The purpose of these studies was to examine mediation and moderation processes for the influence of early adversity and current stressful circumstances on maternal sensitivity. Evidence of mediation was found in Study 1 where maternal depression and mothers’ negative appraisal of their infant mediated the influence of early adversity and low family income on maternal sensitivity. Study 1 also examined the influence of the neighborhood. A moderate-mediation model was tested where the mediating influence afore-stated was hypothesized to vary across levels of neighborhood quality. Partial evidence of moderation was found. In the context of a high quality neighborhood, mothers’ early adversity was not associated with maternal depression. Across levels of neighborhood quality, complex relationships emerged between the variables low family income, maternal depression and mothers’ appraisal of infant temperament. In a context of low neighborhood quality, there was no evidence of a direct association between low family income and maternal sensitivity, rather, low family income operated indirectly through maternal depression. In a context of high neighborhood quality, there was evidence for a direct and indirect association between low family income and maternal sensitivity. Study 2 examined associations between variation in the Arginine Vasopressin 1a receptor gene (AVPR1a) and maternal sensitivity, and whether variation in this gene moderated the influence of mothers’ early adversity on sensitivity. Mothers homozygous for the long alleles of the RS3 microsatellite were significantly less sensitive than mothers heterozygous for the long alleles and those homozygous for the short alleles. Homozygosity for the RS3 long alleles moderated the influence of mothers’ early adversity on their sensitivity; the influence of early adversity on maternal sensitivity was most pronounced for mothers with the RS3 long/long genotype. These results suggest that variation in the AVPR1a gene may be important not only for human maternal behavior, but also for stress reactivity.

The purpose of these studies was to examine mediation and moderation processes for the influence of early adversity and current stressful circumstances on maternal sensitivity. Evidence of mediation was found in Study 1 where maternal depression and mothers’ negative appraisal of their infant mediated the influence of early adversity and low family income on maternal sensitivity. Study 1 also examined the influence of the neighborhood. A moderate-mediation model was tested where the mediating influence afore-stated was hypothesized to vary across levels of neighborhood quality. Partial evidence of moderation was found. In the context of a high quality neighborhood, mothers’ early adversity was not associated with maternal depression. Across levels of neighborhood quality, complex relationships emerged between the variables low family income, maternal depression and mothers’ appraisal of infant temperament. In a context of low neighborhood quality, there was no evidence of a direct association between low family income and maternal sensitivity, rather, low family income operated indirectly through maternal depression. In a context of high neighborhood quality, there was evidence for a direct and indirect association between low family income and maternal sensitivity. Study 2 examined associations between variation in the Arginine Vasopressin 1a receptor gene (AVPR1a) and maternal sensitivity, and whether variation in this gene moderated the influence of mothers’ early adversity on sensitivity. Mothers homozygous for the long alleles of the RS3 microsatellite were significantly less sensitive than mothers heterozygous for the long alleles and those homozygous for the short alleles. Homozygosity for the RS3 long alleles moderated the influence of mothers’ early adversity on their sensitivity; the influence of early adversity on maternal sensitivity was most pronounced for mothers with the RS3 long/long genotype. These results suggest that variation in the AVPR1a gene may be important not only for human maternal behavior, but also for stress reactivity.

abstract: The development of self-regulation is believed to play a crucial role in predicting later psychopathology and is believed to begin in early childhood. The early postpartum period is particularly important in laying the groundwork for later self-regulation as infants' dispositional traits interact with caregivers' co-regulatory behaviors to produce the earliest forms of self-regulation. Moreover, although emerging literature suggests that infants' exposure to maternal stress even before birth may be integral in determining children's self-regulatory capacities, the complex pathways that characterize these developmental processes remain unclear. The current study considers the complex, transactional processes in a high-risk, Mexican American sample. Data were collected from 305 Mexican American infants and their mothers during prenatal, 6- and 12-week home interviews. Mother self-reports of stress were obtained prenatally between 34-37 weeks gestation. Mother reports of infant temperamental negativity and surgency were obtained at 6-weeks as were observed global ratings of maternal sensitivity during a structured peek-a-boo task. Microcoded ratings of infants' engagement orienting and self-comforting behaviors were obtained during the 12-week peek-a-boo task. Study findings suggest that self-comforting and orienting behaviors help to modulate infants' experiences of distress, and also that prenatal stress influences infants' engagement in each of those regulatory behaviors, both directly by influence tendencies to engage in orienting behaviors and indirectly by programming higher levels of infant negativity and surgency, both of which may confer risk for later regulatory disadvantage. Advancing our understandings about the nature of these developmental pathways could have significant implications for targets of early intervention in this high-risk population. / Dissertation/Thesis / M.A. Psychology 2013

Part 1 - Background: Maternal prenatal adversity often results in changes to the hypothalamic- pituitary-adrenal axis (HPA axis) function, such as greater cortisol secretion. Recent evidence suggests that fetal exposure to elevated cortisol levels may cause structural changes to key limbic regions integral to regulation of the HPA axis such as the amydala and hippocampus in children. In the early postnatal months these same structures are particularly vulnerable to the quality of maternal care and parenting styles. However, the relative impact and interaction of such factors is still underreported. Methods: 24 healthy 7-8 year old children (male:female=13:11) underwent an MRI. Amygdala and hippocampal volumes were assessed and used in multiple regression models to determine the impact of prenatal cortisol and postnatal maternal sensitivity. Results: Larger right hippocampal volumes were associated with increases in late gestation cortisol levels (4.6 mm3/nmol of cortisol; FDR corrected p<0.005). Increases in 6th month maternal sensitivity predicted a decrease in right hippocampal volumes at a trend level (FDR corrected p=0.09). There was no interaction effect between cortisol and sensitivity. There were no significant effects on left hippocampus or bilateral amygdala volumes. No sex differences were noted. Discussion: Given previous work we had expected greater amygdala volume and reduced hippocampal volumes to associate with increases in cortisol and decreases in sensitivity. Our results suggest that there may indeed be a programming effect on children’s hippocampi by prenatal cortisol. Findings may be reflective of a positive adaptive response or resilience to adverse prenatal environments. Part 2 - Introduction: Emotion regulation (ER) is an integral component to mental health. ER is thought to incorporate limbic as well prefrontal regions in several cognitive top-down circuits to utilize higher-order executive functions to adequately monitor and inhibit emotion when necessary. However, only recently has research targeted the developmental trajectories of these circuits from childhood. Methods: 29 healthy children aged 7-8 years (mean 7.34 ± 0.48) underwent functional magnetic resonance imaging (fMRI) with an implicit emotion go/nogo cognitive task to assess the developmental state and interaction between cognitive and emotional circuitry using functional connectivity (FC) in this age group. Results: Central executive networks (CEN) and salience networks (SN) showed more diffuse FC than mature networks, with greater inter-network connectivity. During exposure to fearful stimuli, there was greater connectivity within CEN and SN during go trials. Nogo trials were associated with more limbic-cognitive network interaction during concurrent exposure to fearful stimuli than neutral stimuli, Connectivity with the dACC was found to be common between limbic and CEN seeded networks. Discussion: Results indicate that cognitive networks are present but generally less mature than previous results from adult populations. Particularly, diffuse connectivity between the insula and PCC was negatively correlated indicating a developing switch between resting and salience networks. Additionally, greater connectivity for response inhibition tasks (nogo) during fearful stimuli exposure in the dACC, amygdala, anterior prefrontal, and DLPFC, suggests a maturing emotion regulation network, capable of managing cognitive tasks during emotional stimuli presentation. / Thesis / Master of Science (MSc)

The present study systematically reviewed and statistically summarized the current body of literature on the relationship between maternal health literacy and maternal sensitivity, and the effect of these two variables on mothers' care and decision making on distal attachment outcomes. In so doing, a systematic review of the extant peer-reviewed, published literature examining the effectiveness of interventions in effort to improve health literacy and maternal sensitivity, with a focus on increasing the quality of mother-preterm infant attachment outcomes, was undergone. This was followed by four multilevel random effects meta-analyses. Results indicated that mothers who participated in health literacy (maternal sensitivity) interventions had, on average, higher attachment quality, in comparison to those who did not participate. Additionally, maternal age was found to be a statistically significant predictor of the overall average effect size. This suggests that maternal health literacy may be a yet unexplored correlate of mother-preterm infant attachment outcomes.

Hur föräldrar samspelar med barn kan ha stor påverkan på barnets språkliga och kommunikativa utveckling. Föräldrasensitivitet och mind-mindedness är två mått som mäter föräldrars samspel. Föräldrasensitivitet mäter förälderns förmåga att uppfatta och tolka barnets signaler och mind-mindedness innefattar förälderns användande av ord som handlar om barnets mentala processer. Dessa mentaliseringsyttranden kan vara intonade eller icke-intonade utifrån situationen och barnets sinnesstämning. I vilken grad föräldrars mind-mindedness och föräldrasensitivitet påverkar olika delar av den kommunikativa utvecklingen är till stora delar fortfarande okänt. Syftet med föreliggande studie var att undersöka om föräldrasensitivitet och föräldrars mind-mindedness korrelerar med kommunikativa förmågor, om mind-mindedness och föräldrasensitivitet korrelerar med varandra samt om några könsskillnader förelåg. Materialet bestod av 35 inspelade förälder-barndyader som observerats när barnen var ca 16 månader. För att mäta föräldrasensitivitet användes lyhördhetsskalan ”Lyhördhet eller icke-lyhördhet för barnets signaler”. För att mäta mind-mindedness kodades förälder-barndyaderna samt föräldrabeskrivningar utifrån manualen för mind-mindedness av Meins och Fernyhough (2010). De kommunikativa förmågorna mättes dels genom the Swedish Early Communicative Development Inventories och dels genom the Early Social Communication Scales. Resultatet visade att det förelåg samband mellan föräldrasensitivitet och kommunikativa förmågor. Såväl språkförståelse, kommunikativa gester samt delad uppmärksamhet korrelerade med föräldrasensitivitet. Beträffande föräldrars mind-mindedness, konstaterades ett samband mellan en hög andel icke-intonade mentaliseringsyttranden och bristande förmåga till delad uppmärksamhet. Vidare framkom samband mellan mind-mindedness och föräldrasensitivitet: en förälder med hög föräldrasensitivitet använde fler intonade mentaliseringsyttranden än en förälder med låg föräldrasensitivitet. Ett motsvarande omvänt samband uppstod mellan icke-intonade mentaliseringsyttranden och en låg nivå av föräldrasensitivitet, där en icke-lyhörd förälder använde fler icke-intonade mentaliseringsyttranden. Slutligen upptäcktes en könsskillnad som innebar att föräldrar använder fler icke-intonade mentaliseringsyttranden till pojkar än till flickor. / The way a parent interacts with his or her child can have a great effect on communication and language development of the child. Maternal sensitivity and mind-mindedness are two measures used for parent-child interplay. Maternal sensitivity measures the parent’s ability to accurately perceive and interpret the child’s cues while mind-mindedness involves the parent’s use of words and comments regarding the child’s internal state. These comments can be classified as appropriate or non-attuned regarding the situation and the child’s state of mind. To what extent mind-mindedness and maternal sensitivity affect different parts of the child’s communicative development is still mainly unknown. The purpose of the present study was to investigate if maternal sensitivity and mind-mindedness co-vary with communicative abilities, if mind-mindedness and maternal sensitivity co-vary with each other, and finally, if any gender differences was present. The material of the study consisted of 35 videotaped parent-child interactions, which were observed when the children were 16 months of age. To measure maternal sensitivity, the sensitivity scale were used, “Sensitivity vs. Insensitivity to the Baby's Signals”. To measure mind-mindedness, parent-child interplay and parental interviews were coded. The child’s communicative abilities were assessed with the Swedish Early Communicative Development Inventories and with the Early Social Communication Scales. The result showed a correlation between maternal sensitivity and language comprehension, communicative gestures and joint attention. A relationship was found between mind-mindedness and parents’ using more non-attuned mental comments and children’s decreasing ability to respond to joint attention. The results also demonstrated that a sensitive parent uses more appropriate mental comments than a parent who was insensitive. A reversed relationship was found between non-attuned mental comments and a low level of maternal sensitivity, where the insensitive parent used more non-attuned mental comments. Finally, a difference in gender was found, where parents use more non-attuned comments to boys than to girls. / FAS dnr 2008-0875

Introduction. A mother’s verbal and non-verbal behaviour towards her infant is known as maternal responsiveness (MR). Positive MR is associated with better child social and emotional development (SED). A mother’s ability to accurately recognise emotions is thought to enhance MR. Method. Data from 1,122 mother-infant interactions from a longitudinal birth cohort study, was used firstly to examine whether positive MR at 12 months was associated with better child and adolescent SED, and secondly to explore whether better maternal facial and vocal expression recognition at 151 months was associated with positive MR and child SED. MR was measured using the Thorpe Interaction Measure (TIM) from observed mother-infant interactions and SED from questionnaire data adjusting for potential confounding variables. A test of facial expression recognition was used with vocal expression recognition additionally used in mothers. Results. Logistic regression revealed that positive MR was associated with positive SED outcomes in childhood but there was little effect in adolescence. Positive MR was associated with mothers having better facial and vocal expression recognition at 151 months and these recognition skills were associated with children showing less emotional problems at 158 months independent of MR. Adjustments for confounding variables had no effect on these results. Conclusion: These findings support the benefit of positive MR on a child’s SED in middle childhood. Further, the findings suggest that a mother’s facial and vocal expression recognition skills are important to both MR and a child’s SED. Limitations include subjective reporting of SED.

The interplay between child characteristics and parenting is increasingly implicated as crucial to child health outcomes. This study assessed the joint effects of children’s temperamental characteristics and maternal sensitivity on children’s weight status. Data from the National Institute of Child Health and Human Development’s Study of Early Child Care and Youth Development were utilized. Infant temperament, assessed at child’s age of 6 months by maternal report, was categorized into three types: easy, average, and difficult. Maternal sensitivity, assessed at child’s age of 6 months by observing maternal behaviors during mother-child semi-structured interaction, was categorized into two groups: sensitive and insensitive. Children’s height and weight were measured longitudinally from age 2 years to Grade 6, and body mass index (BMI) was calculated. BMI percentile was obtained based on the Centers for Disease Control and Prevention’s BMI charts. Children, who had a BMI ≥ the 85th percentile, were defined as overweight-or-obese. Generalized estimating equations were used to analyze the data. The proportions of children overweight-or-obese increased with age, 15.58% at 2 years old to 34.34% by Grade 6. The joint effects of children’s temperament and maternal sensitivity on a child’s body mass status depended on the child’s age. For instance, children with difficult temperament and insensitive mothers had significantly higher risks for being overweight-or-obese during the school age phase but not during early childhood. Specific combinations of child temperament and maternal sensitivity were associated with the development of obesity during childhood. Findings may hold implications for childhood obesity prevention/intervention programs targeting parents.

Made available in DSpace on 2016-04-04T18:29:25Z (GMT). No. of bitstreams: 1 Ana cristina Araujo do Nascimento 2.pdf: 1713143 bytes, checksum: 3e451b079fa0c587d1e4107b93d36ce0 (MD5) Previous issue date: 2006-02-01 / The work described the mother-infant interaction in the cases of cleft lip and palate under the perspective of the concepts of resilience and maternal sensitivity. The influence of four protection factors for the organization of resilient attributes involved in the facing process of the participants has been investigated: self-description, family integration and organization, social support and the relationship with the health team and with other parents with the same experience. The mother-infant interaction was evaluated according to the observation of indicative behaviors of maternal sensitivity. The research involved six mothers of infants with cleft lip and palate with ages from six months to one year and half. A semi-structured interview comprising twenty questions to evaluate resilient attributes besides a protocol of naturalistic observation of the mother-infant dyad named Maternal Behaviour Q-Sort has been applied. All data have been qualitatively analyzed using the procedures of the thematic analysis as well as a Grounded Theory. The results indicated that the protection factors influenced the presentation of favorable or non favorable attributes to infer the presence of the resilience. The facing process has been compound of the following phases: (prior phase) the ability from the participants to face the problems in general prior to the fissure; (1ST phase) the confront with the fissure; (2ND phase) the second contact with the baby; (3RD phase) the return to home; (4TH phase) the first surgery. For all the participants the mother-infant interaction has been characterized by indicative behaviors of maternal sensitivity. / O trabalho descreveu a intera??o m?e-beb? nos casos de fissura labiopalatina sob a perspectiva dos conceitos de resili?ncia e sensibilidade materna. Foi investigada a influ?ncia de quatro fatores de prote??o para organiza??o dos atributos resilientes no processo de enfrentamento das participantes: a autodescri??o, a integra??o e organiza??o familiar, o suporte social e o relacionamento com a equipe de sa?de e com outros pais com a mesma experi?ncia. A intera??o m?e-beb? foi avaliada segundo a observa??o de comportamentos indicadores da sensibilidade materna. A pesquisa envolveu seis m?es de crian?as com fissura labiopalatina, com idades entre seis meses a um ano e seis meses. Foi aplicada uma entrevista semi-estruturada, composta por vinte quest?es, para avalia??o dos atributos resilientes, al?m de um protocolo de observa??o natural?stica da d?ade m?e-beb?, denominado Maternal Behaviour Q-Sort. Os dados da entrevista foram analisados qualitativamente, utilizando procedimentos da an?lise tem?tica e da Grounded Theory. Os resultados indicaram que os fatores de prote??o influenciaram a manifesta??o de atributos favor?veis ou n?o favor?veis para inferir a presen?a da resili?ncia. O processo de enfrentamento das participantes foi composto pelas seguintes fases: (fase anterior) a habilidade das participantes para enfrentar os problemas em geral, anteriores a fissura; (1? fase) o confronto com a fissura labiopalatina; (2? fase) o segundo contato com o beb?; (3? fase) o retorno a casa; (4? fase) a realiza??o da primeira cirurgia. Para todas as participantes, a intera??o m?e-beb? caracterizou-se por comportamentos indicativos de sensibilidade materna.

The interplay between child characteristics and parenting is increasingly implicated as crucial to child health outcomes. Based on data from a national birth cohort, this study assessed the joint effects of children's temperamental characteristics and maternal sensitivity on the development of childhood obesity. Infant temperament, assessed by maternal report, was categorized into three types: easy, average, and difficult. Maternal sensitivity, assessed by observing maternal behaviors during mother-child semi-structured interaction, was categorized into two groups: sensitive and insensitive. Child's weight and height were measured longitudinally from age two years to Grade 6 and body mass index (BMI) was calculated. Obese (≥ the 95th percentile) and overweight-or-obese (≥ the 85th percentile) were defined based on sex and age specific BMI percentiles. Generalized estimating equations were used to analyze data. The proportions of children who were obese and overweight-or-obese increased as they got older, 5.47% and 15.58% at 2 years of age, to 18.78% and 34.34% at Grade 6. Children with easy temperament and under the care of a sensitive mother were at the lowest risks of obesity and overweight-or-obesity over childhood. The joint effects of children's temperament and maternal sensitivity on overweight-or-obesity largely depended on childhood phases. For instance, children with difficult temperament and under the care of an insensitive mother had much higher risks during school age but not during early childhood. In conclusion, parents may need to tailor their parenting strategies to particular child temperamental characteristics in order to prevent and control the development of childhood obesity.