Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. / Made available in DSpace on 2012-10-17T03:44:01Z (GMT). No. of bitstreams: 0Bitstream added on 2016-01-09T00:58:17Z : No. of bitstreams: 1 137998.pdf: 8432638 bytes, checksum: 2bb86ce73aabd0d2e0113d9742df1ff2 (MD5)

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. / Made available in DSpace on 2012-10-17T11:25:06Z (GMT). No. of bitstreams: 0Bitstream added on 2014-09-25T19:23:29Z : No. of bitstreams: 1 170772.pdf: 26079015 bytes, checksum: a154cdfd6e3ac68d288102be21a4bfba (MD5) / Estudo sobre motivação no trabalho dos oficiais subalternos da 6.ª Brigada de Infantaria Blindada e Hospital da Guarnição de Santa Maria. A população em estudo foi composta de um censo de 88 oficiais subalternos. Concluiu-se que a possibilidade de auto-realização profissional, conhecimento das políticas do Exército e da Organização Militar e o relacionamento geral, nesta ordem, são os principais fatores motivacionais presentes no trabalho dos oficiais em estudo.

Submitted by Beatriz_ Estagiaria (marcianb@ig.com.br) on 2012-04-09T19:31:43Z No. of bitstreams: 1 000016482.pdf: 2708546 bytes, checksum: f6375101f3fd51cdba2772cf10679a96 (MD5) / Made available in DSpace on 2012-04-09T19:31:54Z (GMT). No. of bitstreams: 1 000016482.pdf: 2708546 bytes, checksum: f6375101f3fd51cdba2772cf10679a96 (MD5) / This study has been designed in order to assess a) Motivation level, based on Maslow and Herzberg concepts, and b) Conformity and tencency to order and meticulous-ness, as defined by Comrey in two groups composed of individuals doing routine work and individuals doing non-routine work, respectively. It has been our purpose to prove that the individuals doing routine work tend to be motivated in a inferior level (hygiene seekers), while the individuals doing non-routine work tend to be 'motivated in a superior level (motivation seekers) besides they are less conformistic, orderly and meticulous than the first ones. The results has allowed to conc1ude that, supposed, in our groups, as 1) there was significantly more 'hygiene seekers' than 'motivation seekers' among individuals doing routine work and there was significantly more 'motivation seekers' than 'hygiene seekers' among individuals doing non-routine work. 2) Individuals doing routine work tended to be significantly more motivated by safety needs in comparison with individuals doing non-routine work who tended to be significantly more motivated by self-actualization needs. 3) The conformity and the tendency to order and meticulousness appeared significantly in a higher degree among individuals doing routine work. / Este estudo intentou pesquisar: a) o nível de motivação, baseado em Maslow e Herzberg e b) o conformismo e a tendência à ordem e à meticulosidade, como são definidos por Comrey, em dois grupos compostos por indivíduos que fazem trabalho rotineiro e indivíduos que fazem trabalho não-rotineiro, respectivamente. Nosso propósito foi comprovar que os indivíduos que fazem trabalho rotineiro tendem à ser motivados em nível inferior (hygiene seekers), enquanto que os indivíduos que fazem trabalho não-rotineiro tendem a ser motivados em nível superior (motivation seekers) além do que são menos conformistas, ordeiros e meticulosos que os primeiros. Os resultados permitiram concluir que, como foi suposto, em nossos grupos: 1) Houve significativamente mais 'hygiene seekers' que 'motivation seekers' entre os indivíduos que fazem trabalho rotineiro e significativamente mais 'motivation seekers' que 'hygiene seekers' entre os individuos que fazem trabalho não-rotineiro. 2) Os indivíduos que fazem trabalho rotineiro tenderam a ser significativamente mais motivados por necessidades de segurança em comparação com os indivíduos que fazem trabalho não rotineiro, que tenderam a ser significativamente mais motivados por necessidades de auto-realização. 3) O conformismo e a tendência à ordem e à meticulosidade apareceram significativamente mais entre os indivíduos que fazem trabalho rotineiro.

ANDRADE, Marta Maria Santos de Jesus. Programas de participação nos lucros e resultados - Lei n. 10.101/2000 e comprometimento funcional em indústrias baianas de fertilizantes. 2007 231f. ; Dissertação (mestrado) - Universidade Federal do Ceará, Faculdade de Economia, Administração, Atuária, Contabilidade e Secretariado, Fortaleza-CE, 2007. / Submitted by Dioneide Barros (dioneidebarros@gmail.com) on 2016-03-02T13:40:37Z No. of bitstreams: 1 2007_dis_mmsjandrade.pdf: 1252810 bytes, checksum: cad5fce7390885520bfabb8559b537b6 (MD5) / Approved for entry into archive by Dioneide Barros(dioneidebarros@gmail.com) on 2016-03-09T14:22:54Z (GMT) No. of bitstreams: 1 2007_dis_mmsjandrade.pdf: 1252810 bytes, checksum: cad5fce7390885520bfabb8559b537b6 (MD5) / Made available in DSpace on 2016-03-09T14:22:54Z (GMT). No. of bitstreams: 1 2007_dis_mmsjandrade.pdf: 1252810 bytes, checksum: cad5fce7390885520bfabb8559b537b6 (MD5) Previous issue date: 2007 / The objective of the present research is to evaluate the relative importance of the Program of Participation in Profits and Results (PPLR) – Law number 10.101, for the commitment of employees in comparison with other factors of functional commitment. Exploratory and descriptive research was conducted, through case studies, with the use of a questionnaire middle structured questionnaire and an interview by topic with managers of PPLR and employees of the administrative, commercial, and operational areas of two large fertilizer companies in Bahia. The research involved two managers and seventy nine employees. The results were analyzed quantitatively and qualitatively. The research allowed to confirm that in spite of the importance of the PPLR for organizational strategies and objectives, there was no agreement between the companies in what it concerns to the prevalence of the Program when related to factors of affective, normative compromising and other calculatives related in the study. It is suggested that several aspects compete for the dissonance among the case studies researched, as the geographical location, demographic subjects and the style of the administration. / A presente pesquisa tem como objetivo avaliar a importância relativa do Programa de Participação nos Lucros e Resultados (PPLR) – Lei no. 10.101, para o comprometimento dos empregados em comparação com outros fatores de comprometimento funcional. Realizou-se uma pesquisa exploratória e descritiva, por meio de estudo de caso múltiplo, com a aplicação de um questionário semiestruturado e uma entrevista por pauta, junto a gestores dos PPLR e empregados das áreas administrativa, comercial e operacional de duas grandes empresas de fertilizantes da Bahia. A pesquisa envolveu dois gestores e setenta e nove empregados. Os dados foram tratados quantitativa e qualitativamente. A pesquisa permitiu constatar que, apesar da importância dos PPLR para as estratégias e objetivos organizacionais, não houve consenso entre as empresas pesquisadas no que concerne à prevalência do Programa quando relacionado com fatores de comprometimento afetivos, normativos e demais calculativos relacionados no estudo. Sugere-se que vários aspectos concorrem para a dissonância entre os estudos de caso pesquisados, como a localização geográfica, questões demográficas e o estilo da gestão.

Dissertação (mestrado)-Universidade de São Paulo, Faculdade de Economia e Administração / Made available in DSpace on 2013-07-15T20:43:51Z (GMT). No. of bitstreams: 0

Uma tecnologia importante para reduzir a quantidade de poluentes atmosféricos lançados na atmosfera, é a utilização de catalisadores, que convertem os gases altamente poluentes como o NO, para outros gases inofensivos ao meio ambiente. Neste trabalho, os óxidos do tipo perovskitas La2CuO4, LaNiO3, LaMnO3, La1,4Sr0,6CuO4, La0,7Sr0,3NiO3 e La0,7Sr0,3MnO3 foram preparados através do método da co-precipitação, caracterizados por difração de raios-X, redução a temperatura programada, fisissorção de nitrogênio e análise química, e, posteriormente avaliados frente as reações de redução de NO com CO, e decomposição direta de NO. Ambas as reações foram testadas nas temperaturas de 400oC e 500oC e o tempo de reação foi de 7 à 10 horas. Através dos ensaios catalíticos verificou-se que o catalisador La2CuO4 apresentou a maior atividade para a reação de redução, e quando substituiu-se parcialmente o lantânio pelo estrôncio, houve uma melhora significativa para todos os catalisadores. As análises de DRX indicaram que, mesmo após os ensaios catalíticos, a estrutura cristalina dos catalisadores foi preservada. / A important technology to reduce the atmospheric pollution is the use of catalysts, to transform high pollutant as NO in other inoffensive gases to the environment. In this work, the perovskite oxides La2CuO4, LaNiO3, LaMnO3, La1,4Sr0,6CuO4, La0,7Sr0,3NiO3 e La0,7Sr0,3MnO3 were prepared through co-precipitation method and characterized by X-ray diffraction and temperature programmed reduction, nitrogen physsisorption and subsequent valued on the reduction of NO by CO and the direct decomposition of NO. These reaction were tested at 400oC and 500oC temperatures and times of reaction between 7 and 10 hours. Through the catalytic tests the La2CuO4 catalyst shown the best activity to the reduce reaction, and when the La is partially substituted by strontium all the catalyst showed a better significant for all the catalysts. The XRD analysis shown that the catalytic structure of the catalysts were preserved after the catalytic test yet.

Le monoxyde d'azote (NO) est une molécule produite par l'ensemble des cellules des voies aériennes. Sa synthèse à partir de la L-arginine fait appel à un groupe d'enzymes : les NO synthases (NOS). Il existe trois isoformes de NOS exprimées par des cellules ayant des fonctions diverses conférant ainsi au NO produit une spécificité d'action dépendante de la cellule et de la « situation » ayant entraîné sa synthèse. Les travaux effectués dans le cadre de cette thèse explorent des rôles différents (bronchoréactivité, immunitaires) du NO produit par les voies aériennes ainsi que la mesure du NO dans le contexte de l'anesthésie – réanimation. L'objectif du premier travail était de « revisiter » la fonction régulatrice du tonus bronchique dans le cadre d'une pathologie respiratoire, l'objectif du second travail était méthodologique (étude des sources anatomiques du NO expiré chez le patient sous ventilation mécanique), et l'objectif du troisième travail était d'utiliser la mesure validée dans le second travail pour évaluer les fonctions immunes du NO en réanimation.Premier travail. La compétition entre les NO synthases et les arginases pour leur substrat commun, la L-arginine, pourrait être impliquée dans régulation de la réactivité et du remodelage bronchique chez le patient atteint de BPCO. Le but du premier travail était d'évaluer la relation entre expression de cette balance enzymatique, et les effets pharmacologiques de l'inhibition des NOS et des arginases sur la réactivité bronchique ex vivo à l'acétylcholine de patients sans et avec une BPCO peu sévère. Pour cela, nous avons étudié les bronches de 22 patients. Des études immunohistochimiques nous ont permis de mettre en évidence une expression bronchique NOS-2 plus importante chez les patients BPCO comparée aux patients non BPCO. De plus, les études pharmacologiques réalisées en cuve à organe ont permis de mettre en évidence une tension bronchique de base plus importante chez les BPCO, corrélée à l'expression de la NOS-2 et au degré d'obstruction bronchique (VEMS). L'utilisation d'inhibiteur des NOS diminuait cette tension de base. Nous avons démontré ainsi qu'une augmentation de l'expression NOS-2 chez le BPCO était impliquée dans l'augmentation du tonus bronchique de base et dans l'obstruction bronchique.Second travail. Les variations de NO expiré après chirurgie cardiaque avec circulation extracorporelle (CEC) demeurent controversées. Le but de ce deuxième travail était de déterminer quelle source de NO expiré (bronchique ou alvéolaire) était modifiée après CEC, et d'étudier les effets de la ventilation mécanique pendant la CEC sur ces variations. Nous avons étudié ainsi 32 patients ventilés ou non durant une chirurgie cardiaque avec CEC. Nous avons observé une diminution significative du NO expiré d'origine bronchique après la CEC. Cette diminution n'était pas observée lors du maintien durant la CEC d'une ventilation avec pression expiratoire positive (PEEP). Ce travaille permettait de conclure que la diminution du NO bronchique après la CEC pouvait être liée à une occlusion des petites voies aériennes. Cette atteinte de petites voies aériennes était prévenue par la PEEP.Troisième travail. Enfin, dans ce troisième travail, nous avons émis l'hypothèse que la mesure du NO produit par les voies aériennes (NO expiré et nasal) pouvait constituer un marqueur prédictif de survenue d'infection nosocomiale (fonctions immunitaires du NO). Dans une étude observationnelle chez 45 patients de réanimation ventilés (15 patients ont développé une infection nosocomiale), le NO nasal était le seul marqueur significativement plus bas chez les patients développant une infection nosocomiale (le NO expiré, les dosages d'IL6 et d'IL10 ainsi que le score SOFA n'étaient pas différents entre les deux groupes). Un NO nasal inférieur à 148 ppb 72 heures après l'admission du patient, permettait de prédire la survenue d'une infection nosocomiale avec une sensibilité et une spécificité de 80% et de 70% respectivement et un odds ratio de 2.7. Le développement de ce bio marqueur simple à mesurer permettrait de mettre en place des stratégies préventives (immunonutrition avec de la L-arginine). / In the respiratory tract, NO is produced by a wide variety of cell types and is generated via oxidation of l-arginine that is catalyzed by the enzyme NO synthase (NOS). NOS exists in three distinct isoforms: neuronal NOS (NOS-1), inducible NOS (NOS-2), and endothelial NOS (NOS-3). NO derived from the constitutive isoforms of NOS (NOS-1 and NOS-3) and other NO-adduct molecules (nitrosothiols) have been shown to be modulators of bronchomotor tone. On the other hand, NO derived from NOS-2 seems to be a proinflammatory mediator with immunomodulatory effects. This thesis explores the physiological and pathophysiological role of endogenous nitric oxide in the airways, and the clinical aspects of monitoring nitric oxide in exhaled air of patients with respiratory disease.First Study: competition between nitric oxide synthases (NOSs) and arginases for their common substrate l-arginine could be involved in the regulation of cholinergic airway reactivity and subsequent airway remodeling. The aims of this study were to evaluate the relationships between the expression of this enzymatic balance and the effects of NOS and arginase inhibition on bronchoconstrictive response to acetylcholine of patients without and with early chronic obstructive pulmonary disease (COPD). Twenty-two human bronchi were investigated for immunohistochemistry and modulation of acetylcholine-induced airway constriction. Significantly increased expression of NOS2 in immunoblots of bronchial tissue and staining in smooth muscle cells was evidenced in patients with COPD compared with control subjects. Forced expiratory volume in 1 s (FEV1) and NOS2 expression were negatively correlated. Pharmacological experiments demonstrated that resting tension was elevated in COPD compared with control subjects and was positively correlated with the expression of NOS2. The sole effect of the specific arginase inhibitor Nomega-hydroxy-nor-L-arginine was to decrease sensitivity in COPD patients, whereas NG-nitro-L-arginine methyl ester unexpectedly decreased resting tension because of a non-cGMP-dependent effect. In conclusion, an upregulation of NOS2 expression in COPD patients is involved in airway tone regulation and functional airflow limitation, whereas increased arginase activity is involved in airway sensitivity.Second Study: the change in exhaled NO after cardio-pulmonary bypass remains controversial. The aims were to determine whether exhaled NO sources (alveolar or bronchial) are modified after bypass, and whether mechanical ventilation (MV) settings during bypass modify exhaled NO changes. Thirty-two patients were divided into three groups: without MV during bypass and positive end-expiratory pressure (PEEP) (n=12), dead space MV without PEEP (n=10) and dead space MV with PEEP (n=10). Alveolar NO concentration and bronchial NO flux were calculated before and 1h after surgery using a two-compartment model of NO exchange developed in spontaneous breathing patients. Whereas a significant decrease in bronchial NO was found after bypass in the two groups without PEEP during bypass, this decrease was not observed in patients with dead space ventilation with PEEP. Alveolar NO was not significantly modified whatever the ventilation settings. In conclusion, the impairment of bronchial NO seemed related to airway closure since dead space mechanical ventilation with PEEP prevented its decrease.Third Study: the development of biomarkers able to predict the occurrence of nosocomial infection could help manage preventive strategies, especially in medical patients whose degree of acquired immunosuppression may be variable. We hypothesized that the NO fraction present in the airways (upper and lower) of critically ill patients under mechanical ventilation could constitute such a biomarker. We conducted an observational study in a medical intensive care unit. Forty-five patients (26 men; 72 [25th-75th percentiles] years [56-82]; Simplified Acute Physiology Score II, 63 [50-81], 14 infected) under mechanical ventilation (>3 days) underwent on day 1 and day 3 of their stay: nasal and exhaled (partitioned in bronchial and alveolar sources) bedside NO measurements, determination of urine NO end products and plasma cytokine (IL-6, IL-10) concentrations, and Sequential Organ Failure Assessment score calculation. Nosocomial infection incidence was recorded during the 15 subsequent days. Fifteen patients (33%) acquired a nosocomial infection. Nasal NO was the only marker significantly different between patients with and without subsequent infection (day 1, 52 ppb [20-142] vs. 134 [84-203], P = 0.038; day 3, 98 ppb [22-140] vs. 225 [89-288], P = 0.006, respectively). Nasal NO fraction 148 ppb or less at day 3 had an 80% sensitivity, a 70% specificity, and an odds ratio of 2.7 (95% confidence interval, 1.9-3.8) to predict acquisition of nosocomial infection. Nasal NO seems to be a relatively sensitive and specific biomarker of subsequent nosocomial infection acquisition.

Trabajo de Investigación Requisito para optar al Título de Cirujano Dentista / Autor no autoriza el acceso a texto completo de su documento / Los AINEs son los fármacos más utilizados por los odontólogos para obtener un control del dolor e inflamación. Estos fármacos están formados por dos isomeros, uno R(-) y uno S(+), en una proporción del 50 % cada uno. Se ha demostrado que la actividad terapéutica de estos fármacos reside en el isomero S(+), por lo que, la tendencia actual esta orientada al reemplazo de los fármacos racémicos por sus formas enantioméricamente puras, con el fin de obtener ventajas como la reducción de la dosis del fármaco necesaria para alcanzar un efecto terapéutico determinado e incrementar la potencia y seguridad del fármaco. Dentro de estos nuevos fármacos se encuentra el dexketoprofeno, que es el isomero S(+) del ketoprofeno. En el presente trabajo se estudió la actividad antinociceptiva de ketoprofeno y dexketoprofeno, administrados individualmente y coadministrados en distintas combinaciones de sus dosis efectivas 25 y 50, en el test de las contorsiones abdominales inducidas por una solución de ácido acético al 0.6 %. Se demostró que ambos fármacos poseen actividad antinociceptiva dosis-dependiente, sin embargo dexketoprofeno posee una potencia relativa 5 veces mayor que el ketoprofeno racémico. Posteriormente se determino, por medio de análisis isobolográfico, que los fármacos en estudio al ser coadministrados presentan una interacción de tipo sinérgica o supraaditiva.

Trabajo de Investigación Requisito para optar al Título de Cirujano Dentista / Los fármacos más prescritos para el control del dolor son los antiinflamatorios no esteroidales, moléculas que poseen diferentes estructuras químicas, pero que tienen un mecanismo de acción y efectos adversos comunes. Con el fin de contrarrestarlos, se han desarrollado combinaciones de fármacos que permitan aumentar los efectos analgésicos y disminuir las reacciones adversas. En el presente trabajo se investigó la actividad antinociceptiva e interacción de dexketoprofeno y meloxicam, mediante el ensayo algesiométrico de la formalina en la pata. Se utilizaron ratones, a los cuales se les inyectó en una de las patas traseras, en forma subcutánea, 20 L de solución de formalina al 5%, midiéndose luego el tiempo de lamido de la pata inyectada, durante los 5 minutos inmediatos a la inyección, correspondiente a una primera fase (fase I o algesica aguda), y desde los 20 minutos hasta los 30 minutos post-inyección, período que corresponde a la segunda fase (fase II o inflamatoria). La administración intraperitoneal previa de 10 mg/kg de dexketoprofeno o de meloxicam, demostró tener efecto analgésico en ambas fases, así también la mezcla de los dos fármacos. El pretratamiento de los animales con naltrexona aumenta la acción de la mezcla en ambas fases, probablemente por un efecto sinérgico inducido por la inhibición presináptica de la inhibición de la liberación de péptidos analgésicos que ejerce el antagonista opioide, sin embargo la vía NO-GMPc carece de actividad modulatoria en la acción de los AINEs, demostrada por el pretratamiento con L-NAME.

En el Presente trabajo se estudia el Problema Dual Minimáx; con el objeto de posibilitar el desarrollo del tema en referencia, se ha agrupado el presente trabajo en 4 Capítulos. En el Capitulo l, se establecen conceptos y propiedades matemáticas funda-mentales, En el Capitulo 2. se ·presentan algunos teoremas: básicos de la Programación Matemática con sus respectivas demostraciones, En el Capitulo 3, se define el concepto de Programa Matemático No Lineal y se desarrollan las condiciones de optimización de Kuhn-Tucker, así Como otros teoremas, los cuales permiten caracterizar la solución óptima del problema de Programación No Lineal. En el Capítulo 4. se define, el Dual Minimáx y se desarrollan sus propiedades con respecto del Programa Primal; el desarrollo de los temas de interés viene acompañado de sus respectivos ejemplos, lo cual hace fácil la comprensión de los mismos.