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CONTACT GUIDANCE OF MESENCHYMAL STEM CELLS ON MICROPATTERNED POLYDIMETHYSILOXANEPETERSON, ERIK T. K. 02 October 2006 (has links)
No description available.
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A System for Potentiometric MeasurementBhan, Divjyot K. January 2008 (has links)
No description available.
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Fabrication and Characterization of a Pulsed MEMS-based Micro Flow Sensor for Microfluidic ApplicationsOkulan, Nihat January 2000 (has links)
No description available.
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Silicon MEMS-Based Development and Characterization of Batch Fabricated Microneedles for Biomedical ApplicationsRajaraman, Swaminathan 11 October 2001 (has links)
No description available.
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Structural and Fluidic Analysis of a Pressure-Controlled Torsion Type Check MicrovalveHong, Chien-Chong 11 October 2001 (has links)
No description available.
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DEVELOPMENT OF A NEW MAGNETIC INERCONNECTION TECHNOLOGY FOR MAGNETIC MEMS DEVICE APPLICATIONSSADLER, DANIEL J. 11 October 2001 (has links)
No description available.
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Polymer Microelectromechanical Systems: Fabrication and Applications in Biology and Biological Force MeasurementsFerrell, Nicholas Jay 19 March 2008 (has links)
No description available.
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Detecting Radiation Pressure in Waveguides Using Microelectromechanical ResonatorsPope, Christopher R. P. 04 1900 (has links)
<p>The phenomenon of radiation pressure has fascinated scientists since it was first proposed by Maxwell in the late 19th century. Numerous experiments involving optical forces have been carried out, however the optical force acting on a curved waveguide does not appear to have been previously investigated. An experiment to measure the force acting on a waveguide due to the optical power it contains is proposed here. This experiment takes advantage of the sensitivity of MicroElectroMechanical Systems (MEMS) and the performance of silicon integrated optics in a single hybrid device.</p> <p>Devices are fabricated from silicon-on-insulator (SOI) wafers using conventional micromachining techniques. Anisotropic alkali etches are used to produce smooth vertical side-walls for a mechanical structure and a rib waveguide. An analysis of the electrical systems and measurement techniques is provided. Using these techniques, the resonant operation of the devices is demonstrated by means of capacitive actuation and sensing. The application of this system to the measurement of radiation pressure is discussed.</p> / Master of Applied Science (MASc)
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On the Fluidic Forces and Shape Optimizations of Resonant Curved Cantilever WingsGoussev, Andrey January 2019 (has links)
Artificial flight on millimeter size scales has been a major challenge due to the difficulty in making a feasible flight mechanism in terms of fabrication, thrust and power used. Many have tried to copy animal flight but there has been little success at such sizes. One proposed solution is to make small thrusters out of resonant curved cantilevers which act as wings that follow a simple 1 degree-of-freedom motion. Such wings are free of joint friction, can be planarly fabricated using well documented techniques, can be predictably scaled to different sizes, and have been shown to generate a net thrust.
In this thesis, the work investigates the nature of the wings’ thrust through thorough studies of computational fluid dynamic simulations to understand how they interact with the surrounding fluid and how exactly the forces are generated. Specifically, it considers the role of unsteady lagged fluid waves generated by the wings and explains how the wing-fluid interactions relate to drag coefficients at low to high flapping amplitudes and Reynolds numbers ranging from 100 - 100 000. It then studies the effect of different wing aspect ratios on the net force and power efficiencies. The results are then extended to a general dependence on the wings’ aspect ratio which allows for this parameter to be used in optimizing the wings’ net force/power used. Test wings are then made using an updated fabrication method and Molybdenum as the curve-inducing material in an attempt to produce more environmentally-stable wings with important successes, failures and improvements discussed. Results show that such Molybdenum-based wings are practical for flight, and that resonant curved cantilevers wings can be made more feasible by simple changes to their shape. / Thesis / Master of Applied Science (MASc)
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Fiberoptic Microneedles for Transdermal Light DeliveryKosoglu, Mehmet Alpaslan 11 November 2011 (has links)
Shallow light penetration in tissue has been a technical barrier to the development of photothermal therapies for cancers in the epithelial tissues and skin. This problem can potentially be solved by utilizing minimally invasive probes to deliver light directly to target areas potentially > 2 mm deep within tissue. To develop this solution, fiber optic microneedles capable of delivering light for therapy were manufactured.
We have manufactured fiberoptic microneedles by tapering silica-based optical fibers employing a melt-drawing process. These fiberoptic microneedles were 35 to 139 microns in diameter and 3 mm long. Some of the microneedles were manufactured to have sharper tips (tip diameter < 8 microns) by changing the heat source during the melt-drawing process. All of the microneedles were individually inserted into ex vivo porcine skin samples to demonstrate the feasibility of their application in human tissues. Skin penetration experiments showed that sharp fiber optic microneedles with a minimum average diameter of 73 microns and a maximum tip diameter of 8 microns were able to penetrate skin without buckling. Flat microneedles, which had larger tip diameters, required a minimum average diameter of 125 microns in order to penetrate through porcine skin samples. Force versus displacement plots showed that a sharp tip on a fiber optic microneedle decreased the skin's resistance during insertion. Also, the force acting on a sharp microneedle increased more steadily compared with a microneedle with a flat tip.
Melt-drawn fiberoptic microneedles provided a means to mechanically penetrate dermal tissue and deliver light directly into a localized target area. We also described an alternate fiberoptic microneedle design with the capability of delivering more diffuse, but therapeutically useful photothermal energy using hydrofluoric acid etching of optical fibers. Microneedles etched for 10, 30, and 50 minutes, and an optical fiber control was compared for their ability to deliver diffuse light using three techniques. First, red light delivery from the microneedles was evaluated by imaging the reflectance of the light from a white paper. Second, spatial temperature distribution of the paper in response to near-IR light (1,064 nm, 1 W, CW) was recorded using infrared thermography. Third, ex vivo adipose tissue response during 1,064 nm, (5 W, CW) irradiation was recorded with bright field microscopy. Increasing etching time decreased microneedle diameter (from 125 to 33 microns), resulting in increased uniformity of red and 1,064 nm light delivery along the microneedle axis. For equivalent total energy delivery, microneedles with smaller diameters reduced carbonization in the adipose tissue experiments.
However, thin fiberoptic microneedles designed to minimize tissue disruption and deliver diffuse therapeutic light are limited in their possible clinical application due to a lack of mechanical strength. Fiberoptic microneedles have been embedded in an elastomeric support medium (polydimethylsiloxane, PDMS) to mitigate this issue. The critical buckling force of silica microneedles with 55, 70, and 110 microns diameters and 3 mm length were measured with and without the elastomeric support in place (N = 5). Average increases in the mechanical strength for microneedles of 55, 70, and 110 microns diameters were measured to be 610%, 290%, and 33%, respectively. Aided by mechanical strengthening through an elastomeric support, microneedles with 55 microns diameter were able to repeatedly penetrate ex vivo porcine skin. / Ph. D.
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