidic device displays a promising future for functioning as an in vitro 3D cell culture model that better mimics the close-to-cell microenvironments by imitating cell proliferation, cell-to-cell, and cell-to-extracellular matrix interactions. / Sammanfattning Den främsta orsaken bakom den höga antal misslyckade kliniska läkemedelsprövningar i de initiala faserna antas bero på brist på klinisk relevans. Klinisk relevans är mycket svår att uppnå med dagens verktyg då de saknar de biologiska och fysiologiska förhållandena som återfinns in vivo. Mikrofluidik, kunskapen om vätskemanipulation i små kanaler har visat sig vara lovande vetenskap för att överbrygga klyftan mellan de nuvarande in vitro och de faktiska in vivo funktionerna. I detta arbete utvecklades en matris för sfäroider att växa på inuti en mikrofluidisk kanal för att potentiellt användas till läkemedelsscreening. Först användes Layer-by-Layer teknologi för att jämnt betäckta ytan inuti en mikrofluidisk kanal med polymererna cellulosananofibriller, polyallylamin hydroklorid samt polyetylenimin. Här testades olika designer på mikrofluidiska chip, polymerkoncentrationer samt tryckriktningar. Utifrån detta gick det att fastställa att negativt tryck med en polymerkoncentration på 50 mg/L i en chippdesign med mikropelare var optimal för en jämn ytbetäckning och dessa förhållanden användes sedan för att pröva sfäroidernas tillväxt. Härnäst testades därmed sfäroidernas tillväxt inuti mikrofluidiska kanaler under tre olika förhållanden: ett med polymerbetäckningen, ett utan betäckning och ett då ytan var täckt med proteiner med fästfaktorer. Dessa tre förhållanden jämfördes sedan med varandra och således gick det att konstatera att den polymerbaseradebetäckningen fungerade överlägset som matris för tillväxt av HepG2 lever cancer cell sfäroider eftersom den tycks främja dess tillväxt och bildning. Det pekar mot att ytterligare utveckling av denna cellulostäckta yta skulle innebära en lovande modell för in vitro 3D cellodling som bättre efterliknar den cellulära mikromiljön genom att imitera cellproliferation, interaktioner celler emellan samt mellan cell och extracellulär matrisen.