The currently used biomaterials for surgical implantation include stainless steel, titanium and its alloys. However, due to the non-degradability and the mismatch of the mechanical properties between these metallic implants and human bone, there maybe a long-term adverse effect of inflammation or stress shielding effect. This may lead to bone loss which brings with a higher risk of implant failure. To avoid this problem, implants made of biodegradable materials are the alternatives. Due to the poor mechanical properties of biodegradable polymer especially for load-bearing area, biodegradable metal is used instead. Magnesium is the potential candidate since it is degradable with mechanical properties similar to human bone whilst magnesium ion is an essential element to human bodies. With the advantages of using magnesium for implantations, it can be potentially used for fracture fixation implant and bone substitutes. However, its rapid degradation and release of hydrogen gas may inhibit its use. Hence, modification is required. In this project, plasma immersion ion implantation and deposition (PIII&D) using aluminium oxide as the plasma source was conducted on the magnesium alloys. The corrosion resistance properties of the plasma-treated magnesium alloy were found to display significant improvement in immersion test especially at early time points. The plasma-treated sample was compatible with osteoblasts. Cells attached and grew on the treated sample but not the untreated sample. The animal study showed consistent results with the cell study, and there was a significant increase in bone formation around the treated sample when compared to the untreated sample. The other potential application of magnesium is its usage as a bone substitute. Due to the limitations of autografts and allografts, synthetic bone substitutes are developed. The ideal bone substitutes should have similar properties to those found with autografts. However, no such bone substitutes presently exist; hence, a novel hybrid material is fabricated in this project through the addition of magnesium granules into a biodegradable polymer polycaprolactone (PCL). The immersion test showed that an apatite layer composed of magnesium, calcium, phosphate and hydroxide was formed on the hybrids but not on pure PCL, which suggested that the hybrids were osteoinductive and osteoconductive. The compression test showed that the mechanical properties were enhanced with the incorporation of magnesium granules into pure PCL and were still maintained after 2 months of immersion. Osteoblasts grew well on the PCL-Mg hybrids. The addition of smaller amounts of magnesium granules (0.1g PCL-Mg) resulted in higher ALP activity and up-regulation of different bone markers when compared to the pure PCL. Finally, the animal studies showed that more new bone formation was found around the 0.1g PCL-Mg hybrids especially at early time points, which suggested that the healing time could be shortened. In conclusion, fracture fixation implants and novel bone substitutes based on magnesium were developed in this project. The aluminium oxide coating was able to improve the corrosion resistance properties of magnesium alloy by suppressing the release of magnesium ions. The PCL-Mg hybrids were found to be biodegradable, biocompatible, osteoconductive, osteoinductive and mechanically matched to human bone properties. / published_or_final_version / Orthopaedics and Traumatology / Doctoral / Doctor of Philosophy

published_or_final_version / Physics / Master / Master of Philosophy

No description available.

The greatest advances in medicine during the last century have been in the control of infectious diseases. These successes were based fundamentally upon the discoveries of bacteriologists and others of the relation of micro-organisms to disease processes. On the other hand most of the chronic diseases such as, muscular dystrophy, arthritis, cancer and atherosclerosis have not as yet been shown to have any comparable unifying thread to connect them. [...]

The automotive industry is adopting lightweight materials to improve emissions and fuel economy. Magnesium (Mg) alloys are the lightest of engineering metals, but work is required to assess their structural strength, especially for spot-welded applications. In the present research, fatigue behavior of magnesium spot-welds was characterized and compared with steel and aluminum spot-welds. A fatigue model was proposed to predict the failure location and crack initiation life in magnesium structures. The material under investigation, AZ31B-H24 Mg alloy, and its spot-welds were characterized from microstructural and mechanical perspectives. Microstructure and hardness of the base metal (BM) and different regions in the spot-welds were studied. Under cyclic loading, the BM had an asymmetric hysteresis loop. Cyclic behavior of magnesium spot-welds was measured using different specimen configurations, and the effect of geometrical factors on fatigue life was evaluated. A constitutive model was developed to model the asymmetric hardening behavior of wrought magnesium alloys under cyclic loading. An algorithm for numerical implementation of the proposed model was developed. The numerical formulation was programmed into a user material subroutine to run with the commercial finite element software Abaqus/Standard. The proposed model was verified by solving two problems with available solutions. A number of available fatigue models, as well as a new model proposed in this research were assessed by predicting fatigue life of magnesium spot-welds. The new model used a strain energy damage parameter. All models were evaluated by comparing the predicted and experimental fatigue lives for different Mg spot-welded specimens. The effect of considering the asymmetric hardening behavior of wrought magnesium alloys on the accuracy of the fatigue life prediction was not significant for the available experimental data. This was attributed to the limited experimental data on spot-welded specimens. The proposed material model and fatigue damage parameter were verified by simulating a real-life structure manufactured and fatigue tested by the US Automotive Materials Partnership. The results obtained from the proposed asymmetric model were compared with available symmetric simulation results and experimental data. The asymmetric material model along with the proposed damage parameter resulted in more accurate prediction of fatigue failure location and life.

In order to meet the increasing fuel efficiency requirements, the automotive industry has strived for component weight reduction in order to improve the performance of automotive vehicles through the use of light Al and Mg alloys. Resistance spot welding (RSW) currently is the primary joining method in the manufacturing of automotive assemblies. With the increased use of Al and Mg, there is a pressing need for a technology to produce dissimilar Al/Mg joints, and preferably by RSW since this technology is already prevalent in the industry. Direct welding of Al to Mg usually results in formation of hard and brittle intermetallic compounds and poor quality of the welds. Employing an interlayer is a promising approach to overcome this problem. Current literature, however, does not consider the effects of different interlayers on RSW of Al to Mg. This thesis examines effects of different interlayers on microstructure and mechanical properties of Al/Mg joints made by RSW. Effects of three types of interlayers, specifically pure Ni foil, Au-coated Ni foil and Zn-coated were investigated in details. While only brief investigation of joints made with Sn-coated steel, Zn foil, and Cu foil interlayers was conducted. No joints were achieved with a bare Ni interlayer during Al to Mg alloy resistance spot welding, as coupons separated without applying any force. The Ni interlayer remained intact and Al-Mg intermetallic compounds did not form. Addition of Au coating on Ni surface greatly contributed to the metallurgical bonding at the interfaces and welds easily met requirements of the AWS D17.2 standard. Average lap-shear strength reached 90% of that in similar AZ31B resistance spot welds. Acceptable welds were also produced using galvanised Zn-coated steel interlayer, which easily met strength requirements of the AWS D17.2 standard. Average failure load reached 74% of same size similar AZ31B joints. The steel interlayer was not melted which prevented mixing of Al and Mg. The Zn coating on the steel interlayer was melted and squeezed to the nugget periphery, providing a clean steel surface for welding-brazing in the center and acting as a solder metal at the periphery. A feasibility study of Al/Mg RSW with Sn-coated steel, Zn foil and Cu foil interlayers was also conducted. Mechanical properties of welds made with Sn-coated steel interlayer were very similar to those made with Zn-coated steel interlayer. While welds made with only a Zn foil interlayer were much weaker. The Zn foil completely melted during the welding which resulted in formation of brittle Al-Mg-Zn phases. None of the welds made with Zn foil interlayer met requirements of the AWS D17.2 standard. RSW of Al to Mg with Cu foil interlayer also could not produce welds with acceptable strength.

Hydrochloric acid leaching of saprolite nickel ores has been proposed as an effective means of recovering nickel and cobalt. However, the leach produces a concentrated brine of magnesium chloride which must be hydrolyzed to recover the HCl lixiviant. The processing of carnallite similarly produces a concentrated MgCl2 brine; converting this brine into HCl and MgO provides an attractive way of adding value while effectively disposing of this waste product. Direct pyrohydrolysis of magnesium chloride brines by the reaction, MgCl2,a + H2Oa  MgOs + 2HClg is energy-intensive as large volumes of water must be evaporated. The energy cost is high, and the HCl stream produced is limited to approximately 20 wt% HCl. This thesis explores alternative methods of obtaining HCl from aqueous magnesium chloride solutions. Two methods are considered: the hydrolysis, under autogenous pressure, of concentrated MgCl2 molten salt hydrates; and the precipitation of magnesium hydroxychloride compounds such as 2MgO·MgCl2·6H2O and 3MgO·MgCl2·11H2O, which are subsequently decomposed at high temperature. Considerable experimental difficulties were encountered in studying pressure hydrolysis of molten salt hydrates, despite extensive equipment modifications. Ultimately, the work moved on to precipitation and decomposition of hydroxychlorides. This was found to bear promise, and conceptual flowsheets based on these reactions are presented. A phase stability diagram giving the areas of predominance of the different hydroxychloride phases is presented, and fundamental thermochemical data are derived. The results of a kinetic study on magnesium hydroxychloride thermal decomposition are also presented. / Thesis (Ph.D, Mining Engineering) -- Queen's University, 2011-03-11 10:14:53.455

No description available.

Magnesium sheet for automotive applications is very attractive due to its light weight. The poor formability of magnesium and its alloys at room temperature, however, has limited the applications of these alloys. For this reason, at present, magnesium must be formed at elevated temperatures. This study investigates the hot deformation and fracture characteristics of Mg-1wt% Zn alloys containing a range of Al and Mn levels. Hot-rolled specimens were tensile tested over a range of strain rates and temperatures. Strain rate versus flow stress diagrams plotted on log-log scales revealed a transition in deformation mechanisms as a change in slope (the 'stress exponent'). Specifically, non-uniform deformation (i.e. necking) is observed at high strain rates, while uniform deformation is observed at low rates. This transition is accompanied by a change in fracture mechanism from dimpled rupture at high strain rates to cavitation and cavity interlinkage at low strain rates. Specimens which had a stress exponent of ∼2 and which failed through uniform deformation showing interlinked cavities have been associated with the grain boundary sliding (GBS) deformation mechanism. Specimens which had a stress exponent of ~5 and which failed through necking showing a dimpled fracture surface have been associated with the dislocation creep deformation mechanism. Increasing aluminum appears to somewhat favour the GBS regime as indicated by a slightly decreasing stress exponent. Manganese also appears to favor the GBS regime, since the onset of cavitation appears at higher strain rates compared to alloys without Mn.

In the present study, dilute alloys in the Mg-rich corner of the Mg-Ce-In ternary system in the composition range 0 to 3% In and 0 to 1.5% Ce were synthesized. Cooling curve analysis was used to determine the liquidus points in order to construct the liquidus surface of the ternary phase diagram in the Mg corner. Energy dispersive spectroscopy (EDS), wavelength dispersive spectroscopy (WDS), and x-ray diffraction (XRD) techniques were used to examine phases present at the compositions studied. A thermal arrest presumed to represent a eutectic transformation was discovered at 580°C. Two new intermetallic compounds, designated tau and theta, were found. Trace silicon present in the alloys was found to concentrate in one of the intermetallic compounds. / To further investigate these compounds, an induction furnace was used to synthesize alloys containing the concentrations of Ce and In seen in electron probe micro-analysis (EPMA) examinations of these compounds. The alloys were examined using the cooling curve technique and XRD, and proved to contain the compounds already observed with some variation in dissolved indium content. In addition, differential scanning calorimetry (DSC) was used to confirm the liquidus and solidus values determined using cooling curve analysis. / A diffusion couple with terminal compositions of pure Ce and a Mg-In alloy was prepared in order to determine the equilibrium phases present in the system between these two compositions at 390°C. EPMA was used to identify the zones obtained, and confirmed the presence of several Mg-Ce compounds with 1 at% dissolved indium, as well as a ternary compound corresponding to the theta compound found in the dilute alloys. / Finally, literature values and experimental data were used to calculate a preliminary ternary phase diagram using FACTSage, in collaboration with the CTRC at Ecole Polytechnique, in order to affirm the validity of the experimentally determined values as well as to project the diagram beyond the studied composition range.