In in low-and middle-income countries (LMIC), where there are very few trained physicians and nurses, community health workers (CHWs) are often the only providers of healthcare to millions of people. Such LMIC are countries that are classified, based on their geographic region and Gross National Income (GNI), as low-middle income by the World Bank Group, the worlds largest development bank. Research has shown digital health tools to be an effective strategy to improve the performance of frontline line health workers. The aim of this review was to systematically examine the literature on digital health tools that are used for decision support in LMIC and describe what we can learn from studies that have used these tools. As part of a larger parent study the following databases were searched: PubMed, Embase, Scopus, CINAHL, Global Health Ovid, Cochrane and Global Idex Medicus, to find ariticles in the following domains: training tools, decision support, data capture, commodity tracking, provider to provider communication, provider to patient communication and alerts, reminders, health information content. These domains were selected based on the World Health Organisation (WHO) framework for classifying digital health interventions. Content from all seven of these domains informed a series of reviews however this review focuses on how digital tools are used to provide decision support to FLHWs. Included studies were conducted in LMIC in Africa, Asia, North America and South America with the most common users of the tools being CHWs. Most tools for FLHW decision-support used in the interventions described in included articles were in either the pilot or prototype phases, and offered maternal and child health care services. Although decision support was the primary digital health function of all these studies, there was considerable variation in the number of digital health functions of each tool with most studies reporting decision support and data capture as their primary and secondary functions respectively. All the studies found their intervention to have beneficial effects on one or more of the following outcomes: beneficiary engagement, provider engagement, health effects and process/outputs. These findings show great potential for the use of decision support digital health tools as a means of improving the outcomes of health systems through; reducing the work load of FLHWs, reducing the costs of health care, improving the efficiency of service delivery and/or improving the overall quality of care.

Lack of access to drinking water remains widespread as 2.1 billion people live without safely managed service that includes improved water sources located on premises, available when needed, and free from contamination. Monitoring global access to drinking water is complex, yet essential, particularly in settings where households need to fetch water to meet their basic needs, as multiple factors that relate to accessibility, quantity and quality ought to be considered. The overall objective of this observational study is to increase knowledge surrounding monitoring and assessment of access to drinking water supply in low-and middle-income countries. The dissertation was comprised of five manuscripts which address the objective using various approaches including systematic review (manuscript 1), secondary data analysis (manuscript 2), and primary data analysis (manuscripts 3-5) to gather evidence towards improving access to drinking water. Primary data were collected through a seasonal cohort study conducted in Southern Malawi that included 375 households randomly selected in three different urban and rural sites. Methods used included structured questionnaires, observations, GPS-based measurements, and water quality testing. Findings from this study highlight the importance of conducting appropriate assessment of household behaviours in accessing drinking water in view of improving reliability of the indicators and methods used to monitor access to water. Seasonal variations that may affect water sources' reliability and household’s needs should be put forward to improve benefits of improving access to water and sustainable health outcomes. Further to target reliable and continuous availability from an improved water source at proximity to the household, interventions should aim to ensure safe quality of water at the point of use for mitigating the effect of post-collection contamination, and ensure sufficient quantities of water to allocate for personal and domestic hygiene. Focusing on the benefits of improving access to water at the point of consumption is essential to generate more realistic estimations, suitable interventions and appropriate responses to need. / Graduate

The World Health Organization (WHO) has forecast a global shortage of health workers by 2030, predominantly affecting low- and middle-income countries (LMICs). This sits in tension with the United Nations’ (UN) Sustainable Development Goal 3 (healthy lives and well-being) through universal health coverage (UHC). To address this problem, the WHO encourages task shifting, recruitment, training, and deployment of health workers. In lowand middle-income countries (LMICs), frontline health workers (FLHWs) are responsible for expanding the reach of the health system and providing crucial reproductive, maternal, newborn and child health (RMNCH) services. Adequate and appropriate training is fundamental to the success of FLHWs, particularly in contexts where their scope of work may evolve or expand over time. Digital health solutions (defined as the use of digital, mobile and wireless technologies to support the achievement of health objectives) are increasingly being used to support the training of FLHWs. Strategies may rely on use of digital tools, including mobile phones, as the primary modality for training or as tools which augment traditional face-to-face instruction. Digital health has potential for FLHW training as it allows for listening, learning and teaching through interactive health content accessible even on basic mobile phones. This dissertation explored the literature on FLHWs in LMICs, digital health in LMICs, digital health used by FLHWs, and digital health used for training of FLHWs in LMICs. The journal “ready” component is a systematic review which discusses the various aspects of digital training for FLHWs in LMICs. For the purposes of the systematic review, seven electronic databases were searched for articles published in English from 2008-2018. Combinations of medical subheadings (MeSH) that were used were: “mHealth”, “health worker”, “community health worker” and “low- and middle-income country”. From a total of 2628 identified studies, abstracts were screened with four filters to identify studies about “training”, and eventually a total of 16 studies were included. The included studies were critically appraised and coded descriptively to enable a narrative synthesis of findings. Of the sixteen studies, twelve used mobile and/or smartphones for FLHW training. A wide range of digital platforms were used to provide information (and where relevant enable interaction). Duration of training programs varied from five days to six months. Training content was relevant to the various health services and practice areas the FLHWs worked in. Training focused on continuing education through in-service training of new content or in-service refresher courses. Three training pedagogies were used: 1) didactic training techniques – in four studies information was provided passively without an interactive component; 2) interactive training techniques – six studies used platforms to provide information along with an interactive component via multi-media; and, 3) blended-learning approach – six studies delivered training via didactic and interactive approaches by combining live and distance training. Consistent with the literature review, all studies reported increased knowledge and positive perceptions of digital health for FLHW training. Interactive and blended learning approaches, especially when accessed through mHealth technologies, are feasible, effective, appropriate, cost effective and scalable in LMICs. The conclusion from the literature and systematic reviews were that long-term effects (e.g. change in behaviour, improved service provision) need to be researched further.

Abstract The human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) continue to be a major public health threat, not only within the United States but also on a global scale. Within the U.S. heterosexual population, African Americans (AAs) continue to bear the greatest burden of new HIV infections. Additionally, HIV/AIDS interventions have focused on low-income AA women, virtually ignoring their middle-class counterparts who may be subject to the same sexual risks. The purpose of this quantitative, cross-sectional study was to determine whether if there was an association between the 5 constructs of the Health Belief Model (HBM) and self-efficacy in condom use among middle-income AA women. One hundred and fifty two middleincome AA women were recruited through personal social media accounts and Survey Monkey to participate in this study. Multiple linear regression analyses indicated that 4 of the 5 constructs (i.e. perceived benefits, perceived barriers, cues to action, relationship self-efficacy) were predictors of self-efficacy in condom use, after controlling for age, income, education attainment, and marital status. There was no association between perceived threat and self-efficacy in consistent condom use. The results can inform HIV prevention counseling at the primary care level to reduce the spread of HIV among all AA women. Implications for positive social change include evidence for the need to expand the paradigm for HIV prevention interventions to include middle-income AA women and restructure HIV prevention strategies to address all women of color in the United States.

Background: Symptoms of depression and anxiety are highly prevalent amongst perinatal women in low-resource settings of South Africa, but there is no access to standardised counselling support for these conditions in public health facilities. The aim of this study was to report on the development of a maternal mental health counselling intervention for routine treatment of mild to moderate symptoms of depression and anxiety for primary healthcare in South Africa, as part of the Health Systems Strengthening in sub-Saharan Africa (ASSET) study. Methods: A four-phase study process informed the counselling intervention and training manual designed to train lay health workers. We first conducted a review of manuals from seven counselling interventions for depression and anxiety in low- and middle-income countries and two local health system training programmes to gather information on common counselling components used across maternal mental health and other evidence-based task-sharing interventions. Thereafter, semi-structured interviews were conducted with 20 health workers and 37 pregnant women from four Midwife Obstetric Units in Cape Town to explore mental health views and needs. In the third stage, multi-sector stakeholder engagements further informed the choice of intervention design and service provider. In the final phase, a four-day pre implementation pilot training with community-based health workers refined the counselling content and training material. Results: The manual review identified problem-solving, psychoeducation, basic counselling skills and behavioural activation as common counselling components across interventions. The interviews found that participants mostly identified symptoms of depression and anxiety in behavioural terms and lay health workers and pregnant women demonstrated their understanding through a range of contextual terms. Perceived causes of symptoms related to interpersonal conflict and challenging social circumstances. Stakeholder engagements identified a three session counselling model as most feasible for delivery as part of existing health care practices and community health workers in ward-based outreach teams as the best placed delivery agents. Pilot training of a three-session intervention with community-based health workers resulted in minor adaptations of the counselling assessment method. Conclusion: The study demonstrates how common therapeutic elements can be adapted to a local context and developed into an evidence-based manualised therapeutic programme while remaining sensitive to a health system's needs. While a problem-solving counselling approach, delivered in a structured format, was best suited for training lay health workers, input from health workers and perinatal mothers informed the manualised counselling content. The latter was a critical supplement to align the programme with contextual needs. Stakeholder engagements helped to align the intervention design to health system requirements and guidelines. Structured training practices and ongoing supervision of mental health workers are vital to develop counselling skills over time and to enhance personal support.

Childhood asthma is one of the most common chronic diseases worldwide, including in South Africa. There has been substantial evidence on the role of air pollution in asthma exacerbation but limited research on the role of climate change and how the interaction between climate change and air pollution is affecting childhood asthma, specifically in low and middle-income countries (LMICs). Temperature changes can be used as an effect of climate change to investigate the association between climate change, air pollution and childhood asthma. This study, therefore, used a case study approach aimed at examining the interaction between air pollution and temperature in exacerbating childhood asthma focusing on clinical data obtained from Red Cross War Memorial Children's Hospital, air quality data (City of Cape Town) and temperature data (South African Weather Services) for Cape Town, South Africa for three study years (2009, 2014 and 2019). The protocol (Part A) of the mini dissertation describes childhood asthma literature globally and in LMICs and specifically in South Africa. It also discusses the increasing incidences and prevalence of the disease and possible causes such as air pollution and climate change. Furthermore, it discusses the vulnerability of children to the exposure of interest, being air pollution (PM2.5, PM10, NO2 and O3) and climate change (i.e., temperature). Subsequently, the development of air quality standards is discussed, specifically concerning whether they consider the specific children's vulnerability to exposures. The protocol then describes the study population and methodologies for conducting this study. The journal ready article (Part B) presents the findings of the study. Spearman's correlation was used to measure the degree of association between temperature variables and air pollutants. The results indicated that diurnal temperature was associated with PM2.5 (r=0.579: p< 0.01) and PM10 (r=0.505: p< 0.01). A Poisson regression analysis was applied to evaluate the relationship between asthma exacerbation with air pollutants and temperature variables. In a univariate analysis there was a statistically significant relationship between asthma exacerbation and diurnal temperature for 2019, IRR=0.98 (95% CI,0.97 – 0.99) p< 0.05, maximum temperature 2014, IRR=0.99(95% CI, 0.98 - 1.00) p< 0.05 and for 2019, IRR=0.98(95% CI, 0.97 - 0.99) p< 0.01, average temperature 2014, IRR=0.99(95% CI, 0.98 - 1.00) p< 0.05 and for 2019, IRR=0.98(95% CI, 0.97 - 0.99) p< 0.01. Using a multivariate analysis there v of 110 was no significant relationship between childhood asthma exacerbation and air pollutants (PM10, NO2 and O3) except for PM2.5 IRR=0.12(95% CI, 0.01 - 0.81) p< 0.05. Diurnal temperature statistically significant childhood asthma predictor for 2009, IRR=1.02(95% CI, 1.00 - 1.05) p< 0.05 and for 2014, IRR=0.97(95% CI, 0.96 - 0.99) p< 0.01. Temperature increase, therefore, seems to be related to asthma exacerbation. More research is needed on the relationship between diurnal temperature, childhood asthma, and air pollutants to inform adaptation strategies. The findings of this study are important for the development of climate change and health adaptation and prevention strategies in South Africa, particularly in relation to heat adaptation. These findings are also relevant for the development of air quality guidelines and guidelines to address children, as the most vulnerable population to environmental health exposures. The appendices (Part C) present the analyses that were not included in the protocol (Part A) and article (Part B). These also include documents relating to the study such as ethics approval and permission to conduct research by different entities.

Background: Children require a nurturing environment to develop optimally and reach their full potential. A critical component of this environment is the health and well-being of caregivers so that they can provide responsive caregiving. It is believed that parents or caregivers of children with ASD will have poorer health and well-being than parents or caregivers of children without ASD. Therefore, parents of children with ASD may require more support to enable them to provide responsive caregiving to these children. Methods: This study was a quantitative study that employed an analytical, comparative design. The purpose of this study is to determine if there is a significant difference in the health and well-being of parents with children with ASD and parents of children without ASD in the South African context. Two hundred and eight participants from two schools in Kwa-Zulu Natal completed a paper-based survey containing 3 questionnaires relating to health-related quality of life; stress, anxiety and depression and parental self-efficacy. Parenting constructs such as stress, anxiety and parental self-efficacy are measured and described, and the association between Health-related Quality of Life and constructs such as stress, anxiety and parental self-efficacy is explored. It took place at a special needs school in KZN and mainstream school in the same district. Results: The results of this study demonstrated a poorer HRQOL in some of the areas of parents of a child with ASD compared to parents of a child without ASD. The results from this study demonstrate the importance for health practitioners to focus on the parents' health and well-being as part of the child's intervention. Conclusion: Intervention is mainly child-focussed however it is important for practitioners to understand the caregiver's health and well-being as this will have a positive influence of the child and in turn, lead to successful intervention. It is therefore important to have a family-centred approach. The QOL of the parents or caregivers of children with ASD will improve through support and intervention which will positively impact on the child's development. If the caregiver is receiving the appropriate support, their QOL will improve and they will be able to provide nurturing care that the child needs.

Purpose While epilepsy surgery has been shown to reduce seizure frequency and severity and even cures seizures in children with drug-resistant epilepsy, data from middle-income countries (MIC) are lacking. Method This study is a retrospective review of children with drug-resistant epilepsy who underwent surgical treatment at Red Cross War Memorial Children's Hospital (RCWMCH) between 1 January 2000 and 31 December 2021 (HREC: 140/2020). Results During the 21-year study period, 60 patients underwent epilepsy surgery for drugresistant epilepsy. The median age of the children was seven years (IQR 4.81-10.27years) at the time of surgery, with a male predominance of 33 patients. The most common surgical procedure performed was an anterior temporal lobectomy for temporal lobe epilepsy in 19 cases (31.7%), followed by peri-insular hemispherotomy in 9 cases (15.0%) and frontal lobectomy in 8 cases (13.3%). Of the 60 patients, complete records were available for 55 patients noting complications in 11 (20.0%), of which 4 cases (7.3%) had major complications. Notably, 2 patients (3.6%) had new-onset psychiatric symptoms. The long term outcomes after surgery showed 1-year seizure freedom in 32 patients (58.2%); among these, 21 patients (38.2%) could stop ASM one year after surgery, 17 patients (30.9%) had a recurrence of their seizures, and three had to restart ASM after 2-3 years. Eight patients (14.5%) required repeat surgery. The one-year-Modified Engel scoring for the study population was: 1-A in 52.7%, I-B in 3.6%, I-C in 1.8%, II-A in 15.8%, III-A in 10.9%, IV-A in 3.6% and IV-B in 10.9%. The most common histological finding in anterior temporal lobectomy (ATL) was focal cortical dysplasia (FCD), found in 11 patients (57.9%). The periinsular hemispherotomy (PIH) cases had equal numbers of FCD and Rasmussen's encephalitis in 4 patients (44.4%). The number of FCD in this series is much higher than in international data. Conclusion Epilepsy surgery is an effective and attainable intervention for drug-resistant epilepsy in the paediatric population despite limited resources and challenging aetiological profiles. Low complication rates were comparable to international data, with good seizure freedom outcomes.

Sustainable economic growth is vital to reduce poverty and a challenge to development. To aim and maintain a greater level of economic growth that will assist African countries in reducing poverty, they must investigate the specific determinants of economic growth. In this paper, we determine the impact of economic freedom, political freedom, and foreign direct investment on the gross domestic product. The gross domestic product was observed over a nine year-time period on a sample of 38 low-income and upper-income countries in Africa.

Systematic Review / Advancements in medicine have resulted in decreased neonatal mortality and morbidity associated with congenital anomalies (CA). Unfortunately, the advantages of these developments have been confined to high-income countries (HICs), demonstrated by the comparatively high incidence of congenital anomalies in low and low-middle-income countries (LLMICs). Evidence suggests that neonates in LLMICs encounter considerably more barriers to care than those in HICs due to a malfunctioning referral system and poorly implemented health policies that hinder the timely provision of care. As many CA are now accepted as surgically treatable, the purpose of this study was to understand what inhibits the success of a neonate from obtaining surgery in LLMICs and how that could be improved. Seven databases were searched in this systematic review to identify articles on neonates with surgically treatable CA. A total of 370 studies were identified for screening; 16 were included in the final analysis. Studies were screened and selected individually by two researchers based on the research question, and all disagreements were resolved jointly. Studies were reviewed for factors affecting the delivery of surgical treatment and were then coded as a barrier or a facilitator. Barriers to care were identified in every study, and suggested facilitators were offered by the authors, but these facilitators were not tested in the studies. This study contributes to the literature by providing additional detail on what is known about the surgical referral system in LLMICs. The study findings will inform policymakers and local governments of the realities faced by neonates and their caregivers while navigating through the surgical referral system and establish the need for alternate policy implementation strategies. / Thesis / Master of Science (MSc) / Congenital anomalies (CA) have been identified as a significant contributor to the global burden of disease, accounting for 25.3-38.8 million disability-adjusted life-years worldwide. Many CA have been classified as surgically treatable however, approximately 295,000 neonates die annually due to these conditions. As 94% of CA occur in low- and low- middle-income countries (LLMICs), this study aims to elucidate any barriers and facilitators that may influence accessing surgical treatment. A systematic review has been selected to synthesize the literature regarding what is known about accessing surgery for neonates with CA in LLMICs.