>Magister Scientiae - MSc / For a long time, fire dynamics has been misunderstood and viewed as either a destructive force or an ecological necessity. The Western Cape Province in South Africa experiences the frequent occurrence of fires, due to the prevailing Mediterranean climatic conditions. This climate is known for its hot and dry summers and its cold and wet winters, which, along with the highly flammable indigenous flora of the Western Cape, provide suitable conditions for the occurrence of fires. However, the local environmental and ecological variables that influence the occurrence of fires and that could assist with fire management practices remain poorly understood. The development of an integrated operational monitoring framework is therefore imperative for detecting and mapping the occurrence of fires in the Western Cape, South Africa.

The unique chromosome biology of the fungus fly Sciara coprophila has fascinated investigators for over 80 years. Male meiosis exhibits a monopolar spindle, nonrandom segregation of imprinted chromosomes and nondisjunction of the X chromosome. The unusual mechanism of sex determination requires selective elimination of X chromosomes in embryogenesis. Super-numerary (L) chromosomes are also eliminated from the soma during early cleavage divisions. Distinctive DNA puffs on the larval salivary gland chromosomes are sites of DNA amplification. As a foundation for future genome studies to explore these many unusual phenomena, we have used DNA-Feulgen cytophotometry to determine genome size from hemocyte nuclei of male (X0) and female (XX) larvae and adults. The DNA content of the X chromosome is ∼0.05 pg DNA and the autosomal complement is ∼0.45 pg DNA. Measurements of DNA levels for individual sperm from adults showed that the DNA contribution of the germ line-limited (L) chromosomes constitutes as much as 35% of the DNA of the male gamete. A parallel study using Sciara ocellaris, a related species lacking L chromosomes, confirmed the presence of two X chromosomes in the sperm of this species.

BACKGROUND: Professional interpreters improve care for limited English proficient patients but are underused. Study Design: Mixed methods study evaluating effectiveness and implementation of a rooming protocol to screen patients for language needs and call interpreters OBJECTIVE: Examine barriers and facilitators to protocol implementation and effectiveness to increase interpreter use METHODS: Provider surveys explored baseline and post-implementation attitudes. Simple and multiple logistic regression analyses examined the impact of practicing in the pilot clinics versus comparison clinics on post-implementation responses. Medical Assistants and providers were interviewed regarding barriers and facilitators to implementation. Interview analysis used modified grounded theory. Trends in the number of telephone interpreter calls were examined to determine protocol effectiveness. RESULTS: Context themes included having established teams and workflows; transitioning to a new interpreter vendor; and challenges incorporating the workflow, including providers’ tardiness and clinic understaffing. Evidence themes included beliefs that the protocol improved the patient experience but otherwise mixed responses; preferring live interpreters; and limited buy-in to language screening. Facilitation themes included Medical Assistants needing more support. Providers in the pilot clinics versus comparison clinics had significantly higher odds of positive responses on post-implementation survey questions regarding satisfaction with care (OR 5.3) and communication (OR 6.7). Implementation did not increase the number of telephone interpreter calls in the pilot clinics. CONCLUSION: Ineffectiveness of the protocol was likely due to inconsistent implementation. The protocol may improve patient care but context limited implementation success. The limited buy-in to language screening raises questions about how to better identify patient language needs. / 2019-11-08T00:00:00Z

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第21037号 / 人健博第53号 / 新制||人健||4(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 杉本 直三, 教授 精山 明敏, 教授 安達 泰治 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

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Influence diagrams (ID) are graphical frameworks for decision making in stochastic situations with mathematical models embedded in them. The goal of an optimal algorithm for an ID is to find a strategy that would maximize the expected utility. We will explain a few algorithms for influence diagrams in this thesis. There exists an obvious temporal ordering among decisions in an ID; and any information used in the past will always be available in the future: these two properties are respectively called the “regularity” and “noforgetting” assumptions. A limited memory influence diagram (LIMID) does not follow these two properties. The existing state-of-art depthirst-branch-and-bound (DFBnB) algorithm for solving influence diagrams does not scale very well due to the exponential increase of nodes proportional to the depth of the search (or total stages in the ID). In this paper, we propose and implement an algorithm that combines two widely used methods, depth first branch-andbound search (DFBnB) and value iteration with incremental pruning, for solving IDs and POMDPs, respectively. We describe an algorithm to convert the strategy tree to a strategy graph. Experiments show the effectiveness of these approaches. Algorithms for solving traditional influence diagrams are not easily generalized to solve LIMIDs, however, and only recently have exact algorithms for solving LIMIDs been developed. In this thesis, we provide an exact algorithm for solving LIMIDs that is based on branch-and-bound search. Our approach is related to the approach of solving an influence diagram by converting it to an equivalent decision tree, with the difference that the LIMID is converted to a much smaller decision graph that can be searched more efficiently.

Mississippi leads the nation in chronic disease, obesity, poverty, and food insecurity. Preventing further growth in disease rates, requires a cultural shift towards a ‘healthy eating’ environment. Healthy patterns of food consumption along with physical activity can prevent and reduce these rates. A state-wide ‘healthy eating’ social marketing campaign could motivate voluntary population behavioral change. Three different methodologies were used to develop a strategy for Mississippi: a systematic review of the literature, a state-wide phone survey (quantitative), and focus groups (qualitative). A systematic review of articles published since January 2007 was conducted, using PRISMA guidelines. Five databases were searched with key terms. Past healthy eating campaigns in the US focused on children and parents as the target audiences and consumption of fruits and vegetables as the behavioral outcome. A web-based campaign from Oregon, was one of the successful models; in 2015, their website had over 125,000 monthly users. This campaign appeals to mothers as its primary audience and produces recipes that are tested and ‘kid-approved’; almost all the recipes include fruits and/or vegetables. The phone survey data was analyzed for participants who were responsible for children under the age of 18 in their homes. Values, attitudes, beliefs and barriers were analyzed using univariate frequencies. Chi Square tests were conducted to investigate the differences between demographic groups. The survey found that Mississippi SNAP-eligible and recipients have positive beliefs and attitudes towards ‘healthy eating.’ A majority (60%) agreed that cost was a barrier to ‘healthy eating’ while 35% thought that access to quality fruits and vegetables was lacking. Focus groups (n=17), from 12 counties were conducted with mothers, grandmothers, aunts who were caretakers of young children. Findings indicated participants had a broad range of perceptions and practices for ‘healthy eating.’ They were motivated to eat healthy for their personal health and for their children. Mothers and guardians are motivated to satisfy their children’s hunger, often a barrier to healthy eating. The findings indicate that time, convenience, and cost are also barriers. A consumer-oriented, culturally appropriate social marketing campaign in Mississippi should resonate with mothers and their need to satisfy their children.

We study the impacts of bankruptcy risk on the performance of market-based pollution control policies. In chapter one, we concentrate on emissions trading markets. We find that firms that risk bankruptcy demand more permits than if they were financially secure. Thus, bankruptcy risk in a competitive market for tradable permits causes an inefficient distribution of these permits among firms. Moreover, the equilibrium distribution of permits is dependent on the initial allocation of permits. Thus, the main reasons for implementing emissions trading markets do not hold when some firms are financially insecure. In fact, the inefficiency that is associated with bankruptcy risk is worsened if financially insecure firms are given a smaller share of the initial allocation of permits. In chapter two, we investigate the influences of bankruptcy risk on imperfectly enforced emissions taxes. Under favorable, but not unrealistic conditions, an imperfectly enforced emissions tax produces an efficient allocation of individual emissions control; the aggregate level of control is the same whether enforcement of a tax is sufficient to induce the full compliance of firms or not, and differences in individual violations are independent of firm-level differences. All of these desirable characteristics disappear when some firms under an emissions tax risk bankruptcy—the allocation of emissions control is inefficient, imperfect enforcement causes higher aggregate emissions, and financially insecure firms choose higher violations.

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