The current focus on the Internet of Things (IoT) has led to the emergence of many network scenarios with unlimited use cases, including smart homes, smart cities, smart agriculture, and more. Unmanned aerial vehicles (UAVs), also known as drones, have become increasingly popular due to their versatility and ability to collect and transmit data through various sensors and cameras. With real-time data transmission, autonomy, and cost-effectiveness, UAVs have become valuable tools for different applications, including disaster management, agriculture monitoring, and remote area control. Low-power wide-area network (LPWAN) technology plays a crucial role in enabling IoT, and LoRaWAN is one of the specific LPWAN communication technologies that can provide low power consumption and coverage over a wide range. During a catastrophe, wireless communication is critical for analyzing damaged regions, coordinating rescue and relief team actions, saving lives, and reducing economic losses. UAVs can partially replace damaged or overloaded wireless networks as an alternative wireless network provider. This thesis aimed to simulate a LoRa network and investigate the relationship between the UAV coverage radius and elevation angle, as well as the effect of multipath distortion and signal attenuation on UAV and user distance. By calculating signal-to-noise ratio (SNR) and bit error rate (BER) for LoRa in a line-of-sight (LoS) and non-line-of-sight (NLoS) environment, we provided a comprehensive analysis of LoRaWAN performance in real-life environments for long distances. The results indicate that LoRaWAN communication is reliable in various environments, making it a promising technology for emergency and medical communications. / Det nuvarande fokuset på Internet of Things (IoT) har lett till uppkomsten av många nätverksscenarier med obegränsade användningsfall, inklusive smarta hem, smarta städer, smart jordbruk och mer. Obemannade flygfarkoster (UAV), även kända som drönare, har blivit allt populärare på grund av deras mångsidighet och förmåga att samla in och överföra data genom olika sensorer och kameror. Med realtidsdataöverföring, autonomi och kostnadseffektivitet har UAVs blivit värdefulla verktyg för olika applikationer, inklusive katastrofhantering, jordbruksövervakning och fjärrkontroll av områden. Low-power wide-area network (LPWAN)-teknik spelar en avgörande roll för att möjliggöra IoT, och LoRaWAN är en av de specifika LPWAN-kommunikationsteknikerna som kan ge låg strömförbrukning och täckning över ett brett spektrum. Under en katastrof är trådlös kommunikation avgörande för att analysera skadade regioner, koordinera räddnings- och hjälpteams åtgärder, rädda liv och minska ekonomiska förluster. UAV:er kan delvis ersätta skadade eller överbelastade trådlösa nätverk som en alternativ leverantör av trådlöst nätverk. Detta examensarbete syftade till att simulera ett LoRa-nätverk och undersöka sambandet mellan UAV-täckningsradien och höjdvinkeln, såväl som effekten av flervägsdistorsion och signaldämpning på UAV och användaravstånd. Genom att beräkna signal-brusförhållande (SNR) och bitfelsfrekvens (BER) för LoRa i en siktlinje (LoS) och icke-siktlinje (NLoS) miljö, gav vi en omfattande analys av LoRaWAN prestanda i verkliga miljöer för långa avstånd. Resultaten indikerar att LoRaWAN-kommunikation är tillförlitlig i olika miljöer, vilket gör den till en lovande teknik för akut- och medicinsk kommunikation.

Many applications require adhesives with high strength to withstand the exhaustive loads encountered in regular operation. In aerospace applications, advanced adhesives are needed to bond metals, ceramics, and composites under shear loading. The lap shear test is the experiment of choice for evaluating shear strength capabilities of adhesives. Specifically during single-lap shear testing, two overlapping rectangular tabs bonded by a thin adhesive layer are subject to tension. Shear is imposed as a result. Debonding occurs when the shear strength of the adhesive is surpassed by the load applied by the testing mechanism. This research develops a finite element model (FEM) and material model which allows mechanicians to accurately simulate bonded joints under mechanical loads. Data acquired from physical tests was utilized to correlate the finite element simulations. Lap shear testing has been conducted on various adhesives, specifically SA1-30-MOD, SA10-100, and SA10-05, single base methacrylate adhesives. The adhesives were tested on aluminum, stainless steel, and cold rolled steel adherends. The finite element model simulates what is observed during a physical single-lap shear test consisting of every combination of the mentioned materials. To accomplish this, a three-dimensional model was created and the cohesive zone approach was used to simulate debonding of the tabs from the adhesive. The thicknesses of the metallic tabs and the adhesive layer were recorded and incorporated into the model in order to achieve an accurate solution. From the data, force output and displacement of the tabs are utilized to create curves which were compared to the actual data. Stress and strain were then computed and plotted to verify the validity of the simulations. The modeling and constant determination approach developed here will continue to be used for newly-developed adhesives.

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Este estudo teve como objetivo geral compreender como os serviços de saúde do Sistema Único de Saúde - SUS estão organizados, de modo a contemplar a integralidade da assistência à mulher, quando pensamos os processos de produção de cuidado no controle do câncer de colo uterino, a partir da experiência das mulheres acometidas por esse agravo, identificando e analisando o percurso assistencial dessas mulheres, apontando as dificuldades por elas enfrentadas, na perspectiva da integralidade da atenção. A pesquisa teve como suporte teórico a integralidade da atenção, em suas distintas apreensões, desde sua compreensão, não só como um princípio do SUS, mas também como exercício de boas práticas de produção de cuidado e de referência para políticas governamentais. Estudo de abordagem qualitativa, realizado junto a mulheres com diagnóstico de câncer de colo uterino, no período de 2003-2005, em um município do sul do Brasil. Os dados foram coletados de julho a dezembro de 2006, utilizando-se a observação participante da atenção dispensada às mulheres, nos serviços de saúde, e a entrevista semi-estruturada, para captação do empírico. Para os procedimentos analíticos, optou-se pela análise temática, seguindo as etapas sugeridas por Minayo (1998): ordenação, classificação e análise. Foram identificados dois temas: A procura pela assistência: o acesso ao SUS e a utilização dos serviços de saúde, na busca de atenção integral e A integralidade da atenção à saúde. Na procura pela assistência, as mulheres apontaram seu percurso pelo SUS e a utilização dos serviços de saúde, trazendo suas concepções sobre a organização, o acesso, a assistência recebida e as potencialidades e limites da integralidade, nesse contexto de cuidado. Na integralidade da atenção, a comunicação e a relação com a equipe de saúde têm como centralidade a formação do vínculo, a escuta, o diálogo e o acolhimento entre os trabalhadores de saúde e as mulheres. Conclui-se que, nos serviços de saúde, a integralidade da atenção à saúde está em construção, na medida em que os trabalhadores de saúde ainda executam suas atividades pautadas no modelo biomédico e a constituição das mulheres, como sujeitos sociais é meta ainda a ser conquistada. Considera-se fundamental a reflexão e o investimento maciços na educação permanente dos trabalhadores de saúde comprometidos com os princípios do SUS, para o alcance da integralidade nos atos preventivos, curativos, individuais e coletivos, nos diferentes níveis de atuação e articulados com a participação social. / This study had as general objective to understand how the services of health of the Unique system of Health - (USH) SUS are organized on a way to contemplate the integrality of the attendance to the woman when we thought the processes of care production about the control of the cancer of uterine lap, starting from the women\'s experience attacked by this damage, identifying and analyzing the course of assistance of these women pointing to the difficulties faced for them, in the perspective of the integrality of the attention.The research had as theoretical support the integrality of the attention in their distinct apprehensions, since its understanding, not only as a principle of SUS (USH), but also as exercise of good practices of care production and of reference for government politics.Study of qualitative approach, accomplished close to the women with diagnosis of cancer of uterine lap in the period of 2003-2005, in a municipal district of the south of Brazil. The data were collected from July to December of 2006; being used the participant observation of the attention released to the women in the services of health and the interview semi-structured for the empiric reception. For the analytical procedures he/she opted for the thematic analysis following the stages suggested by Minayo (1998): ordination, classification and analysis.There were identified two themes: the search for the attendance: the access SUS (USH) and the use of the services of health.In the search for the attendance the women point their course for SUS (USH) and the utilization of the services of health bringing their conceptions about the organization, the access, the received attendance and the potentialities and limits of the integrality in this care context. The integrality of the attention to the health, the communication and the relationship with the team of health have as centrality the formation of the bond, the listens, the dialogue and the reception between the workers of health and the women. It is conclude that in the services of health the integrality of the attention to the health is in construction in the measure that the workers of health still execute their ruled activities in the biomedical model and the women\'s constitution, while social subjects is a aim to be conquered.It is considered fundamental the reflection and the solid investment in the workers\' of health permanent education committed with the beginnings of SUS for the reach of the integrality in the preventive actions, curatives, individual and collective in the different performance levels and articulated with the social participation.

Die Anwendung von Birkenblättern (Betulae folium) erfolgt zur Durchspülung der Harnwege. In der vorliegenden Arbeit wurde die Wirkungsweise der Birkenblätter auf verschiedenen Ebenen der Phytopharmakaforschung untersucht. Zunächst wurde in-vitro die Beeinflussung der Metallopeptidasen Neutrale Endopeptidase (NEP, EC 3.4.24.11), Angiotensin-Converting-Enzym (ACE, EC 3.4.15.1) und Leucin-Aminopeptidase (LAP, EC 3.4.11.2) durch Birkenblätterextrakte, -fraktionen und reine Naturstoffe untersucht. Die Auftrennung eines Methanol- und eines Ethylacetatextraktes führte nicht zur Gewinnung einzelner, für die Gesamtwirkungen der Extrakte verantwortlicher Fraktionen bzw. Komponenten. Die Eigenschaft der Flavonoide als wirksamkeitsmitbestimmende Inhaltsstoffe konnte jedoch bestätigt werden. Ein systematisches Screening von Flavonoiden ergab u.a., dass das Ausmaß der Enzymhemmung von der Anzahl der freien phenolischen OH-Funktionen bestimmt wurde und dass Flavonoidaglyka stärker die Enzyme hemmten, als die im Pflanzenmaterial vorliegenden Glykoside (IC50 NEP: Myricetin 42 Mikromol/L, Quercetin 192 Mikromol/L). Die in der Birkenrinde vorkommenden Triterpene Betulinsäure und Betulinol wurden als starke Inhibitoren der LAP erkannt (IC50 LAP: 7,3 +/- 1,4 bzw. 8,8 +/- 1,78 Mikromol/L). In einem nächsten Abschnitt der Arbeit wurden die Absorptionseigenschaften von Hyperosid und Rutin mit einem In-vitro-Perfusionsmodell am isolierten Rattendünndarm untersucht. Sowohl Rutin als auch Hyperosid traten unverändert als Glykoside durch den Darm in das Akzeptorkompartiment über. Auch in Form eines Birkenblätterextraktes wurde Hyperosid am Rattendünndarm absorbiert, der Extrakt veränderte jedoch nicht die Absorptionsrate. Als Mechanismus wurde der passive Transport durch die Poren der Tight junctions der Dünndarmzellen angenommen. Abschließend wurde eine Pilotstudie (n=14) durchgeführt, in der das ausgeschiedene Harnvolumen nach einmaliger Einnahme eines Birkenblättertees im Vergleich zu einer entsprechenden Menge Leitungswasser bestimmt wurde. Bei 50 % der Probanden wurde innerhalb der vierstündigen Testphase eine Zunahme der Harnproduktion beobachtet, bei den anderen 50 % stellte sich eine gegensätzliche Reaktion auf Tee und Placebo ein. Eine signifikante Erhöhung der Harnproduktion konnte somit, unter dem angegebenen Studiendesign, nicht nachgewiesen werden. / Irrigation of the urinary tract is the therapeutic indication for Birch leaf (Betulae folium). In the present thesis, effects and efficacy of Birch leaves were investigated in various fields of medicinal plant research. The effects of Birch leaf extracts, their fractions, and pure natural compounds on the metallopeptidases - Neutral Endopeptidase (NEP, EC 3.4.24.11), Angiotensin Converting Enzyme (ACE, EC 3.4.15.1), and Leucine Aminopeptidase (LAP, EC 3.4.11.2) - were investigated in vitro. Phytochemical separation of extracts obtained by methanol and ethyl acetate did not result in more active fractions compared to those of the whole extracts. The ability of flavonoids to contribute to the efficacy reached by Birch leaf extracts, could be confirmed. A systematic screening could show that the inhibitory potency of flavonoids is dependent on the number of phenolic hydroxyl functions in their chemical structure. Aglycones of flavonoids were more active than their corresponding glycosides occurring in the plant material (IC50 NEP: myricetin 42 mikromol/L, quercetin 192 mikromol/L). Betulinic acid and betulinol, triterpenes of the bark of Betula, inhibited LAP strongly by reaching an IC50 of 7,3 +/- 1,4 mikromol/L and 8,8 +/- 1,78 mikromol/L, respectively. Furthermore, this thesis showed the absorption profiles of hyperoside and rutin in an isolated small intestine model of the rat. Both glycosides were detected in the acceptor compartment without being metabolised. Administration of hyperoside by a Birch leaf extract did not influence the absorption rate. A passive transport through the pores of the tight junctions, localized between the intestinal cells, was considered to be the mechanism of absorption of the flavonol glycosides. Finally, a human pilot study (n=14) was carried out. The excreted urinary volume was determined after a single intake of a Birch leaf infusion or tap water. An increased urine output after 4 hours of the test period was found in 50% of the volunteers. In the contrary, an opposite effect was determined in 50% of the volunteers after administration of the herbal infusion and of a placebo solution. Thus, no significant increase of urine volume could be observed under these test conditions.

Large scale structures such as those in aerospace flight vehicles are made in parts and assembled. Joints are inevitable in these systems and they are potential threats to the structural integrity of the flight vehicles. Fastener and bonded joints are the most commonly used methods of joining in these structures. Among these, adhesive bonding has become more popular with the advent of composite structures, due to the presence of less number of points of stress concentration and the resulting benefit for static strength and fatigue life. In modern aircraft in which maximum percentage of composite materials are being employed due to several benefits, designers are contemplating to replace discrete joints with adhesively bonded joints wherever possible. A detailed literature survey shows that the field of adhesively bonded joints has been extensively studied in the past. Initial publications appeared in late 1950’s and early 1960's, but many of the initial attempts were based on one dimensional (1-D) approximation of the adherents due to lack of computing power. With the current day emphasis on safety and damage tolerance, there is a definite need to study these joints with 2-D and 3-D idealization. In spite of valuable contributions in the literature from several researchers in past 4-5 decades, one finds that there are gaps to be filled, in particular, with reference to static strength prediction and de-bond growth to failure under fatigue loading. This thesis is intended as a modest contribution in this direction covering the methods of strength prediction and also correlations between de-bond growth and fracture parameters. Most commonly used bonded joints are single lap joints. The primary issue in their analysis is the geometric nonlinearity resulting in large deformations due to eccentricity of load path between the adherents. Further, adhesives have very low yield strength and plastic deformation in thin adhesives could affect the mechanics of load transfer. The current work is initiated by carrying out geometric and material nonlinear analysis of adhesively bonded single lap joints between metal-metal (aluminum-aluminum) adherents using standard NASTRAN finite element software. Modified Newton-Raphson iterative technique has been used to economize the computer time and also achieve fast convergence. A convergence study has been conducted to determine the order of mesh size required. Preliminary results are obtained on configurations analysed by earlier workers and the current results are compared with their results. Later, extensive experimental and numerical studies have been taken up on the numerical strength prediction of these joints correlating them to the experimental values. Cohesive failure along the centre line of the adhesive is assumed under both static and fatigue loading. The bonded joints are studied with both 2-D plane stress and plane strain nonlinear FE analysis. The issue in this type of analysis is the presence of theoretical elastic singularity at the ends of the lap length. The normally used maximum stress criterion can not be used in such circumstances. There were attempts in the past to use point stress or average stress criteria for this purpose. In point stress criterion the shear stress (or von-Mises stress) is picked at a characteristic distance away from the ends of the lap length and compared with the corresponding strength value to predict failure. In the average stress criterion the stresses are averaged over a characteristic distance from the ends of lap length and this is compared with the corresponding strength to predict failure. Determination of the characteristic distance in both the cases needs extensive experimental results on static strength of joints. The static strength data is to be correlated with numerical results to determine the characteristic distance in various specimens. In the current thesis a series of specimens with aluminum-aluminum, aluminum-CFRP composite and CFRP-CFRP composite adherents were tested to determine the static strength. In all the specimens the adhesive used was Redux 319 A. These experimental strength data was used to determine characteristic distance using point stress criterion. The consistency of estimates of the characteristic distances in all the specimens shows that the approach is capable of predicting the static strength. The above approaches are capable of predicting the strength of joints with linear material and nonlinear geometric analysis. But when the adhesive yield strength is low, a novel approach is required to predict the static strength. Numerical analysis is conducted using a combined material and geometric nonlinear analysis in NASTRAN software. The plastic zone size from the ends of the lap length is determined at different load levels. Combining the numerical results with experimental failure load data, a failure criterion based on plastic zone size (PZS) is proposed in this thesis and validated. It has been observed that the validation is with limited testing carried out and further experimental programs are required to complete the validation. To the best of the knowledge of the author PZS criterion is used for the first time for failure prediction of bonded joints. The structural integrity of the joints also requires a study of de-bond growth and damage tolerance assurances in the presence of de-bond type of defects. The first step in this direction is to estimate the fracture parameters at the tips of de-bond in the adhesive of lap joints between various adherents. Modified virtual crack closure integral (MVCCI) technique has been developed in the past for estimating Strain Energy Release Rates (SERR) in several crack problems. Large contributions for developing this technique have come from the group where the author has worked. This technique is simple and has the ability to estimate individual SERR components GI and GII in cases of mixed mode fracture. It is seen clearly that the de-bond growth in bonded joint is one of mixed mode. The mode-II component is because of shear stresses transferring the load across the adherents and mode-I component is due to peel stresses developed during the deformation. The mode I SERR component is primarily responsible for de-bond growth and the effect of mode II component on de-bond growth is insignificant. The mesh details for accurately estimating the SERR components are evaluated and those meshes are used to estimate these values for the cases of aluminum-aluminum, aluminum-CFRP composite and composite-composite joints. Obviously, when the adherents are dissimilar, mode I SERR components are the highest and assist faster de-bond growth. Painstaking fatigue de-bond growth experiments were conducted and de-bond growth rate with number of cycles of fatigue loading was determined. MVCCI method is used to estimate SERR components at maximum load and zero load in the fatigue cycle, to determine the SERR range in the fatigue cycle. Since the stress ratio, R of the loading cycle is -1, the minimum load for estimating SERR components is taken as zero. From the experimental data and numerical estimates, a Paris type of equation was developed for the de-bond growth. The thesis concludes with a summary of the achievements in the current work with respect to the structural integrity of adhesively bonded joints and also with suggestions for future work.

Este estudo teve como objetivo geral compreender como os serviços de saúde do Sistema Único de Saúde - SUS estão organizados, de modo a contemplar a integralidade da assistência à mulher, quando pensamos os processos de produção de cuidado no controle do câncer de colo uterino, a partir da experiência das mulheres acometidas por esse agravo, identificando e analisando o percurso assistencial dessas mulheres, apontando as dificuldades por elas enfrentadas, na perspectiva da integralidade da atenção. A pesquisa teve como suporte teórico a integralidade da atenção, em suas distintas apreensões, desde sua compreensão, não só como um princípio do SUS, mas também como exercício de boas práticas de produção de cuidado e de referência para políticas governamentais. Estudo de abordagem qualitativa, realizado junto a mulheres com diagnóstico de câncer de colo uterino, no período de 2003-2005, em um município do sul do Brasil. Os dados foram coletados de julho a dezembro de 2006, utilizando-se a observação participante da atenção dispensada às mulheres, nos serviços de saúde, e a entrevista semi-estruturada, para captação do empírico. Para os procedimentos analíticos, optou-se pela análise temática, seguindo as etapas sugeridas por Minayo (1998): ordenação, classificação e análise. Foram identificados dois temas: A procura pela assistência: o acesso ao SUS e a utilização dos serviços de saúde, na busca de atenção integral e A integralidade da atenção à saúde. Na procura pela assistência, as mulheres apontaram seu percurso pelo SUS e a utilização dos serviços de saúde, trazendo suas concepções sobre a organização, o acesso, a assistência recebida e as potencialidades e limites da integralidade, nesse contexto de cuidado. Na integralidade da atenção, a comunicação e a relação com a equipe de saúde têm como centralidade a formação do vínculo, a escuta, o diálogo e o acolhimento entre os trabalhadores de saúde e as mulheres. Conclui-se que, nos serviços de saúde, a integralidade da atenção à saúde está em construção, na medida em que os trabalhadores de saúde ainda executam suas atividades pautadas no modelo biomédico e a constituição das mulheres, como sujeitos sociais é meta ainda a ser conquistada. Considera-se fundamental a reflexão e o investimento maciços na educação permanente dos trabalhadores de saúde comprometidos com os princípios do SUS, para o alcance da integralidade nos atos preventivos, curativos, individuais e coletivos, nos diferentes níveis de atuação e articulados com a participação social. / This study had as general objective to understand how the services of health of the Unique system of Health - (USH) SUS are organized on a way to contemplate the integrality of the attendance to the woman when we thought the processes of care production about the control of the cancer of uterine lap, starting from the women\'s experience attacked by this damage, identifying and analyzing the course of assistance of these women pointing to the difficulties faced for them, in the perspective of the integrality of the attention.The research had as theoretical support the integrality of the attention in their distinct apprehensions, since its understanding, not only as a principle of SUS (USH), but also as exercise of good practices of care production and of reference for government politics.Study of qualitative approach, accomplished close to the women with diagnosis of cancer of uterine lap in the period of 2003-2005, in a municipal district of the south of Brazil. The data were collected from July to December of 2006; being used the participant observation of the attention released to the women in the services of health and the interview semi-structured for the empiric reception. For the analytical procedures he/she opted for the thematic analysis following the stages suggested by Minayo (1998): ordination, classification and analysis.There were identified two themes: the search for the attendance: the access SUS (USH) and the use of the services of health.In the search for the attendance the women point their course for SUS (USH) and the utilization of the services of health bringing their conceptions about the organization, the access, the received attendance and the potentialities and limits of the integrality in this care context. The integrality of the attention to the health, the communication and the relationship with the team of health have as centrality the formation of the bond, the listens, the dialogue and the reception between the workers of health and the women. It is conclude that in the services of health the integrality of the attention to the health is in construction in the measure that the workers of health still execute their ruled activities in the biomedical model and the women\'s constitution, while social subjects is a aim to be conquered.It is considered fundamental the reflection and the solid investment in the workers\' of health permanent education committed with the beginnings of SUS for the reach of the integrality in the preventive actions, curatives, individual and collective in the different performance levels and articulated with the social participation.

A prototype reinforced concrete moment frame representative of low-rise office buildings in the Central and Eastern United States from the 1950s-1970s was designed and selected for evaluation under seismic loads. A plane frame specimen from the prototype was incorporated into the design of a test-bed of four full-scale, side-by-side nominally identical structures that could be evaluated independently. The testing of the first frame serves as the topic of this dissertation. The specimen was two bays x two stories x 9-ft. wide. A new method for testing full-scale structures under seismic loads was proposed that used a hydraulic linear inertial shaker (LIS) to impart seismic loads. The response of the structure was monitored using 155 strain gages, 38 linear variable differential transformers, six string potentiometers, and 42 accelerometers. The response of the frame to a series of 25 load histories using the nees@UCLA LIS was marked by gradual structural softening and minimal yielding of the steel reinforcing throughout the structure. At a first interstory drift of 1.5% some yielding of the reinforcing bars was measured. Between 1.5% and 2% first interstory drift, a global sway mechanism formed when the failure of a splice at the base of the first story west column led to a cascading set of failures within other first-story column splices. The experimental behavior suggests previous scaled testing of similar structures may have inadequately represented the vulnerability column splices. The design of the test-bed, response of the structure to seismic loads, qualitative evaluation of the test method, and implications on future research are discussed.