Systems of Systems are becoming more the norm in technology applied to tactical military systems. Because of this it is necessary to greatly simplify the way telemetry data is formatted and shared with other systems that depend on near real-time information. This is becoming necessary for developmental testing, operational testing and tactical training in realistic battlefield environments. Interoperable data is necessary to fuse Live, Virtual, and Constructive (LVC) participants to create realistic actual and synthetic environments for both testing and training. This need for simplified data communications is important for testing and training to link participants at different ranges, as well as to link distributed instrumentation capabilities within a single range. Live systems are either deployed tactical systems or developmental systems being evaluated for deployment. Virtual systems consist of actual tactical hardware and software operated in a laboratory environment rather than installed on operating tactical platforms (e.g. aircraft, ships or vehicles) in order to provide realistic data feeds without the expense of operating tactical platforms. Constructive participants consist of models or simulations to provide realistic effects (e.g. weather, electromagnetic threats, adjacent tactical elements, etc.) that are not available, affordable, or practical to use real assets. This Paper will describe the on-going efforts, including successes and lessons learned to-date at White Sands Missile Range, New Mexico.

Accomplishment of the Live, Virtual and Constructive simulation interoperability has been a major goal and a challenge in the Modeling and Simulation (M&S) community. There have been efforts to interoperate individual Live, Virtual and Constructive simulations within a common synthetic environment through suitable technologies such as interface specifications, protocols, and standard middleware architectures. However, achieving interoperability of LVC simulation is a technologically complex since it is affected by multiple factors, and the characteristics are not yet satisfactorily defined and studied. A proper method is absent to measure the potential interoperability degree of LVC simulation. Therefore, there should be an appropriate systematic approach to measure the potential LVC simulation interoperability which includes technical, conceptual and organizational domains. This research aims to design a preliminary systematic approach to measure the potential interoperability degree of an individual Live, Virtual and Constructive simulation and a relevant organization which plans to use the simulation system for simulation interoperability. Specifically, a framework that contains components such as a) LVC simulation interoperability domains, b) interoperability domain factors, c) interoperability maturity levels, d) interoperability determination method is proposed. To accomplish the goal, a set of factors that determine the interoperability degree in LVC simulation environment are identified, and the factors are used to build the key elements of the framework. The proposed methodology for the framework design is based on systematic literature reviews and a survey involving a number of relevant domain experts. A case study is demonstrated to prove the validity and effectiveness of the developed framework. The case study illustrates how the interoperability levels of a simulation system and a relevant organization are effectively measured. This research potentially contributes by providing an understanding of the factors that determine the interoperability degree of LVC simulation, improvement of the LVC simulation interoperability measurement process, and consequently, accomplishment of more effective LVC simulation interoperability.

Each Live, Virtual, and Constructive (LVC) simulation model has been developed and used with many benefits. When system developers created each simulation model, focused on specific standards to fit to their own respective purposes. Consequently, there have been interoperability issues among simulation models that have many limitations. To be specific, despite various efforts to achieve and maintain complete interoperability in LVC simulation environment, substantial limiting factors have remained in technical and managerial fields. Thus, analyzing and prioritizing limiting factors in LVC simulation is the effective way to solve interoperability problems while saving budget and time. The purpose of this research is to analyze the priority of limiting factors in LVC simulation interoperability. Based on the identified limiting factors from the literature review, this study performed Analytic Hierarchy Process (AHP) survey to generate weights of experts* judgement for each limiting factor. Following the AHP survey targeted to LVC simulation experts, this researcher suggest the priority of limiting factors that are needed to be focused on as well as recommendations for future research.

Made available in DSpace on 2016-08-19T17:47:09Z (GMT). No. of bitstreams: 1 Arnaldo Muniz Garcia.pdf: 655892 bytes, checksum: f9f5eda07bd90764780889b563437e7f (MD5) Previous issue date: 2004-01-28 / A cohort prospective study was carried with 350 dogs of various ages at localities Vila Nova and Bom Viver in the municipality of Raposa-MA, from March of 2002 to December of 2003. The objective is to avaluate the behavior of L. (L.) chagasi infection. The chosen areas are a result of the disordered occupation process, contributing with 60% of LVH and LVC cases that were notified by the municipal district. At first, the procedure was made by doing the populational inquiry the two places by means of canine census. The study was processed in two phases, with interval of 7 months among the same ones. In the first phase, 350 dogs participated of the study and by a visiting process a questionnaire with epidemiological, demographical, clinical and behavioral data about the dogs was applied. The testing of Montenegro intradermoreaction (IDRM) was made with the antigen of L. (L.) amazonensis and adapted for dogs, serological examination testing Enzyme Linked Immunsorbent Assay (ELISA), clinical e parasitical were also made in positive animals to IDRM and/or ELISA tests. Starting from clinical and immunological parameters already referred in literature, were defined four diagnoses categories, classifying the dogs according to its evolutionary course in not infected dogs (195), infected (100), Oligosymptomatic sick (41) and polysymptomatic sick (14). The second phase was accomplished with application of the same tests of the first phase with 230 dogs, that reduction was due in function of the losses (36,28%) caused by death, address change and missing. The positive dogs for an or both tests were accompanied bimonthly with reevaluation of the clinical exams. The initial and final prevalence and incidence of the infection were 8,57%, 6,52% and 8% for IDRM; by ELISA 39,71%, 32,6% and 16%; for ELISA and IDRM 44,29%, 37,39% and 21,6% respectively. In what the clinical form refers, the dogs were classified in the following way: infected (28,57%), oligosymptomatic sick (11,71%) and polysymptomatic sick (4%). in agreement with the statistical analyses not adjusted and adjusted, the variable age, race, secondary lesion, physical condition and place were associated the infection for L. (L.) chagasi. The infection for L. (L.) chagasi was present in 52,97% of the canine population of Vila Bom Viver and 34,55% in Vila Nova, demonstrating that in endemic area happens the intense and active circulation of Leishmania. / Realizou-se um estudo de coorte prospectivo com 350 cães com idades variadas nas localidades de Vila Nova e Bom Viver no município da Raposa-MA no período de março de 2002 a dezembro de 2003, com o objetivo de avaliar o comportamento da infecção por L. (L.) chagasi. As áreas escolhidas são resultantes do processo de ocupação desordenada, contribuindo em média com 60% dos casos de LVH e LVC notificados pelo município. Procedeu-se inicialmente com o inquérito populacional nas duas localidades por meio do censo canino. O estudo processou-se em duas fases, com intervalo de 7 meses entre as mesmas. Na primeira fase participaram do estudo 350 cães, e por meio de visita casa/casa aplicou-se um questionário com dados epidemiológicos, demográficos, clínicos e comportamentais dos cães. Realizou-se o teste de intradermorreação de Montenegro (IDRM) com antígeno de L. amazonensis e adequado para cães, teste sorológico Enzyme Linked Immunsorbent Assay (ELISA), clínico e parasitológico dos animais positivos para os testes IDRM e/ou ELISA. A partir de parâmetros clínico e imunológico já referidos na literatura, foram definidas quatro categorias de diagnóstico, classificando os cães segundo o seu curso evolutivo em cães não infectados (195), infectados (100), doente oligossintomático (41) e doente polissintomático (14). A segunda fase foi realizada com aplicação dos mesmos testes da primeira fase com 230 cães, essa redução deveu-se em função das perdas (36,28%) ocasionadas por óbitos, mudança de endereço e desaparecidos. Os cães positivos para um ou ambos os testes foram acompanhados bimestralmente com reavaliação dos exames clínicos. A prevalência inicial, final e incidência da infecção foram 8,57%, 6,52% e 8% por IDRM; por ELISA 39,71%, 32,6% e 16%; por ELISA e IDRM 44,29%, 37,39% e 21,6% respectivamente. No que se refere a forma clinica, os cães foram classificados da seguinte forma: infectados (28,57%), doente oligossintomático (11,71%) e doente polissintomático (4%). De acordo com as análises estatísticas não ajustada e ajustada, as variáveis idade, raça, lesão secundária, condição física e localidade foram associadas a infecção por L. (L.) chagasi. A infecção por L. (L.) chagasi estava presente 52,97% da população canina de Vila Bom Viver e 34,55% em Vila Nova, demonstrando que em área endêmica ocorre a intensa e ativa circulação da Leishmania.

Conducting seamless Live Virtual Constructive (LVC) simulation remains the most challenging issue of Modeling and Simulation (M&S). There is a lack of interoperability, limited reuse and loose integration between the Live, Virtual and/or Constructive assets across multiple Standard Simulation Architectures (SSAs). There have been various theoretical research endeavors about solving these problems but their solutions resulted in complex and inflexible integration, long user-usage time and high cost for LVC simulation. The goal of this research is to provide an Agile Roadmap for the Live Virtual Constructive-Integrating Training Architecture (LVC-ITA) that will address the above problems and introduce interoperable LVC simulation. Therefore, this research describes how the newest M&S technologies can be utilized for LVC simulation interoperability and integration. Then, we will examine the optimal procedure to develop an agile roadmap for the LVC-ITA. In addition, this research illustrated a case study using an Adaptive distributed parallel Simulation environment for Interoperable and reusable Model (AddSIM) that is a component based integrated simulation engine. The agile roadmap of the LVC-ITA that reflects the lessons learned from the case study will contribute to guide M&S communities to an efficient path to increase interaction of M&S simulation across systems.

Live, Virtual, and Constructive (LVC) is a relatively newly developed system of systems concept designed to provide a new way of conducting training for, but not exclusively, fighter pilots. “Train like you fight” is a commonly used quote when talking about LVC. The ability to create an environment where fighter pilots are able to train in an environment that is as much alike their working environment as possible will give the pilots a huge advantage when having to work in such a challenging and dangerous environment like active war. Besides training, other areas to use LVC have been discussed, and one of those areas is system test and analysis for weapon systems. In this thesis the ability to use LVC as a system test and analysis tool is investigated. This is done by the development of a model of what the LVC system looks like, then a suggestion of an LVC-design with the purpose of using the system as a test and analysis tool is presented. The design is based on SWOT-analyses based on previous research and on LVC products existing on the market. To validate this design a workshop with experts was conducted to receive input on the design as well as discuss the possibilities of Sweden implementing LVC in the future. After the workshop the LVC-design was updated with the points from the workshop. / Live, Virtual och Constructive eller LVC är ett relativt nyutvecklat system av systemkoncept som är utformat för att tillhandahålla ett nytt sätt att genomföra träning för, men inte enbart, stridspiloter. "Träna som du slåss" är ett vanligt citat när man talar om LVC. Förmågan att skapa en miljö där stridspiloter kan träna så likt deras arbetsmiljö som möjligt, d.v.s. aktivt krig, kommer att ge piloterna en enorm fördel när de måste arbeta i en så utmanande och farlig omgivning. Förutom träning har andra användningsområden för LVC diskuterats, och ett av dessa områden är systemtest och systemanalys för vapensystem. I denna rapport undersöks just förmågan att använda LVC som ett systemtest- och analysverktyg. Detta görs genom att utveckla en modell för hur LVC systemet ser ut och vilka förändringar som skulle behöva göras för att det ska kunna fungera som ett systemtest- och analysverktyg, detta resulterar i en modell av en LVC-design. Den modellen är baserad på SWOT-analyser som i sin tur är baserade på tidigare forskning och på LVC-produkter som finns på marknaden. För att validera denna modell genomförs en workshop med experter för att få input om modellen samt diskutera möjligheterna för Sverige att eventuellt implementera LVC i framtiden. Efter workshopen uppdaterades LVC-designen med punkter från workshopen.

Made available in DSpace on 2016-04-28T20:18:34Z (GMT). No. of bitstreams: 1 2009 - Daniella Silva Barcelos.pdf: 1592919 bytes, checksum: afab6af83d7cc48d9a18a17cb81cfb37 (MD5) Previous issue date: 2009-03-31 / The canine visceral leshmaniasis is an important public health disease in Brazil and around the word. Dogs are considered important reservoir and source of Leshmania infantum infection to human due to their high prevalences of infection, the presence of amastigote forms in the skin and because they are found in the domestic and peri-domestic environment. The objective of this study was to evaluate the clinic, parasitological and serological aspects of the canine leishmaniasis in dogs naturally infected in two endemic distinct area. Hematological, biochemical and serological assays were performed, as well as the histopatologic exams of the entire ear skin of 41 dogs coming from Concei??o de Jacare?/RJ and 42 dogs of the Campo Grande/MS. When histopathology was used as an auxiliary tool for diagnostic of CVL, the efficacy of detection of the infected animal double compared to the serological test only. The main clinical manifestations as skin lesions, generalized lymphadenomegaly and hepatosplenomegaly were found in dogs from the two studied areas. However, the intensity and frequency of the clinical signs varied between the two localities: while in Concei??o de Jacare?/RJ the majority of animals were asymptomatic, the clinical profile of dogs from Campo Grande/MS was predominantly polysymptomatic. The inflammatory infiltrate constituted a common histological finding in the skin of infected dogs, always associated to the presence of parasites. Nevertheless, the infiltrate in dogs from Campo Grande/MS was predominantly moderate and intense with mononuclear cells and neutrophils in the majority of the dogs. The severity changes in the dermis connected tissue associated to the lost of normal architecture and consequent substitution of the thick collagen fibers by the thin fibers were frequently found in dogs with intense inflammatory infiltrate, necrosis areas and presence of abundant amastigote forms. The amastigote forms were found independently of the symptoms and the geographic area. In animals with clinical signs that harbor few or none amastigotes, the inflammatory infiltrate was mainly constituted by lymphocytes and macrophages. When many parasites were present, the infiltrate was additionally constituted by polymorphonuclears (neutrophils). The association between the presence of polymorphonuclears in intact dog skin with clinical characteristic of CVL would increase diagnostic efficacy. A significant finding was that 75% of asymptomatic dogs with skin parasites were found in both localities. In this sense, the skin may be considered an important reservoir of amastigote forms in asymptomatic dogs. In endemic areas dogs with clinical symptoms are promptly selected to serological test and consequently discarded. In this manner, dogs with no clinical symptoms (but with skin parasites) constitute an important source of infection to the vectors. The same idea may be correlated to sero-negatives animals, a half of the animals with amastigote forms would act as important reservoir hosts to human. / A leishmaniose visceral canina ? uma importante doen?a de sa?de p?blica no Brasil e no mundo. O c?o ? considerado importante reservat?rio e fonte de infec??o da Leshmania infantum para o homem por apresentar altas preval?ncias da infec??o, presen?a de formas amastigotas na pele e por se fazer sempre presente nos ambientes dom?sticos e peridom?sticos. O objetivo desse estudo foi avaliar os aspectos cl?nicos, parasitol?gicos e sorol?gicos da leishmaniose visceral canina em c?es naturalmente infectados em duas ?reas distintas de transmiss?o intensa. Foram realizados exames hematol?gicos, bioqu?micos e sorol?gicos, assim como an?lise histopatol?gica da pele ?ntegra de orelha dos 41 c?es provenientes de Concei??o de Jacare?/RJ e 42 c?es de Campo Grande/MS. Quando utilizou-se a histopatologia como uma ferramenta auxiliar no diagn?stico da LVC, a efic?cia da detec??o dos animais infectados dobrou em rela??o ? utiliza??o somente do teste sorol?gico. As principais manifesta??es cl?nicas como as les?es de pele, hipertrofia generalizada dos linfonodos e hepatoesplenomegalia foram encontradas nos c?es das duas ?reas estudadas. Entretanto, a intensidade e freq??ncia de sinais cl?nicos observados variaram entre as duas localidades: enquanto que em Concei??o de Jacare?/RJ a maioria dos animais mostrou-se assintom?tico, o perfil cl?nico dos c?es estudados em Campo Grande/MS foi predominantemente polissintom?tico. O infiltrado inflamat?rio constituiu um achado histol?gico comum na pele dos c?es infectados, estando sempre associado ? presen?a dos parasitas. Por?m, o infiltrado nos c?es de Campo Grande/MS foi predominantemente moderado e intenso, com a presen?a de c?lulas mononucleares e neutr?filos na maioria dos c?es. As severas altera??es no tecido conjuntivo da derme dos animais, associadas ? perda da arquitetura normal e conseq?ente substitui??o das fibras grossas de col?geno pelas fibras finas, foram freq?entemente evidenciadas nos c?es que apresentaram um intenso infiltrado inflamat?rio, ?reas de necrose e presen?a abundante de formas amastigotas. As formas amastigotas foram encontradas independentemente da sintomatologia observada e da ?rea geogr?fica de ocorr?ncia. Observamos que nos animais com sintomatologia cl?nica que continham poucas ou nenhuma forma amastigota, o infiltrado inflamat?rio era constitu?do principalmente de linf?citos e macr?fagos. Quando muitos parasitas estavam presentes, o infiltrado era adicionalmente constitu?do por polimorfornucleares (neutr?filos). A associa??o da presen?a de polimorfornucleares na pele ?ntegra de c?es com caracter?sticas cl?nicas sugestivas de LVC poderia aumentar a efic?cia do diagn?stico. Importante o fato de termos encontrado, tanto em Concei??o de Jacare?/RJ como em Campo Grande/MS, 75% de c?es assintom?ticos com parasitas na pele. Deste modo a pele pode ser considerada um importante reservat?rio de formas amastigotas em c?es assintom?ticos. Em ?reas end?micas, os c?es com sintomatologia cl?nica s?o aqueles logo direcionados ao exame sorol?gicos e conseq?entemente descartados. Assim, os c?es sem sintomatologia cl?nica (e com parasitas na pele) constituem importantes fontes de infec??o para os vetores. O mesmo racioc?nio diz respeito aos animais soro-negativos, metade deles, por apresentarem as formas amastigotas, estariam atuando como importantes hospedeiros reservat?rios da infec??o para o homem.

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Por favor, corrija esta informação realizando uma nova submissão. on 2016-03-14T21:47:46Z (GMT) / Submitted by AMANDA CARLA ACIPRESTE GALVÃO null (amanda@milgran.com.br) on 2016-03-15T16:34:19Z No. of bitstreams: 1 TESE DE DOUTORADO AMANDA.pdf: 2810723 bytes, checksum: c44702fbccf1142e637672c1cbccb2dd (MD5) / Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-03-15T17:01:42Z (GMT) No. of bitstreams: 1 galvao_aca_dr_jabo.pdf: 2810723 bytes, checksum: c44702fbccf1142e637672c1cbccb2dd (MD5) / Made available in DSpace on 2016-03-15T17:01:42Z (GMT). No. of bitstreams: 1 galvao_aca_dr_jabo.pdf: 2810723 bytes, checksum: c44702fbccf1142e637672c1cbccb2dd (MD5) Previous issue date: 2016-01-29 / A Leishmaniose Visceral Canina (LVC) preocupa as autoridades sanitárias devido ao aumento de sua incidência nos últimos anos, aliado ao fato da situação epidemiológica da enfermidade ser desconhecida na maioria das regiões. Desta forma, o presente estudo objetou realizar o diagnóstico de situação epidemiológica da leishmaniose visceral canina (LVC) no Município de Rio Verde/GO. Para tanto, a pesquisa foi desenvolvida em bairros pré-definidos da região norte do município com a avaliação das condições das três esferas da saúde (animal, humana e ambiental) relacionadas à LVC, por meio de questionários semiestruturados com a participação dos tutores dos animais; a avaliação clínica dos cães e classificação segundo a sintomatologia; a realização do diagnóstico sorológico (ELISA, RIFI e TR DPP) e o geoprocessamento da localidade dos cães reagentes. Na avaliação das condições da saúde animal, os resultados evidenciaram superpopulação canina, especialmente aqueles animais considerados sem controle de mobilidade e sem supervisão, com trânsito livre, sem assistência médicoveterinária. Com relação à saúde humana, destacou-se o convívio íntimo entre o ser humano e o seu animal de estimação, além do agravante do desconhecimento da enfermidade pela população, de seus mecanismos de transmissão, de controle e de prevenção. Sob o olhar ambiental, observou-se problemas de infraestrutura, sendo a falta de saneamento básico a principal delas, além da presença de árvores frutíferas e animais de produção favorecendo o acúmulo de matéria orgânica, facilitando e promovendo o desenvolvimento do vetor. A classificação segundo a avaliação clínica dos cães reagentes (ELISA e RIFI) foi de 65% (13/20) assintomáticos e 35% (7/20) oligossintomáticos. Na avaliação sorológica, 10,38% (55/530) foram reagentes no ELISA, desses 36,37% (20/55) foram reagentes também na RIFI, e desses todas (17/17) as amostras foram consideradas não reagentes no TR DPP®. Os cães positivos no ELISA e RIFI estavam localizados em moradias próximas, reforçando os resultados dos testes. A população, cão e ser humano, e a região estudada apresentam características favoráveis ao desenvolvimento da LVC. Desta forma, existe a necessidade de profissionais capacitados para realizar diagnóstico preciso da enfermidade, iniciando as ações de controle e prevenção, aliado à readequação do protocolo de diagnóstico, pelas autoridades competentes, para as diferentes situações epidemiológicas. / Canine Visceral Leishmaniasis (CVL) is a concern to sanitary authorities due increase on incidence observed recently and lack of knowledge about the disease epidemiological situation in most regions. So, this study focused on to perform epidemiological diagnosis of canine visceral leishmaniasis situation in Rio Verde Municipality, state of Goiás, Brazil. For this purpose, the research was performed in pre-selected neighborhoods in the north region of the municipality embracing all three areas in health (animals, human beings and environment) related to CVL using semi-structured questionnaires to animals’ owners, clinical evaluation of animals and classification according to clinical signs, serological diagnosis (ELISA, RIFI and TR DPP) and geospatial analyses of positive dogs. ). A canine overpopulation, especially on those animals that lives free in streets, without supervision of owners and veterinaries were highlighted. In relation to human health, the close contact among humans and animals and the ignorance about this disease epidemiology, prevention and control by the population were shown. About the environmental situation, infrastructural problems, as the needs of basic sanitation, were observed. Also, fruit trees and production animals’ presence were observed, which favors organic matter accumulation and allows the vector’s development. The clinical classification of the reagents animals (ELISA and RIFI) was 65% (13/20) asymptomatic and 35% (7/20) oligosymptomatic during evaluation on CI. On serological evaluation, 10.38% (55/530) were positive on ELISA and from these animals, 36.37% (20/55) were also positive on RIFI. None of the samples were considered as positive on TR DPP®. The animals considered as positives in ELISA and RIFI were located in nearby houses agreeing with the results of serological tests. The human beings and canine populations in the studied areas have favorable characteristics for the development of CVL. So, trained professionals to perform the disease accurate diagnosis, beginning actions to control and prevention, thus a adjustment of diagnostic protocol, by authorities, to different epidemiological situation.

This research investigates the current state and ability of homestation training infrastructure (TADSS, networks, and facilities) and framework for training (scenarios, databases, and training support packages) to support a Live Virtual Constructive – Integrating Architecture (LVC-IA) delivered Integrated Training Environment (ITE). As combat operations in Central and Southwest Asia come to a close the Army is faced with extreme post-conflict budget cuts and force reductions. Continued evolution of Army training methodology is required to overcome limited resources and maintain force readiness in the anticipated “era of persistent conflict”. A LVC-IA delivered ITE promises to be the next step in the evolution of training. Interoperation of live, virtual, and constructive simulations in a persistent and consistent manner can collectively train brigade and below units on combined arms tasks in a resource constrained homestation environment. However, LVC-IA cannot act alone in establishing the ITE. Prior to the fielding of LVC-IA, local installations must already possess a training infrastructure that optimizes training resources as well as a framework for training that meets Operational Adaptability training requirements. To measure the perceived state and ability of homestation training infrastructure and framework for training to support a LVC-IA delivered ITE, a survey was conducted of homestation training community members at the 18 Army installations scheduled for LVC-IA fielding. Additionally, perceptions regarding the role of LVC-IA in establishing the ITE and emerging resources, useful in the development of local framework for training were sought. Findings, conclusions, limitations, lessons learned, and recommendations for future research are presented.

A infecção de cães pela Leishmania (Leishmania) infantum resulta em um espectro de manifestações imunopatológicas que dependem da interação parasito hospedeiro e são definidas por fatores ambientais e pela genética do hospedeiro. Apesar disso, a imunogenética da leishmaniose visceral canina (LVC) permanece inexplorada. Nós realizamos diagnóstico laboratorial, clínico, ensaio de linfoproliferação (LPA), quantificação de citocinas, teste de hipersensibilidade tardia à leishmanina (LST), quantificação de IgA, IgE, IgG, IgM anti L. (L. ) infantum, IgG anti saliva de flebotomíneo e genotipagem ampla afim de identificar polimorfismos de nucleotídeo único (SNPs) associados aos diferentes perfis de imunidades celular, humoral, resposta clínica e status de infecção em cães de área endêmica, utilizando modelo de componente de variância (EMMAX). O efeito de estrutura da amostra foi controlado em todas as análises. A presença ou ausência de infecção pela L. (L. ) infantum foi associado a regiões contendo os genes PRGR_CANFA, RAB38, NOX4, PRKCI e SMAD7, IL1RA, IL12A_CANFA relacionados à ativação de fagócitos, mecanismos microbicidas, sobrevivência intracelular de patógenos e resposta pró inflamatória; a resposta clínica foi associada a regiões contendo os genes CATA_CANFA, LIAS, IL17A e IL17F relacionados à proteção contra danos do estresse oxidativo e indução de resposta pró inflamatória; o resultado LST+ foi associado à resposta Th1, controle da infecção mas não preveniu a manifestação de sinais clínicos, enquanto o LST- foi associado à resposta Treg e aumento do parasitismo. O resultado do LST foi associado a regiões contendo os genes MEP1B, PTPRM, TLN1, TGFBR1, ITGA9, EPCAM e CALM1 envolvidos com maturação de fagócitos, migração e adesão de leucócitos, estabilidade da sinapse imunológica, diferenciação e proliferação de linfócitos. A linfoproliferação foi dependente da carga parasitária e associada a regiões contendo os genes FOCAD, PIAS2, SMAD2 e IL6R envolvidos com supressão tumoral e diferenciação de linfócitos Th17 ou Treg; o aumento dos níveis de IgA, IgE e IgG anti L. (L. ) infantum foi associado à LVC sintomática enquanto o de IgG anti saliva de Lutzomyia longipalpis foi associado à exposição e infecção assintomática. Quanto à resposta de IgM, foram identificados SNPs nos genes NXN e SH3BP5 relacionados com inibição do crescimento, diferenciação e ativação de linfócitos B e vias de sinalização de TLR4 e TLR9; para IgG anti - L. (L. ) infantum foram identificadas regiões contendo os genes IL17RB, SH2B3 e replicação do loci de susceptibilidade NOX4, RAB38, CTSC envolvidos com linfopoiese, citocinese, resposta pró inflamatória, mecanismos microbicidas, sobrevivência intracelular de Leishmania; os níveis de IgA foram associados a regiões contendo os genes LIN28A e MAFB implicados na predisposição à nefropatia glomerular, já os níveis de IgG anti saliva de Lu. longipalpis foram associados a regiões contendo os genes ERBB2IP, CD180, RAB7A_CANFA, FOXP1, RUNX1, SOD1, Q3HTU8_CANFA, IFNAR1, IFNAR2 e IFNGR2 envolvidos com supressão celular, produção de imunoglobulina via TLR4 e sobrevivência intracelular de Leishmania. Esses resultados apontam regiões cromossômicas úteis para a elucidação da resposta à infecção por L. (L. ) infantum em cães e alvos potenciais para estudos funcionais, estratégias profiláticas e terapêuticas / Leishmania (Leishmania) infantum infection in dogs leads to a range of immunopathological responses, which depend on a parasite - host interaction and are defined by environmental factors and genetic of host. Neverthless, immunogenetic of the canine leishmaniasis (CanL) remains unexplored. We performed diagnosis and clinical evaluation, lymphoproliferation assay (LPA), leishmanin skin test (LST), quantification of cytokine, anti-L. (L. ) infantum IgA, IgE, IgG, IgM, anti- sandfly saliva IgG levels and genome wide association scan of 110.165 SNPs (GWAS) in order to indentify loci associated to clinical, antibody, cell-mediated responses and status of infection in 189 dogs, employng a expedited efficient mix model of association (EMMAX). Control of stratification effects due to sample structure was evideced by the low inflation factors. Status of infection was associated to SNPs in linkage desequilibrium (LD) with PRGR_CANFA, RAB38, NOX4, PRKCI and in the neighborhood of SMAD7, IL1RA, IL12A_CANFA genes related to phagocyte maturation, killing of pathogens and proinflamatory response; clinical outcome was associated to CATA_CANFA, LIAS, IL17A, IL17F loci involved in prevention of oxidative burst mediated injury and proinflamatory response; LST+ was associated to Th1 response although it has not prevented symptoms, whereas LST- was associated to Treg response and enhanced parasite load. Overall, LST response was associated to MEP1B, PTPRM, TLN1, TGFBR1, ITGA9, EPCAM e CALM1 loci committed to phagocyte maturation, leukocyte adhesion and migration, stability in immunological synapse, lymphocyte diferenciation and proliferation. Lymphocyte proliferation was rely on parasit burden and associated to FOCAD, PIAS2 loci in the neighborhood of SMAD2 e IL6R genes, wich are implicated in tumor supression and Treg/Th17 decision; Increased levels of anti-L. (L. ) infantum IgA, IgE, IgG were observed in severity of CanL. In contrast, anti- sandfly saliva IgG was enhenced in asymptomatic dogs. IgM response was associated to NXN e SH3BP5 loci related to fate, growing and activation of B cells; anti-L. (L. ) infantum IgG levels was associated to region containing IL17RB, SH2B3 and replication of NOX4, RAB38, CTSC suscptibility loci involved in proinflamatory response, microbicidal activity, lymphopoiesis and cytokinesis; IgA levels were associated to SNPs on LIN28A and MAFB, wich are implicated glomerular nephropathy, whereas anti-sandfly saliva IgG levels were associated to ERBB2IP, CD180, RAB7A_CANFA, FOXP1, RUNX1, SOD1, Q3HTU8_CANFA, IFNAR1, IFNAR2 e IFNGR2 loci, wich are related to supression of inflamation, antibody response through the TLR4 pathway and survival of intracellular pathogens. These findins provide insights for responses to L. (L. ) infantum infection and point to potential targets for functional investigations, therapeutic and prophylactic strategies