The Gulf of Finland is the most eutrophied water body in the Baltic Sea, which is mainly caused by nutrient loads produced by human activities in its surrounding cities. In order to solve this environmental problem, a computational model based on the understanding the relations between eutrophication, water quality and sediments is needed to forecast the water quality variance in response to the natural and anthropogenic influences. A precise water quality model can be useful to assist the policy making in the Gulf of Finland, and even for the whole Baltic Sea. Kiirikki model, as one of these models describing the water quality of Baltic Sea in response of water quality variance, is a sediment and ecosystem based model, treating different sub-basins and layers as boxes. This study aims to assess the parameters’ sensitivity level on the scale of the Gulf of Finland. Firstly, the Morris sampling strategy is applied to generate economic OAT (One factor At a Time) samples before screening 50 out of 100 trajectories with distance as large as possible. In order to assess their sensitivity, index and indicator are needed. EE (elementary effect) is adopted to be the assessment index and four core eutrophication indicators from HELCOM 2009a are to be analyzed. By comparing the (σ,μ) and (σ,μ*) plots of each parameters’ EE values (σ is standard deviation, μ is mean value and μ* is the absolute mean value), some parameters are identified as potential sensitive parameter, such as the minimum biomass of cyanobacteria (Cmin), critical point of CO2 flux (CCr), the optimal temperature for detritus phosphorous mineralization (Toptgamma), maximum loss rate of algae (RAmax), optimal temperature for the growth of other algae (ToptmuA), Coefficient for temperature limiting factor for the growth of cyanobacteria (aTmuC), half-saturation coefficient of radiation for cyanobacteria (KIC) and so on. In contrast, the other parameters are ruled out as having very low values in terms of σ, μ and μ*. This is because the feature of Morris sampling strategy makes it easier to achieve high variance of the outputs, resulting into generally higher σ. Therefore, further investigation with different strategies is needed after the initial screening of the non-sensitive parameters in this study.

Two groups of male and female rats were given the same dose of alcohol using an artificial rearing procedure on postnatal days 4-10. One group received the alcohol in a condensed manner each day which caused cyclic blood alcohol concentrations (BACs) with high peaks. A second group received the alcohol in a uniform manner over each day which resulted in moderate, stable BACs. Two control groups consisted of male and female rats artificially reared but not exposed to alcohol and rats reared normally by dams. All rats were raised to 90 days of age and then tested for spatial navigation ability in the Morris water maze, which involved locating a hidden underwater platform using distal extramaze cues. Neither the alcohol treatments nor the artificial rearing had any effects on performance of adult male rats relative to suckle controls in this task. In contrast, the condensed alcohol exposure but not the uniform alcohol exposure resulted in detrimental performance in the Morris water maze by adult female rats. When the ability to locate and escape onto a visible platform was examined, there were no differences between the female groups given condensed alcohol exposure or artificially reared on milk solution alone. Thus, exposure to high BACs during the brain growth spurt has a lasting and selective detrimental effect on spatial navigation learning in adult female but not adult male rats.

The present study investigated the effects of forced overexpression of Phox2a/2b, two transcription factors, in the locus coeruleus (LC) of aged rats on noradrenergic and dopaminergic phenotypes in brains. Results showed that a significant increase in Phox2a/2b mRNA levels in the LC region was paralleled by marked enhancement in expression of DBH and TH per se. Furthermore, similar increases in TH protein levels were observed in the substantial nigra and striatum, as well as in the hippocampus and frontal cortex. Overexpression of Phox2 genes also significantly increased BrdU-positive cells in the hippocampal dentate gyrus and NE levels in the striatum. Moreover, this manipulation significantly improved the cognition behavior. The in vitro experiments revealed that norepinephrine treatments may increase the transcription of TH gene through the epigenetic action on the TH promoter. The results indicate that Phox2 genes may play an important role in improving the function of the noradrenergic and dopaminergic neurons in aged animals, and regulation of Phox2 gene expression may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

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The output of the diploma thesis is a functional prototype of a recliner chair 1:1. In the first part of the text, the author deals with history of seating furniture with emphasis on Morris type chairs. The next part includes contemporary ergonomic and anthropometric requirement, after which the author follows with safety issues and applicable standards. In the practical part, she describes the design and production of the relaxing chair. This text is accompanied by numerous illustrations and photos taken during the prototyping for easier orientation and understanding of the author´s proceedings.

Gouverneur Morris had an influence on the foreign policy of the Washington administration. This thesis will be focusing Morris' career as foreign minister to France. Morris served as the American minister to France during the French Revolution and reported to the Washington Administration on the events that transpired during that event. This thesis intends to show what impact Gouverneur Morris had in keeping the Washington administration neutral during this tumultuous time from his own point of view and various others with whom he corresponded with during his time as minister, most notably, George Washington. Morris' private diaries and letters will be used to show the information that Morris was relaying to Washington during the revolution. Along with this, Washington's diaries and letters will show how that information influenced his decision on how to pursue a foreign policy in regards to Europe, in particular France.

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<p>Low back pain (LBP) is a common musculoskeletal condition that can lead to pain, functional limitations and disability. Due to the prevalence of LBP, multiple self-reported outcome measures have been developed, which have resulted in redundancy in the literature. Two frequently used outcome measures are the Roland Morris Questionnaire (RMQ) and the Oswestry Disability Index (ODI). Few authors have performed head-to-head comparison studies to determine which of these outcome measures are the most successful at measuring sensitivity to change. The purpose of this thesis was to answer the question: Is there a difference in the sensitivity to change between the RMQ and the ODI in their ability to measure pain-related functional status in persons with low back pain?</p> <p>The first part of this thesis involves a systematic review of head-to-head comparison studies to determine the difference in the sensitivity to change of the RMQ and the ODI. Five databases were searched and nine articles were located. The second part of this thesis entails the development of a quality criteria form to evaluate head-to-head comparison studies.</p> <p>The third aspect of this research was to perform a head-to-head comparison study of the RMQ and the ODI using data from the nine studies. A small but significant difference was noted in favour of the RMQ in terms of the Spearman rank correlation coefficient between its change scores and the reference standard (Z = 2.36, p = 0.018; Z = 3.28, p = 0.001) and also in the Receiver Operating Characteristic curve area (<em>X</em>²₁ = 8.58, p = 0.003).</p> / Master of Science Rehabilitation Science (MSc)